Welcome to the Sun Lab
We study how transposable elements and repeat-derived nucleic acids reshape cell states, plasticity, immune signaling, and tissue homeostasis.

Siyu Sun, Ph.D.
Principal Investigator
Projects
- Repetitive genome regulation and cell-state plasticity
- Repeat-derived immunity and tissue microenvironment
- Repetitive genome in disease evolution and aging
Publications
View All Publications- Viral Mimicry by Repeats Mediates Evolutionary Trade-Offs in Cancer-Immune Coevolution.; Cancer discovery; Vol 16(8), pp. 1489-1493. 2026 Aug 03.
- Repeats mimic pathogen-associated patterns across a vast evolutionary landscape.; Cell genomics; Vol 5(12), pp. 101011. 2025 Sep 24.
- LINE-1 ORF1p Mimics Viral Innate Immune Evasion Mechanisms in Pancreatic Ductal Adenocarcinoma.; Cancer discovery; Vol 15(5), pp. 1063-1082. 2025 May 02.
- Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion.; Cancer discovery; Vol 15(4), pp. 793-817. 2025 Apr 02.