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Hani A. Awad, Ph.D.

Hani A. Awad, Ph.D.

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Research Lab

My Laboratory interfaces Biomedical Engineering and Orthopaedics. We provide opportunities for state of the art training related to Tissue Engineering and Biomechanics.

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About Me

Professional Background

I completed my graduate work at the University of Cincinnati under the mentorship of Dr. David Butler, a leading expert in tendon and ligament injury and repair, and having later completed a post-doctoral fellowship with Dr. Farshid Guilak at Duke University, at one of the leading orthopaedic resear...
I completed my graduate work at the University of Cincinnati under the mentorship of Dr. David Butler, a leading expert in tendon and ligament injury and repair, and having later completed a post-doctoral fellowship with Dr. Farshid Guilak at Duke University, at one of the leading orthopaedic research laboratories in the country. In the Fall of 2004, I joined the faculty of the University of Rochester as an Assistant Professor in the Departments of Orthopaedics and Biomedical Engineering. My research focuses primarily on tissue engineering of load bearing connective tissues, including ligament and tendon, cartilage, and bone.

Faculty Appointments

Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD)

Donald and Mary Clark Professorship of Orthopaedics - Department of Orthopaedics (SMD)

Professor - Department of Biomedical Engineering (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Bioengineering Laboratory (Mentor: Farshid Guilak), Department of Surgery - Division of Orthopaedic Surgery, Duke University 2000 - 2004

Education

PhD | University of Cincinnati. Engineering Mechanics/Biomechanics. 1999

MS | University of Cincinnati. Engineering Mechanics/Biomechanics. 1995

BS | University of Jordan. Mechanical Engineering. 1993

Awards

Kappa Delta - Ann Doner Vaughan Award. 2007

Early Career Translational Research Award in Biomedical Engineering. 2005

Finalist, PhD Student Presentation Competition. 1998

Finalist, PhD Student Presentation Competition. 1997

Research

My research focuses primarily on Musculoskeletal Tissue Engineering with an emphasis on challenging clinical problems and translational solutions.
Our approach is to develop in vivo and in vitro models of musculoskeletal injury and clinically-translatable outcome measures to assess the efficacy ...
My research focuses primarily on Musculoskeletal Tissue Engineering with an emphasis on challenging clinical problems and translational solutions.
Our approach is to develop in vivo and in vitro models of musculoskeletal injury and clinically-translatable outcome measures to assess the efficacy of regenerative and tissue engineering solutions.
Current research projects include:

1. Tissue Engineering of Massive Bone Allograft Union
2. Allografts and Gdf5 Gene Therapy in Flexor Tendon Tissue Engineering
3. Modulating Stem Cell Differentiation using Novel Allograft Scaffolds for Cartilage Repair
4. Fashioning a Superficial Zone-Like Layer in Bioreactor-Cultivated Tissue Engineered Cartilage
5. Evaluating models of human musculoskeletal disease and trauma

Patents

Targeted Delivery of Therapeutic Agents With Lyophilized Matrices

Issue date: January 21, 2014

Patent #: 8,632,797

Country: United States

Inventors: Hani A Awad, Edward Michael Schwarz

Protecting and Repairing Cartilage and Musculoskeletal Soft Tissues

Issue date: May 30, 2018

Patent #: 2349325

Country: Europe

Inventors: Hani A Awad, Susan Bukata, J. Edward Puzas, Randy N Rosier, Erik R Sampson, Michael J Zuscik

Protecting and Repairing Cartilage and Musculoskeletal Soft Tissues

Issue date: August 20, 2013

Patent #: 8,513,193

Country: United States

Inventors: Hani A Awad, Susan Bukata, J. Edward Puzas, Randy N Rosier, Erik R Sampson, Michael J Zuscik

Protecting and Repairing Cartilage and Musculoskeletal Soft Tissues

Issue date: November 24, 2015

Patent #: 9,192,653

Country: United States

Inventors: Hani A Awad, Susan Bukata, J. Edward Puzas, Randy N Rosier, Erik R Sampson, Michael J Zuscik

Protecting and Repairing Cartilage and Musculoskeletal Soft Tissues

Issue date: May 30, 2018

Patent #: FR2349325

Country: France

Inventors: Hani A Awad, Susan Bukata, J. Edward Puzas, Randy N Rosier, Erik R Sampson, Michael J Zuscik

Protecting and Repairing Cartilage and Musculoskeletal Soft Tissues

Issue date: May 30, 2018

Patent #: 602009052599.9

Country: Germany

Inventors: Hani A Awad, Susan Bukata, J. Edward Puzas, Randy N Rosier, Erik R Sampson, Michael J Zuscik

Protecting and Repairing Cartilage and Musculoskeletal Soft Tissues

Issue date: May 30, 2018

Patent #: GB2349325

Country: United Kingdom

Inventors: Hani A Awad, Susan Bukata, J. Edward Puzas, Randy N Rosier, Erik R Sampson, Michael J Zuscik

Publications

Journal Articles

Biomechanical Effects of Subtalar Joint Fusion and Medial Ligament Reconstruction in Simulated Progressive Collapsing Foot Deformity.

Lee W, Tecle N, Knapp E, Awad H, Oh I

Foot & ankle international.. 2024 January 19 :10711007231220940. Epub 01/19/2024.

Human tendon-on-a-chip for modeling vascular inflammatory fibrosis.

Awad H, Ajalik R, Alenchery R, Linares I, Wright T, Miller B, McGrath J

Research square.. 2023 December 13 Epub 12/13/2023.

Detection of osteoporotic-related bone changes and prediction of distal radius strength using Raman spectra from excised human cadaver finger bones.

Massie C, Knapp E, Awad HA, Berger AJ

Journal of biomechanics.. 2023 October 25161 :111852. Epub 10/25/2023.

