Welcome to the Papasergi-Scott Lab
The Papasergi-Scott laboratory explores molecular mechanisms and spatiotemporal aspects of G protein signaling pathways using structural information from cryo-electron microscopy (cryo-EM), leveraged with biochemical, cellular, and pharmacologic studies. The lab uncovers the dynamic changes of G protein-coupled receptors (GPCRs), G proteins, and downstream effector proteins from molecular detail to organization within signaling complexes and cellular microdomains with the goal of using research insights to uncover novel therapeutic targets and treatments and improve our understanding of disrupted G protein signaling in disease.
Makaia Papasergi-Scott, PhD
Principal Investigator
When Your Career Path Doesn’t Go as Planned | A Nonlinear Journey in Science
Makaia Papasergi-Scott, PhD, shares how her career evolved when things didn’t go as planned, reflecting on graduate school, postdoctoral training, and a research path shaped by challenges, mentorship, and openness to new directions in science, teaching, and leadership.
Publications
View All Publications- Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor.; Nature structural & molecular biology; Vol 31(11), pp. 1692-1701. 2024 Jun 12.
- Time-resolved cryo-EM of G-protein activation by a GPCR.; Nature; Vol 629(8014), pp. 1182-1191. 2024 Mar 13.
- Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor.; Nature; Vol 626(8001), pp. 1141-1148. 2024 Feb 07.
- Time-resolved cryo-EM of G protein activation by a GPCR.; bioRxiv : the preprint server for biology. 2023 Mar 21.
Affiliations
- Biochemistry & Biophysics
- Pharmacology & Physiology
- Center for RNA Biology: From Genome to Therapeutics
- NIH T32 Training Grant in Cellular, Biochemical & Molecular Sciences
- Biochemistry & Molecular Biology Ph.D. Program
- Biophysics, Structural & Computational Biology Ph.D. Program
- Cellular and Molecular Pharmacology and Physiology Ph.D. Program
Contact Us
The Papasergi-Scott Laboratory
Office 4-6718
601 Elmwood Ave
Rochester, NY 14642