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Chao Xie, B.Med.

Chao Xie, B.Med.

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About Me

Faculty Appointments

Associate Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD)

Credentials

Post-doctoral Training & Residency

Postdoctoral Fellow, The Center for Musculoskeletal Research, Department of Orthopedics, University of Rochester NY 2003 - 2007

Postdoctoral Researcher, Department of Urology, University of Rochester NY 2002 - 2003

Education

MSBA | University of Rochester Simon Business School. Medical Management. 2017

M.D. | China-Zunyi Medical Coll, Zunyi. Medicine. 1992

Awards

OREF Award. 2012 - 2014

DePuy J&J Inc. Fellowship. U.S.A.. 2008 - 2009

New Investigator Recognition Awards (NIRA).. 2007

Advanced Worker Award, Liupanshui People's Hospital,. 1995

Outstanding Student Leadership Award, Zunyi Medical College. 1989 - 1990

Research

Publications

Journal Articles

Efficacy of pH-Responsive Surface Functionalized Titanium Screws in Treating Implant-associated S. aureus Osteomyelitis with Biofilms Formation.

Zhou H, Ren Y, Zou K, Jin Y, Liu H, Jiang H, Shi L, Sheng X, Weeks J, Wang H, Xue T, Schwarz EM, Xie C, Deng Z, Wang L, Chu L

Advanced healthcare materials.. 2024 November 27 :e2403261. Epub 11/27/2024.

Vaccines: Do they have a role in orthopedic trauma?

Kates SL, Owen JR, Xie C, Ren Y, Muthukrishnan G, Schwarz EM

Injury.. 2024 November 55 Suppl 6 :111631. Epub 1900 01 01.

Pancreatic fat infiltration is associated with risk of vertebral fracture in older patients with type 2 diabetes: A longitudinal multicenter study.

Wang J, Wei Z, Wang Y, Zhang D, Wang M, Chen X, Xia P, Wang J, Xie C, Chen X

Diabetes research and clinical practice.. 2024 October 22 :111904. Epub 10/22/2024.

Initial therapeutic evidence of a borosilicate bioactive glass (BSG) and FeO magnetic nanoparticle scaffold on implant-associated bone infection.

Jin Y, Liu H, Chu L, Yang J, Li X, Zhou H, Jiang H, Shi L, Weeks J, Rainbolt J, Yang C, Xue T, Pan H, Deng Z, Xie C, Cui X, Ren Y

Bioactive materials.. 2024 October 40 :148-167. Epub 06/08/2024.

Bone mineral density in lower thoracic vertebra for osteoporosis diagnosis in older adults during CT lung cancer screening.

Hu N, Wang M, Yang M, Chen X, Wang J, Xie C, Zhang B, Wang Z, Chen X

BMC geriatrics.. 2024 March 624 (1):237. Epub 03/06/2024.

Longitudinal intravital imaging of the bone marrow for analysis of the race for the surface in a murine osteomyelitis model.

Xie C, Ren Y, Weeks J, Rainbolt J, Mark Kenney H, Xue T, Allen F, Shu Y, Tay AJH, Lekkala S, Yeh SA, Muthukrishnan G, Gill AL, Gill SR, Kim M, Kates SL, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2024 March 42 (3):531-538. Epub 10/17/2023.

2023 International Consensus Meeting on musculoskeletal infection: Summary from the treatment workgroup and consensus on treatment in preclinical models.

Amber Jennings J, Arts C, Falconer R, Ashton N, Williams D, Duffy H, Hamilton J, Markovics A, Gianotti S, Tate J, Montgomery EC, Abuhussein E, Dintakurthi Y, Ren Y, Weeks J, Xie C, Ricciardi B, van Hoogstraten S, Mdingi V, Vanvelk N, Hylen A, Baertl S, Alt V, Morgenstern M, Priddy LB, Tucker LJ, Gautreaux MA, Ducheyne P, Bhattacharyya S, Obremskey WT, Libos A, Cain JD, Hickok NJ, Schwarz EM, Fintan Moriarty T

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2024 March 42 (3):500-511. Epub 01/04/2024.