Preclinical Tendon and Ligament Models: Beyond the 3Rs (Replacement, Reduction, and Refinement) to 5W1H (Why, Who, What, Where, When, How).

Little D, Amadio PC, Awad H, Cone SG, Dyment NA, Fisher MB, Huang AH, Koch DW, Kuntz AF, Madi R, McGilvrey K, Schnabel LV, Shetye SS, Thomopoulos S, Zhao C, Soslowsky LJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 August 12 Epub 08/12/2023.

Guidelines for ex vivo mechanical testing of tendon.

Lake SP, Snedeker JG, Wang VM, Awad H, Screen HRC, Thomopoulos S

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 June 13 Epub 06/13/2023.

PAI-1 mediates TGF-?1 induced myofibroblast activation in tenocytes via mTOR signaling.

Alenchery RG, Ajalik RE, Jerreld K, Midekksa F, Zhong S, Alkatib B, Awad HA

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 May 4 Epub 05/04/2023.

Effects of Acetabular Screws on the Initial Stability of Porous Coated Acetabular Implants in Revision Total Hip Arthroplasty.

Kaplan NB, Barra MF, Jubril A, Knapp E, Awad H, Ginnetti J

Cure?us.. 2023 April 15 (4):e38257. Epub 04/28/2023.

ROLE OF THE MITOCHONDRIAL PERMEABILITY TRANSITION IN BONE METABOLISM AND AGING.

Sautchuk R, Yu C, McArthur M, Massie C, Brookes PS, Porter GA, Awad H, Eliseev RA

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2023 February 13 Epub 02/13/2023.

Identification of Penicillin Binding Protein 4 (PBP4) Inhibitors.

Young M, Walsh DJ, Masters E, Gondil VS, Laskey E, Klaczko M, Awad H, McGrath J, Schwarz EM, Melander C, Dunman PM

Antibiotics.. 2022 October 411 (10)Epub 10/04/2022.

A high-throughput semi-automated bone segmentation workflow for murine hindpaw micro-CT datasets.

Kenney HM, Peng Y, Chen KL, Ajalik R, Schnur L, Wood RW, Schwarz EM, Awad HA

Bone reports.. 2022 June 16 :101167. Epub 01/20/2022.

Transcriptional regulation of Cyclophilin D by BMP/SMAD signaling and its role in osteogenic differentiation.

Sautchuk R, Kalicharan BH, Escalera-Rivera K, Jonason JH, Porter GA, Awad HA, Eliseev RA

eLife.. 2022 May 3011 Epub 05/30/2022.

Polypharmacy, Potentially Inappropriate Medications, and Drug-Drug Interactions in Vulnerable Older Adults With Advanced Cancer Initiating Cancer Treatment.

Ramsdale E, Mohamed M, Yu V, Otto E, Juba K, Awad H, Moorthi K, Plumb S, Patil A, Vogelzang N, Dib E, Mohile S

The oncologist.. 2022 March 28 Epub 03/28/2022.

Altered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse.

Kallenbach JG, Freeberg MAT, Abplanalp D, Alenchery RG, Ajalik RE, Muscat S, Myers JA, Ashton JM, Loiselle A, Buckley MR, van Wijnen AJ, Awad HA

Scientific reports.. 2022 February 2212 (1):3026. Epub 02/22/2022.

Cantilever Bending of Murine Femoral Necks.

Knapp E, Awad HA

Journal of visualized experiments : JoVE.. 2022 January 5 (179)Epub 01/05/2022.

Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery.

Ajalik RE, Alenchery RG, Cognetti JS, Zhang VZ, McGrath JL, Miller BL, Awad HA

Frontiers in bioengineering and biotechnology.. 2022 10 :846230. Epub 03/14/2022.

Sourcing cells for models of human vascular barriers of inflammation.

McCloskey MC, Zhang VZ, Ahmad SD, Walker S, Romanick SS, Awad HA, McGrath JL

Frontiers in medical technology.. 2022 4 :979768. Epub 10/21/2022.

Determination of best Raman spectroscopy spatial offsets for transcutaneous bone quality assessments in human hands.

Chen K, Massie C, Awad HA, Berger AJ

Biomedical optics express.. 2021 December 112 (12):7517-7525. Epub 11/11/2021.

Chondral Damage After Arthroscopic Repair Techniques for Acute Bony Bankart Lesions: A Biomechanical Study.

Greenstein AS, Chen RE, Brown AM, Knapp E, Roberts A, Awad HA, Voloshin I

The American journal of sports medicine.. 2021 July 8 :3635465211023758. Epub 07/08/2021.

A Biomechanical, Cadaveric Evaluation of Single- Versus Double-Row Repair Techniques on Stability of Bony Bankart Lesions.

Greenstein AS, Chen RE, Knapp E, Brown AM, Roberts A, Awad HA, Voloshin I

The American journal of sports medicine.. 2021 February 5 :363546520985184. Epub 02/05/2021.

Improved prediction of femoral fracture toughness in mice by combining standard medical imaging with Raman spectroscopy.

Massie C, Knapp E, Chen K, Berger AJ, Awad HA

Journal of biomechanics.. 2021 January 13116 :110243. Epub 01/13/2021.

A Mouse Femoral Ostectomy Model to Assess Bone Graft Substitutes.

Trombetta RP, Knapp EK, Awad HA

Methods in molecular biology.. 2021 2230 :75-89. Epub 1900 01 01.

Cell Wall Biosynthesis Modulates Bone Invasion and Osteomyelitis Pathogenesis.

Masters EA, Muthukrishnan G, Ho L, Gill AL, de Mesy Bentley KL, Galloway CA, McGrath JL, Awad HA, Gill SR, Schwarz EM

Frontiers in microbiology.. 2021 12 :723498. Epub 08/16/2021.

