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Andrew P. Wojtovich, Ph.D.

Andrew P. Wojtovich, Ph.D.

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About Me

Faculty Appointments

Associate Professor - Department of Anesthesiology and Perioperative Medicine (SMD)

Associate Professor - Department of Pharmacology and Physiology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Postdoctoral Fellowship, Integrative Physiology, University of Rochester, Rochester, NY 2010 - 2014

Education

PhD | University of Rochester School of Medicine & Dentistry. Pharmacology. 2010

MS | University of Rochester School of Medicine & Dentistry. Pharmacology. 2007

BA | Boston University. Biochemistry and Molecular Biology. 2005

MA | Boston University. Biochemistry and Molecular Biology. 2005

Awards

Hypothesis Prize, 3rd place. 2023

Student Supervisor of the Year. 2021

University Research Award. 2018

The Furth Fund Award. 2017

University Research Award. 2015

New Investigator Travel Award,. 2014

24th Annual Genetics Day, 1st Place Poster. 2012

Postdoc Appreciation Week Poster Session, 3rd Prize. 2012

Gordon K. Moe Young Investigator Award. 2012

Postdoctoral Fellowship. 2011

Student Grant Award. 2010

Predoctoral Fellowship. 2008

Cardiovascular Research Symposium Award, 1st Place Poster. 2008

Graduate Student Society Merit Award, 1st Place Poster. 2007

Young Investigator Award. 2007

Undergraduate Research Opportunities Program Research Award. 2004

Research

Publications

Journal Articles

Mitochondrial energy state controls AMPK-mediated foraging behavior in .

Vodi?ková A, Müller-Eigner A, Okoye CN, Bischer AP, Horn J, Koren SA, Selim NA, Wojtovich AP

Science advances.. 2024 April 1910 (16):eadm8815. Epub 04/17/2024.

Oocyte mitochondria link maternal environment to offspring phenotype.

Cooper JF, Nguyen K, Gates D, Wolfrum E, Capan C, Lee H, Williams D, Okoye C, Wojtovich AP, Burton NO

Research square.. 2024 March 29 Epub 03/29/2024.

Mitochondrial complex I ROS production and redox signaling in hypoxia.

Okoye CN, Koren SA, Wojtovich AP

Redox biology.. 2023 October 1667 :102926. Epub 10/16/2023.

Reactive oxygen species drive foraging decisions in Caenorhabditis elegans.

Bischer AP, Baran TM, Wojtovich AP

Redox biology.. 2023 October 1367 :102934. Epub 10/13/2023.

All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ.

Koren SA, Ahmed Selim N, De la Rosa L, Horn J, Farooqi MA, Wei AY, Müller-Eigner A, Emerson J, Johnson GVW, Wojtovich AP

Nature communications.. 2023 September 2714 (1):6036. Epub 09/27/2023.

Using light to drive energy transduction in metazoan aging.

Tiwary V, Galow AM, Wojtovich AP, Peleg S

Trends in biochemical sciences.. 2023 September 11 Epub 09/11/2023.

The C. elegans Innexin INX-20 Regulates Nociceptive Behavioral Sensitivity.

Chaubey AH, Sojka SE, Onukwufor JO, Ezak MJ, Vandermeulen MD, Bowitch A, Vodi?ková A, Wojtovich AP, Ferkey DM

Genetics.. 2023 February 8 Epub 02/08/2023.

Optogenetic rejuvenation of mitochondrial membrane potential extends lifespan.

Berry BJ, Vodi?ková A, Müller-Eigner A, Meng C, Ludwig C, Kaeberlein M, Peleg S, Wojtovich AP

Nature aging.. 2023 February 3 (2):157-161. Epub 12/30/2022.

A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans.

Onukwufor JO, Farooqi MA, Vodi?ková A, Koren SA, Baldzizhar A, Berry BJ, Beutner G, Porter GA, Belousov V, Grossfield A, Wojtovich AP

Nature communications.. 2022 May 313 (1):2403. Epub 05/03/2022.

Exploratory Analysis of Associations Between Whole Blood Mitochondrial Gene Expression and Cancer-Related Fatigue Among Breast Cancer Survivors.

Kleckner AS, Kleckner IR, Culakova E, Wojtovich AP, Klinedinst NJ, Kerns SL, Hardy SJ, Inglis JE, Padula GDA, Mustian KM, Janelsins MC, Dorsey SG, Saligan LN, Peppone LJ

Nursing research.. 2022 April 13 Epub 04/13/2022.

Iron Dysregulation in Mitochondrial Dysfunction and Alzheimer's Disease.

Onukwufor JO, Dirksen RT, Wojtovich AP

Antioxidants.. 2022 March 3111 (4)Epub 03/31/2022.

Site-specific mitochondrial dysfunction in neurodegeneration.

Vodi?ková A, Koren SA, Wojtovich AP

Mitochondrion.. 2022 February 16 Epub 02/16/2022.

Optical Control of CD8 T Cell Metabolism and Effector Functions.

