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Rowe Lab

Intersection of viruses and allergic disease

Allergic diseases such as allergic asthma, allergic rhinitis and atopic eczema have a lifetime prevalence of 30-40%. Starting early in childhood, both genetic and environmental factors are involved in development and progression of these diseases. Respiratory virus infections, such as the common cold, are associated with the development of allergic diseases and known triggers of allergic airway exacerbations. However, despite this strong link between viruses and allergic diseases, we still have a limited understanding of how these diseases influence each other. Our lab is broadly interested in how respiratory virus infections influence the development of allergic diseases and conversely how allergic inflammation alters our normal immune responses during virus infections.

Individuals with atopy – or allergic sensitization – have decreased antiviral immune responses to virus infections. IgE, the antibody associated with allergy and atopy, has been shown to be involved in this process by influencing immune cell functions. We are interested in identifying how IgE-mediated signals influence responses of immune cells to viruses, such as Rhinovirus, the main cause of the common cold. By comparing the functions and antiviral responses of immune cells from individuals with high and low IgE levels, we hope to identify specific pathways and cellular functions regulated by IgE. This research will provide a better understanding of how allergic diseases develop and progress and could potentially discover new targets for improved treatments and even prevention.

Regina K. Rowe, M.D., Ph.D.

Principal Investigator

Regina K. Rowe, M.D., Ph.D.

Publications

5/8/2020
Rowe RK, Pyle DM, Farrar JD, Gill MA. "IgE-mediated regulation of IL-10 and type I IFN enhances rhinovirus-induced Th2 differentiation by primary human monocytes." European journal of immunology.. 2020 May 8; Epub 2020 May 08.

9/21/2019
Chen F, Rowe RK, Gill MA, Farrar JD. "Type I interferon suppresses memory Th2 cell cytokine secretion from allergic subjects." Allergy.. 2019 Sep 21; Epub 2019 Sep 21.

12/26/2018
Rowe RK, Gill MA. "Targeting Antiviral Pathways for Treatment of Allergic Diseases." Journal of the Pediatric Infectious Diseases Society.. 2018 Dec 26; 7(suppl_2):S54-S56.

View All Publications

News

  • July 2021. Funding news! Regina receives an NIH K08 Career Development Award from NIAID.
  • May, 2021. Rowe, Meeks & Mariani Labs receive a collaborative URA award to study neuro-immune interactions in the nasal mucosa. 2021 University Research Awards. See "Recipients."
  • December, 2020. Bailey Matthews joins the lab!
  • February, 2020. Open for business! Rowe Lab established. Follow us on Twitter & Instagram: @rowe_lab

Contact Us

Rowe Lab
University of Rochester Medical Center
601 Elmwood Avenue
Box 850
Rochester, NY 14642

Open Positions: Opportunities are available in our laboratory for highly motivated students, postdoctoral fellows, and research associates who are interested in mechanisms of allergic inflammation, respiratory virus pathogenesis, and innate immunology. Please contact Regina Rowe for more information.