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Peter G. Shrager, Ph.D.

Peter G. Shrager, Ph.D.

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Call Center (585) 276-3000

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About Me

EDUCATION:
Columbia College, New York, Liberal Arts/Engineering, A.B.1962
Columbia Engineering, New York Electrical Engineering B.S.1963
University of California, Berkeley, Biophysics Ph.D.1969

POSTDOCTORAL TRAINING:
Duke University, Durham, NC, Physiology 1969-1971
Cold Spring...
EDUCATION:
Columbia College, New York, Liberal Arts/Engineering, A.B.1962
Columbia Engineering, New York Electrical Engineering B.S.1963
University of California, Berkeley, Biophysics Ph.D.1969

POSTDOCTORAL TRAINING:
Duke University, Durham, NC, Physiology 1969-1971
Cold Spring Harbor, NY, Molecular Biology 1995

FACULTY APPOINTMENTS:
University of Rochester Professor of Neurobiology & Anatomy 1996-present
University of Rochester Professor of Pharmacology & Physiology 1996-present
University of Rochester Professor of Biophysics 1993-1996
University of Rochester Professor of Physiology 1991-1996
University of Rochester Associate Professor of Physiology 1981-1991
University of Rochester Associate Professor of Physiology 1976-1981
University of Rochester Assistant Professor of Physiology 1971-1976

HONORS AND AWARDS:
Phi Beta Kappa
Tau Beta Pi (engineering)
Eta Kappa Nu (electrical engineering)
NIH Predoctoral Fellowship
NIH Postdoctoral Fellowship
NSF Postdoctoral Fellowship
NIH Research Career Development Award
Mellon Fellow
First-Year Teaching Award and First-Year teaching commendations
Graduate Student Society Faculty Teaching Award
Fenn Mentor Award

Faculty Appointments

Professor Emeritus - Department of Neuroscience (SMD)

Credentials

Post-doctoral Training & Residency

Molecular Biology,
Cold Spring Harbor, NY.

Physiology,
Duke University, Durham, NC 1969 - 1971

Education

PhD | Univ of Cal Berkeley. Biophysics. 1969

BS | Columbia University. Electrical Engineering. 1963

Awards

Phi Beta Kappa.

Tau Beta Pi (engineering).

Eta Kappa Nu (electrical engineering).

NIH Predoctoral Fellowship.

NIH Postdoctoral Fellowship.

NSF Postdoctoral Fellowship.

NIH Research Career Development Award.

Mellon Fellow.

First-Year Teaching Award.

Graduate Student Society Faculty Teaching Award.

Fenn Mentor Award.

Research

The focus of this laboratory is on the interaction between neurons and glial cells, particularly myelinating glia. There are two primary areas of interest. Myelinated axons are not uniform, but rather consist of highly discrete domains, populated by unique proteins that confer specialized function...
The focus of this laboratory is on the interaction between neurons and glial cells, particularly myelinating glia. There are two primary areas of interest. Myelinated axons are not uniform, but rather consist of highly discrete domains, populated by unique proteins that confer specialized functional properties. The axon initial segment contains a high density of voltage-dependent sodium channels, as well as an associated set of cytoskeletal, adhesion, and matrix components, all of which allow this region to be the site of integration of synaptic inputs, resulting in the initiation of the action potential. Nodes of Ranvier have a similar composition, but reach that structure through a very different developmental mechanism. Nodes and adjacent paranodes and juxtaparanodes, along with compact myelin in the internodes, allow rapid, reliable, and efficient conduction of impulses. Our laboratory studies the molecular interactions between components of axons and Schwann cells (PNS) or oligodendroglia (CNS) that result in this unique structure. A wide variety of techniques, both molecular and electrophysiological are employed. A second major area is in recovery from spinal cord injury, and other traumatic diseases of the CNS. While axon regeneration can be robust in the PNS, it is markedly limited in the CNS. Among the mechanisms responsible, it has been demonstrated that remaining myelin at the injury site contains several proteins that are inhibitory to neurite outgrowth. This inhibition is mediated by receptors present on neurons that form a complex capable of initiating an intracellular signaling cascade. Using the optic nerve as a well-defined tract of CNS axons, and a series of mutant mice with the relevant proteins genetically deleted, a mechanism is sought through which regeneration can be improved. A question arose in the course of this work. Since these inhibitors and receptors are not likely to have evolved for this purpose, do they mediate other functions in the CNS? It has subsequently been shown that both the inhibitory proteins and their receptors are expressed by neurons at excitatory synapses. Further, in collaboration with Roman Giger, this laboratory has been investigating the role of this system in synaptic plasticity. Of particular interest, long term potentiation and depression, thought to be electrophysiological correlates of memory formation in the hippocampus, are regulated by this growth-inhibitory system. While this is studied for its intrinsic value in neurobiology, it is also relevant in spinal cord injury, where plasticity in remaining neurons is thought to play an important role in recovery of function.