NF-?B activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival.

Best KT, Nichols AEC, Knapp E, Hammert WC, Ketonis C, Jonason JH, Awad HA, Loiselle AE

Science signaling.. 2020 November 1713 (658)Epub 11/17/2020.

Identification of Penicillin Binding Protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice.

Masters EA, de Mesy Bentley KL, Gill AL, Hao SP, Galloway CA, Salminen AT, Guy DR, McGrath JL, Awad HA, Gill SR, Schwarz EM

PLoS pathogens.. 2020 October 2216 (10):e1008988. Epub 10/22/2020.

Lactate Dehydrogenase Inhibition with Oxamate Exerts Bone Anabolic Effect.

Hollenberg AM, Smith CO, Shum LC, Awad H, Eliseev RA

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2020 July 30 Epub 07/30/2020.

A Brief History of Tendon and Ligament Bioreactors: Impact and Future Prospects.

Dyment NA, Barrett JG, Awad H, Bautista CA, Banes A, Butler DL

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 June 24 Epub 06/24/2020.

Peritalar Kinematics With Combined Deltoid-Spring Ligament Reconstruction in Simulated Advanced Adult Acquired Flatfoot Deformity.

MacDonald A, Ciufo D, Vess E, Knapp E, Awad HA, Ketz JP, Flemister AS, Oh I

Foot & ankle international.. 2020 June 4 :1071100720929004. Epub 06/04/2020.

Effects of tamoxifen on tendon homeostasis and healing: Considerations for the use of tamoxifen-inducible mouse models.

Best KT, Studentsova V, Ackerman JE, Nichols AEC, Myers M, Cobb J, Knapp E, Awad HA, Loiselle AE

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 June 2 Epub 06/02/2020.

Teriparatide (rPTH1-34) enhances bone allograft integration in a clinically relevant pig model of segmental mandibulectomy.

Pelled G, Lieber R, Avalos P, Cohn-Yakubovich D, Tawackoli W, Roth J, Knapp E, Schwarz EM, Awad HA, Gazit D, Gazit Z

Journal of tissue engineering and regenerative medicine.. 2020 June 1 Epub 06/01/2020.

The Effects of Splitting an Above Elbow Cast: A biomechanical study.

Vokes J, Obudzinski S, Knapp E, O'Malley S, Awad H, O'Malley N

Injury.. 2020 May 23 Epub 05/23/2020.

Inhibition of the mitochondrial permeability transition improves bone fracture repair.

Shares BH, Smith CO, Sheu TJ, Sautchuk R, Schilling K, Shum LC, Paine A, Huber A, Gira E, Brown E, Awad H, Eliseev RA

Bone.. 2020 April 28 :115391. Epub 04/28/2020.

American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies - Secondary Publication.

O'Keefe RJ, Tuan RS, Lane NE, Awad HA, Barry F, Bunnell BA, Colnot C, Drake MT, Drissi H, Dyment NA, Fortier LA, Guldberg RE, Kandel R, Little DG, Marshall MF, Mao JJ, Nakamura N, Proffen BL, Rodeo SA, Rosen V, Thomopoulos S, Schwarz EM, Serra R

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 March 38 (3):485-502. Epub 01/29/2020.

What Regions of the Distal Clavicle Have the Greatest Bone Mineral Density and Cortical Thickness? A Cadaveric Study.

Chen RE, Soin SP, El-Shaar R, Nicandri GT, Awad HA, Maloney MD, Voloshin I

Clinical orthopaedics and related research.. 2019 December 477 (12):2726-2732. Epub 1900 01 01.

American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies.

O'Keefe RJ, Tuan RS, Lane NE, Barry F, Bunnell BA, Colnot C, Drake MT, Drissi H, Fortier LA, Guldberg RE, Little DG, Marshall MF, Mao JJ, Nakamura N, Robey PG, Rosen V, Rowe DW, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2019 September 23 Epub 09/23/2019.

What Regions of the Distal Clavicle Have the Greatest Bone Mineral Density and Cortical Thickness? A Cadaveric Study.

Chen RE, Soin SP, El-Shaar R, Nicandri GT, Awad HA, Maloney MD, Voloshin I

Clinical orthopaedics and related research.. 2019 August 29 Epub 08/29/2019.

Transcriptomic Analysis of Cellular Pathways in Healing Flexor Tendons of Plasminogen Activator Inhibitor 1 (PAI-1/Serpine1) Null Mice.

Freeberg MAT, Easa A, Lillis JA, Benoit DSW, van Wijnen AJ, Awad HA

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 August 19 Epub 08/19/2019.

Deletion of NFKB1 enhances canonical NF-?B signaling and increases macrophage and myofibroblast content during tendon healing.

Best KT, Lee FK, Knapp E, Awad HA, Loiselle AE

Scientific reports.. 2019 July 299 (1):10926. Epub 07/29/2019.

A murine femoral ostectomy model with hardware exchange to assess antibiotic-impregnated spacers for implant-associated osteomyelitis.

Trombetta RP, de Mesy Bentley KL, Schwarz EM, Kate SL, Awad HA

European cells & materials.. 2019 June 2737 :431-443. Epub 06/27/2019.

An in vitro platform for elucidating the molecular genetics of S. aureus invasion of the osteocyte lacuno-canalicular network during chronic osteomyelitis.

Masters EA, Salminen AT, Begolo S, Luke EN, Barrett SC, Overby CT, Gill AL, de Mesy Bentley KL, Awad HA, Gill SR, Schwarz EM, McGrath JL

Nanomedicine : nanotechnology, biology, and medicine.. 2019 June 24 :102039. Epub 06/24/2019.

Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair.

