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Meera Vir Singh, Ph.D.

Meera Vir Singh, Ph.D.

she/her/hers

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Research Lab

Research Lab

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About Me

Professional Background

Education

2002
BS | University of Pondicherry, India
Botany

2004
MS | University of Pondicherry, India
Life Sciences

2011
PhD | University of Pune, India
Biotechnology

Post-Doctoral training

2011-2016
University of Rochester Medical Center
...
Education

2002
BS | University of Pondicherry, India
Botany

2004
MS | University of Pondicherry, India
Life Sciences

2011
PhD | University of Pune, India
Biotechnology

Post-Doctoral training

2011-2016
University of Rochester Medical Center

Awards

2002
Gold Medal (Valedictorian) for BS degree

2004-2009
Research Fellowship for Doctoral Studies
Center for Scientific and Industrial Research, Government of India

2008
Young Investigator Award
15th Conference on Retroviruses and Opportunistic Infections, USA

2008
International Scholarship Award
XVII International AIDS Conference, Mexico

2013
Young Investigator Award
20th Conference on Retroviruses and Opportunistic Infections, USA

Faculty Appointments

Assistant Professor - Department of Neurology, Stroke Division (SMD)

Assistant Professor - Department of Microbiology and Immunology (SMD) - Joint

Research

Singh laboratory's major research goals are,

1. Understanding the role of inflammatory leukocytes in vascular injury associated with cardiovascular and cerebrovascular disease during viral infections such as HIV and SARS-CoV-2.

2. Delineating the role inter-leukocyte interactions (plat...
Singh laboratory's major research goals are,

1. Understanding the role of inflammatory leukocytes in vascular injury associated with cardiovascular and cerebrovascular disease during viral infections such as HIV and SARS-CoV-2.

2. Delineating the role inter-leukocyte interactions (platelets, monocytes, Dendritic cells and T cells) in anti-HIV immune responses and improvement of Dendritic cell based vaccine strategies.

3. Identification of peripheral signatures of neuro-inflammation during neurodegenerative disorders including HIV associated neurological disease.

Publications

Journal Articles

Initiation of combined antiretroviral therapy confers suboptimal beneficial effects on neurovascular function in people with HIV.

Singh MV, Uddin MN, Singh VB, Peterson AN, Murray KD, Zhuang Y, Tyrell A, Wang L, Tivarus ME, Zhong J, Qiu X, Schifitto G

Frontiers in neurology. 2023 14 :1240300. Epub 08/31/2023.

Executable models of immune signaling pathways in HIV-associated atherosclerosis.

Palshikar MG, Palli R, Tyrell A, Maggirwar S, Schifitto G, Singh MV, Thakar J

NPJ systems biology and applications.. 2022 September 218 (1):35. Epub 09/21/2022.

Human immunodeficiency virus-1 Tat exerts its neurotoxic effects by downregulating Sonic hedgehog signaling.

Khan IA, Worrad AH, Singh MV, Maggirwar SB, Singh VB

Journal of neurovirology.. 2022 February 18 Epub 02/18/2022.

Increased risk for cerebral small vessel disease is associated with quantitative susceptibility mapping in HIV infected and uninfected individuals.

Murray KD, Uddin MN, Tivarus ME, Sahin B, Wang HZ, Singh MV, Qiu X, Wang L, Spincemaille P, Wang Y, Maggirwar SB, Zhong J, Schifitto G

NeuroImage. Clinical.. 2021 August 2832 :102786. Epub 08/28/2021.

Molecular characterization of atherosclerosis in HIV positive persons.

Cornwell A, Palli R, Singh MV, Benoodt L, Tyrell A, Abe JI, Schifitto G, Maggirwar SB, Thakar J

Scientific reports.. 2021 February 511 (1):3232. Epub 02/05/2021.

Platelets function as an acute viral reservoir during HIV-1 infection by harboring virus and T-cell complex formation.

Simpson SR, Singh MV, Dewhurst S, Schifitto G, Maggirwar SB

Blood advances.. 2020 September 224 (18):4512-4521. Epub 1900 01 01.

Novel Mechanism of Microvesicle Regulation by the Antiviral Protein Tetherin During HIV Infection.

