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Edward M. Schwarz, Ph.D.

Edward M. Schwarz, Ph.D.

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About Me

Faculty Appointments

Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD)

Director - Center for Musculoskeletal Research

Richard and Margaret Burton Distinguished Professor in Orthopaedics - Department of Orthopaedics (SMD)

Professor - Department of Biomedical Engineering (SMD) - Joint

Professor - Department of Medicine, Allergy/Immunology and Rheumatology (SMD) - Joint

Professor - Department of Microbiology and Immunology (SMD) - Joint

Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint

Professor - Department of Urology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Laboratory of Inder M. Verma, Ph.D., Laboratory of Genetics
The Salk Institute, La Jolla, California, Concentrations: Gene Therapy, NFkB Signal, Transduction, Transgenic Mice. 1993 - 1997

Training - Pre-doctoral Fellow, Laboratory of Barry R. Bloom, Ph.D., Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York 1988 - 1993

Training - Summer Student - Laboratory of Carl Schildkraut, Ph.D., Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York

Training - Undergraduate Research Laboratory of Donald J. Tipper, Ph.D., Department of Microbiology & Molecular Genetics, University of Massachusetts Medical School, Worcester, Massachusetts 1987 - 1988

Training - Summer Student - Laboratory of Fritz Herz, Ph.D., Department of Pathology, Montefiore Medical Center, Bronx, New York

Education

PhD | Einstein College Medicine. Immunology, All Other. 1993

MA | Einstein College Medicine. Immunology, All Other. 1990

BS | Worcester Polytech Inst. Biology. 1988

Awards

J.R. Neff Award, Musculoskeletal Research Foundation 2007

Orthopaedic Research Society's Kappa Delta Young Investigator Award 2005

Orthopaedic Research Society's Harris Award 2003

New Investigator Research Award, The Association of Bone & Joint Surgeons . 1999

Sinsheimer Award Nominee. 1999

University of Rochester Nominee for the Elison Award. 1999

Research

Dr. Edward Schwarz’s laboratory focuses on inflammatory bone loss, such as that seen in rheumatoid arthritis, infections, tumor metastasis, and wear debris-induced osteolysis around loose prosthetic implants. Dr. Schwarz is also a leader in orthopaedic drug and biologic therapies and stem cell resea...
Dr. Edward Schwarz’s laboratory focuses on inflammatory bone loss, such as that seen in rheumatoid arthritis, infections, tumor metastasis, and wear debris-induced osteolysis around loose prosthetic implants. Dr. Schwarz is also a leader in orthopaedic drug and biologic therapies and stem cell research, for which his lab is developing novel bone-targeted antibiotics for osteomyelitis, passive immunizations for MRSA, and revitalizing allograft approaches for bone and tendon regeneration. Additionally, Dr. Schwarz's lab is interested in developing translational in vivo imaging outcome measures that include near infrared imaging of lymphatic flow to detect arthritic flare and cone beam CT to assess bone healing in patients with orthopaedic implants.

Patents

Method For Introducing An Ultraviolet Light Activated Viral Vector Into The Spinal Column

Issue date: April 27, 2010

Patent #: 7,704,272

Country: United States

Inventors: Paul T Rubery, Edward Michael Schwarz

Light Activated Gene Transduction Using Long Wavelength Ultraviolet Light for Cell Targeted Gene Delivery

Issue date: April 28, 2009

Patent #: 7,524,327

Country: United States

Inventors: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Edward Michael Schwarz

Methods and Compositions Related to Joint Inflammation Diseases

Issue date: October 05, 2010

Patent #: 7,807,389

Country: United States

Inventors: Sally A Haas, Christopher T Ritchlin, Edward Michael Schwarz

Ultraviolet Light for Light Activated GeneTransduction in Gene Delivery

Issue date: December 20, 2006

Patent #: 1472348

Country: Europe

Inventors: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Edward Michael Schwarz

Light Activated Gene Transduction Using Ultraviolet Light for Cell Targeted Gene Delivery

Issue date: April 03, 2008

Patent #: 2003210820

Country: Australia

Inventors: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Edward Michael Schwarz

Methods of Diagnosing Erosive Arthritis

Issue date: January 12, 2011

Patent #: 1604205

Country: Europe

Inventors: Sally A Haas, Christopher T Ritchlin, Edward Michael Schwarz

Light Probe for Ultraviolet Light Activated Gene Transduction

Issue date: April 17, 2008

Patent #: 2004209919

Country: Australia

Inventors: Thomas H Foster, Michael Maloney, Paul T Rubery, Edward Michael Schwarz

Light Activated Gene Transduction Using Ultraviolet Light for Cell Targeted Gene Delivery

Issue date: March 18, 2009

Patent #: 1867715

Country: Europe

Inventors: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Edward Michael Schwarz

Ultraviolet Light for Light Activated GeneTransduction in Gene Delivery

Issue date: December 20, 2006

Patent #: CH1472348

Country: Switzerland/Liechtenstein

Inventors: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Edward Michael Schwarz

Light Activated Gene Transduction (LAGeT) for Cell Targeted Gene Delivery

Issue date: March 18, 2009

Patent #: CH1867715

Country: Switzerland/Liechtenstein

Inventors: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Paul T Rubery, Edward Michael Schwarz

Light Activated Gene Transduction (LAGeT) for Cell Targeted Gene Delivery

Issue date: March 18, 2009

Patent #: GB1867715

Country: United Kingdom

Inventors: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Paul T Rubery, Edward Michael Schwarz

Light Activated Gene Transduction (LAGeT) for Cell Targeted Gene Delivery

Issue date: March 18, 2009

Patent #: FR1867715

Country: France

Inventors: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Paul T Rubery, Edward Michael Schwarz

Light Activated Gene Transduction (LAGeT) for Cell Targeted Gene Delivery

Issue date: March 18, 2009

Patent #: DE1867715

Country: Germany

Inventors: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Paul T Rubery, Edward Michael Schwarz

Light Activated Gene Transduction (LAGeT) for Cell Targeted Gene Delivery

Issue date: March 18, 2009

Patent #: IT1867715

Country: Italy

Inventors: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Paul T Rubery, Edward Michael Schwarz

Methods and Compositions for Treating Inflammatory Conditions

Issue date: November 12, 2013

Patent #: 8,580,755

Country: United States

Inventors: Brendan Boyce, Edward Michael Schwarz, Lianping Xing

Targeted Delivery of Therapeutic Agents With Lyophilized Matrices

Issue date: January 21, 2014

Patent #: 8,632,797

Country: United States

Inventors: Hani A Awad, Edward Michael Schwarz

Methods and Compositions Related to Joint Inflammation Diseases

Issue date: January 12, 2011

Patent #: FR1604205

Country: France

Inventors: Sally A Haas, Christopher T Ritchlin, Edward Michael Schwarz

Methods and Compositions Related to Joint Inflammation Diseases

Issue date: January 12, 2011

Patent #: DE1604205

Country: Germany

Inventors: Sally A Haas, Christopher T Ritchlin, Edward Michael Schwarz

Methods and Compositions Related to Joint Inflammation Diseases

Issue date: January 12, 2011

Patent #: GB1604205

Country: United Kingdom

Inventors: Sally A Haas, Christopher T Ritchlin, Edward Michael Schwarz

DC-STAMP Antibodies

Issue date: July 25, 2017

Patent #: 2,760,330

Country: Canada

Inventors: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward Michael Schwarz

DC-STAMP Antibodies

Issue date: June 07, 2017

Patent #: 2424892

Country: Europe

Inventors: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward Michael Schwarz

DC-STAMP Antibodies

Issue date: April 28, 2015

Patent #: 9,018,358

Country: United States

Inventors: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward Michael Schwarz

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: June 30, 2016

Patent #: 2011248209

Country: Australia

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: July 14, 2020

Patent #: 2,797,121

Country: Canada

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: November 02, 2016

Patent #: 2566891

Country: Europe

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: November 11, 2016

Patent #: 6038777

Country: Japan

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: August 22, 2017

Patent #: 9,737,601

Country: United States

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: November 08, 2016

Patent #: 9,487,577

Country: United States

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: December 17, 2015

Patent #: 2012332777

Country: Australia

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: December 08, 2015

Patent #: 2,853,943

Country: Canada

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: September 18, 2019

Patent #: 2785376

Country: Europe

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: November 13, 2015

Patent #: 5837215

Country: Japan

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

DC-STAMP Antibodies

Issue date: June 05, 2018

Patent #: 9,988,448

Country: United States

Inventors: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward Michael Schwarz

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: April 07, 2017

Patent #: 6120924

Country: Japan

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: March 30, 2017

Patent #: 2015224393

Country: Australia

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Passive Immunization for Staphylococcus Infections

Issue date: August 27, 2020

Patent #: 2014361821

Country: Australia

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Passive Immunization for Staphylococcus Infections

Issue date: June 25, 2021

Patent #: ZL201480067873.2

Country: China, People's Republic of

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Passive Immunization for Staphylococcus Infections

Issue date: September 02, 2020

Patent #: 3079720

Country: Europe

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Passive Immunization for Staphylococcus Infections

Issue date: May 31, 2019

Patent #: 6533226

Country: Japan

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Passive Immunization for Staphylococcus Infections

Issue date: October 21, 2021

Patent #: 10-2318139

Country: Korea, Republic of

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Passive Immunization for Staphylococcus Infections

Issue date: October 16, 2018

Patent #: 10,100,127

Country: United States

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: November 02, 2016

Patent #: BE2566891

Country: Belgium

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: November 02, 2016

Patent #: FR2566891

Country: France

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: November 02, 2016

Patent #: DE2566891

Country: Germany

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: November 02, 2016

Patent #: IT2566891

Country: Italy

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: November 02, 2016

Patent #: NL2566891

Country: Netherlands

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: November 02, 2016

Patent #: 2566891

Country: Spain

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: November 02, 2016

Patent #: CH2566891

Country: Switzerland/Liechtenstein

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: November 02, 2016

Patent #: 2017/01247

Country: Turkey

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: November 02, 2016

Patent #: GB2566891

Country: United Kingdom

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: September 12, 2017

Patent #: 9,758,572

Country: United States

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: October 20, 2017

Patent #: 6227092

Country: Japan

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: June 29, 2018

Patent #: 6360938

Country: Japan

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: May 30, 2019

Patent #: 2017201748

Country: Australia

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

DC-STAMP Antibodies

Issue date: June 07, 2017

Patent #: FR2424892

Country: France

Inventors: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward Michael Schwarz

DC-STAMP Antibodies

Issue date: June 07, 2017

Patent #: DE2424892

Country: Germany

Inventors: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward Michael Schwarz

DC-STAMP Antibodies

Issue date: June 07, 2017

Patent #: IT2424892

Country: Italy

Inventors: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward Michael Schwarz

DC-STAMP Antibodies

Issue date: June 07, 2017

Patent #: ES2424892

Country: Spain

Inventors: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward Michael Schwarz

DC-STAMP Antibodies

Issue date: June 07, 2017

Patent #: GB2424892

Country: United Kingdom

Inventors: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward Michael Schwarz

Passive Immunization for Staphylococcus Infections

Issue date: May 28, 2021

Patent #: 1230085

Country: Hong Kong

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: January 15, 2019

Patent #: 10,179,170

Country: United States

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: October 30, 2018

Patent #: 10,112,986

Country: United States

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: September 06, 2019

Patent #: 6580649

Country: Japan

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: July 26, 2019

Patent #: 6559302

Country: Japan

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Passive Immunization for Staphylococcus Infections

Issue date: March 03, 2020

Patent #: 10,577,431

Country: United States

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: May 19, 2020

Patent #: 10,653,775

Country: United States

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Passive Immunization for Staphylococcus Infections

Issue date: July 16, 2020

Patent #: 6735879

Country: Japan

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: September 18, 2019

Patent #: FR2785376

Country: France

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: September 18, 2019

Patent #: DE2785376

Country: Germany

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: September 18, 2019

Patent #: GB2785376

Country: United Kingdom

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections

Issue date: July 20, 2021

Patent #: 11,065,333

Country: United States

Inventors: John L Daiss, Edward Michael Schwarz, Mark A Sullivan

Passive Immunization for Staphylococcus Infections

Issue date: September 02, 2020

Patent #: FR3079720

Country: France

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Passive Immunization for Staphylococcus Infections

Issue date: September 02, 2020

Patent #: DE3079720

Country: Germany

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Passive Immunization for Staphylococcus Infections

Issue date: September 02, 2020

Patent #: IE3079720

Country: Ireland

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Passive Immunization for Staphylococcus Infections

Issue date: September 02, 2020

Patent #: IT3079720

Country: Italy

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Passive Immunization for Staphylococcus Infections

Issue date: September 02, 2020

Patent #: NL3079720

Country: Netherlands

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Passive Immunization for Staphylococcus Infections

Issue date: September 02, 2020

Patent #: ES3079720

Country: Spain

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Passive Immunization for Staphylococcus Infections

Issue date: September 02, 2020

Patent #: CH3079720

Country: Switzerland/Liechtenstein

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Passive Immunization for Staphylococcus Infections

Issue date: September 02, 2020

Patent #: GB3079720

Country: United Kingdom

Inventors: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward Michael Schwarz, John J Varrone

Publications

Journal Articles

Efforts to Improve Diversity, Equality, and Inclusion in Sports Medicine via Community Engagement Initiatives Within American Cities Divided by Racial, Social, and Economic Factors.