Feigenson M, Jonason JH, Shen J, Loiselle AE, Awad HA, O'Keefe RJ

Annals of biomedical engineering.. 2019 April 12 Epub 04/12/2019.

Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis.

Trombetta RP, Ninomiya MJ, El-Atawneh IM, Knapp EK, de Mesy Bentley KL, Dunman PM, Schwarz EM, Kates SL, Awad HA

Pharmaceutics.. 2019 February 2211 (2)Epub 02/22/2019.

Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy".

Masters EA, Trombetta RP, de Mesy Bentley KL, Boyce BF, Gill AL, Gill SR, Nishitani K, Ishikawa M, Morita Y, Ito H, Bello-Irizarry SN, Ninomiya M, Brodell JD, Lee CC, Hao SP, Oh I, Xie C, Awad HA, Daiss JL, Owen JR, Kates SL, Schwarz EM, Muthukrishnan G

Bone research.. 2019 7 :20. Epub 07/15/2019.

Reconstruction of the Superior Glenoid Labrum With Biceps Tendon Autograft: A Cadaveric Biomechanical Study.

Chen RE, Soin SP, El-Shaar R, Awad HA, Maloney MD, Voloshin I

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.. 2018 December 24 Epub 12/24/2018.

Spatially offset Raman spectroscopy for bone strength prediction.

Shu C, Chen K, Lynch M, Maher JR, Awad HA, Berger AJ

Biomedical optics express.. 2018 October 19 (10):4781-4791. Epub 09/12/2018.

Patient-Specific 3-Dimensional Modeling and Its Use for Preoperative Counseling of Patients Undergoing Hip Arthroscopy.

Childs S, McVicker Z, Trombetta R, Awad H, Elfar J, Giordano B

Orthopaedic journal of sports medicine.. 2018 September 6 (9):2325967118794645. Epub 09/11/2018.

Teriparatide (human PTH) compensates for impaired fracture healing in COX-2 deficient mice.

Yukata K, Xie C, Li TF, Brown ML, Kanchiku T, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ

Bone.. 2018 May 110 :150-159. Epub 02/03/2018.

Targeting the gut microbiome to treat the osteoarthritis of obesity.

Schott EM, Farnsworth CW, Grier A, Lillis JA, Soniwala S, Dadourian GH, Bell RD, Doolittle ML, Villani DA, Awad H, Ketz JP, Kamal F, Ackert-Bicknell C, Ashton JM, Gill SR, Mooney RA, Zuscik MJ

JCI insight.. 2018 April 193 (8)Epub 04/19/2018.

Serpine1 Knockdown Enhances MMP Activity after Flexor Tendon Injury in Mice: Implications for Adhesions Therapy.

Freeberg MAT, Farhat YM, Easa A, Kallenbach JG, Malcolm DW, Buckley MR, Benoit DSW, Awad HA

Scientific reports.. 2018 April 118 (1):5810. Epub 04/11/2018.

Three dimensional printed calcium phosphate and poly(caprolactone) composites with improved mechanical properties and preserved microstructure.

Vella JB, Trombetta RP, Hoffman MD, Inzana J, Awad H, Benoit DSW

Journal of biomedical materials research. Part A.. 2018 March 106 (3):663-672. Epub 11/02/2017.

Diblock Copolymer Hydrophobicity Facilitates Efficient Gene Silencing and Cytocompatible Nanoparticle-Mediated siRNA Delivery to Musculoskeletal Cell Types.

Malcolm DW, Freeberg MAT, Wang Y, Sims KR, Awad HA, Benoit DSW

Biomacromolecules.. 2017 November 1318 (11):3753-3765. Epub 10/11/2017.

Sensitivity of spatially offset Raman spectroscopy (SORS) to subcortical bone tissue.

Feng G, Ochoa M, Maher JR, Awad HA, Berger AJ

Journal of biophotonics.. 2017 August 10 (8):990-996. Epub 05/02/2017.

In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs.

Bez M, Sheyn D, Tawackoli W, Avalos P, Shapiro G, Giaconi JC, Da X, David SB, Gavrity J, Awad HA, Bae HW, Ley EJ, Kremen TJ, Gazit Z, Ferrara KW, Pelled G, Gazit D

Science translational medicine.. 2017 May 179 (390)Epub 1900 01 01.

Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis.

de Mesy Bentley KL, Trombetta R, Nishitani K, Bello-Irizarry SN, Ninomiya M, Zhang L, Chung HL, McGrath JL, Daiss JL, Awad HA, Kates SL, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 May 32 (5):985-990. Epub 01/26/2017.

3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery.

Trombetta R, Inzana JA, Schwarz EM, Kates SL, Awad HA

Annals of biomedical engineering.. 2017 January 45 (1):23-44. Epub 06/20/2016.

Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice.

Beier EE, Sheu TJ, Resseguie EA, Takahata M, Awad HA, Cory-Slechta DA, Puzas JE

Bone research.. 2017 5 :17013. Epub 05/09/2017.

High dose teriparatide (rPTH1-34) therapy increases callus volume and enhances radiographic healing at 8-weeks in a massive canine femoral allograft model.

Nishitani K, Mietus Z, Beck CA, Ito H, Matsuda S, Awad HA, Ehrhart N, Schwarz EM

PloS one.. 2017 12 (10):e0185446. Epub 10/11/2017.

Biomaterials approaches to treating implant-associated osteomyelitis.

Inzana JA, Schwarz EM, Kates SL, Awad HA

Biomaterials.. 2016 March 81 :58-71. Epub 12/18/2015.

3D printed bioceramics for dual antibiotic delivery to treat implant-associated bone infection.

Inzana JA, Trombetta RP, Schwarz EM, Kates SL, Awad HA

European cells & materials.. 2015 November 430 :232-47. Epub 11/04/2015.

