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Makaia Papasergi, Ph.D.

Makaia Papasergi, Ph.D.

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Office (585) 273-4893

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About Me

Faculty Appointments

Assistant Professor - Department of Biochemistry and Biophysics (SMD)

Research

Publications

Journal Articles

Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor.

Batebi H, Pérez-Hernández G, Rahman SN, Lan B, Kamprad A, Shi M, Speck D, Tiemann JKS, Guixà-González R, Reinhardt F, Stadler PF, Papasergi-Scott MM, Skiniotis G, Scheerer P, Kobilka BK, Mathiesen JM, Liu X, Hildebrand PW

Nature structural & molecular biology.. 2024 November 31 (11):1692-1701. Epub 06/12/2024.

Time-resolved cryo-EM of G-protein activation by a GPCR.

Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G

Nature.. 2024 May 629 (8014):1182-1191. Epub 03/13/2024.

Allosteric modulation and G-protein selectivity of the Ca-sensing receptor.

He F, Wu CG, Gao Y, Rahman SN, Zaoralová M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G

Nature.. 2024 February 626 (8001):1141-1148. Epub 02/07/2024.

Structures of Ric-8B in complex with G? protein folding clients reveal isoform specificity mechanisms.

Papasergi-Scott MM, Kwarcinski FE, Yu M, Panova O, Ovrutsky AM, Skiniotis G, Tall GG

Structure.. 2023 May 431 (5):553-564.e7. Epub 03/16/2023.

Time-resolved cryo-EM of G protein activation by a GPCR.

Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G

bioRxiv : the preprint server for biology.. 2023 March 21 Epub 03/21/2023.

Structure determination of inactive-state GPCRs with a universal nanobody.

Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G

Nature structural & molecular biology.. 2022 December 29 (12):1188-1195. Epub 11/17/2022.

The tethered peptide activation mechanism of adhesion GPCRs.

Barros-Álvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G

Nature.. 2022 April 604 (7907):757-762. Epub 04/13/2022.

Protein phosphatase-1 inhibitor-2 promotes PP1 positive regulation of synaptic transmission.

Foley K, Altimimi H, Hou H, Zhang Y, McKee C, Papasergi-Scott MM, Yang H, Mayer A, Ward N, MacLean DM, Nairn AC, Stellwagen D, Xia H

Frontiers in synaptic neuroscience.. 2022 14 :1021832. Epub 10/06/2022.

G-protein activation by a metabotropic glutamate receptor.

Seven AB, Barros-Álvarez X, de Lapeyrière M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G

Nature.. 2021 July 595 (7867):450-454. Epub 06/30/2021.

Structures of metabotropic GABA receptor.

Papasergi-Scott MM, Robertson MJ, Seven AB, Panova O, Mathiesen JM, Skiniotis G

Nature.. 2020 August 584 (7820):310-314. Epub 06/24/2020.

Structures of G? Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms.

Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G

Cell reports.. 2020 March 1730 (11):3699-3709.e6. Epub 03/02/2020.

Structure, Function, and Dynamics of the G? Binding Domain of Ric-8A.

Zeng B, Mou TC, Doukov TI, Steiner A, Yu W, Papasergi-Scott M, Tall GG, Hagn F, Sprang SR

Structure.. 2019 July 227 (7):1137-1147.e5. Epub 05/30/2019.

Production of Phosphorylated Ric-8A proteins using protein kinase CK2.

Yu W, Yu M, Papasergi-Scott MM, Tall GG

Protein expression and purification.. 2019 February 154 :98-103. Epub 10/02/2018.

Dual phosphorylation of Ric-8A enhances its ability to mediate G protein ? subunit folding and to stimulate guanine nucleotide exchange.

Papasergi-Scott MM, Stoveken HM, MacConnachie L, Chan PY, Gabay M, Wong D, Freeman RS, Beg AA, Tall GG

Science signaling.. 2018 May 2911 (532)Epub 05/29/2018.