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URMC / Labs / Rangel-Moreno Lab / Projects / Bronchus Associated Lymphoid Tissue

 

Role of Bronchus Associated Lymphoid Tissue in Pulmonary Immunity

In a collaborative project with Dr. Shabaana Abdul Khader at Washington University in Saint Louis and with support from the NIH, we are defining the contribution of inducible bronchus associated lymphoid tissue (iBALT) in the control of experimental pulmonary tuberculosis. Additionally, in a recent collaboration with Dr. Taylor Edens and Dr. Jay Kolls, we defined how IL17 and type 2 cytokines support IBALT formation during Pneumocystis murina infection (Cell Rep 18(13): 3078-3090:2017).

Germinal center in the lung of mice infected with Pneumocystis murina. PCNA in red, PNA in green and B220 in white.
Germinal center in the lung of mice infected with Pneumocystis murina. PCNA in red, PNA in green and B220 in white.