Biography
RESEARCH: Neuroinflammation in CNS Injury and Alzheimer's Disease.
Twenty years ago evidence from epidemiological studies and investigations of human brain pathology suggested the hypothesis that innate immune activation of the brain, a term now referred to as neuroinflammation, might contribute to the pathogenesis of Alzheimer's and other brain diseases. Based on our pioneering work in the area of cyclooxygenase-2 and inflammation, we initiated a research program that focuses on understanding the role of neuroinflammation in Alzheimer's and other neurodegenerative diseases. Studies conducted in the laboratory with human brain tissue, neuronal cell culture models and mouse models of acute injury and neurodegeneration have pointed to a prominent role for specific proinflammatory cytokines and bioactive prostaglandins in promoting neuroinflammation. Interestingly, our current work in Alzheimer's disease has revealed a potential protective role for neuroinflammation and has led to a focus on the influence of glial expressed cytokines and infiltrating peripheral cells on brain pathology, utilizing genetic and pharmacological approaches in a variety of mouse models. In complementary work, we also have active preclinical projects in the area of brain radiation injury, a critical problem for individuals receiving radiotherapy for brain tumors or bone marrow transplantation. The main goal is to understand the role of neuroinflammation and oxidative stress in promoting injury and to determine whether therapeutic interventions targeting these processes can alleviate late radiation effects, including cognitive changes
Professional Background
EDUCATION:
1976 – 1980 University of Illinois, College of Liberal Arts and Sciences - B.S. with honors in Biology (summa cum laude). Research training with Dr. Sue Carter-Porges, Department of Neural and Behavioral Biology.
1980 – 1987 University of Illinois, College of Liberal Arts and Sciences - M.S., Ph.D. in Microbiology.
1980 – 1987 University of Illinois, School of Medicine, Urbana, Illinois - M.D. with honors.
1987 – 1990 Postdoctoral Fellow, Departments of Medicine and Biochemistry, University of Rochester School of Medicine & Dentistry.
FACULTY APPOINTMENTS:
1990 – 1991 Instructor and Fellow, Departments of Medicine and Biochemistry, University of Rochester School of Medicine & Dentistry
1991 – 1997 Assistant Professor, Departments of Neurology and of Neurobiology and Anatomy, University of Rochester School of Medicine & Dentistry
1997 – 2000 Associate Professor, Departments of Neurology and of Neurobiology and Anatomy, University of Rochester School of Medicine & Dentistry
2000 – Present Associate Professor (Tenured in 2002), Departments of Neurobiology and Anatomy and of Neurology, University of Rochester School of Medicine & Dentistry
HONORS, AWARDS AND FELLOWSHIPS:
1977 – 1980 Edmund J. James Scholar
1980 Phi Kappa Phi (Honorary Society)
1980 B.S. with honors (summa cum laude); Bronze Tablet Recipient
1980 University of Illinois Life Sciences Predoctoral Fellowship
1982 Excellence in Undergraduate Teaching Award
1984 Otto Saphir Memorial Award in Pathology
1984 Alpha Omega Alpha (Honorary Medical Society)
1986 University of Illinois College of Medicine Predoctoral Fellowship
1987 M.D. with honors; Valedictorian Address, Medical School Commencement
1987 Lange Book Award
1988 Proficiency in Pediatrics Book Award
1987 – 1989 NIH Postdoctoral Training Fellow in Endocrinology and Metabolism, University of Rochester
1988 – 1991 Wilmot Cancer Research Postdoctoral Fellowship, University of Rochester
1990 – 1991 New York State Health Research Council Postdoctoral Fellowship for Diabetes Research
1996 – 1999 George W. Corner Dean's Teaching Scholar
1998 Graduate Student Society Faculty Teaching Award
Research
RESEARCH: Neuroinflammation in CNS Injury and Alzheimer's Disease.