The Effect of the Epitendinous Suture on Gliding in a Cadaveric Model of Zone II Flexor Tendon Repair.

Yaseen Z, English C, Stanbury SJ, Chen T, Messing S, Awad H, Elfar JC

The Journal of hand surgery.. 2015 July 40 (7):1363-8. Epub 04/25/2015.

Development of antisense oligonucleotide (ASO) technology against Tgf-? signaling to prevent scarring during flexor tendon repair.

Loiselle AE, Yukata K, Geary MB, Kondabolu S, Shi S, Jonason JH, Awad HA, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2015 June 33 (6):859-66. Epub 1900 01 01.

Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation.

Wang C, Shen J, Yukata K, Inzana JA, O'Keefe RJ, Awad HA, Hilton MJ

Bone.. 2015 April 73 :77-89. Epub 12/16/2014.

Flexor digitorum superficialis repair outside the A2 pulley after zone II laceration: gliding and bowstringing.

Geary MB, English C, Yaseen Z, Awad H, Elfar JC

The Journal of hand surgery.. 2015 April 40 (4):653-9. Epub 02/24/2015.

Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength.

Zhang M, Feigenson M, Sheu TJ, Awad HA, Schwarz EM, Jonason JH, Loiselle AE, O'Keefe RJ

Bone.. 2015 March 72 :92-100. Epub 11/29/2014.

TGF-?1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair.

Farhat YM, Al-Maliki AA, Easa A, O'Keefe RJ, Schwarz EM, Awad HA

Journal of cellular physiology.. 2015 February 230 (2):318-26. Epub 1900 01 01.

Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair.

Lee DJ, Southgate RD, Farhat YM, Loiselle AE, Hammert WC, Awad HA, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2015 January 33 (1):17-24. Epub 09/29/2014.

Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair.

Geary MB, Orner CA, Bawany F, Awad HA, Hammert WC, O'Keefe RJ, Loiselle AE

PloS one.. 2015 10 (8):e0136351. Epub 08/27/2015.

Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.

Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ

Bone.. 2014 May 62 :79-89. Epub 02/12/2014.

3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration.

Inzana JA, Olvera D, Fuller SM, Kelly JP, Graeve OA, Schwarz EM, Kates SL, Awad HA

Biomaterials.. 2014 April 35 (13):4026-34. Epub 02/14/2014.

Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia.

Juneja SC, Vonica A, Zeiss C, Lezon-Geyda K, Yatsula B, Sell DR, Monnier VM, Lin S, Ardito T, Eyre D, Reynolds D, Yao Z, Awad HA, Yu H, Wilson M, Honnons S, Boyce BF, Xing L, Zhang Y, Perkins AS

Bone.. 2014 March 60 :148-61. Epub 12/04/2013.

The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice.

Long T, Zhu Z, Awad HA, Schwarz EM, Hilton MJ, Dong Y

Biomaterials.. 2014 March 35 (9):2752-9. Epub 01/03/2014.

The Effect of Pulley Reconstruction on Maximum Flexion, Bowstringing, and Gliding Coefficient in the Setting of Zone II Repair of FDS and FDP: a Cadaveric Investigation.

Stanbury SJ, English C, Yaseen Z, Reed JD, Chen T, Awad H, Elfar JC

Hand : official journal of the American Association for Hand Surgery.. 2014 March 9 (1):99-104. Epub 1900 01 01.

A mouse model of flexor tendon repair.

Hasslund S, O'Keefe RJ, Awad HA

Methods in molecular biology.. 2014 1130 :73-88. Epub 1900 01 01.

Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes.

David MA, Jones KH, Inzana JA, Zuscik MJ, Awad HA, Mooney RA

PloS one.. 2014 9 (3):e91234. Epub 03/21/2014.

Freeze-dried allograft-mediated gene or protein delivery of growth and differentiation factor 5 reduces reconstructed murine flexor tendon adhesions.

Hasslund S, Dadali T, Ulrich-Vinther M, Søballe K, Schwarz EM, Awad HA

Journal of tissue engineering. 2014 5 :2041731414528736. Epub 03/19/2014.

Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus.

Brown ML, Yukata K, Farnsworth CW, Chen DG, Awad H, Hilton MJ, O'Keefe RJ, Xing L, Mooney RA, Zuscik MJ

PloS one.. 2014 9 (6):e99656. Epub 06/09/2014.

Structural and biomechanical responses of osseous healing: a novel murine nonunion model.

Chaubey A, Grawe B, Meganck JA, Dyment N, Inzana J, Jiang X, Connolley C, Awad H, Rowe D, Kenter K, Goldstein SA, Butler D

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology.. 2013 December 14 (4):247-57. Epub 08/30/2013.

Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur.

Inzana JA, Kung M, Shu L, Hamada D, Xing LP, Zuscik MJ, Awad HA, Mooney RA

Bone.. 2013 November 57 (1):174-83. Epub 08/14/2013.

Overconstrained library-based fitting method reveals age- and disease-related differences in transcutaneous Raman spectra of murine bones.

Maher JR, Inzana JA, Awad HA, Berger AJ

Journal of biomedical optics.. 2013 July 18 (7):077001. Epub 1900 01 01.

Comparison of an all-inside suture technique with traditional pull-out suture and suture anchor repair techniques for flexor digitorum profundus attachment to bone.

Chu JY, Chen T, Awad HA, Elfar J, Hammert WC

The Journal of hand surgery.. 2013 June 38 (6):1084-90. Epub 04/09/2013.

Addition of a suture anchor for coracoclavicular fixation to a superior locking plate improves stability of type IIB distal clavicle fractures.

Madsen W, Yaseen Z, Lafrance R, Chen T, Awad H, Maloney M, Voloshin I

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.. 2013 June 29 (6):998-1004. Epub 1900 01 01.

