Xinping Zhang, B.Med., Ph.D.
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Xinping Zhang, B.Med., Ph.D.
About Me
Faculty Appointments
Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD)
Credentials
Education
PhD, | University of Rochester School of Medicine & Dentistry. Biochemistry. 1999
MS, | China-Shanghai Medical University. Biochemistry. 1993
MD | China-Shanghai Medical University. Medicine. 1990
Awards
MTF J.R. Neff Award. 2008
Orthopaedic Research Society New Investigator Recognition Award. 2005
Orthopaedic Research Society Travel Fellowship Award. 2002
Research
By studying how our body's cells mature to become bone-forming cells, Dr. Zhang hopes to find ways to turn the process of healing on so that the entire bone graft will heal after surgery.
Adult mesenchymal stem cells (MSCs) have enormous potential for bone tissue repair and regeneration. Our research has been focused on understanding the molecular and cellular mechanisms that control the activation, proliferation and differentiation of mesenchymal stem cells during skeletal repair. We are particularly interested in the periosteal stem cells that play key roles in repair and regeneration. Our current program has integrated the following topics:
1) Molecular signals that control mesenchymal stem cell differentiation.
2) Mechanism of skeletal repair and regeneration
3) Stem cell therapy and bone tissue engineering for repair and reconstruction of large segmental defects.
Publications
Journal Articles
Ahamed SHR, Shakil S, Lyu H, Zhang X, Luo J
Proceedings : ... IEEE International Conference on Big Data.. 2022 December 2022 :5865-5870. Epub 1900 01 01.
Schilling K, Zhai Y, Zhou Z, Zhou B, Brown E, Zhang X
eLife.. 2022 November 311 Epub 11/03/2022.
Wang H, Zhou X, Wang J, Zhang X, Zhu M, Wang H
Bioactive materials.. 2022 November 17 :261-275. Epub 01/29/2022.
Parimala Chelvi Ratnamani M, Zhang X, Wang H
Gels.. 2022 April 138 (4)Epub 04/13/2022.
Schilling K, Brown E, Zhang X
Bone.. 2022 January 154 :116257. Epub 11/13/2021.
Lam LRW, Schilling K, Romas S, Misra R, Zhou Z, Caton JG, Zhang X
Dental materials journal.. 2021 September 3040 (5):1208-1216. Epub 06/12/2021.
Zhai Y, Schilling K, Wang T, El Khatib M, Vinogradov S, Brown EB, Zhang X
Biomaterials.. 2021 September 276 :121041. Epub 07/26/2021.
Zhuang Z, John JV, Liao H, Luo J, Rubery P, Mesfin A, Boda SK, Xie J, Zhang X
ACS biomaterials science & engineering.. 2020 November 96 (11):6241-6252. Epub 10/22/2020.
Schilling K, El Khatib M, Plunkett S, Xue J, Xia Y, Vinogradov SA, Brown E, Zhang X
ACS applied materials & interfaces.. 2019 September 1811 (37):33548-33558. Epub 09/04/2019.
Wang T, Zhai Y, Nuzzo M, Yang X, Yang Y, Zhang X
Biomaterials.. 2018 November 182 :279-288. Epub 08/14/2018.
Yukata K, Xie C, Li TF, Brown ML, Kanchiku T, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ
Bone.. 2018 May 110 :150-159. Epub 02/03/2018.
Zhang X
Methods in molecular biology.. 2018 1842 :229-239. Epub 1900 01 01.
Zhang L, Wang T, Chang M, Kaiser C, Kim JD, Wu T, Cao X, Zhang X, Schwarz EM
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 September 32 (9):1870-1883. Epub 07/19/2017.
Wang T, Zhang X, Bikle DD
Journal of cellular physiology.. 2017 May 232 (5):913-921. Epub 10/26/2016.
Antebi B, Zhang L, Sheyn D, Pelled G, Zhang X, Gazit Z, Schwarz EM, Gazit D
Bioengineering.. 2016 March 3 (1)Epub 1900 01 01.
Antebi B, Zhang L, Sheyn D, Pelled G, Zhang X, Gazit Z, Schwarz EM, Gazit D
Bioengineering.. 2016 January 113 (1)Epub 01/11/2016.
Huang C, Ness VP, Yang X, Chen H, Luo J, Brown EB, Zhang X
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2015 July 30 (7):1217-30. Epub 1900 01 01.
Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ
Bone.. 2014 May 62 :79-89. Epub 02/12/2014.
Huang C, Tang M, Yehling E, Zhang X
Molecular therapy : the journal of the American Society of Gene Therapy.. 2014 February 22 (2):430-439. Epub 10/03/2013.
Huang C, Xue M, Chen H, Jiao J, Herschman HR, O'Keefe RJ, Zhang X
PloS one.. 2014 9 (7):e100079. Epub 07/02/2014.
