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Javier Rangel-Moreno, Ph.D.

Javier Rangel-Moreno, Ph.D.

Research Lab

Immune Cells and Disease

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About Me

Professional Background

1996 Bachelor Degree in Chemistry, Bacteriology and Parasitology. National School of Biological Sciences. National Polytechnic Institute. Mexico, DF. Mexico.

2002 Ph. D in Immunology. National School of Biological Sciences. National Polytechnic Institute. Mexico, DF. Mexico.

Faculty Appointments

Research Associate Professor - Department of Medicine, Allergy/Immunology and Rheumatology (SMD)

Credentials

Post-doctoral Training & Residency

Postdoctoral Research Associate with Dr. Troy D. Randall
Department of Medicine
Division of Allergy, Immunology and Rheumatology. University of Rochester. Rochester 2009 - 2010

Research Scientist with Dr. Troy D. Randall
Trudeau Institute
Saranac Lake, NY 2007 - 2009

Postdoctoral fellow with Dr. Troy D. Randall
Trudeau Institute
Saranac Lake, NY 2002 - 2007

Chemist A with Dr. Erasmo Martinez-Cordero
National Institute of Respiratory Diseases

Predoctoral fellow with Dr. Rogelio Hernandez-Pando
National Institute of Medical Sciences and Nutrition
"Salvador Zubiran"
Mexico, DF. Mexico 1996 - 2002

Predoctoral fellow with Dr. Oscar Rojas-Espinosa
National School of Biological Sciences
National Polytechnic Institute
Mexico, DF. Mexico 1994 - 1996

Education

PhD | Mexico-Natl Polytechnic Inst, DF. Immunology. 2002

BS | Mexico-Natl Polytechnic Inst, DF. Chemistry. 1996

Research

Publications

Journal Articles

Sodium-Glucose Cotransporter-2 Inhibitor, Empagliflozin, Suppresses the Inflammatory Immune Response to Influenza Infection.

Constantinesco NJ, Chinnappan B, DeVito LJ, Moras C, Srikanth S, Garcia-Hernandez ML, Rangel-Moreno J, Gopal R

ImmunoHorizons.. 2023 December 17 (12):861-871. Epub 1900 01 01.

Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.

Kang JB, Shen AZ, Gurajala S, Nathan A, Rumker L, Aguiar VRC, Valencia C, Lagattuta KA, Zhang F, Jonsson AH, Yazar S, Alquicira-Hernandez J, Khalili H, Ananthakrishnan AN, Jagadeesh K, Dey K, , Daly MJ, Xavier RJ, Donlin LT, Anolik JH, Powell JE, Rao DA, Brenner MB, Gutierrez-Arcelus M, Luo Y, Sakaue S, Raychaudhuri S

Nature genetics.. 2023 November 30 Epub 11/30/2023.

Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.

Zhang F, Jonsson AH, Nathan A, Millard N, Curtis M, Xiao Q, Gutierrez-Arcelus M, Apruzzese W, Watts GFM, Weisenfeld D, Nayar S, Rangel-Moreno J, Meednu N, Marks KE, Mantel I, Kang JB, Rumker L, Mears J, Slowikowski K, Weinand K, Orange DE, Geraldino-Pardilla L, Deane KD, Tabechian D, Ceponis A, Firestein GS, Maybury M, Sahbudin I, Ben-Artzi A, Mandelin AM, Nerviani A, Lewis MJ, Rivellese F, Pitzalis C, Hughes LB, Horowitz D, DiCarlo E, Gravallese EM, Boyce BF, , Moreland LW, Goodman SM, Perlman H, Holers VM, Liao KP, Filer A, Bykerk VP, Wei K, Rao DA, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S

Nature.. 2023 November 8 Epub 11/08/2023.

Associations between rheumatoid arthritis clinical factors with synovial cell types and states.

Weisenfeld D, Zhang F, Donlin L, Jonsson AH, Apruzzese W, Campbell D, , Rao DA, Wei K, Holers VM, Gravallese E, Moreland L, Goodman S, Brenner M, Raychaudhuri S, Filer A, Anolik J, Bykerk V, Liao KP

Arthritis & rheumatology.. 2023 October 4 Epub 10/04/2023.

Poly(ADP)ribose polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production.

Thirunavukkarasu S, Ahmed M, Rosa BA, Boothby M, Cho SH, Rangel-Moreno J, Mbandi SK, Schreiber V, Gupta A, Zúñiga J, Mitreva M, Kaushal D, Scriba TJ, Khader SA

The Journal of clinical investigation.. 2023 May 18 Epub 05/18/2023.

Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control.

Swanson RV, Gupta A, Foreman TW, Lu L, Choreno-Parra JA, Mbandi SK, Rosa BA, Akter S, Das S, Ahmed M, Garcia-Hernandez ML, Singh DK, Esaulova E, Artyomov MN, Gommerman J, Mehra S, Zuniga J, Mitreva M, Scriba TJ, Rangel-Moreno J, Kaushal D, Khader SA

Nature immunology.. 2023 April 3 Epub 04/03/2023.