Amitrano AM, Berry BJ, Lim K, Kim KD, Waugh RE, Wojtovich AP, Kim M

Frontiers in immunology.. 2021 12 :666231. Epub 06/03/2021.

Decreased Mitochondrial Membrane Potential Activates the Mitochondrial Unfolded Protein Response.

Berry BJ, Nieves TO, Wojtovich AP

microPublication biology.. 2021 2021 Epub 09/10/2021.

Neuronal AMPK coordinates mitochondrial energy sensing and hypoxia resistance in C. elegans.

Berry BJ, Baldzizhar A, Nieves TO, Wojtovich AP

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2020 October 15 Epub 10/15/2020.

Mitochondrial light switches: optogenetic approaches to control metabolism.

Berry BJ, Wojtovich AP

The FEBS journal.. 2020 May 27 Epub 05/27/2020.

Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance.

Berry BJ, Trewin AJ, Milliken AS, Baldzizhar A, Amitrano AM, Lim Y, Kim M, Wojtovich AP

EMBO reports.. 2020 February 11 :e49113. Epub 02/11/2020.

Quantification of reactive oxygen species production by the red fluorescent proteins KillerRed, SuperNova and mCherry.

Onukwufor JO, Trewin AJ, Baran TM, Almast A, Foster TH, Wojtovich AP

Free radical biology & medicine.. 2019 December 10147 :1-7. Epub 12/10/2019.

Mitochondrial Reactive Oxygen Species Generated at the Complex-II Matrix or Intermembrane Space Microdomain Have Distinct Effects on Redox Signaling and Stress Sensitivity in .

Trewin AJ, Bahr LL, Almast A, Berry BJ, Wei AY, Foster TH, Wojtovich AP

Antioxidants & redox signaling.. 2019 September 2031 (9):594-607. Epub 04/22/2019.

Redox Signaling Through Compartmentalization of Reactive Oxygen Species: Implications for Health and Disease.

Wojtovich AP, Berry BJ, Galkin A

Antioxidants & redox signaling.. 2019 September 2031 (9):591-593. Epub 06/19/2019.

Element-Mediated CRISPR Integration of Transgenes in .

Philip NS, Escobedo F, Bahr LL, Berry BJ, Wojtovich AP

G3 : genes - genomes - genetics.. 2019 August 89 (8):2629-2635. Epub 08/08/2019.

Physiologic Implications of Reactive Oxygen Species Production by Mitochondrial Complex I Reverse Electron Transport.

Onukwufor JO, Berry BJ, Wojtovich AP

Antioxidants.. 2019 August 68 (8)Epub 08/06/2019.

Light-induced oxidant production by fluorescent proteins.

Trewin AJ, Berry BJ, Wei AY, Bahr LL, Foster TH, Wojtovich AP

Free radical biology & medicine.. 2018 November 20128 :157-164. Epub 02/06/2018.

Use the Protonmotive Force: Mitochondrial Uncoupling and Reactive Oxygen Species.

Berry BJ, Trewin AJ, Amitrano AM, Kim M, Wojtovich AP

Journal of molecular biology.. 2018 October 19430 (21):3873-3891. Epub 04/04/2018.

Quantification of light-induced miniSOG superoxide production using the selective marker, 2-hydroxyethidium.

Barnett ME, Baran TM, Foster TH, Wojtovich AP

Free radical biology & medicine.. 2018 February 20116 :134-140. Epub 01/31/2018.

Exercise and Mitochondrial Dynamics: Keeping in Shape with ROS and AMPK.

Trewin AJ, Berry BJ, Wojtovich AP

Antioxidants.. 2018 January 67 (1)Epub 01/06/2018.

Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist.

Stoveken HM, Bahr LL, Anders MW, Wojtovich AP, Smrcka AV, Tall GG

Molecular pharmacology.. 2016 September 90 (3):214-24. Epub 06/23/2016.

Chromophore-Assisted Light Inactivation of Mitochondrial Electron Transport Chain Complex II in Caenorhabditis elegans.

Wojtovich AP, Wei AY, Sherman TA, Foster TH, Nehrke K

Scientific reports.. 2016 July 216 :29695. Epub 07/21/2016.

Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.

Wojtovich AP, Smith CO, Urciuoli WR, Wang YT, Xia XM, Brookes PS, Nehrke K

Anesthesiology.. 2016 May 124 (5):1065-76. Epub 1900 01 01.

Direct activation of ?-cell KATP channels with a novel xanthine derivative.

Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS

Molecular pharmacology.. 2014 June 85 (6):858-65. Epub 03/19/2014.

Optogenetic control of ROS production.

Wojtovich AP, Foster TH

Redox biology.. 2014 2 :368-76. Epub 02/03/2014.

Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning.

Wojtovich AP, Urciuoli WR, Chatterjee S, Fisher AB, Nehrke K, Brookes PS

American journal of physiology. Heart and circulatory physiology.. 2013 June 1304 (11):H1439-45. Epub 04/12/2013.

Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.

Wojtovich AP, Smith CO, Haynes CM, Nehrke KW, Brookes PS

Biochimica et biophysica acta.. 2013 May 1827 (5):598-611. Epub 01/02/2013.