Hoffman MD, Xie C, Zhang X, Benoit DS
Biomaterials.. 2013 November 34 (35):8887-98. Epub 08/16/2013.
Lyu S, Huang C, Yang H, Zhang X
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2013 September 31 (9):1382-9. Epub 04/11/2013.
Yazici C, Takahata M, Reynolds DG, Xie C, Samulski RJ, Samulski J, Beecham EJ, Gertzman AA, Spilker M, Zhang X, O'Keefe RJ, Awad HA, Schwarz EM
Molecular therapy : the journal of the American Society of Gene Therapy.. 2011 August 19 (8):1416-25. Epub 01/04/2011.
Wang Q, Huang C, Xue M, Zhang X
Bone.. 2011 March 148 (3):524-32. Epub 11/05/2010.
Wang Q, Huang C, Zeng F, Xue M, Zhang X
The American journal of pathology.. 2010 December 177 (6):3100-11. Epub 10/22/2010.
Liu Y, Zhang X, Xia Y, Yang H
Advanced materials.. 2010 June 1122 (22):2454-7. Epub 1900 01 01.
Tsutsumi R, Xie C, Wei X, Zhang X, Flick LM, Schwarz EM, O'Keefe RJ
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 October 24 (10):1753-62. Epub 1900 01 01.
Wei X, Zhang X, Flick LM, Drissi H, Schwarz EM, O'Keefe RJ
American journal of physiology. Cell physiology.. 2009 August 297 (2):C310-20. Epub 06/03/2009.
Xie C, Liang B, Xue M, Lin AS, Loiselle A, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X
The American journal of pathology.. 2009 August 175 (2):772-85. Epub 07/23/2009.
Clark CA, Li TF, Kim KO, Drissi H, Zuscik MJ, Zhang X, O'Keefe RJ
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2009 June 27 (6):785-92. Epub 1900 01 01.
Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 February 24 (2):251-64. Epub 1900 01 01.
Reduced COX-2 expression in aged mice is associated with impaired fracture healing
Naik A; Xie, C; Kingsley, P; Zuscik, MJ; Schwarz, EM; Awad, H; Guldberg, R; Drissi, H; Puzas, E; Boyce, B; Zhang, X; O'Keefe, RJ.
Journal of Bone & Mineral Research. 2009; 24(2): 251-64.
Rescue of Impaired Fracture Healing in Cox-2-/- mice via Activation of Prostaglandin E2 Receptor Subtype 4
Xie, C; Liang, B; Xue, M; Lin, ASP; Loiselle, A; Schwarz, EM; Guldberg, RE; O'Keefe, RJ; Zhang, X.
The American Journal of Pathology. 2009; 175(2): 772-85.
Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation
Clark, CA; Li, TF; Kim, KO; Drissi, H; Zuscik, MJ; Zhang, X; O'Keefe, RJ.
J. Orthop. Res. 2009; 27(6): 785-92.
PGE2 Signaling Through the EP4 Receptor on Fibroblasts Upregulates RANKL and Stimulates Osteolysis
Tsutsumi, R; Xie, C; Wei, X; Zhang, X; Flick, LM; Schwarz, EM; O'Keefe, RJ.
J Bone Miner Res. 2009; 24(10): 1753-62.
Rescue of impaired fracture healing in COX-2 mice via activation of prostaglandin E2 receptor subtype 4.
Xie, C., Liang, B., Xue, M., Lin, ASP., Loiselle, A. Schwarz, EM, Guildberg, RE., O'Keefe, RJ, Zhang, X.
The American Journal of Pathology. 2009; 175(2): 772-85.
Xie C, Ming X, Wang Q, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X
Bone.. 2008 December 43 (6):1075-83. Epub 08/16/2008.
Yazici C, Yanoso L, Xie C, Reynolds DG, Samulski RJ, Samulski J, Yannariello-Brown J, Gertzman AA, Zhang X, Awad HA, Schwarz EM
Biomaterials.. 2008 October 29 (28):3882-7. Epub 06/30/2008.
Zhang X, Awad HA, O'Keefe RJ, Guldberg RE, Schwarz EM
Clinical orthopaedics and related research.. 2008 August 466 (8):1777-87. Epub 05/29/2008.
Zuscik MJ, Hilton MJ, Zhang X, Chen D, O'Keefe RJ
The Journal of clinical investigation.. 2008 February 118 (2):429-38. Epub 1900 01 01.
Xie C, Xue M, Wang Q, Schwarz EM, O'Keefe RJ, Zhang X
The Journal of bone and joint surgery. American volume.. 2008 February 90 Suppl 1 (Suppl 1):9-13. Epub 1900 01 01.
Zhang, X., Awad, A.H., O'Keefe, R.J., Guldberg, R.J., Schwarz, E.M.
