Mark E. Dumont, Ph.D.

Mark E. Dumont, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Office: (585) 275-2466
Fax: (585) 275-6007

Research Bio

Transmembrane proteins carry out critical functions in transporting ions and metabolites in an out of cells and organelles, in transducing extracellular signals into intracellular responses, in cell-cell recognition, and in catalyzing a variety of enzymatic reactions. They also constitute 20-30% of the protein coding potential of most genomes. However, the structures and molecular mechanisms of the function of membrane proteins remain much more poorly characterized than is the case for most soluble proteins. The Dumont laboratory focuses on understanding mechanisms of membrane protein function at the molecular level.

Recent Journal Articles

Showing the 5 most recent journal articles. 56 available »

2016 Sep 19
Sridharan R, Connelly SM, Naider F, Dumont ME. "Variable Dependence of Signaling Output on Agonist Occupancy of Ste2p, a G Protein Coupled Receptor in Yeast." The Journal of biological chemistry. 2016 Sep 19; Epub 2016 Sep 19.
2016 Aug
Coudray N, Lasala R, Zhang Z, Clark KM, Dumont ME, Stokes DL. "Deducing the symmetry of helical assemblies: Applications to membrane proteins." Journal of structural biology. 2016 Aug; 195(2):167-78. Epub 2016 May 30.
2015 Mar 10
Zuber J, Danial SA, Connelly SM, Naider FR, Dumont ME. "Identification of destabilizing and stabilizing mutations of Ste2p, a G protein-coupled receptor in Saccharomyces cerevisiae." Biochemistry. 2015 Mar 10; 54(9):1787-806. Epub 2015 Feb 24.
Zhu G, Koszelak-Rosenblum M, Connelly SM, Dumont ME, Malkowski MG. "The Crystal Structure of an Integral Membrane Fatty Acid ?-Hydroxylase." The Journal of biological chemistry. 2015 290(50):29820-33. Epub 2015 Oct 28.
Mathew E, Dumont ME. "A Novel Screening Approach for Optimal and Functional Fusion of T4 Lysozyme in GPCRs." Methods in enzymology. 2015 557:27-43. Epub 2015 Mar 24.

Current Appointments

Professor - Department of Biochemistry and Biophysics (SMD) - Primary


PhD | Biophysics | Johns Hopkins University1980
MS | Physics | Western Washington State Coll1975
BA | Physics | Harvard University1972