Reduced Angiogenesis and Delayed Endochondral Ossification in CD163-/- Mice Highlights a Role of M2 Macrophages During Bone Fracture Repair.

Ren Y, Zhang S, Weeks J, Rangel-Moreno J, He B, Xue T, Rainbolt J, Morita Y, Shu Y, Liu Y, Kates SL, Schwarz EM, Xie C

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 March 27 Epub 03/27/2023.

Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.

Kenney HM, Rangel-Moreno J, Peng Y, Chen KL, Bruno J, Embong A, Pritchett E, Fox JI, Becerril-Villanueva E, Gamboa-Domínguez A, Quataert S, Muthukrishnan G, Wood RW, Korman BD, Anolik JH, Xing L, Ritchlin CT, Schwarz EM, Wu CL

Frontiers in immunology.. 2023 14 :1237498. Epub 08/25/2023.

Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation.

Morita Y, Saito M, Rangel-Moreno J, Franchini AM, Owen JR, Martinez JC, Daiss JL, de Mesy Bentley KL, Kates SL, Schwarz EM, Muthukrishnan G

Bone research.. 2022 August 2610 (1):56. Epub 08/26/2022.

CWHM-12, an Antagonist of Integrin-Mediated Transforming Growth Factor-Beta Activation Confers Protection During Early Infection in Mice.

Scott NR, Thirunavukkarasu S, Rangel-Moreno J, Griggs DW, Khader SA

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.. 2022 August 1 Epub 08/01/2022.

Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression.

Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S, Donlin LT, Raychauduri S, Bombardieri M, Pitzalis C, Orange DE, , McDavid A, Anolik JH

Cell reports.. 2022 May 339 (5):110766. Epub 1900 01 01.

Small molecule inhibitors of nuclear export ameliorate lupus by modulating plasma cell generation and survival.

Rangel-Moreno J, Garcia-Hernandez ML, Owen T, Barnard J, Becerril-Villanueva E, Kashyap T, Argueta C, Gamboa-Dominguez A, Tamir S, Landesman Y, Goldman BI, Ritchlin CT, Anolik JH

Arthritis & rheumatology.. 2022 March 25 Epub 03/25/2022.

High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership.

Carlucci PM, Li J, Fava A, Deonaraine KK, Wofsy D, James JA, Putterman C, Diamond B, Davidson A, Fine DM, Monroy-Trujillo J, Atta MG, DeJager W, Guthridge JM, Haag K, Rao DA, Brenner MB, Lederer JA, Apruzzese W, Belmont HM, Izmirly PM, Zaminski D, Wu M, Connery S, Payan-Schober F, Furie R, Dall'Era M, Cho K, Kamen D, Kalunian K, Anolik J, Barnas J, Ishimori M, Weisman MH, , Buyon JP, Petri M

Rheumatology.. 2022 February 25 Epub 02/25/2022.

Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis.

Garcia-Hernandez ML, Rangel-Moreno J, Garcia-Castaneda M, Kenney HM, Paine A, Thullen M, Anandarajah AP, Schwarz EM, Dirksen RT, Ritchlin CT

Frontiers in immunology.. 2022 13 :1026574. Epub 11/07/2022.

Bi-Reporter Vaccinia Virus for Tracking Viral Infections and .

Chiem K, Lorenzo MM, Rangel-Moreno J, Garcia-Hernandez ML, Park JG, Nogales A, Blasco R, Martínez-Sobrido L

Microbiology spectrum.. 2021 November 24 :e0160121. Epub 11/24/2021.

Vaccine-driven lung TRM cells provide immunity against via fibroblast IL-17R signaling.

Iwanaga N, Chen K, Yang H, Lu S, Hoffmann JP, Wanek A, McCombs JE, Song K, Rangel-Moreno J, Norton EB, Kolls JK

Science immunology.. 2021 September 106 (63):eabf1198. Epub 09/10/2021.

Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network.

Deonaraine KK, Carlucci PM, Fava A, Li J, Wofsy D, James JA, Putterman C, Diamond B, Davidson A, Fine DM, Monroy-Trujillo J, Atta MG, Haag K, Rao DA, Apruzzese W, Belmont HM, Izmirly PM, Wu M, Connery S, Payan-Schober F, Furie RA, Berthier CC, Dall'Era M, Cho K, Kamen DL, Kalunian K, Anolik J, Ishimori M, Weisman MH, , Petri MA, Buyon JP

Lupus science & medicine.. 2021 August 8 (1)Epub 1900 01 01.

Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4 T Cell Activation and Control.

Das S, Marin ND, Esaulova E, Ahmed M, Swain A, Rosa BA, Mitreva M, Rangel-Moreno J, Netea MG, Barreiro LB, Divangahi M, Artyomov MN, Kaushal D, Khader SA

mBio.. 2021 July 13 :e0146821. Epub 07/13/2021.

IFN-? and TNF-? drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation.

Zhang F, Mears JR, Shakib L, Beynor JI, Shanaj S, Korsunsky I, Nathan A, , Donlin LT, Raychaudhuri S

Genome medicine.. 2021 April 2013 (1):64. Epub 04/20/2021.