Recent publications (2010-2012)

Raiker, S.J., Lee, H., Duan, Y., Koelzer, K.T., Shrager, P. and Giger, R.J. 2010 Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity. Journal of Neuroscience 30:12432-12445.

Winters, J., Lenk, G., Giger-Mateeva, V., Shrager, P., Meisler, M. and Giger, R..J. 2011 Congenital CNS hypomyelination and reduced number of mature oligodendrocytes in the Fig4 null mouse. Journal of Neuroscience, in review.

Einheber, S., Maurel, P., Meng, X., Rubin, M., Lam, I., Mohandas, N., An, X., Shrager, P., Kissil, J. and Salzer, J. 2011 The 4.1B cytoskeletal protein is required for the normal domain organization of myelinated axons. Glia (online) 10-26-2012 DOI: 10:1002/glia22430.

Publications

Journal Articles

Neuronal protein phosphatase 1? regulates glutamate release, cortical myelination, node of Ranvier formation, and action potential propagation in the optic nerve.

McKee C, Foley K, Andersh KM, Marola OJ, Wadzinski B, Libby RT, Shrager P, Xia H

bioRxiv : the preprint server for biology.. 2024 May 10 Epub 05/10/2024.

Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration.

Schmitd LB, Hafner H, Ward A, Adib EA, Biscola NP, Kohen R, Patel M, Williamson RE, Desai E, Bennett J, Saxman G, Athaiya M, Wilborn D, Shumpert J, Zhao XF, Kawaguchi R, Geschwind DH, Hoke A, Shrager P, Collins CA, Havton LA, Kalinski AL, Giger RJ

bioRxiv : the preprint server for biology.. 2024 March 8 Epub 03/08/2024.

Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS Tau Phosphorylation and Myelination During Development.

McKee C, Shrager P, Mazumder AG, Ganguly A, Mayer A, Foley K, Ward N, Youngman M, Hou H, Xia H

Molecular neurobiology.. 2022 December 59 (12):7486-7494. Epub 10/06/2022.

Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury.

Fernandes KA, Mitchell KL, Patel A, Marola OJ, Shrager P, Zack DJ, Libby RT, Welsbie DS

Experimental eye research.. 2018 June 171 :54-61. Epub 03/08/2018.

Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury.

Syc-Mazurek SB, Fernandes KA, Wilson MP, Shrager P, Libby RT

Molecular neurodegeneration.. 2017 October 212 (1):71. Epub 10/02/2017.

Preferential conduction block of myelinated axons by nitric oxide.

Shrager P, Youngman M

Journal of neuroscience research.. 2017 July 95 (7):1402-1414. Epub 09/10/2016.

Single amino acid deletion in transmembrane segment D4S6 of sodium channel Scn8a (Nav1.6) in a mouse mutant with a chronic movement disorder.

Jones JM, Dionne L, Dell'Orco J, Parent R, Krueger JN, Cheng X, Dib-Hajj SD, Bunton-Stasyshyn RK, Sharkey LM, Dowling JJ, Murphy GG, Shakkottai VG, Shrager P, Meisler MH

Neurobiology of disease.. 2016 May 89 :36-45. Epub 01/22/2016.

PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms.

Mironova YA, Lenk GM, Lin JP, Lee SJ, Twiss JL, Vaccari I, Bolino A, Havton LA, Min SH, Abrams CS, Shrager P, Meisler MH, Giger RJ

eLife.. 2016 March 235 Epub 03/23/2016.

Th Cell Diversity in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis.

Carbajal KS, Mironova Y, Ulrich-Lewis JT, Kulkarni D, Grifka-Walk HM, Huber AK, Shrager P, Giger RJ, Segal BM

The Journal of immunology : official journal of the American Association of Immunologists.. 2015 September 15195 (6):2552-9. Epub 08/03/2015.

DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury.

Fernandes KA, Harder JM, John SW, Shrager P, Libby RT

Neurobiology of disease.. 2014 September 69 :108-16. Epub 05/27/2014.

