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TB559CiNOSF48020xc.IF from lung from mice infected with Mycobacterium tuberculosis and stained with antibodies against iNOS(red) and F4/80 (green)

Rangel-Moreno Lab

Research Overview

Our lab is focused on understanding the complex interactions among immune cells that take place in target tissues. We have a particular interest on defining the distinctive and strategic organization of immune cells in the peripheral tissues and how they contribute to the local induction of pathological or protective immune responses.

Javier Rangel-Moreno, Ph.D.

Javier Rangel-Moreno, Ph.D.

Principal Investigator

Projects

Role of Bronchus Associated Lymphoid Tissue in Pulmonary Immunity

Role of Bronchus Associated Lymphoid Tissue in Pulmonary Immunity

Impact of Radiation on Immunity

Impact of Radiation on Immunity

Tertiary Lymphoid Organs in Cancer

Tertiary Lymphoid Organs in Cancer

Evaluation of Experimental Therapies in a Preclinical Model of Lupus

Evaluation of Experimental Therapies in a Preclinical Model of Lupus

Use of Laser-capture Microdissection to Decipher RNA Signatures in Target Tissues

Use of Laser-capture Microdissection to Decipher RNA Signatures in Target Tissues

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SOPs

Selected Publications

Moyron Quiroz JE, Rangel-Moreno J, Kusser K, Hartson L, Sprague F, Goodrich S, Woodland DL, Lund FE and Randall TD. Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity. Nat Med 10(9): 927-934:2004.

Rangel-Moreno J, Hartson L, Navarro C, Gaxiola M, Selman M and Randall TD. Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis. J Clin Invest 116(12): 3183-3194: 2006.

Rangel-Moreno J, Moyron-Quiroz JE, Hartson L, Kusser K and Randall TD. Pulmonary expression of CXC chemokine lignad 13, CC chemokine ligand 19, and CC chemokine lignad 21 is essential for local immunity to influenza. PNAS USA 104(25): 10577-10582:2007.

Randall TD, Carragher DM and Rangel-Moreno J. Development of secondary lymphoid organs. Annu Rev Immunol 26: 627-650:2008.

Rangel-Moreno J, Carragher DM. Garcia-Hernandez ML, Hwang JY, Kusser K, Hartson L, Kolls JK, Khader SA and Randall TD. The development of inducible bronchus-associated lymphoid tissue is dependent on on IL-17. Nat Immunol 12(7): 639-646:2011.

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Contact Us

  Rangel-Moreno Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642