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Jeffrey J. Hayes, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-4887

Fax: (585) 275-6007

Research Labs

Lab: (585) 275-1706

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Biography

Research

Each eukaryotic cell must execute a complex program of specific gene expression. The DNA of the genome is intimately complexed with proteins into an assembly known as chromatin. Compaction and storage of genomic DNA has long been viewed as the main function of this assembly; however, recent work has demonstrated that in some instances, chromatin structure play an important role in bringing about this pattern of specific expression, and it is likely that the structural elements of chromatin have been integrated into many transcriptional control mechanisms.

The goal of the research in this laboratory is to provide detailed structure information on the protein-DNA interactions and DNA organization within chromatin, and to correlate this information with simple functional assays of the consequences of this organization. Model chromatin complexes will be prepared in vitro and structurally analyzed with chemical approaches. In addition, cloning expression of histone proteins with specific mutations will be useful in the determination of relevant domains within these proteins while facilitating the creation of site-specific probes of protein and DNA structure with chromatin.

Credentials

Faculty Appointments

Education

1983
BS | Bowling Green University
Chemistry

1986
MS | Bowling Green University
Chemistry

1990
PhD | Johns Hopkins University
Chemistry

Publications

Journal Articles

11/14/2017
Gatchalian J, Wang X, Ikebe J, Cox KL, Tencer AH, Zhang Y, Burge NL, Di L, Gibson MD, Musselman CA, Poirier MG, Kono H, Hayes JJ, Kutateladze TG. "Accessibility of the histone H3 tail in the nucleosome for binding of paired readers." Nature communications. 2017 Nov 14; 8(1):1489. Epub 2017 Nov 14.

11/7/2017
Wakabayashi H, Tucker C, Bethlendy G, Kravets A, Welle SL, Bulger M, Hayes JJ, Rustchenko E. "Correction to: NuA4 histone acetyltransferase activity is required for H4 acetylation on a dosage-compensated monosomic chromosome that confers resistance to fungal toxins." Epigenetics & chromatin. 2017 Nov 7; 10(1):52. Epub 2017 Nov 07.

10/23/2017
Wakabayashi H, Tucker C, Bethlendy G, Kravets A, Welle SL, Bulger M, Hayes J, Rustchenko E. "NuA4 histone acetyltransferase activity is required for H4 acetylation on a dosage-compensated monosomic chromosome that confers resistance to fungal toxins." Epigenetics & chromatin. 2017 Oct 23; 10(1):49. Epub 2017 Oct 23.

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