Mitochondrial Physiology and Hypoxic Stress Signaling

Mitochondria play a central role in stroke outcomes. We study ischemia reperfusion injury in neurons using optogenetic tools to control the mitochondrial membrane potential or reactive oxygen species production. Depending on where, when, and how mitochondrial function changes, damage or protective signaling can occur. We use CRISPR/Cas9, C. elegans genetics, primary neurons, and measures of mitochondrial bioenergetics to learn about the mechanisms of this damage or protection in our models.

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