Maloney MD, Haddas R, Schwarz EM, Nelms S, Rizzone K

Clinics in sports medicine.. 2024 April 43 (2):271-277. Epub 07/26/2023.

A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and S. aureus contaminated bone implants in a mouse femur model.

Lekkala S, Ren Y, Weeks J, Lee K, Tay AJH, Liu B, Xue T, Rainbolt J, Xie C, Schwarz EM, Yeh SA

PloS one.. 2024 19 (6):e0296140. Epub 06/20/2024.

The 2023 Orthopaedic Research Society's International Consensus Meeting on Musculoskeletal Infection: Summary from the In Vitro Section.

Hickok NJ, Li B, Oral E, Zaat SAJ, Armbruster DA, Atkins GJ, Chen AF, Coraça-Huber DC, Dai T, Greenfield EM, Kasinath R, Libera M, Marques CNH, Moriarty TF, Scott Phillips K, Raghuraman K, Ren D, Rimondini L, Saeed K, Schaer TP, Schwarz EM, Spiegel C, Stoodley P, Truong VK, Tsang SJ, Wildemann B, Zelmer AR, Zinkernagel AS

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 December 25 Epub 12/25/2023.

The 2023 Orthopaedic Research Society's International Consensus Meeting on musculoskeletal infection: Summary from the host immunity section.

Schwarz EM, Archer NK, Atkins GJ, Bentley KLM, Botros M, Cassat JE, Chisari E, Coraça-Huber DC, Daiss JL, Gill SR, Goodman SB, Harro J, Hernandez CJ, Ivashkiv LB, Kates SL, Marques CNH, Masters EA, Muthukrishnan G, Owen JR, Raafat D, Saito M, Veis DJ, Xie C

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 December 16 Epub 12/16/2023.

2023 International Consensus Meeting on Musculoskeletal Infection: Summary from the Treatment Workgroup and Consensus on Treatment in Preclinical Models.

Amber Jennings J, Arts C, Falconer R, Ashton N, Williams D, Duffy H, Hamilton J, Markovics A, Gianotti S, Tate J, Montgomery EC, Abuhussein E, Dintakurthi Y, Ren Y, Weeks J, Xie C, Ricciardi B, van Hoogstraten S, Mdingi V, Vanvelk N, Hylen A, Baertl S, Alt V, Morgenstern M, Priddy LB, Tucker LJ, Gautreaux MA, Ducheyne P, Bhattacharyya S, Obremskey WT, Libos A, Cain JD, Hickok NJ, Schwarz EM, Fintan Moriarty T

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 December 9 Epub 12/09/2023.

A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and contaminated bone implants in a mouse femur model.

Lekkala S, Ren Y, Weeks J, Lee K, Tay AJH, Liu B, Xue T, Rainbolt J, Xie C, Schwarz EM, Yeh SA

bioRxiv : the preprint server for biology.. 2023 December 8 Epub 12/08/2023.

Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis.

Ren Y, Weeks J, Xue T, Rainbolt J, de Mesy Bentley KL, Shu Y, Liu Y, Masters E, Cherian P, McKenna CE, Neighbors J, Ebetino FH, Schwarz EM, Sun S, Xie C

Bone research.. 2023 October 1811 (1):51. Epub 10/18/2023.

The 2023 Orthopaedic Research Society International Consensus Meeting on musculoskeletal infection.

Moriarty TF, Hickok NJ, Saeed K, Schaer TP, Chen AF, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 October 12 Epub 10/12/2023.

Longitudinal Intravital Imaging of the Bone Marrow (LIMB) for Analysis of the Race for the Surface in a Murine Osteomyelitis Model.

Xie C, Ren Y, Weeks J, Rainbolt J, Mark Kenney H, Xue T, Allen F, Shu Y, Tay AJH, Lekkala S, Yeh SA, Muthukrishnan G, Gill AL, Gill SR, Kim M, Kates SL, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 October 9 Epub 10/09/2023.

Epidemiological updates of post-traumatic related limb osteomyelitis in china: a 10 years multicenter cohort study.

Ren Y, Liu L, Sun D, Zhang Z, Li M, Lan X, Ni J, Yan M, Huang W, Liu Z, Peng A, Zhang Y, Jiang N, Song K, Huang Z, Bi Q, Zhang J, Yang Q, Yang J, Liu Y, Fu W, Tian X, Wang Y, Zhong W, Song X, Abudurexiti A, Xia Z, Jiang Q, Shi H, Liu X, Wang G, Hu Y, Zhang Y, Yin G, Fan J, Feng S, Zhou X, Li Z, He W, Weeks J, Schwarz EM, Kates SL, Huang L, Chai Y, Yu B, Xie Z, Deng Z, Xie C

International journal of surgery.. 2023 May 29 Epub 05/29/2023.

Reduced Angiogenesis and Delayed Endochondral Ossification in CD163-/- Mice Highlights a Role of M2 Macrophages During Bone Fracture Repair.

Ren Y, Zhang S, Weeks J, Rangel-Moreno J, He B, Xue T, Rainbolt J, Morita Y, Shu Y, Liu Y, Kates SL, Schwarz EM, Xie C

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 March 27 Epub 03/27/2023.

The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies.

Zhang H, Liesveld JL, Calvi LM, Lipe BC, Xing L, Becker MW, Schwarz EM, Yeh SA

Bone research.. 2023 March 1411 (1):15. Epub 03/14/2023.

Near-Infrared Imaging of Indocyanine Green Identifies Novel Routes of Lymphatic Drainage from Metacarpophalangeal Joints in Healthy Human Hands.

Kenney HM, Dieudonne G, Yee S, Maki JH, Wood RW, Schwarz EM, Ritchlin CT, Rahimi H

Lymphatic research and biology.. 2023 February 20 Epub 02/20/2023.

Implementation of automated behavior metrics to evaluate voluntary wheel running effects on inflammatory-erosive arthritis and interstitial lung disease in TNF-Tg mice.

Kenney HM, Wood RW, Ramirez G, Bell RD, Chen KL, Schnur L, Rahimi H, Korman BD, Xing L, Ritchlin CT, Schwarz EM, Cole CL

Arthritis research & therapy.. 2023 February 225 (1):17. Epub 02/02/2023.

The Enigmas of Lymphatic Muscle Cells: Where Do They Come From, How Are They Maintained, and Can They Regenerate?

Kenney HM, Peng Y, de Mesy Bentley KL, Xing L, Ritchlin CT, Schwarz EM

Current rheumatology reviews.. 2023 January 27 Epub 01/27/2023.

Targeting synovial lymphatic function as a novel therapeutic intervention for age-related osteoarthritis in mice.

Lin X, Bell RD, Catheline SE, Takano T, McDavid A, Jonason JH, Schwarz EM, Xing L

Arthritis & rheumatology.. 2023 January 10 Epub 01/10/2023.

Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.

Kenney HM, Rangel-Moreno J, Peng Y, Chen KL, Bruno J, Embong A, Pritchett E, Fox JI, Becerril-Villanueva E, Gamboa-Domínguez A, Quataert S, Muthukrishnan G, Wood RW, Korman BD, Anolik JH, Xing L, Ritchlin CT, Schwarz EM, Wu CL

Frontiers in immunology.. 2023 14 :1237498. Epub 08/25/2023.

Distinct mast cell subpopulations within and around lymphatic vessels regulate lymph flow and progression of inflammatory-erosive arthritis in TNF-transgenic mice.

Peng Y, Kenney HM, de Mesy Bentley KL, Xing L, Ritchlin CT, Schwarz EM

Frontiers in immunology.. 2023 14 :1275871. Epub 12/14/2023.

Fracture-related infection.

Moriarty TF, Metsemakers WJ, Morgenstern M, Hofstee MI, Vallejo Diaz A, Cassat JE, Wildemann B, Depypere M, Schwarz EM, Richards RG

Nature reviews. Disease primers.. 2022 October 208 (1):67. Epub 10/20/2022.

Identification of Penicillin Binding Protein 4 (PBP4) Inhibitors.

Young M, Walsh DJ, Masters E, Gondil VS, Laskey E, Klaczko M, Awad H, McGrath J, Schwarz EM, Melander C, Dunman PM

Antibiotics.. 2022 October 411 (10)Epub 10/04/2022.

Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-?-induced inflammatory activation of synovial fibroblasts.

Siegel RJ, Singh AK, Panipinto PM, Shaikh FS, Vinh J, Han SU, Kenney HM, Schwarz EM, Crowson CS, Khuder SA, Khuder BS, Fox DA, Ahmed S

Cellular & molecular immunology.. 2022 September 7 Epub 09/07/2022.

Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation.

Morita Y, Saito M, Rangel-Moreno J, Franchini AM, Owen JR, Martinez JC, Daiss JL, de Mesy Bentley KL, Kates SL, Schwarz EM, Muthukrishnan G

Bone research.. 2022 August 2610 (1):56. Epub 08/26/2022.

Persistent popliteal lymphatic muscle cell coverage defects despite amelioration of arthritis and recovery of popliteal lymphatic vessel function in TNF-Tg mice following anti-TNF therapy.

Kenney HM, Peng Y, Bell RD, Wood RW, Xing L, Ritchlin CT, Schwarz EM

Scientific reports.. 2022 July 2612 (1):12751. Epub 07/26/2022.

A high-throughput semi-automated bone segmentation workflow for murine hindpaw micro-CT datasets.

Kenney HM, Peng Y, Chen KL, Ajalik R, Schnur L, Wood RW, Schwarz EM, Awad HA

Bone reports.. 2022 June 16 :101167. Epub 01/20/2022.

Relapsed boyhood tibia polymicrobial osteomyelitis linked to dermatophytosis: a case report.

Kong P, Ren Y, Yang J, Fu W, Liu Z, Li Z, He W, Wang Y, Zheng Z, Ding M, Schwarz EM, Deng Z, Xie C

BMC surgery.. 2022 May 422 (1):156. Epub 05/04/2022.

What are the immune responses that allow us to live with incurable bone infection, and how can they be augmented to improve outcomes following prosthetic joint infection?

Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2022 April 18 Epub 04/18/2022.

Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model.

Kenney HM, Wu CL, Loiselle AE, Xing L, Ritchlin CT, Schwarz EM

Arthritis research & therapy.. 2022 March 724 (1):64. Epub 03/07/2022.

PTH-Induced Bone Regeneration and Vascular Modulation Are Both Dependent on Endothelial Signaling.

Cohn-Schwartz D, Schary Y, Yalon E, Krut Z, Da X, Schwarz EM, Gazit D, Pelled G, Gazit Z

Cells.. 2022 March 511 (5)Epub 03/05/2022.

Skeletal infections: microbial pathogenesis, immunity and clinical management.

Masters EA, Ricciardi BF, Bentley KLM, Moriarty TF, Schwarz EM, Muthukrishnan G

Nature reviews. Microbiology.. 2022 February 15 Epub 02/15/2022.

Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of Osteomyelitis: Evidence of "Target & Release" Kinetics and Killing of Bacteria Within Canaliculi.

Ren Y, Xue T, Rainbolt J, Bentley KLM, Galloway CA, Liu Y, Cherian P, Neighbors J, Hofstee MI, Ebetino FH, Moriarty TF, Sun S, Schwarz EM, Xie C

Frontiers in cellular and infection microbiology.. 2022 12 :910970. Epub 06/24/2022.

Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With Osteomyelitis and Their Association With Clinical Outcome Following Surgery in a Clinical Pilot.

Sherchand SP, Adhikari RP, Muthukrishnan G, Kanipakala T, Owen JR, Xie C, Aman MJ, Proctor RA, Schwarz EM, Kates SL

Frontiers in cellular and infection microbiology.. 2022 12 :876898. Epub 07/18/2022.

Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis.

Garcia-Hernandez ML, Rangel-Moreno J, Garcia-Castaneda M, Kenney HM, Paine A, Thullen M, Anandarajah AP, Schwarz EM, Dirksen RT, Ritchlin CT

Frontiers in immunology.. 2022 13 :1026574. Epub 11/07/2022.

Quantitative flow chamber system for evaluating in vitro biofilms and the kinetics of S. aureus biofilm formation in human plasma media.

Sutipornpalangkul W, Nishitani K, Schwarz EM

BMC microbiology.. 2021 November 1121 (1):314. Epub 11/11/2021.

Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid.

Adjei-Sowah E, Peng Y, Weeks J, Jonason JH, de Mesy Bentley KL, Masters E, Morita Y, Muthukrishnan G, Cherian P, Hu XE, McKenna CE, Ebetino FH, Sun S, Schwarz EM, Xie C

Antibiotics.. 2021 June 1710 (6)Epub 06/17/2021.