Intramuscular boosting with hIFN-alpha 2b enhances BCGPhipps-induced protection in a murine model of leprosy

Guerrero, GG; Rangel-Moreno, J; Islas-Trujillo OS; Rojas-Espinosa, O.

Microbiology Research. 2021; 12(3): 711-726.

Humanized Mice Exhibit Exacerbated Abscess Formation and Osteolysis During the Establishment of Implant-Associated Osteomyelitis.

Muthukrishnan G, Wallimann A, Rangel-Moreno J, Bentley KLM, Hildebrand M, Mys K, Kenney HM, Sumrall ET, Daiss JL, Zeiter S, Richards RG, Schwarz EM, Moriarty TF

Frontiers in immunology.. 2021 12 :651515. Epub 03/18/2021.

CD4+ T Cells Are Dispensable for Induction of Broad Heterologous HIV Neutralizing Antibodies in Rhesus Macaques.

Sarkar S, Spencer DA, Barnette P, Pandey S, Sutton WF, Basu M, Burch RE, Cleveland JD, Rosenberg AF, Rangel-Moreno J, Keefer MC, Hessell AJ, Haigwood NL, Kobie JJ

Frontiers in immunology.. 2021 12 :757811. Epub 10/20/2021.

The immune landscape in tuberculosis reveals populations linked to disease and latency.

Esaulova E, Das S, Singh DK, Choreño-Parra JA, Swain A, Arthur L, Rangel-Moreno J, Ahmed M, Singh B, Gupta A, Fernández-López LA, de la Luz Garcia-Hernandez M, Bucsan A, Moodley C, Mehra S, García-Latorre E, Zuniga J, Atkinson J, Kaushal D, Artyomov MN, Khader SA

Cell host & microbe.. 2020 December 16 Epub 12/16/2020.

Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis.

Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S

Journal of the American Society of Nephrology : JASN.. 2020 November 4 Epub 11/04/2020.

evades pulmonary immunity by modulating xylose precursor transport.

Li LX, Hole CR, Rangel-Moreno J, Khader SA, Doering TL

Infection and immunity.. 2020 May 18 Epub 05/18/2020.

Notch signalling drives synovial fibroblast identity and arthritis pathology.

Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J, Blazar PE, Lange JK, Thornhill TS, Filer A, Raza K, Donlin LT, Siebel CW, Buckley CD, Raychaudhuri S, Brenner MB

Nature.. 2020 April 22 Epub 04/22/2020.

S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis.

Scott NR, Swanson RV, Al-Hammadi N, Domingo-Gonzalez R, Rangel-Moreno J, Kriel BA, Bucsan AN, Das S, Ahmed M, Mehra S, Treerat P, Cruz-Lagunas A, Jimenez-Alvarez L, Muñoz-Torrico M, Bobadilla-Lozoya K, Vogl T, Walzl G, du Plessis N, Kaushal D, Scriba T, Zuñiga J, Khader S

The Journal of clinical investigation.. 2020 March 5 Epub 03/05/2020.

Neutrophil elastase from myeloid cells promotes TSC2-null tumor growth.

Hammes SR, Gibbons E, Minor B, Rangel-Moreno J, Garcia-Hernandez M, Taya M

Endocrine-related cancer.. 2020 February 1 Epub 02/01/2020.

Immune correlates of tuberculosis disease and risk translate across species.

Khader SA, Rosa BA, Thomas KA, Das S, Rangel-Moreno J, Lu L, Mehra S, Mbandi SK, Thackray LB, Diamond MS, Murphy KM, Means T, Martin J, Kaushal D, Scriba TJ, Mitreva M, Thirunavukkarasu S, Ahmed M

Science translational medicine.. 2020 January 2912 (528)Epub 1900 01 01.

Formation of Lung Inducible Bronchus Associated Lymphoid Tissue Is Regulated by Expressed Determinants.

Dunlap MD, Prince OA, Rangel-Moreno J, Thomas KA, Scordo JM, Torrelles JB, Cox J, Steyn AJC, Zúñiga J, Kaushal D, Khader SA

Frontiers in immunology.. 2020 11 :1325. Epub 06/30/2020.

Inducible Bronchus-Associated Lymphoid Tissue (iBALT) Attenuates Pulmonary Pathology in a Mouse Model of Allergic Airway Disease.

Hwang JY, Silva-Sanchez A, Carragher DM, Garcia-Hernandez ML, Rangel-Moreno J, Randall TD

Frontiers in immunology.. 2020 11 :570661. Epub 09/25/2020.

Mycobacterium tuberculosis HN878 infection induces human-like B cell follicles in mice.

Alberto Choreño-Parra, Bobba S, Rangel-Moreno J, Ahmed M, Mehra S, Rosa B, Martin J, Mitreva M, Kaushal D, Zúñiga J, Khader SA

The Journal of infectious diseases.. 2019 December 13 Epub 12/13/2019.

A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection.

