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Jiyong Zhao, Ph.D.

Jiyong Zhao, Ph.D.

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About Me

Faculty Appointments

Research Associate Professor - Department of Biomedical Genetics (SMD)

Credentials

Residency & Fellowship

Postdoctoral Fellow, Laboratory of Molecular Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School (Advisor: Ed Harlow) 1995 - 2000

Education

PhD | Iowa State University. Zoology. 1994

MS | China-Wuhan Med Coll. Microbiology. 1985

BS | China-Wuhan Med Coll. Biology. 1982

Awards

Postdoctoral Fellowship Award- American Cancer Society Postdoctoral Fellowship. 1997 - 1999

Predoctoral Fellowship Award- Fung Endowment Fellowship for Research. Iowa State University, Ames, Iowa. 1993 - 1994

Predoctoral Fellowship Award- Fung Endowment Fellowship for Research. Iowa State University, Ames, Iowa. 1992 - 1993

Predoctoral Fellowship Award- Competitive Molecular Cellular and Developmental Biology Research Fellowship. Iowa State University. Ames, Iowa. 1991 - 1992

Research

Patents

Methods of Treating B-Cell Cancers

Issue date: February 05, 2013

Patent #: 8,367,633

Country: United States

Inventors: Luojing Chen, Jiyong Zhao

Methods, Pharmaceutical Compositions, Therapeutic Systems, and Compounds for Treating B Cell Malignancies

Issue date: October 04, 2016

Patent #: 9,458,123

Country: United States

Inventors: Jiyong Zhao

Publications

Journal Articles

PKK deletion in basal keratinocytes promotes tumorigenesis after chemical carcinogenesis.

Chen L, Hayden MS, Gilmore ES, Alexander-Savino C, Oleksyn D, Gillespie K, Zhao J, Poligone B

Carcinogenesis.. 2018 March 839 (3):418-428. Epub 1900 01 01.

PKK deficiency in B cells prevents lupus development in Sle lupus mice.

Oleksyn D, Zhao J, Vosoughi A, Zhao JC, Misra R, Pentland AP, Ryan D, Anolik J, Ritchlin C, Looney J, Anandarajah AP, Schwartz G, Calvi LM, Georger M, Mohan C, Sanz I, Chen L

Immunology letters.. 2017 May 185 :1-11. Epub 03/06/2017.

A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells.

Chen L, Oleksyn D, Pulvino M, Sanz I, Ryan D, Ryan C, Lin CS, Poligone B, Pentland AP, Ritchlin C, Zhao J

Immunology letters.. 2016 April 172 :67-78. Epub 02/26/2016.

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.

Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, Spence S, Balakrishnan V, Jordan C, Poligone B, Casulo C, Burack R, Shapiro JL, Bernstein S, Friedberg JW, Deshaies RJ, Land H, Zhao J

Oncotarget.. 2015 June 206 (17):14796-813. Epub 1900 01 01.

PKK suppresses tumor growth and is decreased in squamous cell carcinoma of the skin.

Poligone B, Gilmore ES, Alexander C, Oleksyn D, Gillespie K, Zhao J, Ibrahim S, Pentland AP, Brown M, Chen L

The Journal of investigative dermatology.. 2015 March 135 (3):869-876. Epub 10/06/2014.

Protein kinase C-associated kinase regulates NF-?B activation through inducing IKK activation.

Kim SW, Schifano M, Oleksyn D, Jordan CT, Ryan D, Insel R, Zhao J, Chen L

International journal of oncology.. 2014 October 45 (4):1707-14. Epub 08/04/2014.

Protein kinase C? is required for lupus development in Sle mice.

Oleksyn D, Pulvino M, Zhao J, Misra R, Vosoughi A, Jenks S, Tipton C, Lund F, Schwartz G, Goldman B, Mohan C, Mehta K, Mehta M, Leitgets M, Sanz I, Chen L

Arthritis and rheumatism.. 2013 April 65 (4):1022-31. Epub 1900 01 01.

Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.

Pulvino M, Liang Y, Oleksyn D, Deran M, Van Pelt E, Shapiro J, Sanz I, Chen L, Zhao J

Blood.. 2012 August 23120 (8):1668-77. Epub 07/12/2012.

Protein kinase C-associated kinase is required for NF-kappaB signaling and survival in diffuse large B-cell lymphoma cells.

Kim SW, Oleksyn DW, Rossi RM, Jordan CT, Sanz I, Chen L, Zhao J

Blood.. 2008 February 1111 (3):1644-53. Epub 11/19/2007.

Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.

DeRan M, Pulvino M, Greene E, Su C, Zhao J

Molecular and cellular biology.. 2008 January 28 (1):435-47. Epub 10/29/2007.

Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway.

Le XF, Bedrosian I, Mao W, Murray M, Lu Z, Keyomarsi K, Lee MH, Zhao J, Bast RC

Cell cycle.. 2006 August 5 (15):1654-61. Epub 08/01/2006.

DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway.

Su C, Gao G, Schneider S, Helt C, Weiss C, O'Reilly MA, Bohmann D, Zhao J

The EMBO journal.. 2004 March 1023 (5):1133-43. Epub 02/19/2004.

Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit.

Barbie DA, Kudlow BA, Frock R, Zhao J, Johnson BR, Dyson N, Harlow E, Kennedy BK

Molecular and cellular biology.. 2004 January 24 (2):595-607. Epub 1900 01 01.

NPAT expression is regulated by E2F and is essential for cell cycle progression.

Gao G, Bracken AP, Burkard K, Pasini D, Classon M, Attwooll C, Sagara M, Imai T, Helin K, Zhao J

Molecular and cellular biology.. 2003 April 23 (8):2821-33. Epub 1900 01 01.

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.

Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E

Genes & development.. 2000 September 1514 (18):2283-97. Epub 1900 01 01.

Spontaneously immortalized IL-2 dependent T cell lines demonstrate p16 overexpression, normal pRb/p53 and upregulation of cyclins E or D2.

Siwicki, J.; Hedberg, Y.; Nowak, R.; Loden, M.; Zhao, J.; Landberg, G.; Roos, G.

Exp. Gernotol. 2000; 35: 375-388.

Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry.

Zhao J, Dynlacht B, Imai T, Hori T, Harlow E

Genes & development.. 1998 February 1512 (4):456-61. Epub 1900 01 01.

Mimosine differentially inhibits DNA replication and cell cycle progression in somatic cells compared to embryonic cells of Xenopus laevis.

Wang Y, Zhao J, Clapper J, Martin LD, Du C, DeVore ER, Harkins K, Dobbs DL, Benbow RM

Experimental cell research.. 1995 March 217 (1):84-91. Epub 1900 01 01.

Inhibition of DNA replication in cell-free extracts of Xenopus laevis eggs by extracts of Xenopus laevis oocytes.

Zhao J, Benbow RM

Developmental biology.. 1994 July 164 (1):52-62. Epub 1900 01 01.

An inhibitor of DNA topoisomerase I from Xenopus laevis ovaries.

Zhao J, Benbow RM

Biochemistry.. 1993 October 1232 (40):10622-8. Epub 1900 01 01.

On the nature of origins of DNA replication in eukaryotes.

Benbow RM, Zhao J, Larson DD

BioEssays : news and reviews in molecular, cellular and developmental biology.. 1992 October 14 (10):661-70. Epub 1900 01 01.

Polyelectrolyte precipitation of beta-galactosidase fusions containing poly-aspartic acid tails.

Zhao JY, Ford CF, Glatz CE, Rougvie MA, Gendel SM

Journal of biotechnology.. 1990 June 14 (3-4):273-83. Epub 1900 01 01.

DNA unwinding and strand synthesis during replication in Xenopus laevis embryos.

Benbow, R. M.; Poll, E. H. A.; Zhao, J.; Marini, N. J.; Stowers, D. J.

Papis, T.S. (ed) Gene Regulation and AIDS: Transcriptional Activation, Retroviruses, and Pathogenesis. Portfolio Publishing Company, Houston. 1990; : 69-86.

Degradation of phenanthrene by Pseudomonas sp. P12.

Zhang, S.; Zhao, J.; Chen, Y.; Wang, Z.

Acta Environmental Science Sinica. 1989; 9: 80-85.

Biosynthesis of indigo involving transferring naphthalene-degrading plasmid DNA from Pseudomonas to E. coli. 16,

Wu, Y.; Zhang, S.; Ma, G.; Song, D.; Zhao, J.

Acta Genetics Sinica. 1989; 16: 318-324.

[Analysis of degradative plasmids by pyrolysis gas liquid chromatography].

Zhu XM, Zhao JY, Luo QX, Wang ZT

Wei sheng wu xue bao = Acta microbiologica Sinica.. 1988 March 28 (1):62-7. Epub 1900 01 01.

Isolation of a naphthalene-degrading plasmid and its in situ transfer among bacteria in a waste water treatment plant.

Zhao, J.; Wang, Z.; Jian, H.

Acta Environmental Science Sinica. 1988; 8: 84-92.

Books

Protein-Protein Interactions, A Molecular Cloning Manual, 2ed edition (2004)

Chapter: Identification of protein-protein interactions by screening cDNA expression libraries.

Authors: Zhao, J

Publisher: Cold Spring Harbor Laboratory Press, New York 2004

Gene Regulation & AIDS: Transcriptional Activation, Retroviruses, & Pathogenesis (1990)

Chapter: DNA unwinding and strand synthesis during replication in Xenopus laevis embryos. in Papis, T.S.

Authors: Benbow, R. M., Poll, E. H. A., Zhao, J., Marini, N. J. and Stowers, D. J

Publisher: Portfolio Publishing Company, Houston. 1990