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Pediatrics / Scheible Lab / Lab Members

 

Lab Members

Kristin Scheible, MD, Principal InvestigatorPrincipal Investigator

Our lab seeks to elucidate the molecular programs that determine age-related immune cell-intrinsic behavior, the specific pathways through which early exposures disrupt normal immune development, and finally, the clinical consequences of abnormal immune development during infancy.

Dr. Scheible is a member of the Society for Pediatric Research and fellow, of the American Academy of Pediatrics.

 

Nathan LaniewskiNathan Laniewski

Senior Technical Associate/Lab Manager

It’s all about the “ABCs” – “Always be clustering!”

I develop wet-bench and bioinformatics workflows to generate and analyze single cell data (flow/mass cytometry).  Due to a surprising amount of heterogeneity among immune cell subsets – even in “naïve” neonates – high-dimensional clustering techniques are needed to efficiently profile and characterize these cells.

 

Darline Castro MelendezDarline Castro-Melendez

Ph.D. Candidate, IMV program

Environmental exposures and the neonatal immune system

I am fortunate to carry out an exciting research project defining the relationship between Per-and Polyfluoroalkyl Substances (PFAS) on the developing neonatal immune system. I am applying a systems immunology approach to determine the relationship between PFAS exposure in utero and infant T cell phenotype and function postnatally using high-dimensional analysis.

 

Janiret Narvaez-MirandaJaniret-Narvaez-M

Ph.D. Candidate, TBS program

Infant’s Gut Microbiome and Vaccine responses

As a translational sciences graduate student, my goal in the lab is to bring observations made in the lab from “Bench to Bedside.” My project evaluates the relationship between the infant gut microbiome and rotavirus vaccine responses and assesses breast milk exposure's potential impact on this relationship.