Periosteum is essential for the initiation of structural bone graft healing: implication
Perspective: Engineering Periosteum for Structural Bone Graft Healing
Zhang, X; Awad, HA; O'Keefe, RJ; Guldberg, RE, Schwarz, EM;.
Clinical Orthopaedics & Related Research. 2008; 466(8): 1777-87.
COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing
Xie, C; Xue, M; Lin, A; Schwarz, E; Guldberg, R; O'Keefe, R, Zhang, X.
Bone. 2008; 43(6): 1075-83.
The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings
Yazici, C; Yanoso, L; Xie, C; Reynolds, DG; Samulski, RJ; Samulski, J; Yannariello-Brown, J; Gertzmann, AA; Zhang, X; Awad, HA; Schwarz, EM.
Biomaterials. 2008; 29(28): 3882-7.
Zhang X, Sun B
The journal of physical chemistry. B. 2007 September 20111 (37):10881-5. Epub 08/28/2007.
Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM
Tissue engineering.. 2007 August 13 (8):1973-85. Epub 1900 01 01.
Bärnighausen T, Liu Y, Zhang X, Sauerborn R
BMC health services research.. 2007 July 207 :114. Epub 07/20/2007.
Wang Q, Wei X, Zhu T, Zhang M, Shen R, Xing L, O'Keefe RJ, Chen D
The Journal of biological chemistry.. 2007 April 6282 (14):10742-8. Epub 01/10/2007.
Xie C, Reynolds D, Awad H, Rubery PT, Pelled G, Gazit D, Guldberg RE, Schwarz EM, O'Keefe RJ, Zhang X
Tissue engineering.. 2007 March 13 (3):435-45. Epub 1900 01 01.
Chen M, Lichtler AC, Sheu TJ, Xie C, Zhang X, O'Keefe RJ, Chen D
Genesis : the journal of genetics and development.. 2007 January 45 (1):44-50. Epub 1900 01 01.
Radiographic Prediction of Biomechanical Strength in Structural Bone Grafts.
Reynolds, D.G., Hock, C., Shaikh, S., Jacobson, J., Zhang, X., Rubery, P.T., Beck, C., O'Keefe, R.J., Lerner, A., Schwarz, E.M., Awad H.
J. Biomech.
Xie, C., Xue, M., Naik, A., Lin, A., Schwarz, E., Guldberg, R., O'Keefe R, J., and Zhang, X.
Cox-2 deficient bone healing environment impairs initiation of
Targeted Gene Delivery for Femoral Allografts: A Novel Acellular Tissue Engineering Approach
Ghen, M; Lichtler, AC; Sheu, TJ; Xie, C; Zhang X; O'Keefe, RJ; Chen D.
Genesis. 2007; 45(1): 44-50.
Reynolds DG, Hock C, Shaikh S, Jacobson J, Zhang X, Rubery PT, Beck CA, O'keefe RJ, Lerner AL, Schwarz EM, Awad HA
Journal of biomechanics.. 2007 40 (14):3178-86. Epub 05/23/2007.
Zhang X, Sun B, Friend RH, Guo H, Nau D, Giessen H
Nano letters.. 2006 April 6 (4):651-5. Epub 1900 01 01.
O'Keefe RJ, Tiyapatanaputi P, Xie C, Li TF, Clark C, Zuscik MJ, Chen D, Drissi H, Schwarz E, Zhang X
Annals of the New York Academy of Sciences.. 2006 April 1068 :532-42. Epub 1900 01 01.
Murugan R, Ramakrishna S
Tissue engineering.. 2006 March 12 (3):435-47. Epub 1900 01 01.
Robertson, G., Xie, C., Chen, D., Awad, H., Schwarz, E.M., O'Keefe, R.J., Guldberg R.E., Zhang, X.
Alteration of femoral bone morphology and density in cox-2-/-
Zhang X, Xie C, Lin AS, Ito H, Awad H, Lieberman JR, Rubery PT, Schwarz EM, O'Keefe RJ, Guldberg RE
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 December 20 (12):2124-37. Epub 08/08/2005.
Koefoed M, Ito H, Gromov K, Reynolds DG, Awad HA, Rubery PT, Ulrich-Vinther M, Soballe K, Guldberg RE, Lin AS, O'Keefe RJ, Zhang X, Schwarz EM
Molecular therapy : the journal of the American Society of Gene Therapy.. 2005 August 12 (2):212-8. Epub 1900 01 01.
Wei X, Zhang X, Zuscik MJ, Drissi MH, Schwarz EM, O'Keefe RJ
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 July 20 (7):1136-48. Epub 02/14/2005.
Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM
Environmental health perspectives.. 2005 June 113 (6):749-55. Epub 1900 01 01.
