Department of Pediatrics / Michmerhuizen Lab / Publications

Publications

1. Umeda M
2. Hiltenbrand R
3. Michmerhuizen NL
4. Barajas JM
5. Thomas Iii ME
6. Arthur B
7. Walsh MP
8. Song G
9. Ma J
10. Westover T
11. Kumar A
12. Pölönen P
13. Mecucci C
14. Di Giacomo D
15. Locatelli F
16. Masetti R
17. Bertuccio SN
18. Pigazzi M
19. Pruett-Miller SM
20. Pounds S
21. Rubnitz J
22. Inaba H
23. Papadopoulos KP
24. Wick MJ
25. Iacobucci I
26. Mullighan CG
27. Klco JM
Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia.; Blood; Vol 146(17), pp. 2102-2118. 2025 Oct 23.
1. Michmerhuizen NL
2. Heikamp EB
3. Iacobucci I
4. Umeda M
5. Arthur B
6. Mishra V
7. Park CS
8. Di Giacomo D
9. Hiltenbrand R
10. Gao Q
11. Radko-Juettner S
12. Lott J
13. Martucci C
14. Subramanyam V
15. Hatton C
16. Wenge DV
17. Baviskar P
18. Portola P
19. Claquin A
20. Chandra B
21. Baggett DW
22. Khalighifar A
23. Huang H
24. Zhou P
25. Long L
26. Shi H
27. Sun Y
28. Papachristou EK
29. Sekhar Reddy Chilamakuri C
30. de Luna Vitorino FN
31. Gongora JM
32. Wu H
33. Pounds SB
34. Janke LJ
35. Kentsis A
36. D'Santos CS
37. Garcia BA
38. Kriwacki RW
39. Chi H
40. Klco JM
41. Armstrong SA
42. Mullighan CG
KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia.; Cancer discovery; Vol 15(10), pp. 2096-2116. 2025 Oct 06.
1. Gensterblum-Miller E
2. Bhangale A
3. Majid DA
4. Pienkowski VM
5. Rydzanicz M
6. Janiszewska J
7. Kostrzewska-Poczekaj M
8. Chang C
9. Brummel C
10. Michmerhuizen NL
11. Wang J
12. Sandford E
13. Tewari M
14. Wierzbicka M
15. Birkeland AC
16. McHugh JB
17. Spector ME
18. Giefing M
19. Jarmuz-Szymczak M
20. Heft Neal ME
21. Brenner JC
Long read sequencing identifies complex structural variant landscape and recurrent TERT rearrangements in mucoepidermoid carcinoma.; Oral oncology; Vol 159, pp. 107108. 2024 Nov 15.
1. Ludwig ML
2. Michmerhuizen NL
3. Wang J
4. Birkeland AC
5. Majchrowski BK
6. Nimmagadda S
7. Zhai J
8. Bhangale A
9. Kulkarni A
10. Jiang H
11. Swiecicki PL
12. Brenner JC
Multi-kinase compensation rescues EGFR knockout in a cell line model of head and neck squamous cell carcinoma.; Archives of oral biology; Vol 156, pp. 105822. 2023 Oct 11.
1. Chandra B
2. Michmerhuizen NL
3. Shirnekhi HK
4. Tripathi S
5. Pioso BJ
6. Baggett DW
7. Mitrea DM
8. Iacobucci I
9. White MR
10. Chen J
11. Park CG
12. Wu H
13. Pounds S
14. Medyukhina A
15. Khairy K
16. Gao Q
17. Qu C
18. Abdelhamed S
19. Gorman SD
20. Bawa S
21. Maslanka C
22. Kinger S
23. Dogra P
24. Ferrolino MC
25. Di Giacomo D
26. Mecucci C
27. Klco JM
28. Mullighan CG
29. Kriwacki RW
Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation.; Cancer discovery; Vol 12(4), pp. 1152-1169. 2022 Apr 01.