Twenty years ago evidence from epidemiological studies and investigations of human brain pathology suggested the hypothesis that innate immune activation of the brain, a term now referred to as neuroinflammation, might contribute to the pathogenesis of Alzheimer's and other brain diseases. Based on our pioneering work in the area of cyclooxygenase-2 and inflammation, we initiated a research program that focuses on understanding the role of neuroinflammation in Alzheimer's and other neurodegenerative diseases. Studies conducted in the laboratory with human brain tissue, neuronal cell culture models and mouse models of acute injury and neurodegeneration have pointed to a prominent role for specific proinflammatory cytokines and bioactive prostaglandins in promoting neuroinflammation. Interestingly, our current work in Alzheimer's disease has revealed a potential protective role for neuroinflammation and has led to a focus on the influence of glial expressed cytokines and infiltrating peripheral cells on brain pathology, utilizing genetic and pharmacological approaches in a variety of mouse models. In complementary work, we also have active preclinical projects in the area of brain radiation injury, a critical problem for individuals receiving radiotherapy for brain tumors or bone marrow transplantation. The main goal is to understand the role of neuroinflammation and oxidative stress in promoting injury and to determine whether therapeutic interventions targeting these processes can alleviate late radiation effects, including cognitive changes
RECENT PUBLICATIONS:
Cherry, J.D., B. Liu, J.L. Frost, C.A. Lemere, J.P. Williams, J.A. Olschowka and M.K. O'Banion. 2012. Galactic cosmic radiation leads to cognitive impairment and increased Ab plaque accumulation in a mouse model of Alzheimer's disease. PLOS ONE 7:e53275. PMCID in process.
Dilmanian, F.A., A.L. Jenkins, J. Olschowka, Z. Zhong, J.Y. Park, N.R. Desnoyers, S. Sobotka, G.R. Fois, C.R. Messina, M. Morales, S.D. Hurley, L.A. Trojanczyk, S. Ahmad, N. Shahrabi, P.K. Coyle, A.G. Meek and M.K. O'Banion. 2012. X-ray microbeam irradiation of the contusion-injured rat spinal cord temporarily improves hind-limb function. Rad. Res. Dec 5 [Epub ahead of print]. PMCID in process.
Wu, M.D., A.M. Hein, M.J. Moravan, S.S. Shaftel, J.A. Olschowka and M.K. O'Banion. 2012. Adult murine hippocampal neurogenesis is inhibited by sustained IL-1? and not rescued by voluntary running. Brain Behav. Immun. 26:292-300. PMCID: PMC3258353
Matousek, S.B., S. Ghosh, S.S. Shaftel, S. Kyrkanides, J.A. Olschowka and M.K. O'Banion. 2012. Chronic IL-1?-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration. J. Neuroimmune Pharmacol. 7:156-164. PMCID: PMC3302720
Hein, A. M., T. J. Zarcone, D. B. Parfitt, S. B. Matousek, D. M. Carbonari, J. A. Olschowka and M. K. O'Banion. 2012. Behavioral, structural and molecular changes following long-term hippocampal IL-1? overexpression in transgenic mice. J. Neuroimmune Pharmacol. 7:145-155. PMCID: PMC3214690
Kyrkanides S., R.H. Tallents, J.N. Miller, M.E. Olschowka, R. Johnson, M. Yang, J.A. Olschowka, S.M. Brouxhon and M.K. O'Banion. 2011. Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice. J. Neuroinflammation 8:112. PMCID: PMC3179730
Moravan, M.J., D.A. Olschowka, J.P. Williams and M.K. O'Banion. 2011. Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain. Radiat. Res. 176:459-473. PMCID: PMC3191189.