Chiem K, Rangel-Moreno J, Nogales A, Martinez-Sobrido L

Journal of visualized experiments : JoVE.. 2019 August 14 (150)Epub 08/14/2019.

Publisher Correction: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.

Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la, Ulland TK, Darby M, Park E, Karim F, Melocchi L, Madansein R, Dullabh KJ, Dunlap M, Marin-Agudelo N, Ebihara T, Ndung'u T, Kaushal D, Pym AS, Kolls JK, Steyn A, Zúñiga J, Horsnell W, Yokoyama WM, Shalek AK, Kløverpris HN, Colonna M, Leslie A, Khader SA

Nature.. 2019 July 24 Epub 07/24/2019.

Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.

Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la, K Ulland, Darby M, Park E, Karim F, Melocchi L, Madansein R, Dullabh KJ, Dunlap M, Marin-Agudelo N, Ebihara T, Ndung'u T, Kaushal D, Pym AS, Kolls JK, Steyn A, Zúñiga J, Horsnell W, Yokoyama WM, Shalek AK, Kløverpris HN, Colonna M, Leslie A, Khader SA

Nature.. 2019 June 5 Epub 06/05/2019.

Protective role of B cells in sterile particulate-induced lung injury.

Atif SM, Mack DG, McKee AS, Rangel-Moreno J, Martin AK, Getahun A, Maier LA, Cambier JC, Tuder R, Fontenot AP

JCI insight.. 2019 May 165 Epub 05/16/2019.

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.

Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, Apruzzese W, Eisenhaure TM, Lieb DJ, Boyle DL, Mandelin AM, Boyce BF, DiCarlo E, Gravallese EM, Gregersen PK, Moreland L, Firestein GS, Hacohen N, Nusbaum C, Lederer JA, Perlman H, Pitzalis C, Filer A, Holers VM, Bykerk VP, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S

Nature immunology.. 2019 May 6 Epub 05/06/2019.

Selective sexual dimorphism in musculoskeletal-cardiopulmonary pathologies and mortality in the TNF-transgenic mouse model of rheumatoid arthritis.

Bell DR, Wu E, Rudmann C, Forney M, Kaiser C, Wood R, Chakkalakal J, Paris N, Klose A, Xiao GQ, Rangel-Moreno J, Garcia-Hernandez M, Ritchlin C, Schwarz E, Rahimi H

Arthritis & rheumatology.. 2019 April 10 Epub 04/10/2019.

A novel fluorescent and bioluminescent Bi-Reporter influenza A virus (BIRFLU) to evaluate viral infections.

Nogales A, Ávila-Pérez G, Rangel-Moreno J, Chiem K, DeDiego ML, Martínez-Sobrido L

Journal of virology.. 2019 March 13 Epub 03/13/2019.

Epigenetic Suppression of SERPINB1 Promotes Inflammation-Mediated Prostate Cancer Progression.

Lerman I, Ma X, Seger C, Maolake A, Garcia-Hernandez ML, Rangel-Moreno J, Ackerman J, Nastiuk KL, Susiarjo M, Hammes SR

Molecular cancer research : MCR.. 2019 January 4 Epub 01/04/2019.

B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation.

Sun W, Meednu N, Rosenberg A, Rangel-Moreno J, Wang V, Glanzman J, Owen T, Zhou X, Zhang H, Boyce BF, Anolik JH, Xing L

Nature communications.. 2018 December 39 (1):5127. Epub 12/03/2018.

Publisher Correction: Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.

Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA

Nature microbiology.. 2018 November 3 (11):1327. Epub 1900 01 01.

Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.

Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA

Nature microbiology.. 2018 October 3 (10):1099-1108. Epub 09/17/2018.

Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema.

Sundar IK, Rashid K, Gerloff J, Rangel-Moreno J, Li D, Rahman I

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2018 September 32 (9):4955-4971. Epub 04/09/2018.

A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis.

Dunlap MD, Howard N, Das S, Scott N, Ahmed M, Prince O, Rangel-Moreno J, Rosa BA, Martin J, Kaushal D, Kaplan G, Mitreva M, Kim KW, Randolph GJ, Khader SA

Mucosal immunology.. 2018 August 16 Epub 08/16/2018.

Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue.

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A, , Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH

Arthritis research & therapy.. 2018 July 1120 (1):139. Epub 07/11/2018.

STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection.

Gopal R, Lee B, McHugh KJ, Rich HE, Ramanan K, Mandalapu S, Clay ME, Seger PJ, Enelow RI, Manni ML, Robinson KM, Rangel-Moreno J, Alcorn JF

Frontiers in immunology.. 2018 9 :2151. Epub 09/25/2018.

Interleukin-17 limits hypoxia-inducible factor 1? and development of hypoxic granulomas during tuberculosis.