Increased myocellular lipid and IGFBP-3 expression in a pre-clinical model of pancreatic cancer-related skeletal muscle wasting.

Cole CL, Bachman JF, Ye J, Murphy J, Gerber SA, Beck CA, Boyce BF, Muthukrishnan G, Chakkalakal JV, Schwarz EM, Linehan D

Journal of cachexia, sarcopenia and muscle.. 2021 May 7 Epub 05/07/2021.

Lymphatic muscle cells contribute to dysfunction of the synovial lymphatic system in inflammatory arthritis in mice.

Liang Q, Zhang L, Xu H, Li J, Chen Y, Schwarz EM, Shi Q, Wang Y, Xing L

Arthritis research & therapy.. 2021 February 1923 (1):58. Epub 02/19/2021.

Introduction for the Journal of Orthopaedic Research Special Issue on musculoskeletal infection.

Schwarz EM, Arts JJC, Chen AF

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2021 January 17 Epub 01/17/2021.

Humanized Mice Exhibit Exacerbated Abscess Formation and Osteolysis During the Establishment of Implant-Associated Osteomyelitis.

Muthukrishnan G, Wallimann A, Rangel-Moreno J, Bentley KLM, Hildebrand M, Mys K, Kenney HM, Sumrall ET, Daiss JL, Zeiter S, Richards RG, Schwarz EM, Moriarty TF

Frontiers in immunology.. 2021 12 :651515. Epub 03/18/2021.

Interleukin-27 and Its Diverse Effects on Bacterial Infections.

Morita Y, Masters EA, Schwarz EM, Muthukrishnan G

Frontiers in immunology.. 2021 12 :678515. Epub 05/17/2021.

Cell Wall Biosynthesis Modulates Bone Invasion and Osteomyelitis Pathogenesis.

Masters EA, Muthukrishnan G, Ho L, Gill AL, de Mesy Bentley KL, Galloway CA, McGrath JL, Awad HA, Gill SR, Schwarz EM

Frontiers in microbiology.. 2021 12 :723498. Epub 08/16/2021.

Demonstration of Functional Deficiencies in Popliteal Lymphatic Vessels From TNF-Transgenic Mice With Inflammatory Arthritis.

Scallan JP, Bouta EM, Rahimi H, Kenney HM, Ritchlin CT, Davis MJ, Schwarz EM

Frontiers in physiology.. 2021 12 :745096. Epub 09/27/2021.

Emerging Electron Microscopy and 3D Methodologies to Interrogate Staphylococcus aureus Osteomyelitis in Murine Models.

de Mesy Bentley KL, Galloway CA, Muthukrishnan G, Echternacht SR, Masters EA, Zeiter S, Schwarz EM, Leckenby JI

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 December 30 Epub 12/30/2020.

Distinct Vasculotropic vs. Osteotropic Features of S. agalactiae vs. S. aureus Implant-Associated Bone Infection in Mice.

Masters EA, Hao SP, Mark Kenney H, Morita Y, Galloway CA, de Mesy Bentley KL, Ricciardi BF, Boyce BF, Schwarz EM, Oh I

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 December 18 Epub 12/18/2020.

Clinical Utilization of Species-Specific Immunoassays for Identification of S. aureus and Streptococcus agalactiae in Orthopaedic Infections.

Sulovari A, Ninomiya MJ, Beck CA, Ricciardi BF, Ketonis C, Mesfin A, Kaplan NB, Soin SP, McDowell SM, Mahmood B, Daiss JL, Schwarz EM, Oh I

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 December 4 Epub 12/04/2020.

Antimicrobial Resistance, the COVID-19 Pandemic, and Lessons for the Orthopaedic Community.

Metsemakers WJ, Zalavras C, Schwarz EM, Chen AF, Trampuz A, Moriarty TF

The Journal of bone and joint surgery. American volume.. 2020 December 2 Epub 12/02/2020.

Species-Specific Immunoassay Aids Identification of Pathogen and Tracks Infectivity in Foot Infection.

Hao SP, Masters EA, Ninomiya MJ, Beck CA, Schwarz EM, Daiss JL, Oh I

Foot & ankle international.. 2020 November 9 :1071100720965136. Epub 11/09/2020.

Identification of Penicillin Binding Protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice.

Masters EA, de Mesy Bentley KL, Gill AL, Hao SP, Galloway CA, Salminen AT, Guy DR, McGrath JL, Awad HA, Gill SR, Schwarz EM

PLoS pathogens.. 2020 October 2216 (10):e1008988. Epub 10/22/2020.

Lineage tracing reveals evidence of a popliteal lymphatic muscle progenitor cell that is distinct from skeletal and vascular muscle progenitors.

Kenney HM, Bell RD, Masters EA, Xing L, Ritchlin CT, Schwarz EM

Scientific reports.. 2020 October 2210 (1):18088. Epub 10/22/2020.

IsdB antibody-mediated sepsis following S. aureus surgical site infection.

Nishitani K, Ishikawa M, Morita Y, Yokogawa N, Xie C, de Mesy Bentley KL, Ito H, Kates SL, Daiss JL, Schwarz EM

JCI insight.. 2020 October 25 (19)Epub 10/02/2020.

Lack of Humoral Immunity Against Glucosaminidase Is Associated with Postoperative Complications in Staphylococcus aureus Osteomyelitis.

Kates SL, Owen JR, Beck CA, Xie C, Muthukrishnan G, Daiss JL, Schwarz EM

The Journal of bone and joint surgery. American volume.. 2020 August 27 Epub 08/27/2020.

A Bioinformatic Approach to Utilize a Patient's Antibody-Secreting Cells against to Detect Challenging Musculoskeletal Infections.

Muthukrishnan G, Soin S, Beck CA, Grier A, Brodell JD, Lee CC, Ackert-Bicknell CL, Lee FE, Schwarz EM, Daiss JL

ImmunoHorizons.. 2020 June 224 (6):339-351. Epub 06/22/2020.

Teriparatide (rPTH1-34) enhances bone allograft integration in a clinically relevant pig model of segmental mandibulectomy.

Pelled G, Lieber R, Avalos P, Cohn-Yakubovich D, Tawackoli W, Roth J, Knapp E, Schwarz EM, Awad HA, Gazit D, Gazit Z

Journal of tissue engineering and regenerative medicine.. 2020 June 1 Epub 06/01/2020.

Altered Lymphatic Vessel Anatomy and Markedly Diminished Lymph Clearance in the Rheumatoid Hand with Active Arthritis.

Bell RD, Rahimi H, Kenney HM, Lieberman AA, Wood RW, Schwarz EM, Ritchlin CT

Arthritis & rheumatology.. 2020 May 18 Epub 05/18/2020.

TNF Induces Obliterative Pulmonary Vascular Disease in a Novel Model of Connective Tissue Disease Associated Pulmonary Arterial Hypertension (CTD-PAH).

Bell RD, White RJ, Garcia-Hernandez ML, Wu E, Rahimi H, Marangoni RG, Slattery P, Duemmel S, Nuzzo M, Huertas N, Yee M, O'Reilly MA, Morrell C, Ritchlin CT, Schwarz EM, Korman BD

Arthritis & rheumatology.. 2020 May 10 Epub 05/10/2020.

Lack of Additional Advanced Graduate Training by Orthopaedic Surgeons in Academic Practice: Current Employment and Recruitment Trends.

Anderson DE, Kuhns BD, Kaupp S, Schwarz EM, Rubery PT, Mannava S

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews.. 2020 May 4 (5):e2000003. Epub 1900 01 01.

Bacterial toxins in musculoskeletal infections.

Saeed K, Sendi P, Arnold WV, Bauer TW, Coraça-Huber DC, Chen AF, Choe H, Daiss JL, Ghert M, Hickok NJ, Nishitani K, Springer BD, Stoodley P, Sculco TP, Brause BD, Parvizi J, McLaren AC, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 April 7 Epub 04/07/2020.

Biofilm Producing Staphylococcus epidermidis (RP62A Strain) Inhibits Osseous Integration Without Osteolysis and Histopathology in a Murine Septic Implant Model.

Tomizawa T, Ishikawa M, Bello-Irizarry SN, de Mesy Bentley KL, Ito H, Kates SL, Daiss JL, Beck C, Matsuda S, Schwarz EM, Nishitani K

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 April 38 (4):852-860. Epub 11/19/2019.

American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies - Secondary Publication.

O'Keefe RJ, Tuan RS, Lane NE, Awad HA, Barry F, Bunnell BA, Colnot C, Drake MT, Drissi H, Dyment NA, Fortier LA, Guldberg RE, Kandel R, Little DG, Marshall MF, Mao JJ, Nakamura N, Proffen BL, Rodeo SA, Rosen V, Thomopoulos S, Schwarz EM, Serra R

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 March 38 (3):485-502. Epub 01/29/2020.

Deriving a dose and regimen for anti-glucosaminidase antibody passive-immunisation for patients with Staphylococcus aureus osteomyelitis.

Lee CC, Southgate RD, Jiao C, Gersz E, Owen JR, Kates SL, Beck CA, Xie C, Daiss JL, Post V, Moriarty TF, Zeiter S, Schwarz EM, Muthukrishnan G

European cells & materials.. 2020 January 3139 :96-107. Epub 01/31/2020.

Adjuvant antibiotic-loaded bone cement: Concerns with current use and research to make it work.

Schwarz EM, McLaren AC, Sculco TP, Brause B, Bostrom M, Kates SL, Parvizi J, Alt V, Arnold WV, Carli A, Chen AF, Choe H, Coraça-Huber DC, Cross M, Ghert M, Hickok N, Jennings JA, Joshi M, Metsemakers WJ, Ninomiya M, Nishitani K, Oh I, Padgett D, Ricciardi B, Saeed K, Sendi P, Springer B, Stoodley P, Wenke JC

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 January 30 Epub 01/30/2020.

New Developments and Future Challenges in Prevention, Diagnosis, and Treatment of Prosthetic Joint Infection.

Ricciardi BF, Muthukrishnan G, Masters EA, Kaplan N, Daiss JL, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 January 22 Epub 01/22/2020.

American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies.

O'Keefe RJ, Tuan RS, Lane NE, Barry F, Bunnell BA, Colnot C, Drake MT, Drissi H, Fortier LA, Guldberg RE, Little DG, Marshall MF, Mao JJ, Nakamura N, Robey PG, Rosen V, Rowe DW, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2020 January 35 (1):3-17. Epub 09/23/2019.

Dual Energy X-ray Absorptiometry (DEXA) as a longitudinal outcome measure of cancer-related muscle wasting in mice.

Cole CL, Beck CA, Robinson D, Ye J, Mills B, Gerber SA, Schwarz EM, Linehan D

PloS one.. 2020 15 (6):e0230695. Epub 06/19/2020.

Use of Fitbit Data to Evaluate the Effects of an Athletic Performance and Injury Prevention Training Program on Daily Physical Levels in Underrepresented Minority Female High School Athletes: A Prospective Study.

Cole CL, Vasalos K, Nicandri G, Apt C, Osterling E, Ferrara Z, Maloney MD, Schwarz EM, Rizzone K

Orthopedics and sports medicine : open access journal.. 2020 4 (2):370-376. Epub 07/10/2020.

TNF-Induced Interstitial Lung Disease in a Murine Arthritis Model: Accumulation of Activated Monocytes, Conventional Dendritic Cells, and CD21/CD23 B Cell Follicles Is Prevented with Anti-TNF Therapy.

Wu EK, Henkes ZI, McGowan B, Bell RD, Velez MJ, Livingstone AM, Ritchlin CT, Schwarz EM, Rahimi H

The Journal of immunology : official journal of the American Association of Immunologists.. 2019 December 1203 (11):2837-2849. Epub 10/28/2019.

Avian Reticuloendotheliosis Viral Oncogene Related B Regulates Lymphatic Endothelial Cells during Vessel Maturation and Is Required for Lymphatic Vessel Function in Adult Mice.

Liang Q, Zhang L, Wood RW, Ji RC, Boyce BF, Schwarz EM, Wang Y, Xing L

The American journal of pathology.. 2019 December 189 (12):2516-2530. Epub 09/17/2019.

iNOS dependent and independent phases of lymph node expansion in mice with TNF-induced inflammatory-erosive arthritis.

Bell RD, Slattery PN, Wu EK, Xing L, Ritchlin CT, Schwarz EM

Arthritis research & therapy.. 2019 November 1421 (1):240. Epub 11/14/2019.

Mechanisms of Immune Evasion and Bone Tissue Colonization That Make Staphylococcus aureus the Primary Pathogen in Osteomyelitis.

Muthukrishnan G, Masters EA, Daiss JL, Schwarz EM

Current osteoporosis reports.. 2019 November 13 Epub 11/13/2019.

An in vitro platform for elucidating the molecular genetics of S. aureus invasion of the osteocyte lacuno-canalicular network during chronic osteomyelitis.