A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel.

Wojtovich AP, Nadtochiy SM, Urciuoli WR, Smith CO, Grunnet M, Nehrke K, Brookes PS

PeerJ.. 2013 1 :e48. Epub 03/05/2013.

A cell-based phenotypic assay to identify cardioprotective agents.

Guo S, Olm-Shipman A, Walters A, Urciuoli WR, Devito S, Nadtochiy SM, Wojtovich AP, Brookes PS

Circulation research.. 2012 March 30110 (7):948-57. Epub 03/06/2012.

Mitochondrial ATP-sensitive potassium channel activity and hypoxic preconditioning are independent of an inwardly rectifying potassium channel subunit in Caenorhabditis elegans.

Wojtovich AP, Distefano P, Sherman T, Brookes PS, Nehrke K

FEBS letters.. 2012 February 17586 (4):428-34. Epub 01/21/2012.

Ischemic preconditioning: the role of mitochondria and aging.

Wojtovich AP, Nadtochiy SM, Brookes PS, Nehrke K

Experimental gerontology.. 2012 January 47 (1):1-7. Epub 11/10/2011.

Redox regulation of the mitochondrial K(ATP) channel in cardioprotection.

Queliconi BB, Wojtovich AP, Nadtochiy SM, Kowaltowski AJ, Brookes PS

Biochimica et biophysica acta.. 2011 July 1813 (7):1309-15. Epub 11/20/2010.

SLO-2 is cytoprotective and contributes to mitochondrial potassium transport.

Wojtovich AP, Sherman TA, Nadtochiy SM, Urciuoli WR, Brookes PS, Nehrke K

PloS one.. 2011 6 (12):e28287. Epub 12/01/2011.

An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays.

Gunter TE, Gerstner B, Lester T, Wojtovich AP, Malecki J, Swarts SG, Brookes PS, Gavin CE, Gunter KK

Toxicology and applied pharmacology.. 2010 November 15249 (1):65-75. Epub 08/26/2010.

A novel mitochondrial K(ATP) channel assay.

Wojtovich AP, Williams DM, Karcz MK, Lopes CM, Gray DA, Nehrke KW, Brookes PS

Circulation research.. 2010 April 16106 (7):1190-6. Epub 02/25/2010.

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.

Gohil VM, Sheth SA, Nilsson R, Wojtovich AP, Lee JH, Perocchi F, Chen W, Clish CB, Ayata C, Brookes PS, Mootha VK

Nature biotechnology.. 2010 March 28 (3):249-55. Epub 02/14/2010.

Mitochondrial biotransformation of omega-(phenoxy)alkanoic acids, 3-(phenoxy)acrylic acids, and omega-(1-methyl-1H-imidazol-2-ylthio)alkanoic acids: a prodrug strategy for targeting cytoprotective antioxidants to mitochondria.

Roser KS, Brookes PS, Wojtovich AP, Olson LP, Shojaie J, Parton RL, Anders MW

Bioorganic & medicinal chemistry.. 2010 February 1518 (4):1441-8. Epub 01/15/2010.

The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria.

Wojtovich AP, Nehrke KW, Brookes PS

Acta biochimica Polonica. 2010 57 (4):431-4. Epub 11/19/2010.

Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.

Miller CL, Oikawa M, Cai Y, Wojtovich AP, Nagel DJ, Xu X, Xu H, Florio V, Rybalkin SD, Beavo JA, Chen YF, Li JD, Blaxall BC, Abe JI, Yan C

Circulation research.. 2009 November 6105 (10):956-64. Epub 09/24/2009.

The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels.

Wojtovich AP, Brookes PS

Basic research in cardiology.. 2009 March 104 (2):121-9. Epub 02/26/2009.

The C. elegans mitochondrial K+(ATP) channel: a potential target for preconditioning.

Wojtovich AP, Burwell LS, Sherman TA, Nehrke KW, Brookes PS

Biochemical and biophysical research communications.. 2008 November 21376 (3):625-8. Epub 09/20/2008.

Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks.

di Bernardo D, Thompson MJ, Gardner TS, Chobot SE, Eastwood EL, Wojtovich AP, Elliott SJ, Schaus SE, Collins JJ

Nature biotechnology.. 2005 March 23 (3):377-83. Epub 1900 01 01.

Books

Biochim Biophys Acta (2013)

Chapter: Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel

Authors: Wojtovich AP, Smith CO, Haynes CM, Nehrke K, Brookes PS

Publisher: Bioenergetics 2013

Ischemic preconditioning: The role of mitochondria and aging. (2012)

Authors: Wojtovich AP, Nadtochiy SM, Brookes PS, Nehrke K

Publisher: Exp Gerontol. 2012

Free Radical Effects on Membranes, (2008)

Chapter: The interaction of mitochondrial membranes with reactive oxygen and nitrogen species

Authors: Brookes PS, Wojtovich AP, Burwell LS, Hoffman DL, Nadtochiy SM.

Publisher: Elsevier, NY 2008