Domingo-Gonzalez R, Das S, Griffiths KL, Ahmed M, Bambouskova M, Gopal R, Gondi S, Muñoz-Torrico M, Salazar-Lezama MA, Cruz-Lagunas A, Jiménez-Álvarez L, Ramirez-Martinez G, Espinosa-Soto R, Sultana T, Lyons-Weiler J, Reinhart TA, Arcos J, de la Luz Garcia-Hernandez M, Mastrangelo MA, Al-Hammadi N, Townsend R, Balada-Llasat JM, Torrelles JB, Kaplan G, Horne W, Kolls JK, Artyomov MN, Rangel-Moreno J, Zúñiga J, Khader SA

JCI insight.. 2017 October 52 (19)Epub 10/05/2017.

A novel nanoemulsion vaccine induces mucosal Interleukin-17 responses and confers protection upon Mycobacterium tuberculosis challenge in mice.

Ahmed M, Smith DM, Hamouda T, Rangel-Moreno J, Fattom A, Khader SA

Vaccine.. 2017 September 535 (37):4983-4989. Epub 07/31/2017.

Infiltrating Myeloid Cells Exert Protumorigenic Actions via Neutrophil Elastase.

Lerman I, Garcia-Hernandez ML, Rangel-Moreno J, Chiriboga L, Pan C, Nastiuk KL, Krolewski JJ, Sen A, Hammes SR

Molecular cancer research : MCR.. 2017 September 15 (9):1138-1152. Epub 05/16/2017.

Neutrophils Slow Disease Progression in Murine Lupus via Modulation of Autoreactive Germinal Centers.

Bird AK, Chang M, Barnard J, Goldman BI, Meednu N, Rangel-Moreno J, Anolik JH

The Journal of immunology : official journal of the American Association of Immunologists.. 2017 July 15199 (2):458-466. Epub 06/05/2017.

Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection.

Treerat P, Prince O, Cruz-Lagunas A, Muñoz-Torrico M, Salazar-Lezama MA, Selman M, Fallert-Junecko B, Reinhardt TA, Alcorn JF, Kaushal D, Zuñiga J, Rangel-Moreno J, Kolls JK, Khader SA

Mucosal immunology.. 2017 July 10 (4):1069-1081. Epub 03/01/2017.

Rationalized design of a mucosal vaccine protects against challenge in mice.

Ahmed M, Jiao H, Domingo-Gonzalez R, Das S, Griffiths KL, Rangel-Moreno J, Nagarajan UM, Khader SA

Journal of leukocyte biology.. 2017 June 101 (6):1373-1381. Epub 03/03/2017.

Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.

Eddens T, Elsegeiny W, Garcia-Hernadez ML, Castillo P, Trevejo-Nunez G, Serody K, Campfield BT, Khader SA, Chen K, Rangel-Moreno J, Kolls JK

Cell reports.. 2017 March 2818 (13):3078-3090. Epub 1900 01 01.

HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population.

Aguilar-Medina M, Escamilla-Tilch M, Frías-Castro LO, Romero-Quintana G, Estrada-García I, Estrada-Parra S, Granados J, Arambula Meraz E, Sánchez-Schmitz G, Khader SA, Rangel-Moreno J, Ramos-Payán R

Annals of human genetics.. 2017 January 81 (1):35-40. Epub 12/27/2016.

A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression.

García-Hernández ML, Uribe-Uribe NO, Espinosa-González R, Kast WM, Khader SA, Rangel-Moreno J

Frontiers in immunology.. 2017 8 :563. Epub 05/17/2017.

Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy.

Griffiths KL, Ahmed M, Das S, Gopal R, Horne W, Connell TD, Moynihan KD, Kolls JK, Irvine DJ, Artyomov MN, Rangel-Moreno J, Khader SA

Nature communications.. 2016 December 227 :13894. Epub 12/22/2016.

Inhibition of G Protein ?? Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice.

Rangel-Moreno J, To JY, Owen T, Goldman BI, Smrcka AV, Anolik JH

Arthritis & rheumatology.. 2016 September 68 (9):2244-56. Epub 1900 01 01.

Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation.

Solleti SK, Srisuma S, Bhattacharya S, Rangel-Moreno J, Bijli KM, Randall TD, Rahman A, Mariani TJ

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2016 July 30 (7):2615-26. Epub 04/08/2016.

Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis.

Meednu N, Zhang H, Owen T, Sun W, Wang V, Cistrone C, Rangel-Moreno J, Xing L, Med B, Anolik JH

Arthritis & rheumatology.. 2016 April 68 (4):805-16. Epub 1900 01 01.

Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis.

Monin L, Griffiths KL, Lam WY, Gopal R, Kang DD, Ahmed M, Rajamanickam A, Cruz-Lagunas A, Zúñiga J, Babu S, Kolls JK, Mitreva M, Rosa BA, Ramos-Payan R, Morrison TE, Murray PJ, Rangel-Moreno J, Pearce EJ, Khader SA

The Journal of clinical investigation.. 2015 December 125 (12):4699-713. Epub 11/16/2015.

Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis.

Kaushal D, Foreman TW, Gautam US, Alvarez X, Adekambi T, Rangel-Moreno J, Golden NA, Johnson AM, Phillips BL, Ahsan MH, Russell-Lodrigue KE, Doyle LA, Roy CJ, Didier PJ, Blanchard JL, Rengarajan J, Lackner AA, Khader SA, Mehra S

Nature communications.. 2015 October 136 :8533. Epub 10/13/2015.