Gestational iron deficiency differentially alters the structure and function of white and gray matter brain regions of developing rats.

Greminger AR, Lee DL, Shrager P, Mayer-Pröschel M

The Journal of nutrition.. 2014 July 144 (7):1058-66. Epub 04/17/2014.

The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons.

Einheber S, Meng X, Rubin M, Lam I, Mohandas N, An X, Shrager P, Kissil J, Maurel P, Salzer JL

Glia.. 2013 February 61 (2):240-53. Epub 10/26/2012.

The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons.

Einheber, S., Maurel, P., Meng, X., Rubin, M., Lam, I., Mohandas, N., An, X., Shrager, P., Kissil, J. and Salzer, J.

Glia. 2012; .

Congenital CNS hypomyelination in the Fig4 null mouse is rescued by neuronal expression of the PI(3,5)P(2) phosphatase Fig4.

Winters JJ, Ferguson CJ, Lenk GM, Giger-Mateeva VI, Shrager P, Meisler MH, Giger RJ

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2011 November 3031 (48):17736-51. Epub 1900 01 01.

Congenital CNS hypomyelination and reduced number of mature oligodendrocytes in the Fig4 null mouse.

Winters, J., Lenk, G., Giger-Mateeva, V., Shrager, P., Meisler, M. and Giger, R..J.

Journal of Neuroscience. 2011; .

Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity.

Raiker SJ, Lee H, Baldwin KT, Duan Y, Shrager P, Giger RJ

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2010 September 1530 (37):12432-45. Epub 1900 01 01.

A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier.

Feinberg K, Eshed-Eisenbach Y, Frechter S, Amor V, Salomon D, Sabanay H, Dupree JL, Grumet M, Brophy PJ, Shrager P, Peles E

Neuron.. 2010 February 2565 (4):490-502. Epub 1900 01 01.

A glial signal consisting of Gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier.

Feinberg, K., Eshed-Eisenbach, Y., Frechter, S., Amor, V., Salomon, D., Sabanay, H., Dupree, J.L., Grumet, M., Brophy, P.J., Shrager, P., and Peles, E.

Neuron. 2010; : 1-14.

Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity.

Raiker, S.J., Lee, H., Duan, Y., Koelzer, K.T., Shrager, P. and Giger, R.J.

Journal of Neuroscience. 2010; 30: 12432-12445.

Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength.

Lee H, Raiker SJ, Venkatesh K, Geary R, Robak LA, Zhang Y, Yeh HH, Shrager P, Giger RJ

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 March 1228 (11):2753-65. Epub 1900 01 01.

Synaptic function for the Nogo-66 receptor NgR1: Regulation of dendritic spine morphology and activity-dependent synaptic strength.

Lee, H., Raiker, S., Venkatesh, K., Geary, R., Robak, L.A., Zhang, Y., Yeh, H.H., Shrager, P. and Giger, R.J.

Journal of Neuroscience. 2008; : 2753-2765.

Neurofascin assembles a specialized extracellular matrix at the axon initial segment.

Hedstrom KL, Xu X, Ogawa Y, Frischknecht R, Seidenbecher CI, Shrager P, Rasband MN

The Journal of cell biology.. 2007 August 27178 (5):875-86. Epub 08/20/2007.

Neurofascin assembles a specialized extracellular matrix at the axon initial segment.

Hedstrom, K.L., Xu, X., Ogawa, Y., Frishnecht, R., Seidenbecher, C.I., Shrager, P. and Rasband, M.N.

Journal of Cell Biology. 2007; 178: 875-886.

Early events in node of Ranvier formation during myelination and remyelination in the PNS.

Schafer DP, Custer AW, Shrager P, Rasband MN

Neuron glia biology. 2006 May 2 (2):69-79. Epub 1900 01 01.

Neuregulin-1 type III determines the ensheathment fate of axons.

Taveggia C, Zanazzi G, Petrylak A, Yano H, Rosenbluth J, Einheber S, Xu X, Esper RM, Loeb JA, Shrager P, Chao MV, Falls DL, Role L, Salzer JL

Neuron.. 2005 September 147 (5):681-94. Epub 1900 01 01.

Dependence of axon initial segment formation on Na+ channel expression.

Xu X, Shrager P

Journal of neuroscience research.. 2005 February 1579 (4):428-41. Epub 1900 01 01.

Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture.

Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O'Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LL

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2004 April 2124 (16):4030-42. Epub 1900 01 01.

The role of the ankyrin-binding protein NrCAM in node of Ranvier formation.

