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Siyu Sun, Ph.D.

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Siyu Sun, Ph.D.

About Me
Credentials
Research
Publications

About Me

Faculty Appointments

Assistant Professor - Department of Microbiology and Immunology (SMD)

Credentials

Education

PhD | New York University. System and Computational Biology. 2020

MS | New York University. Molecular and Genetic Biology. 2013

BS | Ludong University, Mainland China. Biology. 2011

Research

Publications

Journal Articles

Viral Mimicry by Repeats Mediates Evolutionary Trade-Offs in Cancer-Immune Coevolution.

Sun S, Greenbaum BD

Cancer discovery.. 2026 August 316 (8):1489-1493. Epub 1900 01 01.

Repeats mimic pathogen-associated patterns across a vast evolutionary landscape.

Šulc P, Di Gioacchino A, Solovyov A, Sun S, Martis S, Marhon SA, Lindholm HT, Chen R, Hosseini A, Jiang H, Ly BH, Taylor MS, Mehdipour P, Abdel-Wahab O, Rusk N, Vabret N, LaCava J, De Carvalho DD, Monasson R, Cocco S, Greenbaum BD

Cell genomics.. 2025 December 105 (12):101011. Epub 09/24/2025.

LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma.

You E, Patel BK, Rojas AS, Sun S, Danaher P, Ho NI, Phillips IE, Raabe MJ, Song Y, Xu KH, Kocher JR, Richieri PM, Shin P, Taylor MS, Nieman LT, Greenbaum BD, Ting DT

Cancer discovery.. 2025 May 215 (5):1063-1082. Epub 1900 01 01.

Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion.

Ishak CA, Marhon SA, Tchrakian N, Hodgson A, Loo Yau H, Gonzaga IM, Peralta M, Lungu IM, Gomez S, Liang SB, Shen SY, Chen R, Chen J, Chatterjee B, Wanniarachchi KN, Lee J, Zehrbach N, Hosseini A, Mehdipour P, Sun S, Solovyov A, Ettayebi I, Francis KE, He A, Wu T, Feng S, da Silva Medina T, Campos de Almeida F, Bayani J, Li J, MacDonald S, Wang Y, Garcia SS, Arthofer E, Diab N, Srivastava A, Austin PT, Sabatini PJB, Greenbaum BD, O'Brien CA, Shepherd TG, Tsao MS, Chiappinelli KB, Oza AM, Clarke BA, Rottapel R, Lheureux S, De Carvalho DD

Cancer discovery.. 2025 April 215 (4):793-817. Epub 1900 01 01.

Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer.

You E, Danaher P, Lu C, Sun S, Zou L, Phillips IE, Rojas AS, Ho NI, Song Y, Raabe MJ, Xu KH, Richieri PM, Li H, Aston N, Porter RL, Patel BK, Nieman LT, Schurman N, Hudson BM, North K, Church SE, Deshpande V, Liss AS, Kim TK, Cui Y, Kim Y, Greenbaum BD, Aryee MJ, Ting DT

Cell.. 2024 December 12187 (25):7232-7247.e23. Epub 10/08/2024.

Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms.

Sun S, You E, Hong J, Hoyos D, Del Priore IS, Tsanov KM, Mattagajasingh O, Di Gioacchino A, Marhon SA, Chacon-Barahona J, Li H, Jiang H, Hozeifi S, Rosas-Bringas O, Xu KH, Song Y, Lang ER, Rojas AS, Nieman LT, Patel BK, Murali R, Chanda P, Karacay A, Vabret N, De Carvalho DD, Zenklusen D, LaCava J, Lowe SW, Ting DT, Iacobuzio-Donahue CA, Solovyov A, Greenbaum BD

Immunity.. 2024 December 1057 (12):2879-2894.e11. Epub 11/21/2024.

Interferon response and epigenetic modulation by mutations drive ovarian tumor immunogenicity.

Brodeur MN, Dopeso H, Zhu Y, Longhini ALF, Gazzo A, Sun S, Koche RP, Qu R, Rosenberg L, Hamard PJ, Bykov Y, Green H, Gusain L, Chiappinelli KB, Ozsoy MA, Chui MH, Basili T, Gardner R, Walderich S, DeStanchina E, Greenbaum B, Gönen M, Vabret N, Weigelt B, Zamarin D

Science advances.. 2024 December 610 (49):eadk4851. Epub 12/04/2024.

Human LINE-1 ORF1p retrotransposition independent function in pancreatic cancer

Eunae You; Bidish Patel; Alexandra Rojas; Natalie Ho; Siyu Sun; Michael Raabe; Yuhui Song; Ildiko Phillips; Katherine Xu; Peter Richieri; Linda Nieman; Benjamin Greenbaum; David Ting.

Cancer Research. 2024; 84(6 Supplement): 7480.

Satellite repeat RNA expression in epithelial ovarian cancer associates with a tumor-immunosuppressive phenotype.

Porter RL, Sun S, Flores MN, Berzolla E, You E, Phillips IE, Kc N, Desai N, Tai EC, Szabolcs A, Lang ER, Pankaj A, Raabe MJ, Thapar V, Xu KH, Nieman LT, Rabe DC, Kolin DL, Stover EH, Pepin D, Stott SL, Deshpande V, Liu JF, Solovyov A, Matulonis UA, Greenbaum BD, Ting DT

The Journal of clinical investigation.. 2022 August 15132 (16)Epub 1900 01 01.

Abstract B007: Endogenous retrotransposable elements induction in SMARCA4-deficient ovarian cancer is associated with immunomodulatory changes in the tumor microenvironment

Melica Brodeur; Siyu Sun; Yingjie Zhu; Benjamin Greenbaum; Britta Weigelt; Dmitriy Zamarin.

Cancer Research. 2022; 82(23 Supplement 2): B007.

Cellular quiescence in budding yeast.

Sun S, Gresham D

Yeast.. 2021 January 38 (1):12-29. Epub 01/25/2021.

Repeats mimic immunostimulatory viral features across a vast evolutionary landscape

Petr Sulc; Andrea Di Gioacchino; Alexander Solovyov; Sajid A Marhon; Siyu Sun; Håvard T Lindholm; Raymond Chen; Amir Hosseini; Hua Jiang; Bao-Han Ly; Parinaz Mehdipour; Omar Abdel-Wahab; Nicolas Vabret; John Lacava; Daniel D de Carvalho; Rémi Monasson; Simona Cocco; Benjamin D Greenbaum.

bioRxiv. 2021; .

Genetic interaction profiles of regulatory kinases differ between environmental conditions and cellular states.

Sun S, Baryshnikova A, Brandt N, Gresham D

Molecular systems biology.. 2020 May 16 (5):e9167. Epub 1900 01 01.

Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation.

Yang J, Sun S, Zhang S, Gonzalez M, Dong Q, Chi Z, Chen YH, Li F

PLoS genetics.. 2018 August 14 (8):e1007572. Epub 08/08/2018.

Ectopic centromere nucleation by CENP--a in fission yeast.

Gonzalez M, He H, Dong Q, Sun S, Li F

Genetics.. 2014 December 198 (4):1433-46. Epub 10/07/2014.

Cell cycle-dependent deposition of CENP-A requires the Dos1/2-Cdc20 complex.

Gonzalez M, He H, Sun S, Li C, Li F

Proceedings of the National Academy of Sciences of the United States of America.. 2013 January 8110 (2):606-11. Epub 12/24/2012.