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Edward M. Schwarz, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Research Labs

Faculty Appointments

Biography

Dr. Edward Schwarz is the Burton Professor of Orthopaedics and Director of the Center for Musculoskeletal Research at the University of Rochester Medical Center, in Rochester, NY. His laboratory focuses on inflammatory bone loss, such as that seen in rheumatoid arthritis, infections, tumor metastasis and wear debris-induced osteolysis around loose prosthetic implants.

Dr. Schwarz is also a leader in orthopaedic biologic therapy and stem cell research, for which his lab has developed a novel passive immunization for MRSA and revitalizing allograft approaches for bone and tendon regeneration.

Dr. Schwarz's lab is also interested in developing translational in vivo imaging outcome measures include near infrared imaging of lymphatic flow to detect arthritic flare, and cone beam CT to assess bone healing in patients with orthopaedic implants. More recently, Dr. Schwarz's lab has combined these biologic therapy technologies and outcome measures with biocompatible carriers and stem cells to generate novel tissue engineering constructs for bone, cartilage, ligament and tendon.

Research

Dr. Edward Schwarz is the Burton Professor of Orthopaedics and Director of the Center for Musculoskeletal Research at the University of Rochester Medical Center, in Rochester, NY. His laboratory focuses on inflammatory bone loss, such as that seen in rheumatoid arthritis, infections, tumor metastasis and wear debris-induced osteolysis around loose prosthetic implants.
Dr. Schwarz is also a leader in orthopaedic biologic therapy and stem cell research, for which his lab has developed a novel passive immunization for MRSA and revitalizing allograft approaches for bone and tendon regeneration.

Dr. Schwarz's lab is also interested in developing translational in vivo imaging outcome measures include near infrared imaging of lymphatic flow to detect arthritic flare, and cone beam CT to assess bone healing in patients with orthopaedic implants. More recently, Dr. Schwarz's lab has combined these biologic therapy technologies and outcome measures with biocompatible carriers and stem cells to generate novel tissue engineering constructs for bone, cartilage, ligament and tendon.

Credentials

Education

1988
BS | Worcester Polytech Inst
Biology

1990
MA | Einstein College Medicine
Immunology, All Other

1993
PhD | Einstein College Medicine
Immunology, All Other

Post-doctoral Training & Residency

1993 - 1997
Laboratory of Inder M. Verma, Ph.D., Laboratory of Genetics The Salk Institute, La Jolla, California, Concentrations: Gene Therapy, NFkB Signal, Transduction, Transgenic Mice.

1988 - 1993
Training - Pre-doctoral Fellow, Laboratory of Barry R. Bloom, Ph.D., Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York

1987 - 0
Training - Summer Student - Laboratory of Carl Schildkraut, Ph.D., Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York

1987 - 1988
Training - Undergraduate Research Laboratory of Donald J. Tipper, Ph.D., Department of Microbiology & Molecular Genetics, University of Massachusetts Medical School, Worcester, Massachusetts

1986 - 0
Training - Summer Student - Laboratory of Fritz Herz, Ph.D., Department of Pathology, Montefiore Medical Center, Bronx, New York

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Awards

2007
J.R. Neff Award, Musculoskeletal Research Foundation

2005
Orthopaedic Research Society's Kappa Delta Young Investigator Award

2003
Orthopaedic Research Society's Harris Award

1999
University of Rochester Nominee for the Elison Award.

1999
Sinsheimer Award Nominee
Location: University of Rochester

1999
New Investigator Research Award, The Association of Bone & Joint Surgeons .

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Patents

Patent Title: Ultraviolet Light for Light Activated GeneTransduction in Gene Delivery
Patent #: 1472348
Issue Date: Dec 20, 2006
Country: Europe
Invented By: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Edward M Schwarz

Patent Title: Ultraviolet Light for Light Activated GeneTransduction in Gene Delivery
Patent #: CH1472348
Issue Date: Dec 20, 2006
Country: Switzerland/Liechtenstein
Invented By: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Edward M Schwarz

Patent Title: Targeted Delivery of Therapeutic Agents With Lyophilized Matrices
Patent #: 8,632,797
Issue Date: Jan 21, 2014
Country: United States
Invented By: Hani A Awad, Edward M Schwarz