Custer AW, Kazarinova-Noyes K, Sakurai T, Xu X, Simon W, Grumet M, Shrager P

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003 November 523 (31):10032-9. Epub 1900 01 01.

Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1.

Poliak S, Salomon D, Elhanany H, Sabanay H, Kiernan B, Pevny L, Stewart CL, Xu X, Chiu SY, Shrager P, Furley AJ, Peles E

The Journal of cell biology.. 2003 September 15162 (6):1149-60. Epub 09/08/2003.

Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits.

Chen C, Bharucha V, Chen Y, Westenbroek RE, Brown A, Malhotra JD, Jones D, Avery C, Gillespie PJ, Kazen-Gillespie KA, Kazarinova-Noyes K, Shrager P, Saunders TL, Macdonald RL, Ransom BR, Scheuer T, Catterall WA, Isom LL

Proceedings of the National Academy of Sciences of the United States of America.. 2002 December 2499 (26):17072-7. Epub 12/12/2002.

Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta2-subunits.

Chen, C; Bharucha, V; Chen, Y; Westenbroek, RE; Brown, A; Malhotra, JD; Jones, D; Avery, C; Gillespie, PJ; Kazen-Gillespie, KA; Kazarinova-Noyes, K; Shrager, P; Saunders, TL; Macdonald, RL; Ransom, BR; Scheuer, T; Catterall, WA,; Isom, LL.

Proceedings of the National Academy of Sciences. 2002; 99: 17072-17077.

Molecular constituents of the node of Ranvier.

Kazarinova-Noyes K, Shrager P

Molecular neurobiology.. 2002 26 (2-3):167-82. Epub 1900 01 01.

Contactin associates with Na+ channels and increases their functional expression.

Kazarinova-Noyes K, Malhotra JD, McEwen DP, Mattei LN, Berglund EO, Ranscht B, Levinson SR, Schachner M, Shrager P, Isom LL, Xiao ZC

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2001 October 121 (19):7517-25. Epub 1900 01 01.

No obvious abnormality in mice deficient in receptor protein tyrosine phosphatase beta.

Harroch S, Palmeri M, Rosenbluth J, Custer A, Okigaki M, Shrager P, Blum M, Buxbaum JD, Schlessinger J

Molecular and cellular biology.. 2000 October 20 (20):7706-15. Epub 1900 01 01.

Ion channel sequestration in central nervous system axons.

Rasband MN, Shrager P

The Journal of physiology.. 2000 May 15525 Pt 1 (Pt 1):63-73. Epub 1900 01 01.

K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve.

Rasband, M.N.; Trimmer, J.S.; Peles, E.; Levinson, S.R.; Shrager, P.

Journal of Neurocytology. 2000; 28: 319-331.

Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels.

Poliak S, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E

Neuron.. 1999 December 24 (4):1037-47. Epub 1900 01 01.

Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS.

Rasband MN, Peles E, Trimmer JS, Levinson SR, Lux SE, Shrager P

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1999 September 119 (17):7516-28. Epub 1900 01 01.

Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS.

Weber P, Bartsch U, Rasband MN, Czaniera R, Lang Y, Bluethmann H, Margolis RU, Levinson SR, Shrager P, Montag D, Schachner M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1999 June 119 (11):4245-62. Epub 1900 01 01.

Dynamic potassium channel distributions during axonal development prevent aberrant firing patterns.

Vabnick I, Trimmer JS, Schwarz TL, Levinson SR, Risal D, Shrager P

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1999 January 1519 (2):747-58. Epub 1900 01 01.

K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve.

Rasband MN, Trimmer JS, Peles E, Levinson SR, Shrager P

Journal of neurocytology.. 1999 28 (4-5):319-31. Epub 1900 01 01.

Ion channel redistribution and function during development of the myelinated axon.

Vabnick I, Shrager P

Journal of neurobiology.. 1998 October 37 (1):80-96. Epub 1900 01 01.

Disruption and reorganization of sodium channels in experimental allergic neuritis.

Novakovic SD, Levinson SR, Schachner M, Shrager P

Muscle & nerve.. 1998 August 21 (8):1019-32. Epub 1900 01 01.

Nerve conduction block by nitric oxide that is mediated by the axonal environment.

Shrager P, Custer AW, Kazarinova K, Rasband MN, Mattson D

Journal of neurophysiology.. 1998 February 79 (2):529-36. Epub 1900 01 01.

Potassium channel distribution, clustering, and function in remyelinating rat axons.