Masters EA, Salminen AT, Begolo S, Luke EN, Barrett SC, Overby CT, Gill AL, de Mesy Bentley KL, Awad HA, Gill SR, Schwarz EM, McGrath JL

Nanomedicine : nanotechnology, biology, and medicine.. 2019 October 21 :102039. Epub 06/24/2019.

Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor-Transgenic Mouse Model of Rheumatoid Arthritis.

Bell DR, Wu E, Rudmann C, Forney M, Kaiser C, Wood R, Chakkalakal J, Paris N, Klose A, Xiao GQ, Rangel-Moreno J, Garcia-Hernandez M, Ritchlin C, Schwarz E, Rahimi H

Arthritis & rheumatology.. 2019 September 71 (9):1512-1523. Epub 07/22/2019.

Restrictive lung disease in TNF-transgenic mice: correlation of pulmonary function testing and micro-CT imaging.

Wu EK, Eliseeva S, Rahimi H, Schwarz EM, Georas SN

Experimental lung research.. 2019 September 45 (7):175-187. Epub 07/18/2019.

Evidence of differential microbiomes in healing versus non-healing diabetic foot ulcers prior to and following foot salvage therapy.

MacDonald A, Brodell JD, Daiss JL, Schwarz EM, Oh I

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 July 37 (7):1596-1603. Epub 03/28/2019.

A murine femoral ostectomy model with hardware exchange to assess antibiotic-impregnated spacers for implant-associated osteomyelitis.

Trombetta RP, de Mesy Bentley KL, Schwarz EM, Kate SL, Awad HA

European cells & materials.. 2019 June 2737 :431-443. Epub 06/27/2019.

The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28.

Kiontke KC, Herrera RA, Vuong E, Luo J, Schwarz EM, Fitch DHA, Portman DS

Developmental cell.. 2019 May 2049 (4):542-555.e9. Epub 04/04/2019.

2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections.

Saeed K, McLaren AC, Schwarz EM, Antoci V, Arnold WV, Chen AF, Clauss M, Esteban J, Gant V, Hendershot E, Hickok N, Higuera CA, Coraça-Huber DC, Choe H, Jennings JA, Joshi M, Li WT, Noble PC, Phillips KS, Pottinger PS, Restrepo C, Rohde H, Schaer TP, Shen H, Smeltzer M, Stoodley P, Webb JCJ, Witsø E

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 May 37 (5):1007-1017. Epub 02/12/2019.

2018 International Consensus Meeting on Musculoskeletal Infection: Research Priorities from the General Assembly Questions.

Schwarz EM, Parvizi J, Gehrke T, Aiyer A, Battenberg A, Brown SA, Callaghan JJ, Citak M, Egol K, Garrigues GE, Ghert M, Goswami K, Green A, Hammoud S, Kates SL, McLaren AC, Mont MA, Namdari S, Obremskey WT, O'Toole R, Raikin S, Restrepo C, Ricciardi B, Saeed K, Sanchez-Sotelo J, Shohat N, Tan T, Thirukumaran CP, Winters B

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 May 37 (5):997-1006. Epub 04/25/2019.

Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis.

Trombetta RP, Ninomiya MJ, El-Atawneh IM, Knapp EK, de Mesy Bentley KL, Dunman PM, Schwarz EM, Kates SL, Awad HA

Pharmaceutics.. 2019 February 2211 (2)Epub 02/22/2019.

Attenuated Joint Tissue Damage Associated With Improved Synovial Lymphatic Function Following Treatment With Bortezomib in a Mouse Model of Experimental Posttraumatic Osteoarthritis.

Wang W, Lin X, Xu H, Sun W, Bouta EM, Zuscik MJ, Chen D, Schwarz EM, Xing L

Arthritis & rheumatology.. 2019 February 71 (2):244-257. Epub 01/05/2019.

Reinterpreting Evidence of Rheumatoid Arthritis-Associated Interstitial Lung Disease to Understand Etiology.

Wu EK, Ambrosini RD, Kottmann RM, Ritchlin CT, Schwarz EM, Rahimi H

Current rheumatology reviews.. 2019 15 (4):277-289. Epub 1900 01 01.

Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy".

Masters EA, Trombetta RP, de Mesy Bentley KL, Boyce BF, Gill AL, Gill SR, Nishitani K, Ishikawa M, Morita Y, Ito H, Bello-Irizarry SN, Ninomiya M, Brodell JD, Lee CC, Hao SP, Oh I, Xie C, Awad HA, Daiss JL, Owen JR, Kates SL, Schwarz EM, Muthukrishnan G

Bone research.. 2019 7 :20. Epub 07/15/2019.

Use of PROMIS and Functional Movement System (FMS) Testing to Evaluate the Effects of Athletic Performance and Injury Prevention Training in Female High School Athletes.

Cole CL, Vasalos K, Nicandri G, Apt C, Osterling E, Ferrara Z, Maloney MD, Schwarz EM, Rizzone K

Orthopedics and sports medicine : open access journal.. 2019 3 (2):255-258. Epub 12/18/2019.

Tracking Anti- Antibodies Produced and during Foot Salvage Therapy for Diabetic Foot Infections Reveals Prognostic Insights and Evidence of Diversified Humoral Immunity.

Oh I, Muthukrishnan G, Ninomiya MJ, Brodell JD, Smith BL, Lee CC, Gill SR, Beck CA, Schwarz EM, Daiss JL

Infection and immunity.. 2018 December 86 (12)Epub 11/20/2018.

Staphylococcus aureus Evasion of Host Immunity in the Setting of Prosthetic Joint Infection: Biofilm and Beyond.

Ricciardi BF, Muthukrishnan G, Masters E, Ninomiya M, Lee CC, Schwarz EM

Current reviews in musculoskeletal medicine.. 2018 September 11 (3):389-400. Epub 1900 01 01.

Exacerbated Foot Infections in Obese/Diabetic Mice Are Associated with Impaired Germinal Center Reactions, Ig Class Switching, and Humoral Immunity.

Farnsworth CW, Schott EM, Benvie A, Kates SL, Schwarz EM, Gill SR, Zuscik MJ, Mooney RA

The Journal of immunology : official journal of the American Association of Immunologists.. 2018 July 15201 (2):560-572. Epub 06/01/2018.

Obesity/type 2 diabetes increases inflammation, periosteal reactive bone formation, and osteolysis during Staphylococcus aureus implant-associated bone infection.

Farnsworth CW, Schott EM, Benvie AM, Zukoski J, Kates SL, Schwarz EM, Gill SR, Zuscik MJ, Mooney RA

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2018 June 36 (6):1614-1623. Epub 01/03/2018.

Immunotherapy synergizes with debridement and antibiotic therapy in a murine 1-stage exchange model of MRSA implant-associated osteomyelitis.

Yokogawa N, Ishikawa M, Nishitani K, Beck CA, Tsuchiya H, Mesfin A, Kates SL, Daiss JL, Xie C, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2018 June 36 (6):1590-1598. Epub 02/05/2018.

Teriparatide (human PTH) compensates for impaired fracture healing in COX-2 deficient mice.

Yukata K, Xie C, Li TF, Brown ML, Kanchiku T, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ

Bone.. 2018 May 110 :150-159. Epub 02/03/2018.

Osteoblast-osteoclast interactions.

Chen X, Wang Z, Duan N, Zhu G, Schwarz EM, Xie C

Connective tissue research.. 2018 March 59 (2):99-107. Epub 03/21/2017.

Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis.

Bouta EM, Bell RD, Rahimi H, Xing L, Wood RW, Bingham CO, Ritchlin CT, Schwarz EM

Nature reviews. Rheumatology.. 2018 February 14 (2):94-106. Epub 01/11/2018.

Longitudinal micro-CT as an outcome measure of interstitial lung disease in TNF-transgenic mice.

Bell RD, Rudmann C, Wood RW, Schwarz EM, Rahimi H

PloS one.. 2018 13 (1):e0190678. Epub 01/10/2018.

Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes: A Case Report.

de Mesy Bentley KL, MacDonald A, Schwarz EM, Oh I

JBJS case connector.. 2018 8 (1):e8. Epub 1900 01 01.

The Role of Systemic Inflammation in Cancer-Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention.

Cole CL, Kleckner IR, Jatoi A, Schwarz EM, Dunne RF

JCSM clinical reports.. 2018 3 (2)Epub 1900 01 01.

Surface topography of silicon nitride affects antimicrobial and osseointegrative properties of tibial implants in a murine model.

Ishikawa M, de Mesy Bentley KL, McEntire BJ, Bal BS, Schwarz EM, Xie C

Journal of biomedical materials research. Part A.. 2017 December 105 (12):3413-3421. Epub 09/26/2017.

Teriparatide Treatment Improves Bone Defect Healing Via Anabolic Effects on New Bone Formation and Non-Anabolic Effects on Inhibition of Mast Cells in a Murine Cranial Window Model.

Zhang L, Wang T, Chang M, Kaiser C, Kim JD, Wu T, Cao X, Zhang X, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 September 32 (9):1870-1883. Epub 07/19/2017.

Brief Report: Treatment of Tumor Necrosis Factor-Transgenic Mice With Anti-Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte/Macrophage Egress.

Bouta EM, Kuzin I, de Mesy Bentley K, Wood RW, Rahimi H, Ji RC, Ritchlin CT, Bottaro A, Xing L, Schwarz EM

Arthritis & rheumatology.. 2017 June 69 (6):1187-1193. Epub 04/04/2017.

Adaptive Upregulation of Clumping Factor A (ClfA) by Staphylococcus aureus in the Obese, Type 2 Diabetic Host Mediates Increased Virulence.

Farnsworth CW, Schott EM, Jensen SE, Zukoski J, Benvie AM, Refaai MA, Kates SL, Schwarz EM, Zuscik MJ, Gill SR, Mooney RA

Infection and immunity.. 2017 June 85 (6)Epub 05/23/2017.

Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis.

de Mesy Bentley KL, Trombetta R, Nishitani K, Bello-Irizarry SN, Ninomiya M, Zhang L, Chung HL, McGrath JL, Daiss JL, Awad HA, Kates SL, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 May 32 (5):985-990. Epub 01/26/2017.

3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery.

Trombetta R, Inzana JA, Schwarz EM, Kates SL, Awad HA

Annals of biomedical engineering.. 2017 January 45 (1):23-44. Epub 06/20/2016.

Epidemiological, Clinical and Microbiological Characteristics of Patients with Post-Traumatic Osteomyelitis of Limb Fractures in Southwest China: A Hospital-Based Study.

Peng J, Ren Y, He W, Li Z, Yang J, Liu Y, Zheng Z, Kates SL, Schwarz EM, Xie C, Xu Y

Journal of bone and joint infection.. 2017 2 (3):149-153. Epub 05/04/2017.

Utilization of longitudinal ultrasound to quantify joint soft-tissue changes in a mouse model of posttraumatic osteoarthritis.

Xu H, Bouta EM, Wood RW, Schwarz EM, Wang Y, Xing L

Bone research.. 2017 5 :17012. Epub 06/13/2017.

High dose teriparatide (rPTH1-34) therapy increases callus volume and enhances radiographic healing at 8-weeks in a massive canine femoral allograft model.

Nishitani K, Mietus Z, Beck CA, Ito H, Matsuda S, Awad HA, Ehrhart N, Schwarz EM

PloS one.. 2017 12 (10):e0185446. Epub 10/11/2017.

Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential.

Rahimi H, Bell R, Bouta EM, Wood RW, Xing L, Ritchlin CT, Schwarz EM

Arthritis research & therapy.. 2016 September 118 :194. Epub 09/01/2016.

Increased numbers of CD23(+) CD21(hi) Bin-like B cells in human reactive and rheumatoid arthritis lymph nodes.

Kuzin II, Kates SL, Ju Y, Zhang L, Rahimi H, Wojciechowski W, Bernstein SH, Burack R, Schwarz EM, Bottaro A

European journal of immunology.. 2016 July 46 (7):1752-7. Epub 05/06/2016.

Antioxidant impregnated ultra-high molecular weight polyethylene wear debris particles display increased bone remodeling and a superior osteogenic:osteolytic profile vs. conventional UHMWPE particles in a murine calvaria model.

Chen Y, Hallab NJ, Liao YS, Narayan V, Schwarz EM, Xie C

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2016 May 34 (5):845-51. Epub 11/23/2015.

Orthopaedic device-related infection: current and future interventions for improved prevention and treatment.

Moriarty TF, Kuehl R, Coenye T, Metsemakers WJ, Morgenstern M, Schwarz EM, Riool M, Zaat SAJ, Khana N, Kates SL, Richards RG

EFORT open reviews.. 2016 April 1 (4):89-99. Epub 03/13/2017.

Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice.

Liang Q, Ju Y, Chen Y, Wang W, Li J, Zhang L, Xu H, Wood RW, Schwarz EM, Boyce BF, Wang Y, Xing L

Arthritis research & therapy.. 2016 March 1218 :62. Epub 03/12/2016.