Long-Lasting Impact of Neonatal Exposure to Total Body Gamma Radiation on Secondary Lymphoid Organ Structure and Function.

Rangel-Moreno J, de la Luz Garcia-Hernandez M, Ramos-Payan R, Biear J, Hernady E, Sangster MY, Randall TD, Johnston CJ, Finkelstein JN, Williams JP

Radiation research.. 2015 October 184 (4):352-66. Epub 09/23/2015.

IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs.

Barone F, Nayar S, Campos J, Cloake T, Withers DR, Toellner KM, Zhang Y, Fouser L, Fisher B, Bowman S, Rangel-Moreno J, Garcia-Hernandez ML, Randall TD, Lucchesi D, Bombardieri M, Pitzalis C, Luther SA, Buckley CD

Proceedings of the National Academy of Sciences of the United States of America.. 2015 September 1112 (35):11024-9. Epub 08/18/2015.

Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge.

Monin L, Griffiths KL, Slight S, Lin Y, Rangel-Moreno J, Khader SA

Mucosal immunology.. 2015 September 8 (5):1099-109. Epub 01/28/2015.

Successive Intramuscular Boosting with IFN-Alpha Protects Mycobacterium bovis BCG-Vaccinated Mice against M. lepraemurium Infection.

Guerrero GG, Rangel-Moreno J, Islas-Trujillo S, Rojas-Espinosa Ó

BioMed research international.. 2015 2015 :414027. Epub 09/21/2015.

Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection.

Gopal R, Monin L, Slight S, Uche U, Blanchard E, A Fallert Junecko B, Ramos-Payan R, Stallings CL, Reinhart TA, Kolls JK, Kaushal D, Nagarajan U, Rangel-Moreno J, Khader SA

PLoS pathogens.. 2014 May 10 (5):e1004099. Epub 05/15/2014.

Long-term B cell depletion in murine lupus eliminates autoantibody-secreting cells and is associated with alterations in the kidney plasma cell niche.

Wang W, Rangel-Moreno J, Owen T, Barnard J, Nevarez S, Ichikawa HT, Anolik JH

The Journal of immunology : official journal of the American Association of Immunologists.. 2014 April 1192 (7):3011-20. Epub 02/26/2014.

Neutrophil-mediated IFN activation in the bone marrow alters B cell development in human and murine systemic lupus erythematosus.

Palanichamy A, Bauer JW, Yalavarthi S, Meednu N, Barnard J, Owen T, Cistrone C, Bird A, Rabinovich A, Nevarez S, Knight JS, Dedrick R, Rosenberg A, Wei C, Rangel-Moreno J, Liesveld J, Sanz I, Baechler E, Kaplan MJ, Anolik JH

The Journal of immunology : official journal of the American Association of Immunologists.. 2014 February 1192 (3):906-18. Epub 12/30/2013.

Mucosal pre-exposure to Th17-inducing adjuvants exacerbates pathology after influenza infection.

Gopal R, Rangel-Moreno J, Fallert Junecko BA, Mallon DJ, Chen K, Pociask DA, Connell TD, Reinhart TA, Alcorn JF, Ross TM, Kolls JK, Khader SA

The American journal of pathology.. 2014 January 184 (1):55-63. Epub 11/01/2013.

S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis.

Gopal R, Monin L, Torres D, Slight S, Mehra S, McKenna K, Fallert Junecko BA, Reinhart TA, Kolls J, Báez-Saldaña R, Cruz-Lagunas A, Rodríguez-Reyna TS, Kumar NP, Tessier P, Roth J, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Cumming B, Kasprowicz VO, Steyn AJ, Babu S, Kaushal D, Zúñiga J, Vogl T, Rangel-Moreno J, Khader SA

American journal of respiratory and critical care medicine.. 2013 November 1188 (9):1137-46. Epub 1900 01 01.

Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis.

Perez-Nazario N, Rangel-Moreno J, O'Reilly MA, Pasparakis M, Gigliotti F, Wright TW

The Journal of immunology : official journal of the American Association of Immunologists.. 2013 November 1191 (9):4720-30. Epub 09/27/2013.

IL-10 restrains IL-17 to limit lung pathology characteristics following pulmonary infection with Francisella tularensis live vaccine strain.

Slight SR, Monin L, Gopal R, Avery L, Davis M, Cleveland H, Oury TD, Rangel-Moreno J, Khader SA

The American journal of pathology.. 2013 November 183 (5):1397-1404. Epub 09/03/2013.

Interleukin-17-dependent CXCL13 mediates mucosal vaccine-induced immunity against tuberculosis.

Gopal R, Rangel-Moreno J, Slight S, Lin Y, Nawar HF, Fallert Junecko BA, Reinhart TA, Kolls J, Randall TD, Connell TD, Khader SA

Mucosal immunology.. 2013 September 6 (5):972-84. Epub 01/09/2013.