Rasband MN, Trimmer JS, Schwarz TL, Levinson SR, Ellisman MH, Schachner M, Shrager P

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1998 January 118 (1):36-47. Epub 1900 01 01.

Sodium channel distribution in axons of hypomyelinated and MAG null mutant mice.

Vabnick I, Messing A, Chiu SY, Levinson SR, Schachner M, Roder J, Li C, Novakovic S, Shrager P

Journal of neuroscience research.. 1997 October 1550 (2):321-36. Epub 1900 01 01.

The clustering of axonal sodium channels during development of the peripheral nervous system.

Vabnick I, Novakovi? SD, Levinson SR, Schachner M, Shrager P

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1996 August 1516 (16):4914-22. Epub 1900 01 01.

Immunocytochemical investigations of sodium channels along nodal and internodal portions of demyelinated axons.

England JD, Levinson SR, Shrager P

Microscopy research and technique.. 1996 August 134 (5):445-51. Epub 1900 01 01.

Clusters of axonal Na+ channels adjacent to remyelinating Schwann cells.

Novakovic SD, Deerinck TJ, Levinson SR, Shrager P, Ellisman MH

Journal of neurocytology.. 1996 June 25 (6):403-12. Epub 1900 01 01.

Na+ channel aggregation in remyelinating mouse sciatic axons following transection.

Tzoumaka EE, Novakovi? SD, Levinson SR, Shrager P

Glia.. 1995 October 15 (2):188-94. Epub 1900 01 01.

Control of myelination, axonal growth, and synapse formation in spinal cord explants by ion channels and electrical activity.

Shrager P, Novakovic SD

Brain research. Developmental brain research.. 1995 August 2888 (1):68-78. Epub 1900 01 01.

Survival, development, and electrical activity of central nervous system myelinated axons exposed to tumor necrosis factor in vitro.

Dugandzija-Novakovi? S, Shrager P

Journal of neuroscience research.. 1995 January 140 (1):117-26. Epub 1900 01 01.

Clustering of Na+ channels and node of Ranvier formation in remyelinating axons.

Dugandzija-Novakovi? S, Koszowski AG, Levinson SR, Shrager P

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1995 January 15 (1 Pt 2):492-503. Epub 1900 01 01.

Resolving three types of chloride channels in demyelinated Xenopus axons.

Wu JV, Shrager P

Journal of neuroscience research.. 1994 August 1538 (6):613-20. Epub 1900 01 01.

Single channel characterization of multiple types of potassium channels in demyelinated Xenopus axons.

Wu JV, Rubinstein CT, Shrager P

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1993 December 13 (12):5153-63. Epub 1900 01 01.

Axonal coding of action potentials in demyelinated nerve fibers.

Shrager P

Brain research.. 1993 August 13619 (1-2):278-90. Epub 1900 01 01.

Channel reconstitution in liposomes and planar bilayers with HPLC-purified MIP26 of bovine lens.

Shen L, Shrager P, Girsch SJ, Donaldson PJ, Peracchia C

The Journal of membrane biology.. 1991 October 124 (1):21-32. Epub 1900 01 01.

A computational test of the requirements for conduction in demyelinated axons.

Hines M, Shrager P

Restorative neurology and neuroscience.. 1991 January 13 (2):81-93. Epub 1900 01 01.

A computational test of the requirements for conduction in demyelinated axons.

Hines, M.; Shrager, P.

Restorative Neurology and Neuroscience. 1991; 3: 81-93.

Remyelination of nerve fibers in the transected frog sciatic nerve.

Rubinstein CT, Shrager P

Brain research.. 1990 August 6524 (2):303-12. Epub 1900 01 01.

Optical measurement of conduction in single demyelinated axons.

Shrager P, Rubinstein CT

The Journal of general physiology.. 1990 May 95 (5):867-89. Epub 1900 01 01.

Sodium channels in single demyelinated mammalian axons.

Shrager P

Brain research.. 1989 March 27483 (1):149-54. Epub 1900 01 01.

Ionic channels and signal conduction in single remyelinating frog nerve fibres.

Shrager P

The Journal of physiology.. 1988 October 404 :695-712. Epub 1900 01 01.

Nerve conduction block by nitric oxide that is mediated by the axonal environment.

Shrager, P.; Custer, A.W.; Kazarinova, K.; Rasband, M.N.; Mattson, D.

Journal of Neurophysiology. 1988; 79: 529-536.

Potassium channel distribution, clustering, and function in remyelinating rat axons.

