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Mark E. Dumont, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-2466

Fax: (585) 275-6007

Research Labs

Faculty Appointments

Biography

Research

Transmembrane proteins carry out critical functions in transporting ions and metabolites in an out of cells and organelles, in transducing extracellular signals into intracellular responses, in cell-cell recognition, and in catalyzing a variety of enzymatic reactions. They also constitute 20-30% of the protein coding potential of most genomes. However, the structures and molecular mechanisms of the function of membrane proteins remain much more poorly characterized than is the case for most soluble proteins. The Dumont laboratory focuses on understanding mechanisms of membrane protein function at the molecular level.

Credentials

Education

1972
BA | Harvard University
Physics

1975
MS | Western Washington State Coll
Physics

1980
PhD | Johns Hopkins University
Biophysics

Publications

Journal Articles

2019
Zhu H, Mathew E, Connelly SM, Zuber J, Sullivan M, Piepenbrink MS, Kobie JJ, Dumont ME. "Identification of variant HIV envelope proteins with enhanced affinities for precursors to anti-gp41 broadly neutralizing antibodies." PloS one.. 2019 14(9):e0221550. Epub 2019 Sep 10.

2018
Mathew E, Zhu H, Connelly SM, Sullivan MA, Brewer MG, Piepenbrink MS, Kobie JJ, Dewhurst S, Dumont ME. "Display of the HIV envelope protein at the yeast cell surface for immunogen development." PloS one.. 2018 13(10):e0205756. Epub 2018 Oct 18.

2/2017
Clark KM, Jenkins JL, Fedoriw N, Dumont ME. "Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors." Protein science : a publication of the Protein Society.. 2017 Feb 0; 26(2):242-257. Epub 2016 Nov 11.

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