Weber EA, Singh MV, Singh VB, Jackson JW, Ture SK, Suwunnakorn S, Morrell CN, Maggirwar SB

Journal of the American Heart Association.. 2020 August 21 :e015998. Epub 08/21/2020.

Monocytes complexed to platelets differentiate into functionally deficient dendritic cells.

Singh MV, Suwunnakorn S, Simpson SR, Weber EA, Singh VB, Kalinski P, Maggirwar SB

Journal of leukocyte biology.. 2020 July 14 Epub 07/14/2020.

Pathomechanisms of HIV-Associated Cerebral Small Vessel Disease: A Comprehensive Clinical and Neuroimaging Protocol and Analysis Pipeline.

Murray KD, Singh MV, Zhuang Y, Uddin MN, Qiu X, Weber MT, Tivarus ME, Wang HZ, Sahin B, Zhong J, Maggirwar SB, Schifitto G

Frontiers in neurology. 2020 11 :595463. Epub 12/15/2020.

Inhibition of Tropomyosin Receptor Kinase A Signaling Negatively Regulates Megakaryopoiesis and induces Thrombopoiesis.

Kizilyer A, Singh MV, Singh VB, Suwunnakorn S, Palis J, Maggirwar SB

Scientific reports.. 2019 February 269 (1):2781. Epub 02/26/2019.

Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV Individuals: Implications for Atherogenesis.

Singh MV, Kotla S, Le NT, Ko KA, Heo KS, Wang Y, Fujii Y, Vu HT, McBeath E, Thomas TN, Gi YJ, Tao Y, Medina JL, Taunton J, Carson N, Dogra V, Doyley MM, Tyrell A, Lu W, Qiu X, Stirpe NE, Gates K, Hurley C, Fujiwara K, Maggirwar S, Schifitto G, Abe JI

Circulation.. 2018 October 26 Epub 10/26/2018.

Sonic Hedgehog mimetic prevents leukocyte infiltration into the CNS during acute HIV infection.

Singh VB, Singh MV, Piekna-Przybylska D, Gorantla S, Poluektova LY, Maggirwar SB

Scientific reports.. 2017 August 297 (1):9578. Epub 08/29/2017.

Preventive and therapeutic challenges in combating Zika virus infection: are we getting any closer?

Singh MV, Weber EA, Singh VB, Stirpe NE, Maggirwar SB

Journal of neurovirology.. 2017 June 23 (3):347-357. Epub 01/23/2017.

Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice.

Singh VB, Singh MV, Gorantla S, Poluektova LY, Maggirwar SB

Scientific reports.. 2016 May 316 :26876. Epub 05/31/2016.

Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis.

Jackson JW, Singh MV, Singh VB, Jones LD, Davidson GA, Ture S, Morrell CN, Schifitto G, Maggirwar SB

PloS one.. 2016 11 (6):e0157115. Epub 06/06/2016.

Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse.

Kiebala M, Singh MV, Piepenbrink MS, Qiu X, Kobie JJ, Maggirwar SB

PloS one.. 2015 10 (6):e0130061. Epub 06/15/2015.

Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation.

Singh MV, Davidson DC, Jackson JW, Singh VB, Silva J, Ramirez SH, Maggirwar SB

The Journal of immunology : official journal of the American Association of Immunologists.. 2014 May 15192 (10):4674-84. Epub 04/11/2014.

Detection of circulating platelet-monocyte complexes in persons infected with human immunodeficiency virus type-1.

Singh MV, Davidson DC, Kiebala M, Maggirwar SB

Journal of virological methods.. 2012 May 181 (2):170-6. Epub 02/23/2012.

Excess soluble CD40L contributes to blood brain barrier permeability in vivo: implications for HIV-associated neurocognitive disorders.

Davidson DC, Hirschman MP, Sun A, Singh MV, Kasischke K, Maggirwar SB

PloS one.. 2012 7 (12):e51793. Epub 12/12/2012.

Irreversible loss of pDCs by apoptosis during early HIV infection may be a critical determinant of immune dysfunction.

Meera S, Madhuri T, Manisha G, Ramesh P

Viral immunology.. 2010 June 23 (3):241-9. Epub 1900 01 01.