Rasband, M.N.; Trimmer, J.S.; Schwarz, T.L.; Levinson, S.R.; Ellisman, M.H.; Schachner, M.; Shrager, P.

Journal of Neuroscience. 1988; 18: 36-47.

The distribution of sodium and potassium channels in single demyelinated axons of the frog.

Shrager P

The Journal of physiology.. 1987 November 392 :587-602. Epub 1900 01 01.

Optical recording of action potential propagation in demyelinated frog nerve.

Shrager P, Chiu SY, Ritchie JM, Zecevic D, Cohen LB

Biophysical journal.. 1987 February 51 (2):351-5. Epub 1900 01 01.

Loose patch clamp recording of ionic currents in demyelinated frog nerve fibers.

Chiu SY, Shrager P, Ritchie JM

Brain research.. 1985 December 16359 (1-2):338-42. Epub 1900 01 01.

Voltage-dependent sodium and potassium channels in mammalian cultured Schwann cells.

Shrager P, Chiu SY, Ritchie JM

Proceedings of the National Academy of Sciences of the United States of America.. 1985 February 82 (3):948-52. Epub 1900 01 01.

Voltage-dependent sodium and potassium channels in mammalian cultured Schwann cells.

Shrager, P.; S.Y. Chiu; J.M. Ritchie.

Proceedings of the National Academy of Sciences

Neuronal-type Na+ and K+ channels in rabbit cultured Schwann cells.

Chiu SY, Schrager P, Ritchie JM

Nature.. 1984 311 (5982):156-7. Epub 1900 01 01.

The periaxonal space of crayfish giant axons.

Shrager P, Starkus JC, Lo MV, Peracchia C

The Journal of general physiology.. 1983 August 82 (2):221-44. Epub 1900 01 01.

Influence of ionic current on Na+ channel gating in crayfish giant axon.

Shrager P, Lo MV

Nature.. 1982 April 1296 (5856):450-2. Epub 1900 01 01.

Modification of sodium and potassium channel gating kinetics by ether and halothane.

Bean BP, Shrager P, Goldstein DA

The Journal of general physiology.. 1981 March 77 (3):233-53. Epub 1900 01 01.

Modification of slow sodium inactivation in nerve after internal perfusion with trypsin.

Starkus JG, Shrager P

The American journal of physiology.. 1978 November 235 (5):C238-44. Epub 1900 01 01.

Slow sodium inactivation in nerve after exposure to sulhydryl blocking reagents.

Shrager P

The Journal of general physiology.. 1977 February 69 (2):183-202. Epub 1900 01 01.

Density and distribution of tetrodotoxin receptors in normal and detubulated frog sartorius muscle.

Jaimovich E, Venosa RA, Shrager P, Horowicz P

The Journal of general physiology.. 1976 April 67 (4):399-416. Epub 1900 01 01.

Specific chemical groups involved in the control of ionic conductance in nerve.

Shrager P

Annals of the New York Academy of Sciences.. 1975 December 30264 :293-303. Epub 1900 01 01.

Ionic conductance changes in voltage clamped crayfish axons at low pH.

Shrager P

The Journal of general physiology.. 1974 December 64 (6):666-90. Epub 1900 01 01.

Inhibition of the receptor for tetrodotoxin in nerve membranes by reagents modifying carboxyl groups.

Shrager P, Profera C

Biochimica et biophysica acta.. 1973 August 9318 (1):141-6. Epub 1900 01 01.

Biochemical characterization of a lipid-dependent membrane protein antigen in HK sheep red cells.

Shrager P, Tosteson DC, Lauf PK

Biochimica et biophysica acta.. 1972 December 1290 (1):186-99. Epub 1900 01 01.

Internal perfusion of crayfish, giant axons: action of tannic acid, DDT, and TEA.

Shrager PG, Macey RI, Strickholm A

Journal of cellular physiology.. 1969 August 74 (1):77-90. Epub 1900 01 01.

Chemical modification of crayfish axons by protein crosslinking aldehydes.

Shrager PG, Strickholm A, Macey RI

Journal of cellular physiology.. 1969 August 74 (1):91-100. Epub 1900 01 01.

The pH dependency of relative ion permeabilities in the crayfish giant axon.

Strickholm A, Wallin BG, Shrager P

Biophysical journal.. 1969 July 9 (7):873-83. Epub 1900 01 01.

Electronics and the blind.

Shrager, P.; Susskind, C.

Advances in Electronics and Electron Physics. 1964; 20: 261-301.