Clark CA, Schwarz EM, Zhang X, Ziran NM, Drissi H, O'Keefe RJ, Zuscik MJ
Biochemical and biophysical research communications.. 2005 March 18328 (3):764-76. Epub 1900 01 01.
Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, Zhang X, Rubery PT, Rabinowitz J, Samulski RJ, Nakamura T, Soballe K, O'Keefe RJ, Boyce BF, Schwarz EM
Nature medicine.. 2005 March 11 (3):291-7. Epub 02/13/2005.
Zhang X, Naik A, Xie C, Reynolds D, Palmer J, Lin A, Awad H, Guldberg R, Schwarz E, O'Keefe R
Journal of musculoskeletal & neuronal interactions.. 2005 5 (4):360-2. Epub 1900 01 01.
Gu X, Feng Y, Shi C, Li M, Fu Z, Zhang X
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 2005 25 (6):632-5. Epub 1900 01 01.
Guldberg RE, Oest M, Lin AS, Ito H, Chao X, Gromov K, Goater JJ, Koefoed M, Schwarz EM, O'Keefe RJ, Zhang X
Journal of musculoskeletal & neuronal interactions.. 2004 December 4 (4):399-400. Epub 1900 01 01.
Tiyapatanaputi P, Rubery PT, Carmouche J, Schwarz EM, O'keefe RJ, Zhang X
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 November 22 (6):1254-60. Epub 1900 01 01.
Li TF, Zuscik MJ, Ionescu AM, Zhang X, Rosier RN, Schwarz EM, Drissi H, O'Keefe RJ
Experimental cell research.. 2004 October 15300 (1):159-69. Epub 1900 01 01.
Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ
Bone.. 2004 May 34 (5):809-17. Epub 1900 01 01.
Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 January 22 (1):6-12. Epub 1900 01 01.
Bukata, S., Gelinas, J., Wei, X., Rosier, R. N., Puzas, J. E., Zhang, X., Schwarz, E. M., Song, X. R., Griswold, D. E., O'Keefe, R. J.
PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a COX-2
A Novel Murine Segmental Femoral Graft Model. J. of Othopaedic Research.
Tiyapatanaputi, P., Rubery, P. T, Carmouche, J, Schwarz, E. M., O'Keefe, R. J. and Zhang, X.
J. of Othopaedic Research. 2004; : 1254-60.
Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 September 21 (5):908-13. Epub 1900 01 01.
Flick LM, Weaver JM, Ulrich-Vinther M, Abuzzahab F, Zhang X, Dougall WC, Anderson D, O'Keefe RJ, Schwarz EM
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 July 21 (4):676-84. Epub 1900 01 01.
Effects of receptor activator of NFkB (RANK) signaling blockade on fracture healing.
Flick, L. M., Weaver, J. M., Ulrich-Vinther, M., Abuzzahab, F., Zhang, X., Dougal, W.C., Anderson, D., O'Keefe, R. J., Schwarz, E. M.
J. of Orthopaedic Research. 2003; : 676-84.
Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ
The Journal of clinical investigation.. 2002 June 109 (11):1405-15. Epub 1900 01 01.
Mungo DV, Zhang X, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 January 20 (1):159-62. Epub 1900 01 01.
COX-2 Regulates Mesenchymal Cell Differentiation into Osteoblast Lineage and is Critically Involved in Bone Repair. Journal of Clinical Investigation
Zhang, X., Schwarz, E. M., Young, D. A., R., Puzas, J. E., Rosier, R. N., O'Keefe, R.J.
2002; : 1405-15.
Evidence for a 4 Direct Role of COX-2 in Implant Wear Debris Induced Osteolysis
J. Bone. Min. Res. 2001; 16 (4): 660-669.
The role of COX-2 in bone repair.
Zhang, X., Zhang, Y, Schwarz, E., O'Keefe, R. J.
Current opinion in Orthopaedics. 2001; : 397-402,.
Zhang X, Morham SG, Langenbach R, Baggs RB, Young DA
Experimental cell research.. 2000 February 1254 (2):232-40. Epub 1900 01 01.
Zhang X, Morham SG, Langenbach R, Young DA
The Journal of experimental medicine.. 1999 August 16190 (4):451-59. Epub 1900 01 01.
2001. COX-1 and COX-2 expression in osteoid osteomas. J. Ortho. Res.,
Mungo, D. V., Zhang, X., O'Keefe, R.J., Rosier, R.N., Puzas, J.E., Schwarz, E.M.
20(1): 159-62.
2003. Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition.
Puzas, J.E., O'Keefe, R.J., Schwarz, E.M., and Zhang, X.
J Musculoskelet Neuronal Interact. : 308-312; Discussion 320-301.
Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation.
Clark, CA, Li, RF., Kim, KO., Drissi, H., Zuscik, MJ., Zhang, X., O'Keefe, RJ.
Journal of Orthopaedic Research. 6: 785-92.