The 2023 Orthopaedic Research Society's International Consensus Meeting on musculoskeletal infection: Summary from the host immunity section.

Schwarz EM, Archer NK, Atkins GJ, Bentley KLM, Botros M, Cassat JE, Chisari E, Coraça-Huber DC, Daiss JL, Gill SR, Goodman SB, Harro J, Hernandez CJ, Ivashkiv LB, Kates SL, Marques CNH, Masters EA, Muthukrishnan G, Owen JR, Raafat D, Saito M, Veis DJ, Xie C

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2024 March 42 (3):518-530. Epub 12/16/2023.

Opportunistic Muscle Evaluation During Chest CT Is Associated With Vertebral Compression Fractures in Old Adults: A Longitudinal Study.

Wang M, Tang H, Chen X, Liu J, Hu N, Cui W, Zhang C, Xie C, Chen X

The journals of gerontology. Series A, Biological sciences and medical sciences.. 2024 February 179 (2)Epub 1900 01 01.

Age and gender differences in erector spinae area and their role in sarcopenia evaluation in a Chinese population.

Wei Z, Gao X, Liu Y, Hu N, Chen X, Xie C, Wang J, Chen X

The journal of nutrition, health & aging.. 2024 January 28 (1):100009. Epub 12/06/2023.

Initial therapeutic evidence of a borosilicate bioactive glass (BSG) and Fe3O4 magnetic nanoparticle scaffold on implant-associated Staphylococcal aureus bone infection

Ying Jin a 1, Hang Liu a 1, Lei Chu a 1, Jin Yang b, Xiuyang Li a c, Hang Zhou a, Haitao Jiang a, Lei Shi a, Jason Weeks d, Joshua Rainbolt d, Changjiang Yang e, Thomas Xue d, Haobo Pan e, Zhongliang Deng a 2, Chao Xie d, Xu Cui e 2, Youliang Ren a 2.

Bioactive Materials

A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and S. aureus contaminated bone implants in a mouse femur model.

Lekkala S, Ren Y, Weeks J, Lee K, Tay AJH, Liu B, Xue T, Rainbolt J, Xie C, Schwarz EM, Yeh SA

PloS one.. 2024 19 (6):e0296140. Epub 06/20/2024.

A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and contaminated bone implants in a mouse femur model.

Lekkala S, Ren Y, Weeks J, Lee K, Tay AJH, Liu B, Xue T, Rainbolt J, Xie C, Schwarz EM, Yeh SA

bioRxiv : the preprint server for biology.. 2023 December 8 Epub 12/08/2023.

Reduced angiogenesis and delayed endochondral ossification in CD163 mice highlights a role of M2 macrophages during bone fracture repair.

Ren Y, Zhang S, Weeks J, Rangel-Moreno J, He B, Xue T, Rainbolt J, Morita Y, Shu Y, Liu Y, Kates SL, Schwarz EM, Xie C

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 November 41 (11):2384-2393. Epub 04/08/2023.

Sarcopenia assessed by computed tomography or magnetic resonance imaging is associated with the loss of response to biologic therapies in adult patients with Crohn's disease.

Liu J, Tang H, Lin T, Wang J, Cui W, Xie C, Wang Z, Chen Y, Chen X

Clinical and translational science.. 2023 November 16 (11):2209-2221. Epub 09/05/2023.

Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis.

Ren Y, Weeks J, Xue T, Rainbolt J, de Mesy Bentley KL, Shu Y, Liu Y, Masters E, Cherian P, McKenna CE, Neighbors J, Ebetino FH, Schwarz EM, Sun S, Xie C

Bone research.. 2023 October 1811 (1):51. Epub 10/18/2023.

Epidemiological updates of post-traumatic related limb osteomyelitis in china: a 10 years multicentre cohort study.