Biomaterials approaches to treating implant-associated osteomyelitis.

Inzana JA, Schwarz EM, Kates SL, Awad HA

Biomaterials.. 2016 March 81 :58-71. Epub 12/18/2015.

Controlling Arteriogenesis and Mast Cells Are Central to Bioengineering Solutions for Critical Bone Defect Repair Using Allografts.

Antebi B, Zhang L, Sheyn D, Pelled G, Zhang X, Gazit Z, Schwarz EM, Gazit D

Bioengineering.. 2016 March 3 (1)Epub 1900 01 01.

PTH Induces Systemically Administered Mesenchymal Stem Cells to Migrate to and Regenerate Spine Injuries.

Sheyn D, Shapiro G, Tawackoli W, Jun DS, Koh Y, Kang KB, Su S, Da X, Ben-David S, Bez M, Yalon E, Antebi B, Avalos P, Stern T, Zelzer E, Schwarz EM, Gazit Z, Pelled G, Bae HM, Gazit D

Molecular therapy : the journal of the American Society of Gene Therapy.. 2016 February 24 (2):318-330. Epub 11/20/2015.

Controlling Arteriogenesis and Mast Cells Are Central to Bioengineering Solutions for Critical Bone Defect Repair Using Allografts.

Antebi B, Zhang L, Sheyn D, Pelled G, Zhang X, Gazit Z, Schwarz EM, Gazit D

Bioengineering.. 2016 January 113 (1)Epub 01/11/2016.

Relationship Between Lymph Node Volume and Pain Following Certolizumab Therapy for Rheumatoid Arthritis Flare: A Pilot Study.

Rahimi H, Dieudonne G, Kheyfits V, Bouta EM, Wood RW, Barrett R, Moorehead S, Schwarz EM, Ritchlin CT

Clinical medicine insights. Arthritis and musculoskeletal disorders. 2016 9 :203-208. Epub 12/14/2016.

3D printed bioceramics for dual antibiotic delivery to treat implant-associated bone infection.

Inzana JA, Trombetta RP, Schwarz EM, Kates SL, Awad HA

European cells & materials.. 2015 November 430 :232-47. Epub 11/04/2015.

Quantifying the natural history of biofilm formation in vivo during the establishment of chronic implant-associated Staphylococcus aureus osteomyelitis in mice to identify critical pathogen and host factors.

Nishitani K, Sutipornpalangkul W, de Mesy Bentley KL, Varrone JJ, Bello-Irizarry SN, Ito H, Matsuda S, Kates SL, Daiss JL, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2015 September 33 (9):1311-9. Epub 05/18/2015.

A Diagnostic Serum Antibody Test for Patients With Staphylococcus aureus Osteomyelitis.

Nishitani K, Beck CA, Rosenberg AF, Kates SL, Schwarz EM, Daiss JL

Clinical orthopaedics and related research.. 2015 September 473 (9):2735-49. Epub 05/27/2015.

Increased Insulin mRNA Binding Protein-3 Expression Correlates with Vascular Enhancement of Renal Cell Carcinoma by Intravenous Contrast-CT and is Associated with Bone Metastasis.

Xie C, Li Y, Li Q, Chen Y, Yao J, Yin G, Bi Q, O'Keefe RJ, Schwarz EM, Tyler W

Journal of bone oncology.. 2015 September 4 (3):69-76. Epub 09/12/2015.

TNF signals are dispensable for the generation of CD23+ CD21/35-high CD1d-high B cells in inflamed lymph nodes.

Kuzin II, Bouta EM, Schwarz EM, Bottaro A

Cellular immunology.. 2015 August 296 (2):133-7. Epub 04/28/2015.

A humoral immune defect distinguishes the response to Staphylococcus aureus infections in mice with obesity and type 2 diabetes from that in mice with type 1 diabetes.

Farnsworth CW, Shehatou CT, Maynard R, Nishitani K, Kates SL, Zuscik MJ, Schwarz EM, Daiss JL, Mooney RA

Infection and immunity.. 2015 June 83 (6):2264-74. Epub 03/23/2015.

Validation of power Doppler versus contrast-enhanced magnetic resonance imaging quantification of joint inflammation in murine inflammatory arthritis.

Bouta EM, Banik PD, Wood RW, Rahimi H, Ritchlin CT, Thiele RG, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2015 April 30 (4):690-4. Epub 1900 01 01.

Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength.

Zhang M, Feigenson M, Sheu TJ, Awad HA, Schwarz EM, Jonason JH, Loiselle AE, O'Keefe RJ

Bone.. 2015 March 72 :92-100. Epub 11/29/2014.

TGF-?1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair.

Farhat YM, Al-Maliki AA, Easa A, O'Keefe RJ, Schwarz EM, Awad HA

Journal of cellular physiology.. 2015 February 230 (2):318-26. Epub 1900 01 01.

The role of the lymphatic system in inflammatory-erosive arthritis.

Bouta EM, Li J, Ju Y, Brown EB, Ritchlin CT, Xing L, Schwarz EM

Seminars in cell & developmental biology.. 2015 February 38 :90-7. Epub 01/15/2015.

Passive immunization with anti-glucosaminidase monoclonal antibodies protects mice from implant-associated osteomyelitis by mediating opsonophagocytosis of Staphylococcus aureus megaclusters.

Varrone JJ, de Mesy Bentley KL, Bello-Irizarry SN, Nishitani K, Mack S, Hunter JG, Kates SL, Daiss JL, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2014 October 32 (10):1389-96. Epub 07/03/2014.

Validation of GAITRite and PROMIS as high-throughput physical function outcome measures following ACL reconstruction.

Papuga MO, Beck CA, Kates SL, Schwarz EM, Maloney MD

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2014 June 32 (6):793-801. Epub 02/14/2014.

Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.

Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ

Bone.. 2014 May 62 :79-89. Epub 02/12/2014.

3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration.

Inzana JA, Olvera D, Fuller SM, Kelly JP, Graeve OA, Schwarz EM, Kates SL, Awad HA

Biomaterials.. 2014 April 35 (13):4026-34. Epub 02/14/2014.

In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice.

Bouta EM, Wood RW, Brown EB, Rahimi H, Ritchlin CT, Schwarz EM

The Journal of physiology.. 2014 March 15592 (6):1213-23. Epub 01/13/2014.

The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice.

Long T, Zhu Z, Awad HA, Schwarz EM, Hilton MJ, Dong Y

Biomaterials.. 2014 March 35 (9):2752-9. Epub 01/03/2014.

Regenerative medicine: Cartilage transplants hold promise for challenging bone defects.

Nishitani K, Schwarz EM

Nature reviews. Rheumatology.. 2014 March 10 (3):129-30. Epub 01/14/2014.

A127: validating popliteal lymph node phenotype and bin expansion as biomarkers of rheumatoid arthritis knee flare in clinical pilot studies.

Rahimi H, Wood R, Kuzin I, Tyler W, Dieudonne G, Kates S, Ritchlin CT, Schwarz EM

Arthritis & rheumatology.. 2014 March 66 Suppl 3 :S166-7. Epub 1900 01 01.

The 1st International Consensus Meeting on Periprosthetic Joint Infection.

Schwarz EM, Alt V, Kates SL

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2014 January 32 Suppl 1 :S1. Epub 1900 01 01.

The murine femoral bone graft model and a semiautomated histomorphometric analysis tool.

Dhillon RS, Zhang L, Schwarz EM, Boyce BF, Xie C

Methods in molecular biology.. 2014 1130 :45-59. Epub 1900 01 01.

Freeze-dried allograft-mediated gene or protein delivery of growth and differentiation factor 5 reduces reconstructed murine flexor tendon adhesions.

Hasslund S, Dadali T, Ulrich-Vinther M, Søballe K, Schwarz EM, Awad HA

Journal of tissue engineering. 2014 5 :2041731414528736. Epub 03/19/2014.

Divergent gene activation in peripheral blood and tissues of patients with rheumatoid arthritis, psoriatic arthritis and psoriasis following infliximab therapy.

Rosenberg A, Fan H, Chiu YG, Bolce R, Tabechian D, Barrett R, Moorehead S, Baribaud F, Liu H, Peffer N, Shealy D, Schwarz EM, Ritchlin CT

PloS one.. 2014 9 (10):e110657. Epub 10/21/2014.

TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.

Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH

Journal of cell science.. 2013 December 15126 (Pt 24):5704-13. Epub 10/21/2013.

Anti-glucosaminidase IgG in sera as a biomarker of host immunity against Staphylococcus aureus in orthopaedic surgery patients.

Gedbjerg N, Larosa R, Hunter JG, Varrone JJ, Kates SL, Schwarz EM, Daiss JL

The Journal of bone and joint surgery. American volume.. 2013 November 2095 (22):e171. Epub 1900 01 01.

Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice.

Ju Y, Li J, Xie C, Ritchlin CT, Xing L, Hilton MJ, Schwarz EM

Genesis : the journal of genetics and development.. 2013 September 51 (9):667-75. Epub 07/09/2013.

PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis.

Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2013 March 28 (3):586-97. Epub 1900 01 01.

Bone fragility beyond strength and mineral density: Raman spectroscopy predicts femoral fracture toughness in a murine model of rheumatoid arthritis.

Inzana JA, Maher JR, Takahata M, Schwarz EM, Berger AJ, Awad HA

Journal of biomechanics.. 2013 February 2246 (4):723-30. Epub 12/20/2012.

Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow.

Li J, Ju Y, Bouta EM, Xing L, Wood RW, Kuzin I, Bottaro A, Ritchlin CT, Schwarz EM

Arthritis and rheumatism.. 2013 January 65 (1):130-8. Epub 1900 01 01.

Cellular and molecular factors in flexor tendon repair and adhesions: a histological and gene expression analysis.

Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA

Connective tissue research.. 2013 54 (3):218-26. Epub 04/15/2013.

Power Doppler ultrasound phenotyping of expanding versus collapsed popliteal lymph nodes in murine inflammatory arthritis.

Bouta EM, Ju Y, Rahimi H, de Mesy-Bentley KL, Wood RW, Xing L, Schwarz EM

PloS one.. 2013 8 (9):e73766. Epub 09/09/2013.

Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk.

Takahata M, Maher JR, Juneja SC, Inzana J, Xing L, Schwarz EM, Berger AJ, Awad HA

Arthritis and rheumatism.. 2012 November 64 (11):3649-59. Epub 1900 01 01.

Quantifying massive allograft healing of the canine femur in vivo and ex vivo: a pilot study.

Santoni BG, Ehrhart N, Betancourt-Benitez R, Beck CA, Schwarz EM

Clinical orthopaedics and related research.. 2012 September 470 (9):2478-87. Epub 1900 01 01.

Platelet-rich plasma therapy - future or trend?

Dhillon RS, Schwarz EM, Maloney MD

Arthritis research & therapy.. 2012 August 814 (4):219. Epub 08/08/2012.

Conditional activation of ?-catenin signaling in mice leads to severe defects in intervertebral disc tissue.

Wang M, Tang D, Shu B, Wang B, Jin H, Hao S, Dresser KA, Shen J, Im HJ, Sampson ER, Rubery PT, Zuscik MJ, Schwarz EM, O'Keefe RJ, Wang Y, Chen D

Arthritis and rheumatism.. 2012 August 64 (8):2611-23. Epub 1900 01 01.

CD23+ CD21(high) CD1d(high) B cells in inflamed lymph nodes are a locally differentiated population with increased antigen capture and activation potential.

Moshkani S, Kuzin II, Adewale F, Jansson J, Sanz I, Schwarz EM, Bottaro A

The Journal of immunology : official journal of the American Association of Immunologists.. 2012 June 15188 (12):5944-53. Epub 05/16/2012.

Validation of 3-dimensional ultrasound versus magnetic resonance imaging quantification of popliteal lymph node volume as a biomarker of erosive inflammatory arthritis in mice.

Ju Y, Rahimi H, Li J, Wood RW, Xing L, Schwarz EM

Arthritis and rheumatism.. 2012 June 64 (6):2048-50. Epub 02/21/2012.

Endogenous tissue engineering: PTH therapy for skeletal repair.

Takahata M, Awad HA, O'Keefe RJ, Bukata SV, Schwarz EM

Cell and tissue research.. 2012 March 347 (3):545-52. Epub 05/31/2011.

Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression.

Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2012 February 30 (2):325-33. Epub 08/01/2011.

Delayed short-course treatment with teriparatide (PTH(1-34)) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction.

Takahata M, Schwarz EM, Chen T, O'Keefe RJ, Awad HA

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2012 January 27 (1):26-37. Epub 1900 01 01.

Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP).

Chiu YH, Mensah KA, Schwarz EM, Ju Y, Takahata M, Feng C, McMahon LA, Hicks DG, Panepento B, Keng PC, Ritchlin CT

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2012 January 27 (1):79-92. Epub 1900 01 01.

Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury.

Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA, O'Keefe RJ

PloS one.. 2012 7 (7):e40602. Epub 07/11/2012.