Patents
Patent Title: Stably-Transfromed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase
Patent #: 688282
Issue Date: Jul 02, 1998
Country: Australia
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase
Patent #: 1013106
Issue Date: Feb 12, 2000
Country: Hong Kong
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase
Patent #: 0667911
Issue Date: May 06, 1999
Country: Europe
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase
Patent #: LU0667911
Issue Date: May 06, 1999
Country: Luxembourg
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase
Patent #: MC0667911
Issue Date: May 06, 1999
Country: Monaco
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase
Patent #: DK0667911
Issue Date: May 06, 1999
Country: Denmark
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase
Patent #: ES0667911
Issue Date: May 06, 1999
Country: Spain
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase
Patent #: GR0667911
Issue Date: May 06, 1999
Country: Greece
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase
Patent #: IT0667911
Issue Date: May 06, 1999
Country: Italy
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase
Patent #: PT0667911
Issue Date: May 06, 1999
Country: Portugal
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase
Patent #: SE0667911
Issue Date: May 06, 1999
Country: Sweden
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase
Patent #: NL0667911
Issue Date: May 06, 1999
Country: Netherlands
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase
Patent #: 256,776
Issue Date: Feb 20, 1998
Country: New Zealand
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase
Patent #: AT179756
Issue Date: May 06, 1999
Country: Austria
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase
Patent #: CH0667911
Issue Date: May 06, 1999
Country: Switzerland/Liechtenstein
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase
Patent #: FR0667911
Issue Date: May 06, 1999
Country: France
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase
Patent #: GB0667911
Issue Date: May 06, 1999
Country: United Kingdom
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase
Patent #: IE0667911
Issue Date: May 06, 1999
Country: Ireland
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase
Patent #: BE0667911
Issue Date: May 06, 1999
Country: Belgium
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase
Patent #: DE0667911
Issue Date: May 06, 1999
Country: Germany
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion
Patent Title: Screening Assays for Inhibitors of Mammalian Prostaglandin H Synthase-2
Patent #: 5,837,479
Issue Date: Nov 17, 1998
Country: United States
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Mammalian Prostaglandin H Synthase-2
Patent #: 6,048,850
Issue Date: Apr 11, 2000
Country: United States
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
Patent Title: Mammalian Prostaglandin H Synthase-2
Patent #: 5,807,733
Issue Date: Sep 15, 1998
Country: United States
Invented By:
Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young
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Publications
Journal Articles
2/10/2023
Hinshaw RG, Schroeder MK, Ciola J, Varma C, Colletti B, Liu B, Liu GG, Shi Q, Williams JP, O'Banion MK, Caldarone BJ, Lemere CA. "High-Energy, Whole-Body Proton Irradiation Differentially Alters Long-Term Brain Pathology and Behavior Dependent on Sex and Alzheimer's Disease Mutations." International journal of molecular sciences.. 2023 Feb 10; 24(4)Epub 2023 Feb 10.
11/2/2022
Porsteinsson AP, Rangaraju S, Spires-Jones TL, O'Banion MK. "Alzheimer's Disease and Related Dementias: From Risk Factors to Disease Pathogenesis." The European journal of neuroscience.. 2022 Nov 2; Epub 2022 Nov 02.
11/1/2022
Zablotska LB, Zupunski L, Leuraud K, Lopes J, Hinkle J, Pugeda T, Delgado T, Olschowka J, Williams J, O'Banion MK, Boice JD, Cohen SS, Mumma MT, Dauer LT, Britten RA, Stephenson S. "Radiation and CNS effects: Summary of evidence from a recent symposium of the Radiation Research Society." International journal of radiation biology.. 2022 Nov 1; :1-19. Epub 2022 Nov 01.
Books & Chapters
2001
Chapter Title: The cyclooxygenases in neuroinflammation and neurodegeneration: emerging perspectives.
Book Title: Inflammatory Events in Neurodegeneration
Author List: Maida, M. E.; M. K. O'Banion
Edited By: A. Cambell and S. C. Bondy
Published By: Prominent Press 2001 in Scottsdale, AZ.
1999
Chapter Title: Localization and distribution of cyclooxygenase-2 in brain tissue by immunohistochemistry.
Book Title: Eicosanoid Protocols
Author List: O'Banion, M. K.; J. A. Olschowka
Edited By: E. A. Lianos
Published By: Academic Press 1999 in New York
1998
Chapter Title: COX-2 in Alzheimer's disease
Book Title: Clinical Significance and Potential of Selective COX-2 Inhibitors.
Author List: O'Banion, M. K.
Edited By: J. R. Vane and R. M. Botting
Published By: William Harvey Press 1998 in London
VIEW ALL PUBLICATIONS