1. Michmerhuizen NL
2. Ludwig ML
3. Birkeland AC
4. Nimmagadda S
5. Zhai J
6. Wang J
7. Jewell BM
8. Genouw D
9. Remer L
10. Kim D
11. Foltin SK
12. Bhangale A
13. Kulkarni A
14. Bradford CR
15. Swiecicki PL
16. Carey TE
17. Jiang H
18. Brenner JC
Small molecule profiling to define synergistic EGFR inhibitor combinations in head and neck squamous cell carcinoma.; Head & neck; Vol 44(5), pp. 1192-1205. 2022 Feb 27.
1. Michmerhuizen NL
2. Heenan C
3. Wang J
4. Leonard E
5. Bellile E
6. Loganathan SK
7. Wong SY
8. Lei YL
9. Brenner JC
Combined Pik3ca-H1047R and loss-of-function Notch1 alleles decrease survival time in a 4-nitroquinoline N-oxide-driven head and neck squamous cell carcinoma model.; Oral oncology; Vol 126, pp. 105770. 2022 Feb 13.
1. Michmerhuizen NL
2. Klco JM
3. Mullighan CG
Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies.; Blood; Vol 136(20), pp. 2275-2289. 2020 Nov 12.
1. Heft Neal ME
2. Michmerhuizen NL
3. Kovatch KJ
4. Owen JHJ
5. Zhai J
6. Jiang H
7. McKean EL
8. Prince MEP
9. Brenner JC
Advancement of PI3 Kinase Inhibitor Combination Therapies for PI3K-Aberrant Chordoma.; Journal of neurological surgery. Part B, Skull base; Vol 83(1), pp. 87-98. 2020 Oct 12.
1. Michmerhuizen NL
2. Owen JH
3. Heft Neal ME
4. Mann JE
5. Leonard E
6. Wang J
7. Zhai J
8. Jiang H
9. McHugh JB
10. Brenner JC
11. Prince MEP
Rationale for the advancement of PI3K pathway inhibitors for personalized chordoma therapy.; Journal of neuro-oncology; Vol 147(1), pp. 25-35. 2020 Feb 17.
1. Heath BR
2. Michmerhuizen NL
3. Donnelly CR
4. Sansanaphongpricha K
5. Sun D
6. Brenner JC
7. Lei YL
Head and Neck Cancer Immunotherapy beyond the Checkpoint Blockade.; Journal of dental research; Vol 98(10), pp. 1073-1080. 2019 Jul 24.
1. Michmerhuizen NL
2. Leonard E
3. Matovina C
4. Harris M
5. Herbst G
6. Kulkarni A
7. Zhai J
8. Jiang H
9. Carey TE
10. Brenner JC
Rationale for Using Irreversible Epidermal Growth Factor Receptor Inhibitors in Combination with Phosphatidylinositol 3-Kinase Inhibitors for Advanced Head and Neck Squamous Cell Carcinoma.; Molecular pharmacology; Vol 95(5), pp. 528-536. 2019 Mar 11.
1. Ludwig ML
2. Kulkarni A
3. Birkeland AC
4. Michmerhuizen NL
5. Foltin SK
6. Mann JE
7. Hoesli RC
8. Devenport SN
9. Jewell BM
10. Shuman AG
11. Spector ME
12. Carey TE
13. Jiang H
14. Brenner JC
The genomic landscape of UM-SCC oral cavity squamous cell carcinoma cell lines.; Oral oncology; Vol 87, pp. 144-151. 2018 Nov 08.
1. Gingerich MA
2. Smith JD
3. Michmerhuizen NL
4. Ludwig M
5. Devenport S
6. Matovina C
7. Brenner C
8. Chinn SB
Comprehensive review of genetic factors contributing to head and neck squamous cell carcinoma development in low-risk, nontraditional patients.; Head & neck; Vol 40(5), pp. 943-954. 2018 Feb 10.
1. Hoesli R
2. Birkeland AC
3. Rosko AJ
4. Issa M
5. Chow KL
6. Michmerhuizen NL
7. Mann JE
8. Chinn SB
9. Shuman AG
10. Prince ME
11. Wolf GT
12. Bradford CR
13. McHugh JB
14. Brenner JC
15. Spector ME
Proportion of CD4 and CD8 tumor infiltrating lymphocytes predicts survival in persistent/recurrent laryngeal squamous cell carcinoma.; Oral oncology; Vol 77, pp. 83-89. 2017 Dec 23.