Engineering superficial zone features in tissue engineered cartilage.

Chen T, Hilton MJ, Brown EB, Zuscik MJ, Awad HA

Biotechnology and bioengineering.. 2013 May 110 (5):1476-86. Epub 12/27/2012.

PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis.

Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2013 March 28 (3):586-97. Epub 1900 01 01.

Bone fragility beyond strength and mineral density: Raman spectroscopy predicts femoral fracture toughness in a murine model of rheumatoid arthritis.

Inzana JA, Maher JR, Takahata M, Schwarz EM, Berger AJ, Awad HA

Journal of biomechanics.. 2013 February 2246 (4):723-30. Epub 12/20/2012.

Cellular and molecular factors in flexor tendon repair and adhesions: a histological and gene expression analysis.

Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA

Connective tissue research.. 2013 54 (3):218-26. Epub 04/15/2013.

Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk.

Takahata M, Maher JR, Juneja SC, Inzana J, Xing L, Schwarz EM, Berger AJ, Awad HA

Arthritis and rheumatism.. 2012 November 64 (11):3649-59. Epub 1900 01 01.

Insights into interstitial flow, shear stress, and mass transport effects on ECM heterogeneity in bioreactor-cultivated engineered cartilage hydrogels.

Chen T, Buckley M, Cohen I, Bonassar L, Awad HA

Biomechanics and modeling in mechanobiology.. 2012 May 11 (5):689-702. Epub 08/19/2011.

Endogenous tissue engineering: PTH therapy for skeletal repair.

Takahata M, Awad HA, O'Keefe RJ, Bukata SV, Schwarz EM

Cell and tissue research.. 2012 March 347 (3):545-52. Epub 05/31/2011.

Delayed short-course treatment with teriparatide (PTH(1-34)) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction.

Takahata M, Schwarz EM, Chen T, O'Keefe RJ, Awad HA

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2012 January 27 (1):26-37. Epub 1900 01 01.

Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury.

Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA, O'Keefe RJ

PloS one.. 2012 7 (7):e40602. Epub 07/11/2012.

Gene expression analysis of the pleiotropic effects of TGF-?1 in an in vitro model of flexor tendon healing.

Farhat YM, Al-Maliki AA, Chen T, Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA

PloS one.. 2012 7 (12):e51411. Epub 12/10/2012.

Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1.

Zhao L, Huang J, Zhang H, Wang Y, Matesic LE, Takahata M, Awad H, Chen D, Xing L

Stem cells.. 2011 October 29 (10):1601-10. Epub 1900 01 01.

Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis.

Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ

Science translational medicine.. 2011 September 213 (101):101ra93. Epub 1900 01 01.

TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease.

Papuga MO, Kwok E, You Z, Rubery PT, Dougherty PE, Pryhuber G, Beck CA, Hilton MJ, Awad HA, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 September 29 (9):1367-74. Epub 03/28/2011.

Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur.

Yazici C, Takahata M, Reynolds DG, Xie C, Samulski RJ, Samulski J, Beecham EJ, Gertzman AA, Spilker M, Zhang X, O'Keefe RJ, Awad HA, Schwarz EM

Molecular therapy : the journal of the American Society of Gene Therapy.. 2011 August 19 (8):1416-25. Epub 01/04/2011.

Establishment of an index with increased sensitivity for assessing murine arthritis.

Sampson ER, Beck CA, Ketz J, Canary KL, Hilton MJ, Awad H, Schwarz EM, Chen D, O'Keefe RJ, Rosier RN, Zuscik MJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 August 29 (8):1145-51. Epub 03/03/2011.

Raman spectroscopy detects deterioration in biomechanical properties of bone in a glucocorticoid-treated mouse model of rheumatoid arthritis.

Maher JR, Takahata M, Awad HA, Berger AJ

Journal of biomedical optics.. 2011 August 16 (8):087012. Epub 1900 01 01.

Neonatal hyperoxia causes pulmonary vascular disease and shortens life span in aging mice.

Yee M, White RJ, Awad HA, Bates WA, McGrath-Morrow SA, O'Reilly MA

The American journal of pathology.. 2011 June 178 (6):2601-10. Epub 05/06/2011.

The impact of Smad3 loss of function on TGF-? signaling and radiation-induced capsular contracture.

Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O'keefe RJ, Langstein HN

Plastic and reconstructive surgery.. 2011 June 127 (6):2263-9. Epub 1900 01 01.

Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing.

Katzel EB, Wolenski M, Loiselle AE, Basile P, Flick LM, Langstein HN, Hilton MJ, Awad HA, Hammert WC, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 May 29 (5):684-93. Epub 09/14/2010.

EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair.

Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2011 April 26 (4):792-802. Epub 1900 01 01.

Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model.

Reynolds DG, Takahata M, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA

Bone.. 2011 March 148 (3):562-70. Epub 10/13/2010.

Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects.

Jacobson JA, Yanoso Scholl L, Reynolds DG, Dadali T, Bradica G, Bukata S, Puzas JE, Zuscik MJ, Rosier R, O'Keefe RJ, Schwarz E, Awad H

Tissue engineering. Part A.. 2011 February 17 (3-4):389-98. Epub 10/29/2010.

Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering.

Yanoso-Scholl L, Jacobson JA, Bradica G, Lerner AL, O'Keefe RJ, Schwarz EM, Zuscik MJ, Awad HA

Journal of biomedical materials research. Part A.. 2010 December 195 (3):717-26. Epub 1900 01 01.

A novel animal model for studying silicone gel-related capsular contracture.

Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O'keefe RJ, Langstein HN

Plastic and reconstructive surgery.. 2010 November 126 (5):1483-91. Epub 1900 01 01.

Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity.