Gene expression analysis of the pleiotropic effects of TGF-?1 in an in vitro model of flexor tendon healing.

Farhat YM, Al-Maliki AA, Chen T, Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA

PloS one.. 2012 7 (12):e51411. Epub 12/10/2012.

Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomes.

Bouta EM, Wood RW, Perry SW, Brown EB, Ritchlin CT, Xing L, Schwarz EM

Annals of the New York Academy of Sciences.. 2011 December 1240 :47-52. Epub 1900 01 01.

Investigation of the peak action wavelength of light-activated gene transduction.

Myakishev-Rempel M, Kuper J, Mintz B, Hutchinson S, Voris J, Zavislan K, Offley S, Nardia FB, Yaseen Z, Yen T, Zavislan JM, Maloney MD, Schwarz EM

Gene therapy.. 2011 November 18 (11):1043-51. Epub 04/14/2011.

Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis.

Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ

Science translational medicine.. 2011 September 213 (101):101ra93. Epub 1900 01 01.

TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease.

Papuga MO, Kwok E, You Z, Rubery PT, Dougherty PE, Pryhuber G, Beck CA, Hilton MJ, Awad HA, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 September 29 (9):1367-74. Epub 03/28/2011.

CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice.

Li J, Zhou Q, Wood R, Kuzin I, Bottaro A, Ritchlin C, Xing L, Schwarz E

Arthritis research & therapy.. 2011 August 3113 (4):R138. Epub 08/31/2011.

Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur.

Yazici C, Takahata M, Reynolds DG, Xie C, Samulski RJ, Samulski J, Beecham EJ, Gertzman AA, Spilker M, Zhang X, O'Keefe RJ, Awad HA, Schwarz EM

Molecular therapy : the journal of the American Society of Gene Therapy.. 2011 August 19 (8):1416-25. Epub 01/04/2011.

Establishment of an index with increased sensitivity for assessing murine arthritis.

Sampson ER, Beck CA, Ketz J, Canary KL, Hilton MJ, Awad H, Schwarz EM, Chen D, O'Keefe RJ, Rosier RN, Zuscik MJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 August 29 (8):1145-51. Epub 03/03/2011.

Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials.

Dhillon RS, Schwarz EM

Materials.. 2011 June 154 (6):1117-1131. Epub 06/15/2011.

The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model.

Sampson ER, Martin BA, Morris AE, Xie C, Schwarz EM, O'Keefe RJ, Rosier RN

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2011 June 26 (6):1283-94. Epub 1900 01 01.

Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials.

Dhillon RS, Schwarz EM

Materials.. 2011 June 4 (6):1117-1131. Epub 06/15/2011.

Anti-Glucosaminidase Monoclonal Antibodies as a Passive Immunization for Methicillin-Resistant Staphylococcus aureus (MRSA) Orthopaedic Infections.

Varrone JJ, Li D, Daiss JL, Schwarz EM

BoneKEy osteovision. 2011 April 18 :187-194. Epub 1900 01 01.

EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair.

Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2011 April 26 (4):792-802. Epub 1900 01 01.

The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy.

Sampson ER, Amin V, Schwarz EM, O'Keefe RJ, Rosier RN

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 April 29 (4):623-32. Epub 10/18/2010.

Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model.

Reynolds DG, Takahata M, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA

Bone.. 2011 March 148 (3):562-70. Epub 10/13/2010.

Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects.

Jacobson JA, Yanoso Scholl L, Reynolds DG, Dadali T, Bradica G, Bukata S, Puzas JE, Zuscik MJ, Rosier R, O'Keefe RJ, Schwarz E, Awad H

Tissue engineering. Part A.. 2011 February 17 (3-4):389-98. Epub 10/29/2010.

Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering.

Yanoso-Scholl L, Jacobson JA, Bradica G, Lerner AL, O'Keefe RJ, Schwarz EM, Zuscik MJ, Awad HA

Journal of biomedical materials research. Part A.. 2010 December 195 (3):717-26. Epub 1900 01 01.

Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity.

Papuga MO, Proulx ST, Kwok E, You Z, Rubery PT, Dougherty PE, Hilton MJ, Awad HA, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2010 September 28 (9):1220-8. Epub 1900 01 01.

TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways.

Gunnell LM, Jonason JH, Loiselle AE, Kohn A, Schwarz EM, Hilton MJ, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2010 August 25 (8):1784-97. Epub 1900 01 01.

Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis.

Li TF, Gao L, Sheu TJ, Sampson ER, Flick LM, Konttinen YT, Chen D, Schwarz EM, Zuscik MJ, Jonason JH, O'Keefe RJ

Arthritis and rheumatism.. 2010 August 62 (8):2359-69. Epub 1900 01 01.

Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy.

Li J, Kuzin I, Moshkani S, Proulx ST, Xing L, Skrombolas D, Dunn R, Sanz I, Schwarz EM, Bottaro A

The Journal of immunology : official journal of the American Association of Immunologists.. 2010 June 1184 (11):6142-50. Epub 04/30/2010.

RANKL induces heterogeneous DC-STAMP(lo) and DC-STAMP(hi) osteoclast precursors of which the DC-STAMP(lo) precursors are the master fusogens.

Mensah KA, Ritchlin CT, Schwarz EM

Journal of cellular physiology.. 2010 April 223 (1):76-83. Epub 1900 01 01.

Mediation of nonerosive arthritis in a mouse model of lupus by interferon-alpha-stimulated monocyte differentiation that is nonpermissive of osteoclastogenesis.

Mensah KA, Mathian A, Ma L, Xing L, Ritchlin CT, Schwarz EM

Arthritis and rheumatism.. 2010 April 62 (4):1127-37. Epub 1900 01 01.

Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw.

Li D, Gromov K, Proulx ST, Xie C, Li J, Crane DP, Søballe K, O'Keefe RJ, Awad HA, Xing L, Schwarz EM

Annals of the New York Academy of Sciences.. 2010 March 1192 (1):84-94. Epub 1900 01 01.

The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis.

Schwarz EM, Proulx ST, Ritchlin CT, Boyce BF, Xing L

Advances in experimental medicine and biology.. 2010 658 :1-10. Epub 1900 01 01.

CD16 (FcRgammaIII) as a potential marker of osteoclast precursors in psoriatic arthritis.

Chiu YG, Shao T, Feng C, Mensah KA, Thullen M, Schwarz EM, Ritchlin CT

Arthritis research & therapy.. 2010 12 (1):R14. Epub 01/26/2010.

The emerging field of osteoimmunology.

Mensah KA, Li J, Schwarz EM

Immunologic research.. 2009 December 45 (2-3):100-13. Epub 01/30/2009.

PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis.

Tsutsumi R, Xie C, Wei X, Zhang X, Flick LM, Schwarz EM, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 October 24 (10):1753-62. Epub 1900 01 01.

Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation.

Darowish M, Rahman R, Li P, Bukata SV, Gelinas J, Huang W, Flick LM, Schwarz EM, O'Keefe RJ

Bone.. 2009 October 45 (4):661-8. Epub 06/12/2009.

Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis.

Guo R, Zhou Q, Proulx ST, Wood R, Ji RC, Ritchlin CT, Pytowski B, Zhu Z, Wang YJ, Schwarz EM, Xing L

Arthritis and rheumatism.. 2009 September 60 (9):2666-76. Epub 1900 01 01.

Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis.

Crane DP, Gromov K, Li D, Søballe K, Wahnes C, Büchner H, Hilton MJ, O'Keefe RJ, Murray CK, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2009 August 27 (8):1008-15. Epub 1900 01 01.

Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4.

Xie C, Liang B, Xue M, Lin AS, Loiselle A, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X

The American journal of pathology.. 2009 August 175 (2):772-85. Epub 07/23/2009.

Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression.

Loiselle AE, Bragdon GA, Jacobson JA, Hasslund S, Cortes ZE, Schwarz EM, Mitten DJ, Awad HA, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2009 June 27 (6):833-40. Epub 1900 01 01.

muCT-based measurement of cortical bone graft-to-host union.

Reynolds DG, Shaikh S, Papuga MO, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 May 24 (5):899-907. Epub 1900 01 01.

Reduced COX-2 expression in aged mice is associated with impaired fracture healing.

Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 February 24 (2):251-64. Epub 1900 01 01.

COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing.

Xie C, Ming X, Wang Q, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X

Bone.. 2008 December 43 (6):1075-83. Epub 08/16/2008.

Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT.

Tsutsumi R, Hock C, Bechtold CD, Proulx ST, Bukata SV, Ito H, Awad HA, Nakamura T, O'Keefe RJ, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 October 26 (10):1340-6. Epub 1900 01 01.

The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings.

Yazici C, Yanoso L, Xie C, Reynolds DG, Samulski RJ, Samulski J, Yannariello-Brown J, Gertzman AA, Zhang X, Awad HA, Schwarz EM

Biomaterials.. 2008 October 29 (28):3882-7. Epub 06/30/2008.

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.

Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ, Zuscik MJ, Rosier RN

Arthritis and rheumatism.. 2008 October 58 (10):3132-44. Epub 1900 01 01.

Teriparatide (1-34 human PTH) regulation of osterix during fracture repair.

Kaback LA, Soung do Y, Naik A, Geneau G, Schwarz EM, Rosier RN, O'Keefe RJ, Drissi H

Journal of cellular biochemistry.. 2008 September 1105 (1):219-26. Epub 1900 01 01.

Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.

Guo R, Yamashita M, Zhang Q, Zhou Q, Chen D, Reynolds DG, Awad HA, Yanoso L, Zhao L, Schwarz EM, Zhang YE, Boyce BF, Xing L

The Journal of biological chemistry.. 2008 August 22283 (34):23084-92. Epub 06/19/2008.

A perspective: engineering periosteum for structural bone graft healing.

Zhang X, Awad HA, O'Keefe RJ, Guldberg RE, Schwarz EM

Clinical orthopaedics and related research.. 2008 August 466 (8):1777-87. Epub 05/29/2008.

Altered bone remodeling in psoriatic arthritis.

Mensah KA, Schwarz EM, Ritchlin CT

Current rheumatology reports.. 2008 August 10 (4):311-7. Epub 1900 01 01.

Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging.

Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Calvi LM, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM

Arthritis and rheumatism.. 2008 July 58 (7):2019-29. Epub 1900 01 01.

Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis.

Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH

Oncogene.. 2008 June 527 (25):3605-14. Epub 01/28/2008.

Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction.

Hasslund S, Jacobson JA, Dadali T, Basile P, Ulrich-Vinther M, Søballe K, Schwarz EM, O'Keefe RJ, Mitten DJ, Awad HA

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 June 26 (6):824-33. Epub 1900 01 01.

VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism.

Zhang Q, Guo R, Lu Y, Zhao L, Zhou Q, Schwarz EM, Huang J, Chen D, Jin ZG, Boyce BF, Xing L

The Journal of biological chemistry.. 2008 May 9283 (19):13491-9. Epub 03/20/2008.

Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism.

Yao Z, Xing L, Qin C, Schwarz EM, Boyce BF

The Journal of biological chemistry.. 2008 April 11283 (15):9917-24. Epub 02/04/2008.

The effect of etanercept on osteoclast precursor frequency and enhancing bone marrow oedema in patients with psoriatic arthritis.

Anandarajah AP, Schwarz EM, Totterman S, Monu J, Feng CY, Shao T, Haas-Smith SA, Ritchlin CT

Annals of the rheumatic diseases.. 2008 March 67 (3):296-301. Epub 10/29/2007.

Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery.

Basile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Søballe K, Nishio Y, Drissi MH, Langstein HN, Mitten DJ, O'Keefe RJ, Schwarz EM, Awad HA

Molecular therapy : the journal of the American Society of Gene Therapy.. 2008 March 16 (3):466-73. Epub 01/08/2008.

Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation.

Xie C, Xue M, Wang Q, Schwarz EM, O'Keefe RJ, Zhang X

The Journal of bone and joint surgery. American volume.. 2008 February 90 Suppl 1 (Suppl 1):9-13. Epub 1900 01 01.

Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification.

Kaback LA, Soung do Y, Naik A, Smith N, Schwarz EM, O'Keefe RJ, Drissi H

Journal of cellular physiology.. 2008 January 214 (1):173-82. Epub 1900 01 01.

Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity.

Li D, Gromov K, Søballe K, Puzas JE, O'Keefe RJ, Awad H, Drissi H, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 January 26 (1):96-105. Epub 1900 01 01.

What potential biologic treatments are available for osteolysis?

Schwarz EM,

The Journal of the American Academy of Orthopaedic Surgeons.. 2008 16 Suppl 1 :S72-5. Epub 1900 01 01.

Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography.

Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM

Arthritis and rheumatism.. 2007 December 56 (12):4024-37. Epub 1900 01 01.

MRI and quantification of draining lymph node function in inflammatory arthritis.

Proulx ST, Kwok E, You Z, Beck CA, Shealy DJ, Ritchlin CT, Boyce BF, Xing L, Schwarz EM

Annals of the New York Academy of Sciences.. 2007 November 1117 :106-23. Epub 07/23/2007.

Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner.

Dong YF, Soung do Y, Chang Y, Enomoto-Iwamoto M, Paris M, O'Keefe RJ, Schwarz EM, Drissi H

Molecular endocrinology.. 2007 November 21 (11):2805-20. Epub 08/07/2007.

New roles for osteoclasts in bone.

Boyce BF, Yao Z, Zhang Q, Guo R, Lu Y, Schwarz EM, Xing L

Annals of the New York Academy of Sciences.. 2007 November 1116 :245-54. Epub 1900 01 01.

Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations.

Zuscik MJ, Ma L, Buckley T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ

Environmental health perspectives.. 2007 September 115 (9):1276-82. Epub 1900 01 01.

Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation.

Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2007 August 22 (8):1260-70. Epub 1900 01 01.

Recent advances in gene delivery for structural bone allografts.

Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM

Tissue engineering.. 2007 August 13 (8):1973-85. Epub 1900 01 01.

NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1.

Yamashita T, Yao Z, Li F, Zhang Q, Badell IR, Schwarz EM, Takeshita S, Wagner EF, Noda M, Matsuo K, Xing L, Boyce BF

The Journal of biological chemistry.. 2007 June 22282 (25):18245-18253. Epub 05/07/2007.

Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering.

Xie C, Reynolds D, Awad H, Rubery PT, Pelled G, Gazit D, Guldberg RE, Schwarz EM, O'Keefe RJ, Zhang X

Tissue engineering.. 2007 March 13 (3):435-45. Epub 1900 01 01.

Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts.

Reynolds DG, Hock C, Shaikh S, Jacobson J, Zhang X, Rubery PT, Beck CA, O'keefe RJ, Lerner AL, Schwarz EM, Awad HA

Journal of biomechanics.. 2007 40 (14):3178-86. Epub 05/23/2007.

Clinical development of anti-RANKL therapy.

Schwarz EM, Ritchlin CT

Arthritis research & therapy.. 2007 9 Suppl 1 (Suppl 1):S7. Epub 1900 01 01.

Increased lymphangiogenesis in joints of mice with inflammatory arthritis.

Zhang Q, Lu Y, Proulx ST, Guo R, Yao Z, Schwarz EM, Boyce BF, Xing L

Arthritis research & therapy.. 2007 9 (6):R118. Epub 1900 01 01.

Alteration of femoral bone morphology and density in COX-2-/- mice.

Robertson G, Xie C, Chen D, Awad H, Schwarz EM, O'Keefe RJ, Guldberg RE, Zhang X

Bone.. 2006 October 39 (4):767-72. Epub 05/30/2006.

Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes.

Li TF, Chen D, Wu Q, Chen M, Sheu TJ, Schwarz EM, Drissi H, Zuscik M, O'Keefe RJ

The Journal of biological chemistry.. 2006 July 28281 (30):21296-21304. Epub 05/10/2006.

Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.

Dong YF, Soung do Y, Schwarz EM, O'Keefe RJ, Drissi H

Journal of cellular physiology.. 2006 July 208 (1):77-86. Epub 1900 01 01.

Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone disease.

Boyce BF, Schwarz EM, Xing L

Current opinion in rheumatology.. 2006 July 18 (4):427-32. Epub 1900 01 01.

Initial observations of reduced uroflow in transgenic adenocarcinoma of murine prostate.

Wood RW, Baggs RB, Schwarz EM, Messing EM

Urology.. 2006 June 67 (6):1324-8. Epub 1900 01 01.

Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene.

Nishio Y, Dong Y, Paris M, O'Keefe RJ, Schwarz EM, Drissi H

Gene.. 2006 May 10372 :62-70. Epub 03/29/2006.

Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression.

Yao Z, Li P, Zhang Q, Schwarz EM, Keng P, Arbini A, Boyce BF, Xing L

The Journal of biological chemistry.. 2006 April 28281 (17):11846-55. Epub 02/06/2006.

Safety and efficacy of ultraviolet-a light-activated gene transduction for gene therapy of articular cartilage defects.

Maloney MD, Goater JJ, Parsons R, Ito H, O'Keefe RJ, Rubery PT, Drissi MH, Schwarz EM

The Journal of bone and joint surgery. American volume.. 2006 April 88 (4):753-61. Epub 1900 01 01.

Autoimmunity and bone.

Schwarz EM, Looney RJ, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT

Annals of the New York Academy of Sciences.. 2006 April 1068 :275-83. Epub 1900 01 01.

COX-2 has a critical role during incorporation of structural bone allografts.

O'Keefe RJ, Tiyapatanaputi P, Xie C, Li TF, Clark C, Zuscik MJ, Chen D, Drissi H, Schwarz E, Zhang X

Annals of the New York Academy of Sciences.. 2006 April 1068 :532-42. Epub 1900 01 01.

Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

Kaneki H, Guo R, Chen D, Yao Z, Schwarz EM, Zhang YE, Boyce BF, Xing L

The Journal of biological chemistry.. 2006 February 17281 (7):4326-33. Epub 12/22/2005.

Anti-RANKL therapy for inflammatory bone disorders: Mechanisms and potential clinical applications.

Anandarajah AP, Schwarz EM

Journal of cellular biochemistry.. 2006 February 197 (2):226-32. Epub 1900 01 01.

Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB.

Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN

Experimental cell research.. 2006 January 1312 (1):40-50. Epub 11/02/2005.

Periprosthetic osteolysis: an immunologist's update.

Looney RJ, Schwarz EM, Boyd A, O'Keefe RJ

Current opinion in rheumatology.. 2006 January 18 (1):80-7. Epub 1900 01 01.

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2006 January 21 (1):4-16. Epub 09/19/2005.

A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival.

Andela VB, Schwarz EM, O'Keefe RJ, Puzas EJ, Rosenblatt JD, Rosier RN

FEBS letters.. 2005 December 19579 (30):6814-20. Epub 11/28/2005.

Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase.

Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN

Journal of cellular biochemistry.. 2005 December 1596 (6):1262-73. Epub 1900 01 01.

Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering.

Zhang X, Xie C, Lin AS, Ito H, Awad H, Lieberman JR, Rubery PT, Schwarz EM, O'Keefe RJ, Guldberg RE

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 December 20 (12):2124-37. Epub 08/08/2005.

Osteoclast precursors, RANKL/RANK, and immunology.

Xing L, Schwarz EM, Boyce BF

Immunological reviews.. 2005 December 208 :19-29. Epub 1900 01 01.

Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: a role for free radicals, NFkappaB, and TNFalpha.

Soloviev A, Schwarz EM, Darowish M, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2005 November 23 (6):1258-65. Epub 06/09/2005.

Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis.

Wang Y, Belflower RM, Dong YF, Schwarz EM, O'Keefe RJ, Drissi H

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 September 20 (9):1624-36. Epub 05/23/2005.

Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2.

Zhang Q, Badell IR, Schwarz EM, Boulukos KE, Yao Z, Boyce BF, Xing L

Arthritis and rheumatism.. 2005 September 52 (9):2708-18. Epub 1900 01 01.

TNF-alpha and pathologic bone resorption.

Boyce BF, Li P, Yao Z, Zhang Q, Badell IR, Schwarz EM, O'Keefe RJ, Xing L

The Keio journal of medicine.. 2005 September 54 (3):127-31. Epub 1900 01 01.

Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta.

Dong Y, Drissi H, Chen M, Chen D, Zuscik MJ, Schwarz EM, O'Keefe RJ

Journal of cellular biochemistry.. 2005 August 195 (5):1057-68. Epub 1900 01 01.

Biological effects of rAAV-caAlk2 coating on structural allograft healing.

Koefoed M, Ito H, Gromov K, Reynolds DG, Awad HA, Rubery PT, Ulrich-Vinther M, Soballe K, Guldberg RE, Lin AS, O'Keefe RJ, Zhang X, Schwarz EM

Molecular therapy : the journal of the American Society of Gene Therapy.. 2005 August 12 (2):212-8. Epub 1900 01 01.

Pseudosynovial fluid from loosened total hip prosthesis induces osteoclast formation.

Mandelin J, Liljeström M, Li TF, Ainola M, Hukkanen M, Salo J, Santavirta S, Konttinen YT

Journal of biomedical materials research. Part B, Applied biomaterials.. 2005 July 74 (1):582-8. Epub 1900 01 01.

Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles.

Wei X, Zhang X, Zuscik MJ, Drissi MH, Schwarz EM, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 July 20 (7):1136-48. Epub 02/14/2005.

Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency.

Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM

Environmental health perspectives.. 2005 June 113 (6):749-55. Epub 1900 01 01.

Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone.

Gordon AH, O'Keefe RJ, Schwarz EM, Rosier RN, Puzas JE

Cancer research.. 2005 April 1565 (8):3209-17. Epub 1900 01 01.

Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development.

Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'Keefe RJ, Stein GS, Drissi MH

Journal of cellular physiology.. 2005 April 203 (1):133-43. Epub 1900 01 01.

Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K.

Mandelin J, Li TF, Hukkanen M, Liljeström M, Salo J, Santavirta S, Konttinen YT

The Journal of rheumatology.. 2005 April 32 (4):713-20. Epub 1900 01 01.

Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation.

Clark CA, Schwarz EM, Zhang X, Ziran NM, Drissi H, O'Keefe RJ, Zuscik MJ

Biochemical and biophysical research communications.. 2005 March 18328 (3):764-76. Epub 1900 01 01.

Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy.

Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, Zhang X, Rubery PT, Rabinowitz J, Samulski RJ, Nakamura T, Soballe K, O'Keefe RJ, Boyce BF, Schwarz EM

Nature medicine.. 2005 March 11 (3):291-7. Epub 02/13/2005.

[Corrosiveness of Ti-Fe-Mo-Mn-Nb-Zr alloys in various pH lactic acids].

Yu S, Zhang X, He Z, Liu Y

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi.. 2005 February 22 (1):91-4. Epub 1900 01 01.

TGF-beta signaling in chondrocytes.

Li TF, O'Keefe RJ, Chen D

Frontiers in bioscience : a journal and virtual library.. 2005 January 110 :681-8. Epub 01/01/2005.

Bone implant interface, osteolysis and potential therapies.

Schwarz EM, O'Keefe RJ, Looney RJ

Journal of musculoskeletal & neuronal interactions.. 2004 December 4 (4):390-2. Epub 1900 01 01.

Functional integration of tissue-engineered bone constructs.

Guldberg RE, Oest M, Lin AS, Ito H, Chao X, Gromov K, Goater JJ, Koefoed M, Schwarz EM, O'Keefe RJ, Zhang X

Journal of musculoskeletal & neuronal interactions.. 2004 December 4 (4):399-400. Epub 1900 01 01.

A novel murine segmental femoral graft model.

Tiyapatanaputi P, Rubery PT, Carmouche J, Schwarz EM, O'keefe RJ, Zhang X

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 November 22 (6):1254-60. Epub 1900 01 01.

Dynamic exercises in patients with rheumatoid arthritis.

Anandarajah AP, Schwarz EM

Annals of the rheumatic diseases.. 2004 November 63 (11):1359-61. Epub 1900 01 01.

PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling.

Li TF, Zuscik MJ, Ionescu AM, Zhang X, Rosier RN, Schwarz EM, Drissi H, O'Keefe RJ

Experimental cell research.. 2004 October 15300 (1):159-69. Epub 1900 01 01.

Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway.

Li TF, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H

Experimental cell research.. 2004 September 10299 (1):128-36. Epub 1900 01 01.

RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis.

Ritchlin CT, Schwarz EM, O'Keefe RJ, Looney RJ

Journal of musculoskeletal & neuronal interactions.. 2004 September 4 (3):276-84. Epub 1900 01 01.

Uroflow in murine urethritis.

Leung YY, Schwarz EM, Silvers CR, Messing EM, Wood RW

Urology.. 2004 August 64 (2):378-82. Epub 1900 01 01.

Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivo.

Ferguson CM, Schwarz EM, Puzas JE, Zuscik MJ, Drissi H, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 July 22 (4):687-96. Epub 1900 01 01.

In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector.

Ulrich-Vinther M, Duch MR, Søballe K, O'Keefe RJ, Schwarz EM, Pedersen FS

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 July 22 (4):726-34. Epub 1900 01 01.

5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes.

Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN

Journal of cellular biochemistry.. 2004 May 1592 (2):316-31. Epub 1900 01 01.

Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation.

Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ

Bone.. 2004 May 34 (5):809-17. Epub 1900 01 01.

CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter.

Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ

Journal of cellular physiology.. 2004 March 198 (3):428-40. Epub 1900 01 01.

RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis.

Li P, Schwarz EM, O'Keefe RJ, Ma L, Boyce BF, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2004 February 19 (2):207-13. Epub 1900 01 01.

[The influence of Ce on microstructures and mechanics performances of Ti-Fe-Mo-Mn-Nb-Zr alloys].

Yu S, Zhang X, He Z, Gao Z, Wang C

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi.. 2004 February 21 (1):102-6. Epub 1900 01 01.

PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway.

Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 January 22 (1):6-12. Epub 1900 01 01.

Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells.

Ito H, Goater JJ, Tiyapatanaputi P, Rubery PT, O'Keefe RJ, Schwarz EM

Gene therapy.. 2004 January 11 (1):34-41. Epub 1900 01 01.

Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice.

Li P, Schwarz EM, O'Keefe RJ, Ma L, Looney RJ, Ritchlin CT, Boyce BF, Xing L

Arthritis and rheumatism.. 2004 January 50 (1):265-76. Epub 1900 01 01.

Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes.

Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ

Journal of cellular biochemistry.. 2003 December 1590 (6):1287-98. Epub 1900 01 01.

Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition.

Puzas JE, O'Keefe RJ, Schwarz EM, Zhang X

Journal of musculoskeletal & neuronal interactions.. 2003 December 3 (4):308-12; discussion 320-1. Epub 1900 01 01.

Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo.

Schwarz EM, Campbell D, Totterman S, Boyd A, O'Keefe RJ, Looney RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 November 21 (6):1049-55. Epub 1900 01 01.

The mevalonate synthesis pathway as a therapeutic target in cancer.

Andela VB, Pirri M, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosenblatt JD, Rosier RN

Clinical orthopaedics and related research.. 2003 October (415 Suppl):S59-66. Epub 1900 01 01.

NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone.

Andela VB, Gordon AH, Zotalis G, Rosier RN, Goater JJ, Lewis GD, Schwarz EM, Puzas JE, O'Keefe RJ

Clinical orthopaedics and related research.. 2003 October (415 Suppl):S75-85. Epub 1900 01 01.

Smad6 is induced by BMP-2 and modulates chondrocyte differentiation.

Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 September 21 (5):908-13. Epub 1900 01 01.

ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development.

Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2003 September 18 (9):1593-604. Epub 1900 01 01.

ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation.

Ionescu AM, Schwarz EM, Zuscik MJ, Drissi H, Puzas JE, Rosier RN, O'Keefe RJ

Experimental cell research.. 2003 August 1288 (1):198-207. Epub 1900 01 01.

The TNF-alpha transgenic mouse model of inflammatory arthritis.

Li P, Schwarz EM

Springer seminars in immunopathology.. 2003 August 25 (1):19-33. Epub 1900 01 01.

Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healing.

Flick LM, Weaver JM, Ulrich-Vinther M, Abuzzahab F, Zhang X, Dougall WC, Anderson D, O'Keefe RJ, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 July 21 (4):676-84. Epub 1900 01 01.

Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5.

Li X, Schwarz EM, Zuscik MJ, Rosier RN, Ionescu AM, Puzas JE, Drissi H, Sheu TJ, O'Keefe RJ

Endocrinology.. 2003 June 144 (6):2514-23. Epub 1900 01 01.

Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB.

Andela VB, Gingold BI, Souza MD, O'Keefe RJ, Puzas EJ, Schwarz EM, Rosier RN

Cancer letters.. 2003 May 8194 (1):37-43. Epub 1900 01 01.

Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis.

Ritchlin CT, Haas-Smith SA, Li P, Hicks DG, Schwarz EM

The Journal of clinical investigation.. 2003 March 111 (6):821-31. Epub 1900 01 01.

A phage display technique identifies a novel regulator of cell differentiation.

Sheu TJ, Schwarz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE

The Journal of biological chemistry.. 2003 January 3278 (1):438-43. Epub 10/25/2002.

Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation.

Huang W, O'Keefe RJ, Schwarz EM

Arthritis research & therapy.. 2003 5 (1):R49-59. Epub 11/12/2002.

Articular cartilage biology.

Ulrich-Vinther M, Maloney MD, Schwarz EM, Rosier R, O'Keefe RJ

The Journal of the American Academy of Orthopaedic Surgeons.. 2003 11 (6):421-30. Epub 1900 01 01.

Mechanisms of bone resorption and new bone formation in spondyloarthropathies.

Huang W, Schwarz EM

Current rheumatology reports.. 2002 December 4 (6):513-7. Epub 1900 01 01.

Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB.

Andela VB, Sheu TJ, Puzas EJ, Schwarz EM, O'Keefe RJ, Rosier RN

Biochemical and biophysical research communications.. 2002 September 20297 (2):237-41. Epub 1900 01 01.

Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A.

Zuscik MJ, O'Keefe RJ, Gunter TE, Puzas JE, Schwarz EM, Rosier RN

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 September 20 (5):1079-90. Epub 1900 01 01.

Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis.

Ulrich-Vinther M, Carmody EE, Goater JJ, S balle K, O'Keefe RJ, Schwarz EM

The Journal of bone and joint surgery. American volume.. 2002 August 84 (8):1405-12. Epub 1900 01 01.

Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes.

Ulrich-Vinther M, Maloney MD, Goater JJ, Søballe K, Goldring MB, O'Keefe RJ, Schwarz EM

Arthritis and rheumatism.. 2002 August 46 (8):2095-104. Epub 1900 01 01.

The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles.

Soloviev A, Schwarz EM, Kuprash DV, Nedospasov SA, Puzas JE, Rosier RN, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 July 20 (4):714-22. Epub 1900 01 01.

Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes.

Zuscik MJ, Pateder DB, Puzas JE, Schwarz EM, Rosier RN, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 July 20 (4):811-8. Epub 1900 01 01.

Growth plate chondrocyte maturation is regulated by basal intracellular calcium.

Zuscik MJ, D'Souza M, Ionescu AM, Gunter KK, Gunter TE, O'Keefe RJ, Schwarz EM, Puzas JE, Rosier RN

Experimental cell research.. 2002 June 10276 (2):310-9. Epub 1900 01 01.

Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair.

Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ

The Journal of clinical investigation.. 2002 June 109 (11):1405-15. Epub 1900 01 01.

Determination of responsiveness in biological systems is dependent on highly sensitive quantitative measures.

O'Keefe RJ

Annals of the New York Academy of Sciences.. 2002 June 961 :206. Epub 1900 01 01.

Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis.

Yin G, Liu W, An P, Li P, Ding I, Planelles V, Schwarz EM, Min W

Molecular therapy : the journal of the American Society of Gene Therapy.. 2002 May 5 (5 Pt 1):547-54. Epub 1900 01 01.

Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae.

Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 May 17 (5):915-22. Epub 1900 01 01.

Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles.

Carmody EE, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ

Arthritis and rheumatism.. 2002 May 46 (5):1298-308. Epub 1900 01 01.

Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor metastasis.

Andela VB, Rosenblatt JD, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosier RN

Clinical orthopaedics and related research.. 2002 April (397):228-39. Epub 1900 01 01.

Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors.

Good CR, O'Keefe RJ, Puzas JE, Schwarz EM, Rosier RN

Journal of surgical oncology.. 2002 March 79 (3):174-9. Epub 1900 01 01.

Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis.

Goater JJ, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 March 20 (2):169-73. Epub 1900 01 01.

In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis.

Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 February 17 (2):192-9. Epub 1900 01 01.

Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes.

Pateder DB, Sheu TJ, O'Keefe RJ, Puzas JE, Schwarz EM, Constine LS, Okunieff P, Rosier RN

Radiation research.. 2002 January 157 (1):62-8. Epub 1900 01 01.

COX-1 and COX-2 expression in osteoid osteomas.

Mungo DV, Zhang X, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 January 20 (1):159-62. Epub 1900 01 01.

Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear.

Looney RJ, Boyd A, Totterman S, Seo GS, Tamez-Pena J, Campbell D, Novotny L, Olcott C, Martell J, Hayes FA, O'Keefe RJ, Schwarz EM

Arthritis research.. 2002 4 (1):59-63. Epub 10/03/2001.

Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis.

Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM

The Journal of bone and joint surgery. American volume.. 2001 December 83 (12):1789-97. Epub 1900 01 01.

PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling.

Pateder DB, Ferguson CM, Ionescu AM, Schwarz EM, Rosier RN, Puzas JE, O'Keefe RJ

Journal of cellular physiology.. 2001 September 188 (3):343-51. Epub 1900 01 01.

Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components.

Pollice PF, Rosier RN, Looney RJ, Puzas JE, Schwarz EM, O'Keefe RJ

The Journal of bone and joint surgery. American volume.. 2001 July 83 (7):1057-61. Epub 1900 01 01.

The role of autocrine growth factors in radiation damage to the epiphyseal growth plate.

Pateder DB, Eliseev RA, O'Keefe RJ, Schwarz EM, Okunieff P, Constine LS, Puzas JE, Rosier RN

Radiation research.. 2001 June 155 (6):847-57. Epub 1900 01 01.

PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling.

Ionescu AM, Schwarz EM, Vinson C, Puzas JE, Rosier R, Reynolds PR, O'Keefe RJ

The Journal of biological chemistry.. 2001 April 13276 (15):11639-47. Epub 01/02/2001.

Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis.

Zhang X, Morham SG, Langenbach R, Young DA, Xing L, Boyce BF, Puzas EJ, Rosier RN, O'Keefe RJ, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2001 April 16 (4):660-70. Epub 1900 01 01.

Efficacy of etanercept for wear debris-induced osteolysis.

Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2001 February 16 (2):338-47. Epub 1900 01 01.

BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog.

Grimsrud CD, Romano PR, D'Souza M, Puzas JE, Schwarz EM, Reynolds PR, Roiser RN, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2001 January 19 (1):18-25. Epub 1900 01 01.

Degradative pathways in tissues of the temporomandibular joint. Use of in vitro and in vivo models to characterize matrix metalloproteinase and cytokine activity.

Puzas JE, Landeau JM, Tallents R, Albright J, Schwarz EM, Landesberg R

Cells, tissues, organs. 2001 169 (3):248-56. Epub 1900 01 01.

Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB.

Andela VB, Schwarz EM, Puzas JE, O'Keefe RJ, Rosier RN

Cancer research.. 2000 December 160 (23):6557-62. Epub 1900 01 01.

Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation.

Ferguson CM, Schwarz EM, Reynolds PR, Puzas JE, Rosier RN, O'Keefe RJ

Endocrinology.. 2000 December 141 (12):4728-35. Epub 1900 01 01.

Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis.

Schwarz EM, Benz EB, Lu AP, Goater JJ, Mollano AV, Rosier RN, Puzas JE, Okeefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2000 November 18 (6):849-55. Epub 1900 01 01.

The adeno-associated virus vector for orthopaedic gene therapy.

Schwarz EM

Clinical orthopaedics and related research.. 2000 October (379 Suppl):S31-9. Epub 1900 01 01.

Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo.

Chi H, Yang X, Kingsley PD, O'Keefe RJ, Puzas JE, Rosier RN, Shears SB, Reynolds PR

Molecular and cellular biology.. 2000 September 20 (17):6496-507. Epub 1900 01 01.

NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes.

Li P, Sanz I, O'Keefe RJ, Schwarz EM

The Journal of immunology : official journal of the American Association of Immunologists.. 2000 June 1164 (11):5990-7. Epub 1900 01 01.

PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes.

Pateder DB, Rosier RN, Schwarz EM, Reynolds PR, Puzas JE, D'Souza M, O'Keefe RJ

Experimental cell research.. 2000 May 1256 (2):555-62. Epub 1900 01 01.

Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis.

Schwarz EM, Lu AP, Goater JJ, Benz EB, Kollias G, Rosier RN, Puzas JE, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2000 May 18 (3):472-80. Epub 1900 01 01.

Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis.

Goater J, Müller R, Kollias G, Firestein GS, Sanz I, O'Keefe RJ, Schwarz EM

The Journal of rheumatology.. 2000 April 27 (4):983-9. Epub 1900 01 01.

Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysis.

Schwarz EM, Looney RJ, O'Keefe RJ

Arthritis research.. 2000 2 (3):165-8. Epub 03/27/2000.

Late recurrence of giant-cell tumor of bone. A report of four cases.

Scully SP, Mott MP, Temple HT, O'Keefe RJ, O'Donnell RJ, Mankin HJ

The Journal of bone and joint surgery. American volume.. 1994 August 76 (8):1231-3. Epub 1900 01 01.

Books

Kelley's Textbook of Rheumatology (2003)

Chapter: Signal Transduction in Rheumatic Diseases

Authors: Schwarz, E.M.

Publisher: W.B. Saunders Company 2003

Molecular Biology in Orthopaedics (2003)

Chapter: Biologic Agents as Antiresorptive Therapy

Authors: Schwarz, E.M.

Publisher: American Academy of Orthopaedic Surgeons: 241 2003

Implant Wear in Total Joint Replacement (2001)

Authors: Wright. T.M. Goodman, S.B., Schwarz, E.M.

Publisher: American Academy of Orthopaedic Surgeons 2001

Current Opinion in Orthopedics (2000)

Authors: O'Keefe, R.J. and Schwarz, E.M.

Publisher: Lippincott Williams & Wilkins 2000

Current Opinion in Orthopedics (2000)

Authors: O'Keefe, R. J., Puzas, J.E. and Schwarz, E.M.

Publisher: Lippicott Williams & Wilkins 2000