Research Bio
Transmembrane proteins carry out critical functions in transporting ions and metabolites in an out of cells and organelles, in transducing extracellular signals into intracellular responses, in cell-cell recognition, and in catalyzing a variety of enzymatic reactions. They also constitute 20-30% of the protein coding potential of most genomes. However, the structures and molecular mechanisms of the function of membrane proteins remain much more poorly characterized than is the case for most soluble proteins. The Dumont laboratory focuses on understanding mechanisms of membrane protein function at the molecular level.
2014 Jan
Sridharan R, Zuber J, Connelly SM, Mathew E, Dumont ME. "Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors." Biochimica et biophysica acta. 2014 Jan; 1838(1 Pt A):15-33. Epub 2013 Sep 18. |
2013 Mar 29
Pryor EE, Horanyi PS, Clark KM, Fedoriw N, Connelly SM, Koszelak-Rosenblum M, Zhu G, Malkowski MG, Wiener MC, Dumont ME. "Structure of the integral membrane protein CAAX protease Ste24p." Science. 2013 Mar 29; 339(6127):1600-4. |
2013 Feb
Pieper U, Schlessinger A, Kloppmann E, Chang GA, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, Stroud RM, Stevens RC, Sali A. "Coordinating the impact of structural genomics on the human ?-helical transmembrane proteome." Nature structural & molecular biology. 2013 Feb; 20(2):135-8. |
2013 Jan
Mathew E, Ding FX, Naider F, Dumont ME. "Functional fusions of T4 lysozyme in the third intracellular loop of a G protein-coupled receptor identified by a random screening approach in yeast." Protein engineering, design & selection : PEDS. 2013 Jan; 26(1):59-71. Epub 2012 Oct 16. |
2012 Oct
Gehret AU, Connelly SM, Dumont ME. "Functional and physical interactions among Saccharomyces cerevisiae ?-factor receptors." Eukaryotic cell. 2012 Oct; 11(10):1276-88. Epub 2012 Aug 24. |