1. Birkeland AC
2. Foltin SK
3. Michmerhuizen NL
4. Hoesli RC
5. Rosko AJ
6. Byrd S
7. Yanik M
8. Nor JE
9. Bradford CR
10. Prince ME
11. Carey TE
12. McHugh JB
13. Spector ME
14. Brenner JC
Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma.; Oral oncology; Vol 68, pp. 5-8. 2017 Mar 10.
1. Mann JE
2. Hoesli R
3. Michmerhuizen NL
4. Devenport SN
5. Ludwig ML
6. Vandenberg TR
7. Matovina C
8. Jawad N
9. Mierzwa M
10. Shuman AG
11. Spector ME
12. Brenner JC
Surveilling the Potential for Precision Medicine-driven PD-1/PD-L1-targeted Therapy in HNSCC.; Journal of Cancer; Vol 8(3), pp. 332-344. 2017 Feb 09.
1. Hoesli RC
2. Ludwig ML
3. Michmerhuizen NL
4. Rosko AJ
5. Spector ME
6. Brenner JC
7. Birkeland AC
Genomic sequencing and precision medicine in head and neck cancers.; European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology; Vol 43(5), pp. 884-892. 2016 Dec 15.
1. Michmerhuizen NL
2. Leonard E
3. Kulkarni A
4. Brenner JC
Differential compensation mechanisms define resistance to PI3K inhibitors in PIK3CA amplified HNSCC.; Otorhinolaryngology-head and neck surgery; Vol 1(2), pp. 44-50. 2016 Jun 07.
1. Birkeland AC
2. Yanik M
3. Tillman BN
4. Scott MV
5. Foltin SK
6. Mann JE
7. Michmerhuizen NL
8. Ludwig ML
9. Sandelski MM
10. Komarck CM
11. Carey TE
12. Prince ME
13. Bradford CR
14. McHugh JB
15. Spector ME
16. Brenner JC
Identification of Targetable ERBB2 Aberrations in Head and Neck Squamous Cell Carcinoma.; JAMA otolaryngology-- head & neck surgery; Vol 142(6), pp. 559-67. 2016 Jun 01.
1. Michmerhuizen NL
2. Birkeland AC
3. Bradford CR
4. Brenner JC
Genetic determinants in head and neck squamous cell carcinoma and their influence on global personalized medicine.; Genes & cancer; Vol 7(5-6), pp. 182-200. 2016 May.
1. Pope WH
2. Bowman CA
3. Russell DA
4. Jacobs-Sera D
5. Asai DJ
6. Cresawn SG
7. Jacobs WR
8. Hendrix RW
9. Lawrence JG
10. Hatfull GF
Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity.; eLife; Vol 4, pp. e06416. 2015 Apr 28.
1. van Dongen MA
2. Rattan R
3. Silpe J
4. Dougherty C
5. Michmerhuizen NL
6. Van Winkle M
7. Huang B
8. Choi SK
9. Sinniah K
10. Orr BG
11. Banaszak Holl MM
Poly(amidoamine) dendrimer-methotrexate conjugates: the mechanism of interaction with folate binding protein.; Molecular pharmaceutics; Vol 11(11), pp. 4049-58. 2014 Oct 01.
1. Timmer CM
2. Michmerhuizen NL
3. Witte AB
4. Van Winkle M
5. Zhou D
6. Sinniah K
An isothermal titration and differential scanning calorimetry study of the G-quadruplex DNA-insulin interaction.; The journal of physical chemistry. B; Vol 118(7), pp. 1784-90. 2014 Feb 04.
1. Burgess DE
2. Knoblock KF
3. Daugherty T
4. Robertson NP
Cytotoxic and hemolytic effects of Tritrichomonas foetus on mammalian cells.; Infection and immunity; Vol 58(11), pp. 3627-32. 1990 Nov.