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Singh Lab

Welcome to the Singh Lab

The research program in Singh lab is broadly focused on immune-pathogenesis of viral infections such as Human Immunodeficiency Virus (HIV) and SARS-CoV-2.

Despite successful anti-retroviral therapy, HIV infection is associated with persistent chronic immune activation and low levels of background viral replication. Due to this, people living with HIV are susceptible to age-related co-morbidities such as vascular disease, neurocognitive impairment, liver disease etc. Singh lab focuses on investigating the role of platelets and monocytes in exacerbating the progression of these co-morbidities.

SARS-CoV-2 infection is associated with aberrant platelet activation and increased levels of platelet-monocyte interaction. Studies have indicated that, up to 30% of individuals experience worse cognitive outcomes 1-2 years after infection. Our laboratory is currently investigating the associations between leukocyte, endothelial activation, and neurological sequelae post-Covid infection.

Singh lab has multiple collaborations within University of Rochester and with other national academic institutions. We are actively engaged in Human Subject Research and employ cutting-edge technologies in all our research endeavors.

Mentoring Philosophy: I believe in "Mentoring from the Middle” because mentoring is rarely a one-way-street. Every person needs a mentoring team to become a well-rounded, independent professional and I encourage my mentees to find mentors with diverse skills and perspectives.  I like to develop customized mentoring plan for each of my mentees to best fit their needs. I expect hard work, rigor and diligence from everyone including myself.  I am earnestly committed to nurturing a diverse and inclusive environment.

Lab Members

Meera Vir Singh, Ph.D.

Meera Vir Singh, Ph.D.
Principal Investigator


Platelet-Monocyte Interaction

Role of Platelet-Monocyte Interaction in Promoting Pro-Atherogenic State in HIV-Infected Individuals

Brain Structural Functional Connectome

Brain Structural and Functional Connectome in HIV associated Neuroinflammation

Deregulation Dendritic Cell Function

Platelet-Mediated Deregulation of Dendritic Cell Function in People Living with HIV Infection 

SARS-CoV-2 Infection

Brain Signature of SARS-CoV-2 Infection and Its Impact on Long-Term Cognitive Functioning in Older Adults 

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