Papuga MO, Proulx ST, Kwok E, You Z, Rubery PT, Dougherty PE, Hilton MJ, Awad HA, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2010 September 28 (9):1220-8. Epub 1900 01 01.

Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw.

Li D, Gromov K, Proulx ST, Xie C, Li J, Crane DP, Søballe K, O'Keefe RJ, Awad HA, Xing L, Schwarz EM

Annals of the New York Academy of Sciences.. 2010 March 1192 :84-94. Epub 1900 01 01.

Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice.

Yan Y, Tang D, Chen M, Huang J, Xie R, Jonason JH, Tan X, Hou W, Reynolds D, Hsu W, Harris SE, Puzas JE, Awad H, O'Keefe RJ, Boyce BF, Chen D

Journal of cell science.. 2009 October 1122 (Pt 19):3566-78. Epub 09/08/2009.

Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression.

Loiselle AE, Bragdon GA, Jacobson JA, Hasslund S, Cortes ZE, Schwarz EM, Mitten DJ, Awad HA, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2009 June 27 (6):833-40. Epub 1900 01 01.

muCT-based measurement of cortical bone graft-to-host union.

Reynolds DG, Shaikh S, Papuga MO, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 May 24 (5):899-907. Epub 1900 01 01.

Reduced COX-2 expression in aged mice is associated with impaired fracture healing.

Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 February 24 (2):251-64. Epub 1900 01 01.

Chondrogenic differentiation of adipose-derived adult stem cells by a porous scaffold derived from native articular cartilage extracellular matrix.

Cheng NC, Estes BT, Awad HA, Guilak F

Tissue engineering. Part A.. 2009 February 15 (2):231-41. Epub 1900 01 01.

Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT.

Tsutsumi R, Hock C, Bechtold CD, Proulx ST, Bukata SV, Ito H, Awad HA, Nakamura T, O'Keefe RJ, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 October 26 (10):1340-6. Epub 1900 01 01.

The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings.

Yazici C, Yanoso L, Xie C, Reynolds DG, Samulski RJ, Samulski J, Yannariello-Brown J, Gertzman AA, Zhang X, Awad HA, Schwarz EM

Biomaterials.. 2008 October 29 (28):3882-7. Epub 06/30/2008.

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.

Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ, Zuscik MJ, Rosier RN

Arthritis and rheumatism.. 2008 October 58 (10):3132-44. Epub 1900 01 01.

Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.

Guo R, Yamashita M, Zhang Q, Zhou Q, Chen D, Reynolds DG, Awad HA, Yanoso L, Zhao L, Schwarz EM, Zhang YE, Boyce BF, Xing L

The Journal of biological chemistry.. 2008 August 22283 (34):23084-92. Epub 06/19/2008.

A perspective: engineering periosteum for structural bone graft healing.

Zhang X, Awad HA, O'Keefe RJ, Guldberg RE, Schwarz EM

Clinical orthopaedics and related research.. 2008 August 466 (8):1777-87. Epub 05/29/2008.

Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging.

Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Calvi LM, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM

Arthritis and rheumatism.. 2008 July 58 (7):2019-29. Epub 1900 01 01.

Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction.

Hasslund S, Jacobson JA, Dadali T, Basile P, Ulrich-Vinther M, Søballe K, Schwarz EM, O'Keefe RJ, Mitten DJ, Awad HA

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 June 26 (6):824-33. Epub 1900 01 01.

Inhibition of beta-catenin signaling causes defects in postnatal cartilage development.

Chen M, Zhu M, Awad H, Li TF, Sheu TJ, Boyce BF, Chen D, O'Keefe RJ

Journal of cell science.. 2008 May 1121 (Pt 9):1455-65. Epub 04/08/2008.

Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery.

Basile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Søballe K, Nishio Y, Drissi MH, Langstein HN, Mitten DJ, O'Keefe RJ, Schwarz EM, Awad HA

Molecular therapy : the journal of the American Society of Gene Therapy.. 2008 March 16 (3):466-73. Epub 01/08/2008.

Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity.

Li D, Gromov K, Søballe K, Puzas JE, O'Keefe RJ, Awad H, Drissi H, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 January 26 (1):96-105. Epub 1900 01 01.

Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation.

Butler DL, Juncosa-Melvin N, Boivin GP, Galloway MT, Shearn JT, Gooch C, Awad H

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 January 26 (1):1-9. Epub 1900 01 01.

Screw orientation and plate type (variable- vs. fixed-angle) effect strength of fixation for in vitro biomechanical testing of the Synthes CSLP.

Dipaola CP, Jacobson JA, Awad H, Conrad BP, Rechtine GR

The spine journal : official journal of the North American Spine Society.. 2008 8 (5):717-22. Epub 11/05/2007.

Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography.

Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM

Arthritis and rheumatism.. 2007 December 56 (12):4024-37. Epub 1900 01 01.

Recent advances in gene delivery for structural bone allografts.

Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM

Tissue engineering.. 2007 August 13 (8):1973-85. Epub 1900 01 01.

Screw pull-out force is dependent on screw orientation in an anterior cervical plate construct.

DiPaola CP, Jacobson JA, Awad H, Conrad BP, Rechtine GR

Journal of spinal disorders & techniques.. 2007 July 20 (5):369-73. Epub 1900 01 01.

Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering.

Xie C, Reynolds D, Awad H, Rubery PT, Pelled G, Gazit D, Guldberg RE, Schwarz EM, O'Keefe RJ, Zhang X

Tissue engineering.. 2007 March 13 (3):435-45. Epub 1900 01 01.

Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts.

Reynolds DG, Hock C, Shaikh S, Jacobson J, Zhang X, Rubery PT, Beck CA, O'keefe RJ, Lerner AL, Schwarz EM, Awad HA

Journal of biomechanics.. 2007 40 (14):3178-86. Epub 05/23/2007.

