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Mark E. Dumont, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-2466

Fax: (585) 275-6007

Research Labs

Biography

Research

Transmembrane proteins carry out critical functions in transporting ions and metabolites in an out of cells and organelles, in transducing extracellular signals into intracellular responses, in cell-cell recognition, and in catalyzing a variety of enzymatic reactions. They also constitute 20-30% of the protein coding potential of most genomes. However, the structures and molecular mechanisms of the function of membrane proteins remain much more poorly characterized than is the case for most soluble proteins. The Dumont laboratory focuses on understanding mechanisms of membrane protein function at the molecular level.

Credentials

Faculty Appointments

Education

1972
BA | Harvard University
Physics

1975
MS | Western Washington State Coll
Physics

1980
PhD | Johns Hopkins University
Biophysics

Publications

Journal Articles

2/2017
Clark KM, Jenkins JL, Fedoriw N, Dumont ME. "Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors." Protein science : a publication of the Protein Society.. 2017 Feb 0; 26(2):242-257. Epub 2016 Nov 11.

1/2017
Coudray N, L Seyler S, Lasala R, Zhang Z, Clark KM, Dumont ME, Rohou A, Beckstein O, Stokes DL. "Structure of the SLC4 transporter Bor1p in an inward-facing conformation." Protein science : a publication of the Protein Society.. 2017 Jan 0; 26(1):130-145. Epub 2016 Oct 21.

11/11/2016
Sridharan R, Connelly SM, Naider F, Dumont ME. "Variable Dependence of Signaling Output on Agonist Occupancy of Ste2p, a G Protein-coupled Receptor in Yeast." The Journal of biological chemistry.. 2016 Nov 11; 291(46):24261-24279. Epub 2016 Sep 19.

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