Pulmonary expression of oncostatin M (OSM) promotes inducible BALT formation independently of IL-6, despite a role for IL-6 in OSM-driven pulmonary inflammation.

Botelho FM, Rangel-Moreno J, Fritz D, Randall TD, Xing Z, Richards CD

The Journal of immunology : official journal of the American Association of Immunologists.. 2013 August 1191 (3):1453-64. Epub 06/24/2013.

Neonatal irradiation sensitizes mice to delayed pulmonary challenge.

Johnston CJ, Manning CM, Rangel-Moreno J, Randall TD, Hernady E, Finkelstein JN, Williams JP

Radiation research.. 2013 April 179 (4):475-84. Epub 03/15/2012.

CXCR5? T helper cells mediate protective immunity against tuberculosis.

Slight SR, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko BA, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart TA, Randall TD, Khader SA

The Journal of clinical investigation.. 2013 February 123 (2):712-26. Epub 01/02/2013.

Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse.

Torrado E, Fountain JJ, Robinson RT, Martino CA, Pearl JE, Rangel-Moreno J, Tighe M, Dunn R, Cooper AM

PloS one.. 2013 8 (4):e61681. Epub 04/16/2013.

Lipocalin 2 regulates inflammation during pulmonary mycobacterial infections.

Guglani L, Gopal R, Rangel-Moreno J, Junecko BF, Lin Y, Berger T, Mak TW, Alcorn JF, Randall TD, Reinhart TA, Chan YR, Khader SA

PloS one.. 2012 7 (11):e50052. Epub 11/20/2012.

IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung.

Khader SA, Guglani L, Rangel-Moreno J, Gopal R, Fallert Junecko BA, Fountain JJ, Martino C, Pearl JE, Tighe M, Lin YY, Slight S, Kolls JK, Reinhart TA, Randall TD, Cooper AM

The Journal of immunology : official journal of the American Association of Immunologists.. 2011 November 15187 (10):5402-7. Epub 10/14/2011.

The development of inducible bronchus-associated lymphoid tissue depends on IL-17.

Rangel-Moreno J, Carragher DM, de la Luz Garcia-Hernandez M, Hwang JY, Kusser K, Hartson L, Kolls JK, Khader SA, Randall TD

Nature immunology.. 2011 June 1212 (7):639-46. Epub 06/12/2011.

Profiling early lung immune responses in the mouse model of tuberculosis.

Kang DD, Lin Y, Moreno JR, Randall TD, Khader SA

PloS one.. 2011 January 136 (1):e16161. Epub 01/13/2011.

Induction of BALT in the absence of IL17

Rangel-Moreno, J; Carragher, DM; de la Luz Garcia-Hernandez, M; Hwang, JY; Kusser, K; Hartson, L; Kolls, JK; Khader, SA and Randall, TD.

Nat Immunol. 2011; 13(1): 2.

Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis.

Cruz A, Fraga AG, Fountain JJ, Rangel-Moreno J, Torrado E, Saraiva M, Pereira DR, Randall TD, Pedrosa J, Cooper AM, Castro AG

The Journal of experimental medicine.. 2010 August 2207 (8):1609-16. Epub 07/12/2010.

Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b.

Zhang S, Rozell M, Verma RK, Albu DI, Califano D, VanValkenburgh J, Merchant A, Rangel-Moreno J, Randall TD, Jenkins NA, Copeland NG, Liu P, Avram D

The Journal of experimental medicine.. 2010 August 2207 (8):1687-99. Epub 07/26/2010.

Bronchus-associated lymphoid tissue (BALT) and survival in a vaccine mouse model of tularemia.

Chiavolini D, Rangel-Moreno J, Berg G, Christian K, Oliveira-Nascimento L, Weir S, Alroy J, Randall TD, Wetzler LM

PloS one.. 2010 June 165 (6):e11156. Epub 06/16/2010.

In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity.

Khader SA, Rangel-Moreno J, Fountain JJ, Martino CA, Reiley WW, Pearl JE, Winslow GM, Woodland DL, Randall TD, Cooper AM

The Journal of immunology : official journal of the American Association of Immunologists.. 2009 December 15183 (12):8004-14. Epub 1900 01 01.

Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis.

Lin Y, Ritchea S, Logar A, Slight S, Messmer M, Rangel-Moreno J, Guglani L, Alcorn JF, Strawbridge H, Park SM, Onishi R, Nyugen N, Walter MJ, Pociask D, Randall TD, Gaffen SL, Iwakura Y, Kolls JK, Khader SA

Immunity.. 2009 November 2031 (5):799-810. Epub 10/22/2009.

Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens.

Rangel-Moreno J, Moyron-Quiroz JE, Carragher DM, Kusser K, Hartson L, Moquin A, Randall TD

Immunity.. 2009 May 30 (5):731-43. Epub 05/07/2009.

Ectopic lymphoid tissues and local immunity.

Carragher DM, Rangel-Moreno J, Randall TD

Seminars in immunology.. 2008 February 20 (1):26-42. Epub 02/19/2008.