Alteration of femoral bone morphology and density in COX-2-/- mice.

Robertson G, Xie C, Chen D, Awad H, Schwarz EM, O'Keefe RJ, Guldberg RE, Zhang X

Bone.. 2006 October 39 (4):767-72. Epub 05/30/2006.

Clonal analysis of the differentiation potential of human adipose-derived adult stem cells.

Guilak F, Lott KE, Awad HA, Cao Q, Hicok KC, Fermor B, Gimble JM

Journal of cellular physiology.. 2006 January 206 (1):229-37. Epub 1900 01 01.

The effects of ZD6474, an inhibitor of VEGF signaling, on cutaneous wound healing in mice.

Ko J, Ross J, Awad H, Hurwitz H, Klitzman B

The Journal of surgical research.. 2005 December 129 (2):251-9. Epub 09/02/2005.

Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering.

Zhang X, Xie C, Lin AS, Ito H, Awad H, Lieberman JR, Rubery PT, Schwarz EM, O'Keefe RJ, Guldberg RE

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 December 20 (12):2124-37. Epub 08/08/2005.

Biological effects of rAAV-caAlk2 coating on structural allograft healing.

Koefoed M, Ito H, Gromov K, Reynolds DG, Awad HA, Rubery PT, Ulrich-Vinther M, Soballe K, Guldberg RE, Lin AS, O'Keefe RJ, Zhang X, Schwarz EM

Molecular therapy : the journal of the American Society of Gene Therapy.. 2005 August 12 (2):212-8. Epub 1900 01 01.

Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice.

Xiao Z, Awad HA, Liu S, Mahlios J, Zhang S, Guilak F, Mayo MS, Quarles LD

Developmental biology.. 2005 July 15283 (2):345-56. Epub 1900 01 01.

Influence of oxygen on the proliferation and metabolism of adipose derived adult stem cells.

Wang DW, Fermor B, Gimble JM, Awad HA, Guilak F

Journal of cellular physiology.. 2005 July 204 (1):184-91. Epub 1900 01 01.

Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia.

Liu S, Brown TA, Zhou J, Xiao ZS, Awad H, Guilak F, Quarles LD

Journal of the American Society of Nephrology : JASN.. 2005 June 16 (6):1645-53. Epub 04/20/2005.

Evaluating postoperative analgesics in mice using telemetry.

Goecke JC, Awad H, Lawson JC, Boivin GP

Comparative medicine.. 2005 February 55 (1):37-44. Epub 1900 01 01.

Periosteal stem cells are essential for bone revitalization and repair.

Zhang X, Naik A, Xie C, Reynolds D, Palmer J, Lin A, Awad H, Guldberg R, Schwarz E, O'Keefe R

Journal of musculoskeletal & neuronal interactions.. 2005 5 (4):360-2. Epub 1900 01 01.

Molecular diffusion in tissue-engineered cartilage constructs: effects of scaffold material, time, and culture conditions.

Leddy HA, Awad HA, Guilak F

Journal of biomedical materials research. Part B, Applied biomaterials.. 2004 August 1570 (2):397-406. Epub 1900 01 01.

Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds.

Awad HA, Wickham MQ, Leddy HA, Gimble JM, Guilak F

Biomaterials.. 2004 July 25 (16):3211-22. Epub 1900 01 01.

Adipose-derived adult stem cells for cartilage tissue engineering.

Guilak F, Awad HA, Fermor B, Leddy HA, Gimble JM

Biorheology. 2004 41 (3-4):389-99. Epub 1900 01 01.

Effects of transforming growth factor beta1 and dexamethasone on the growth and chondrogenic differentiation of adipose-derived stromal cells.

Awad HA, Halvorsen YD, Gimble JM, Guilak F

Tissue engineering.. 2003 December 9 (6):1301-12. Epub 1900 01 01.

Repair of patellar tendon injuries using a cell-collagen composite.

Awad HA, Boivin GP, Dressler MR, Smith FN, Young RG, Butler DL

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 May 21 (3):420-31. Epub 1900 01 01.

A potential mechanism for age-related declines in patellar tendon biomechanics.

Dressler MR, Butler DL, Wenstrup R, Awad HA, Smith F, Boivin GP

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 November 20 (6):1315-22. Epub 1900 01 01.

Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo.

Erickson GR, Gimble JM, Franklin DM, Rice HE, Awad H, Guilak F

Biochemical and biophysical research communications.. 2002 January 18290 (2):763-9. Epub 1900 01 01.

In vitro characterization of mesenchymal stem cell-seeded collagen scaffolds for tendon repair: effects of initial seeding density on contraction kinetics.

Awad HA, Butler DL, Harris MT, Ibrahim RE, Wu Y, Young RG, Kadiyala S, Boivin GP

Journal of biomedical materials research.. 2000 August 51 (2):233-40. Epub 1900 01 01.

Perspectives on cell and collagen composites for tendon repair.

Butler DL, Awad HA

Clinical orthopaedics and related research.. 1999 October (367 Suppl):S324-32. Epub 1900 01 01.

Autologous mesenchymal stem cell-mediated repair of tendon.

Awad HA, Butler DL, Boivin GP, Smith FN, Malaviya P, Huibregtse B, Caplan AI

Tissue engineering.. 1999 June 5 (3):267-77. Epub 1900 01 01.

Books

Functional Tissue Engineering (2003)

Chapter: Assessment of function in Tendon and Ligament Repair

Authors: Butler D, Dressler M, Awad H

Publisher: Springer-Verlag, New York, NY 2003

Tissue Engineering and Biodegradable Equivalents (2002)

Chapter: Biomaterials for Cartilage Tissue Engineering

Authors: Awad H, Erickson G, Guilak F

Publisher: Marcel Dekker Inc., New York, NY 2002