Ren Y, Liu L, Sun D, Zhang Z, Li M, Lan X, Ni J, Yan M, Huang W, Liu Z, Peng A, Zhang Y, Jiang N, Song K, Huang Z, Bi Q, Zhang J, Yang Q, Yang J, Liu Y, Fu W, Tian X, Wang Y, Zhong W, Song X, Abudurexiti A, Xia Z, Jiang Q, Shi H, Liu X, Wang G, Hu Y, Zhang Y, Yin G, Fan J, Feng S, Zhou X, Li Z, He W, Weeks J, Schwarz EM, Kates SL, Huang L, Chai Y, Yu B, Xie Z, Deng Z, Xie C

International journal of surgery.. 2023 September 1109 (9):2721-2731. Epub 09/01/2023.

A Computed Tomography-based Radiomics Nomogram for Predicting Osteoporotic Vertebral Fractures: A Longitudinal Study.

Wang M, Chen X, Cui W, Wang X, Hu N, Tang H, Zhang C, Shen J, Xie C, Chen X

The Journal of clinical endocrinology and metabolism.. 2023 May 17108 (6):e283-e294. Epub 1900 01 01.

Evidence of Bisphosphonate-Conjugated Sitafloxacin Eradication of Established Methicillin-Resistant S. aureus Infection with Osseointegration in Murine Models of Implant-Associated Osteomyelitis.

Xie C, Ren Y, Weeks J, Xue T, Rainbolt J, Bentley KM, Shu Y, Liu Y, Masters E, Cherian P, McKenna C, Neighbors J, Ebetino F, Schwarz E, Sun S

Research square.. 2023 May 11 Epub 05/11/2023.

Relapsed boyhood tibia polymicrobial osteomyelitis linked to dermatophytosis: a case report.

Kong P, Ren Y, Yang J, Fu W, Liu Z, Li Z, He W, Wang Y, Zheng Z, Ding M, Schwarz EM, Deng Z, Xie C

BMC surgery.. 2022 May 422 (1):156. Epub 05/04/2022.

Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of Osteomyelitis: Evidence of "Target & Release" Kinetics and Killing of Bacteria Within Canaliculi.

Ren Y, Xue T, Rainbolt J, Bentley KLM, Galloway CA, Liu Y, Cherian P, Neighbors J, Hofstee MI, Ebetino FH, Moriarty TF, Sun S, Schwarz EM, Xie C

Frontiers in cellular and infection microbiology.. 2022 12 :910970. Epub 06/24/2022.

Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With Osteomyelitis and Their Association With Clinical Outcome Following Surgery in a Clinical Pilot.

Sherchand SP, Adhikari RP, Muthukrishnan G, Kanipakala T, Owen JR, Xie C, Aman MJ, Proctor RA, Schwarz EM, Kates SL

Frontiers in cellular and infection microbiology.. 2022 12 :876898. Epub 07/18/2022.

Bone infection: a clinical priority for clinicians, scientists and educators.

Moriarty TF, Muthukrishnan G, Daiss JL, Xie C, Nishitani K, Morita Y, Awad H, de Mesy Bentley KL, Masters E, Bui T, Yan M, Owen J, Mooney B, Gill S, Puetzler J, Wenke JC, Morgenstern M, Metsemakers WJ, Noll C, Joeris A, Richards RG, Schwarz EM, Kates SL

European cells & materials.. 2021 October 1842 :312-333. Epub 10/18/2021.

Serum antibodies against Staphylococcus aureus can prognose treatment success in patients with bone infections.

Muthukrishnan G, Beck CA, Owen JR, Xie C, Kates SL, Daiss JL

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2021 October 39 (10):2169-2176. Epub 12/25/2020.

IgG4-specific responses in patients with Staphylococcus aureus bone infections are not predictive of postoperative complications.

Owen JR, Campbell MP, Mott MD, Beck CA, Xie C, Muthukrishnan G, Daiss JL, Schwarz EM, Kates SL

European cells & materials.. 2021 September 2242 :156-165. Epub 09/22/2021.

Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid.