B cells promote resistance to heterosubtypic strains of influenza via multiple mechanisms.

Rangel-Moreno J, Carragher DM, Misra RS, Kusser K, Hartson L, Moquin A, Lund FE, Randall TD

The Journal of immunology : official journal of the American Association of Immunologists.. 2008 January 1180 (1):454-63. Epub 1900 01 01.

Development of secondary lymphoid organs.

Randall TD, Carragher DM, Rangel-Moreno J

Annual review of immunology.. 2008 26 :627-50. Epub 1900 01 01.

Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza.

Rangel-Moreno J, Moyron-Quiroz JE, Hartson L, Kusser K, Randall TD

Proceedings of the National Academy of Sciences of the United States of America.. 2007 June 19104 (25):10577-82. Epub 06/11/2007.

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.

Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, Locksley RM, Haynes L, Randall TD, Cooper AM

Nature immunology.. 2007 April 8 (4):369-77. Epub 03/11/2007.

The function of local lymphoid tissues in pulmonary immune responses.

Moyron-Quiroz J, Rangel-Moreno J, Carragher DM, Randall TD

Advances in experimental medicine and biology.. 2007 590 :55-68. Epub 1900 01 01.

Role of lymphotoxin and homeostatic chemokines in the development and function of local lymphoid tissues in the respiratory tract.

Rangel-Moreno J, Carragher D, Randall TD

Inmunología (Barcelona, Spain : 1987). 2007 26 (1):13-28. Epub 1900 01 01.

Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis.

Rangel-Moreno J, Hartson L, Navarro C, Gaxiola M, Selman M, Randall TD

The Journal of clinical investigation.. 2006 December 116 (12):3183-94. Epub 1900 01 01.

Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs.

Moyron-Quiroz JE, Rangel-Moreno J, Hartson L, Kusser K, Tighe MP, Klonowski KD, Lefrançois L, Cauley LS, Harmsen AG, Lund FE, Randall TD

Immunity.. 2006 October 25 (4):643-54. Epub 1900 01 01.

CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfection.

Lee BO, Rangel-Moreno J, Moyron-Quiroz JE, Hartson L, Makris M, Sprague F, Lund FE, Randall TD

The Journal of immunology : official journal of the American Association of Immunologists.. 2005 November 1175 (9):5827-38. Epub 1900 01 01.

Role of CXC chemokine ligand 13, CC chemokine ligand (CCL) 19, and CCL21 in the organization and function of nasal-associated lymphoid tissue.

Rangel-Moreno J, Moyron-Quiroz J, Kusser K, Hartson L, Nakano H, Randall TD

The Journal of immunology : official journal of the American Association of Immunologists.. 2005 October 15175 (8):4904-13. Epub 1900 01 01.

The complex role of lymphotoxin in immunity

Rangel-Moreno J; Moyron-Quiroz, JE; and Randall, TD.

Mod. Aspects Immunobiol. 2005; 15: 41-46.

Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity.

Moyron-Quiroz JE, Rangel-Moreno J, Kusser K, Hartson L, Sprague F, Goodrich S, Woodland DL, Lund FE, Randall TD

Nature medicine.. 2004 September 10 (9):927-34. Epub 08/15/2004.

Transfer factors as immunotherapy and supplement of chemotherapy in experimental pulmonary tuberculosis.

Fabre RA, Pérez TM, Aguilar LD, Rangel MJ, Estrada-Garcìa I, Hernández-Pando R, Estrada Parra S

Clinical and experimental immunology.. 2004 May 136 (2):215-23. Epub 1900 01 01.

CD40, but not CD154, expression on B cells is necessary for optimal primary B cell responses.

Lee BO, Moyron-Quiroz J, Rangel-Moreno J, Kusser KL, Hartson L, Sprague F, Lund FE, Randall TD

The Journal of immunology : official journal of the American Association of Immunologists.. 2003 December 1171 (11):5707-17. Epub 1900 01 01.

The role of prostaglandin E2 in the immunopathogenesis of experimental pulmonary tuberculosis.

Rangel Moreno J, Estrada García I, De La Luz García Hernández M, Aguilar Leon D, Marquez R, Hernández Pando R

Immunology.. 2002 June 106 (2):257-66. Epub 1900 01 01.

Interactions between hormone-mediated and vaccine-mediated immunotherapy for pulmonary tuberculosis in BALB/c mice.

Hernandez-Pando R, Pavon L, Orozco EH, Rangel J, Rook GA

Immunology.. 2000 July 100 (3):391-8. Epub 1900 01 01.

Secretion antigens of Mycobacterium tuberculosis: a comparison between a reference strain and seven wild isolates.

Rojas-Espinosa O, Rangel-Moreno J, Amador-Jiménez A, Parra-Maldonado R, Arce-Paredes P, Torres-López J

Archives of medical research.. 1999 30 (3):171-8. Epub 1900 01 01.

Books

Encyclopedia of Molecular Mechanisms of Disease (2009)

Chapter: Rheumatoid lung disease.

Authors: Rangel-Moreno, J and Randall, TD

Publisher: Springer 2009