Adjei-Sowah E, Peng Y, Weeks J, Jonason JH, de Mesy Bentley KL, Masters E, Morita Y, Muthukrishnan G, Cherian P, Hu XE, McKenna CE, Ebetino FH, Sun S, Schwarz EM, Xie C

Antibiotics.. 2021 June 1710 (6)Epub 06/17/2021.

Distinct expression trend of signature antigens of Staphylococcus aureus osteomyelitis correlated with clinical outcomes.

Fu W, He W, Ren Y, Li Z, Liu J, Liu Y, Xie Z, Xu J, Bi Q, Kong M, Lee CC, Daiss JL, Muthukrishnan G, Owen JR, Kates SL, Peng J, Xie C

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2021 February 39 (2):265-273. Epub 12/29/2020.

Lack of Humoral Immunity Against Glucosaminidase Is Associated with Postoperative Complications in Staphylococcus aureus Osteomyelitis.

Kates SL, Owen JR, Beck CA, Xie C, Muthukrishnan G, Daiss JL, Schwarz EM

The Journal of bone and joint surgery. American volume.. 2020 November 4102 (21):1842-1848. Epub 1900 01 01.

IsdB antibody-mediated sepsis following S. aureus surgical site infection.

Nishitani K, Ishikawa M, Morita Y, Yokogawa N, Xie C, de Mesy Bentley KL, Ito H, Kates SL, Daiss JL, Schwarz EM

JCI insight.. 2020 October 25 (19)Epub 10/02/2020.

Deriving a dose and regimen for anti-glucosaminidase antibody passive-immunisation for patients with Staphylococcus aureus osteomyelitis.

Lee CC, Southgate RD, Jiao C, Gersz E, Owen JR, Kates SL, Beck CA, Xie C, Daiss JL, Post V, Moriarty TF, Zeiter S, Schwarz EM, Muthukrishnan G

European cells & materials.. 2020 January 3139 :96-107. Epub 01/31/2020.

Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy".

Masters EA, Trombetta RP, de Mesy Bentley KL, Boyce BF, Gill AL, Gill SR, Nishitani K, Ishikawa M, Morita Y, Ito H, Bello-Irizarry SN, Ninomiya M, Brodell JD, Lee CC, Hao SP, Oh I, Xie C, Awad HA, Daiss JL, Owen JR, Kates SL, Schwarz EM, Muthukrishnan G

Bone research.. 2019 7 :20. Epub 07/15/2019.

Immunotherapy synergizes with debridement and antibiotic therapy in a murine 1-stage exchange model of MRSA implant-associated osteomyelitis.

Yokogawa N, Ishikawa M, Nishitani K, Beck CA, Tsuchiya H, Mesfin A, Kates SL, Daiss JL, Xie C, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2018 June 36 (6):1590-1598. Epub 02/05/2018.

Teriparatide (human PTH) compensates for impaired fracture healing in COX-2 deficient mice.

Yukata K, Xie C, Li TF, Brown ML, Kanchiku T, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ

Bone.. 2018 May 110 :150-159. Epub 02/03/2018.

Osteoblast-osteoclast interactions.

Chen X, Wang Z, Duan N, Zhu G, Schwarz EM, Xie C

Connective tissue research.. 2018 March 59 (2):99-107. Epub 03/21/2017.

Surface topography of silicon nitride affects antimicrobial and osseointegrative properties of tibial implants in a murine model.

Ishikawa M, de Mesy Bentley KL, McEntire BJ, Bal BS, Schwarz EM, Xie C

Journal of biomedical materials research. Part A.. 2017 December 105 (12):3413-3421. Epub 09/26/2017.

Notch activation enhances mesenchymal stem cell sheet osteogenic potential by inhibition of cellular senescence.

Tian Y, Xu Y, Xue T, Chen L, Shi B, Shu B, Xie C, Max Morandi M, Jaeblon T, Marymont JV, Dong Y

Cell death & disease.. 2017 February 28 (2):e2595. Epub 02/02/2017.

Clinical outcome of bone cement-augmented pedicle screw fixation for thoracolumbar refractures after percutaneous kyphoplasty.

WANG Yuanzheng, LI Bo, GUO Tao, PENG Zhi, DAI Tao, Edward M. Schwarz, XIE Chao.

Chinese Journal of Trauma. 2017; 33(11): 1005-1010.

Epidemiological, Clinical and Microbiological Characteristics of Patients with Post-Traumatic Osteomyelitis of Limb Fractures in Southwest China: A Hospital-Based Study.

Peng J, Ren Y, He W, Li Z, Yang J, Liu Y, Zheng Z, Kates SL, Schwarz EM, Xie C, Xu Y

Journal of bone and joint infection.. 2017 2 (3):149-153. Epub 05/04/2017.

Antioxidant impregnated ultra-high molecular weight polyethylene wear debris particles display increased bone remodeling and a superior osteogenic:osteolytic profile vs. conventional UHMWPE particles in a murine calvaria model.

Chen Y, Hallab NJ, Liao YS, Narayan V, Schwarz EM, Xie C

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2016 May 34 (5):845-51. Epub 11/23/2015.

Regional characteristics of postoperative bacterial infection and antibiotic resistance following traumatic limb fractures.

Ren YL, Peng JC, Li ZD, Liu XM, Yang J, Kates SL, Schwarz EM, Xie C.

Chin. J Orthop Trauma. 2016; 18(3): 226-232.

Application of 3D printing technology in the treatment of acetabular posterior wall fractures

Wang F, Wang GD, Xie C, Liu XM, Schwarz EM, Cai XH, Qi FY, Zhong YJ.

Chin. J Orthop Trauma. 2016; 18(2): 120-125.

Increased Insulin mRNA Binding Protein-3 Expression Correlates with Vascular Enhancement of Renal Cell Carcinoma by Intravenous Contrast-CT and is Associated with Bone Metastasis.

Xie C, Li Y, Li Q, Chen Y, Yao J, Yin G, Bi Q, O'Keefe RJ, Schwarz EM, Tyler W

Journal of bone oncology.. 2015 September 4 (3):69-76. Epub 09/12/2015.

Decreased BMP2 signal in GIT1 knockout mice slows bone healing.

Sheu TJ, Zhou W, Fan J, Zhou H, Zuscik MJ, Xie C, Yin G, Berk BC

Molecular and cellular biochemistry.. 2014 December 397 (1-2):67-74. Epub 08/20/2014.

Ischemic preconditioning enhances autophagy but suppresses autophagic cell death in rat spinal neurons following ischemia-reperfusion.

Fan J, Zhang Z, Chao X, Gu J, Cai W, Zhou W, Yin G, Li Q

Brain research.. 2014 May 81562 :76-86. Epub 03/25/2014.

Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.

Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ

Bone.. 2014 May 62 :79-89. Epub 02/12/2014.

The murine femoral bone graft model and a semiautomated histomorphometric analysis tool.

Dhillon RS, Zhang L, Schwarz EM, Boyce BF, Xie C

Methods in molecular biology.. 2014 1130 :45-59. Epub 1900 01 01.

Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice.

Yin G, Sheu TJ, Menon P, Pang J, Ho HC, Shi S, Xie C, Smolock E, Yan C, Zuscik MJ, Berk BC

PloS one.. 2014 9 (2):e89127. Epub 02/19/2014.

The effect of mesenchymal stem cells delivered via hydrogel-based tissue engineered periosteum on bone allograft healing.

Hoffman MD, Xie C, Zhang X, Benoit DS

Biomaterials.. 2013 November 34 (35):8887-98. Epub 08/16/2013.

Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice.

Ju Y, Li J, Xie C, Ritchlin CT, Xing L, Hilton MJ, Schwarz EM

Genesis : the journal of genetics and development.. 2013 September 51 (9):667-75. Epub 07/09/2013.

Anti-oxidation treatment of ultra high molecular weight polyethylene components to decrease periprosthetic osteolysis: evaluation of osteolytic and osteogenic properties of wear debris particles in a murine calvaria model.

Green JM, Hallab NJ, Liao YS, Narayan V, Schwarz EM, Xie C

Current rheumatology reports.. 2013 May 15 (5):325. Epub 1900 01 01.

PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis.

Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2013 March 28 (3):586-97. Epub 1900 01 01.

Dual differentiation-exogenous mesenchymal stem cell therapy for traumatic spinal cord injury repair in a murine hemisection model.

Liu H, Schwarz EM, Xie C

Stem cells international.. 2013 2013 :928982. Epub 08/20/2013.

Reinforcement of electrospun membranes using nanoscale Al2O3 whiskers for improved tissue scaffolds.

Dong Z, Wu Y, Wang Q, Xie C, Ren Y, Clark RL

Journal of biomedical materials research. Part A.. 2012 April 100 (4):903-10. Epub 01/24/2012.

Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression.

Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2012 February 30 (2):325-33. Epub 08/01/2011.

Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur.

Yazici C, Takahata M, Reynolds DG, Xie C, Samulski RJ, Samulski J, Beecham EJ, Gertzman AA, Spilker M, Zhang X, O'Keefe RJ, Awad HA, Schwarz EM

Molecular therapy : the journal of the American Society of Gene Therapy.. 2011 August 19 (8):1416-25. Epub 01/04/2011.

The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model.

Sampson ER, Martin BA, Morris AE, Xie C, Schwarz EM, O'Keefe RJ, Rosier RN

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2011 June 26 (6):1283-94. Epub 1900 01 01.

Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw.

Li D, Gromov K, Proulx ST, Xie C, Li J, Crane DP, Søballe K, O'Keefe RJ, Awad HA, Xing L, Schwarz EM

Annals of the New York Academy of Sciences.. 2010 March 1192 (1):84-94. Epub 1900 01 01.

PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis.

Tsutsumi R, Xie C, Wei X, Zhang X, Flick LM, Schwarz EM, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 October 24 (10):1753-62. Epub 1900 01 01.

Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4.

Xie C, Liang B, Xue M, Lin AS, Loiselle A, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X

The American journal of pathology.. 2009 August 175 (2):772-85. Epub 07/23/2009.

Reduced COX-2 expression in aged mice is associated with impaired fracture healing.

Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 February 24 (2):251-64. Epub 1900 01 01.

Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik M, Chen D

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 January 24 (1):12-21. Epub 1900 01 01.

COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing.

Xie C, Ming X, Wang Q, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X

Bone.. 2008 December 43 (6):1075-83. Epub 08/16/2008.

Antitumoral activity and osteogenic potential of mesenchymal stem cells expressing the urokinase-type plasminogen antagonist amino-terminal fragment in a murine model of osteolytic tumor.

Fritz V, Noël D, Bouquet C, Opolon P, Voide R, Apparailly F, Louis-Plence P, Bouffi C, Drissi H, Xie C, Perricaudet M, Müller R, Schwarz E, Jorgensen C

Stem cells.. 2008 November 26 (11):2981-90. Epub 08/28/2008.

The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings.

Yazici C, Yanoso L, Xie C, Reynolds DG, Samulski RJ, Samulski J, Yannariello-Brown J, Gertzman AA, Zhang X, Awad HA, Schwarz EM

Biomaterials.. 2008 October 29 (28):3882-7. Epub 06/30/2008.

Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation.

Xie C, Xue M, Wang Q, Schwarz EM, O'Keefe RJ, Zhang X

The Journal of bone and joint surgery. American volume.. 2008 February 90 Suppl 1 (Suppl 1):9-13. Epub 1900 01 01.

Conditional activation of the [beta]-catenin gene in articular chondrocytes in adult mice leads to osteoarthritis-like phenotype

Di Chen, Mei Zhu, Dezhi Tang, Qiuqian Wu, Mo Chen, Chao Xie, Randy Rosier, Regis OKeefe, Michael Zuscik.

Bone. 2008; 43: S27.

Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering.

Xie C, Reynolds D, Awad H, Rubery PT, Pelled G, Gazit D, Guldberg RE, Schwarz EM, O'Keefe RJ, Zhang X

Tissue engineering.. 2007 March 13 (3):435-45. Epub 1900 01 01.

Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase.

Chen M, Lichtler AC, Sheu TJ, Xie C, Zhang X, O'Keefe RJ, Chen D

Genesis : the journal of genetics and development.. 2007 January 45 (1):44-50. Epub 1900 01 01.

Alteration of femoral bone morphology and density in COX-2-/- mice.

Robertson G, Xie C, Chen D, Awad H, Schwarz EM, O'Keefe RJ, Guldberg RE, Zhang X

Bone.. 2006 October 39 (4):767-72. Epub 05/30/2006.

COX-2 has a critical role during incorporation of structural bone allografts.

O'Keefe RJ, Tiyapatanaputi P, Xie C, Li TF, Clark C, Zuscik MJ, Chen D, Drissi H, Schwarz E, Zhang X

Annals of the New York Academy of Sciences.. 2006 April 1068 :532-42. Epub 1900 01 01.

Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering.

Zhang X, Xie C, Lin AS, Ito H, Awad H, Lieberman JR, Rubery PT, Schwarz EM, O'Keefe RJ, Guldberg RE

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 December 20 (12):2124-37. Epub 08/08/2005.

Periosteal stem cells are essential for bone revitalization and repair.

Zhang X, Naik A, Xie C, Reynolds D, Palmer J, Lin A, Awad H, Guldberg R, Schwarz E, O'Keefe R

Journal of musculoskeletal & neuronal interactions.. 2005 5 (4):360-2. Epub 1900 01 01.

Functional integration of tissue-engineered bone constructs.

Guldberg RE, Oest M, Lin AS, Ito H, Chao X, Gromov K, Goater JJ, Koefoed M, Schwarz EM, O'Keefe RJ, Zhang X

Journal of musculoskeletal & neuronal interactions.. 2004 December 4 (4):399-400. Epub 1900 01 01.

Subfertility and defective folliculogenesis in female mice lacking androgen receptor.

Hu YC, Wang PH, Yeh S, Wang RS, Xie C, Xu Q, Zhou X, Chao HT, Tsai MY, Chang C

Proceedings of the National Academy of Sciences of the United States of America.. 2004 August 3101 (31):11209-14. Epub 07/26/2004.

Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor.

Yeh S, Hu YC, Wang PH, Xie C, Xu Q, Tsai MY, Dong Z, Wang RS, Lee TH, Chang C

The Journal of experimental medicine.. 2003 December 15198 (12):1899-908. Epub 1900 01 01.

Evaluation of image in double primary bladder and colon cancer

Xie, Chao; Ma,Tianxing; Su, Ping.

Radiology Practice. 2002; 17: 91.

Evaluation of CT scanning in preoperative staging and postoperative follow-up of primary bladder cancer.

Xie, Chao; Su, Ping; Ma, Tianxing; Huang, Ming; Zhang, Zhiping; Gao, Depei.

Journal of Clinical Radiology. 2001; 20: 524-526.

Carcinosarcoma of urinary bladder

Xie, Chao; Huang, Ming; Ma, Tianxing.

Chinese Journal of Radiology. 2000; 34: 502-503.

Evaluation of HRCT scanning in invasion of bronchogenic carcinoma to adjacent tissue

Xie, Chao; Su, Ping.

Medicine and Pharmacy of Yunan. 1999; 20: 76.

Double hypotensive barium meal examination of superior digestive tract: detection and significance of micro-construction

Xie, Chao; Li, Tieyi.

Journal of Practice Radiology. 1998; 14: 109-110.

Radiological diagnosis of mini-type nodes tuberculosis of mediastinum pot-pulmonary lymph nodes

Xie, Chao; Zhang, Dachun; Wu Jie; Yang, Dezhi; Liu, Houben; Li, Zhiheng.

Guizhou Medical Journal. 1997; 21: 87-88.

Left intrahepatic ductal-gastric fistulae (one case report).

Xie, Chao; Zhang, Dachun.

Chinese Journal of Radiology. 1996; 30: 399.