Patent Title: Passive Immunization for Staphylococcus Infections
Patent #: 6533226
Issue Date: May 31, 2019
Country: Japan
Invented By: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward M Schwarz, John J Varrone

Patent Title: Passive Immunization for Staphylococcus Infections
Patent #: 10,100,127
Issue Date: Oct 16, 2018
Country: United States
Invented By: Sheila Bello-Irizarry, James Brodell, John L Daiss, Edward M Schwarz, John J Varrone

Patent Title: Methods of Diagnosing Erosive Arthritis
Patent #: 1604205
Issue Date: Jan 12, 2011
Country: Europe
Invented By: Sally A Haas, Christopher T Ritchlin, Edward M Schwarz

Patent Title: Methods and Compositions for Treating Inflammatory Conditions
Patent #: 8,580,755
Issue Date: Nov 12, 2013
Country: United States
Invented By: Brendan Boyce, Edward M Schwarz, Lianping Xing

Patent Title: Methods and Compositions Related to Joint Inflammation Diseases
Patent #: FR1604205
Issue Date: Jan 12, 2011
Country: France
Invented By: Sally A Haas, Christopher T Ritchlin, Edward M Schwarz

Patent Title: Methods and Compositions Related to Joint Inflammation Diseases
Patent #: DE1604205
Issue Date: Jan 12, 2011
Country: Germany
Invented By: Sally A Haas, Christopher T Ritchlin, Edward M Schwarz

Patent Title: Methods and Compositions Related to Joint Inflammation Diseases
Patent #: GB1604205
Issue Date: Jan 12, 2011
Country: United Kingdom
Invented By: Sally A Haas, Christopher T Ritchlin, Edward M Schwarz

Patent Title: Methods and Compositions Related to Joint Inflammation Diseases
Patent #: 7,807,389
Issue Date: Oct 05, 2010
Country: United States
Invented By: Sally A Haas, Christopher T Ritchlin, Edward M Schwarz

Patent Title: Method For Introducing An Ultraviolet Light Activated Viral Vector Into The Spinal Column
Patent #: 7,704,272
Issue Date: Apr 27, 2010
Country: United States
Invented By: Paul T Rubery, Edward M Schwarz

Patent Title: Light Probe for Ultraviolet Light Activated Gene Transduction
Patent #: 2004209919
Issue Date: Apr 17, 2008
Country: Australia
Invented By: Thomas H Foster, Michael Maloney, Paul T Rubery, Edward M Schwarz

Patent Title: Light Activated Gene Transduction Using Ultraviolet Light for Cell Targeted Gene Delivery
Patent #: 1867715
Issue Date: Mar 18, 2009
Country: Europe
Invented By: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Edward M Schwarz

Patent Title: Light Activated Gene Transduction Using Ultraviolet Light for Cell Targeted Gene Delivery
Patent #: 2003210820
Issue Date: Apr 03, 2008
Country: Australia
Invented By: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Edward M Schwarz

Patent Title: Light Activated Gene Transduction Using Long Wavelength Ultraviolet Light for Cell Targeted Gene Delivery
Patent #: 7,524,327
Issue Date: Apr 28, 2009
Country: United States
Invented By: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Edward M Schwarz

Patent Title: Light Activated Gene Transduction (LAGeT) for Cell Targeted Gene Delivery
Patent #: CH1867715
Issue Date: Mar 18, 2009
Country: Switzerland/Liechtenstein
Invented By: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Paul T Rubery, Edward M Schwarz

Patent Title: Light Activated Gene Transduction (LAGeT) for Cell Targeted Gene Delivery
Patent #: GB1867715
Issue Date: Mar 18, 2009
Country: United Kingdom
Invented By: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Paul T Rubery, Edward M Schwarz

Patent Title: Light Activated Gene Transduction (LAGeT) for Cell Targeted Gene Delivery
Patent #: DE1867715
Issue Date: Mar 18, 2009
Country: Germany
Invented By: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Paul T Rubery, Edward M Schwarz

Patent Title: Light Activated Gene Transduction (LAGeT) for Cell Targeted Gene Delivery
Patent #: IT1867715
Issue Date: Mar 18, 2009
Country: Italy
Invented By: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Paul T Rubery, Edward M Schwarz

Patent Title: Light Activated Gene Transduction (LAGeT) for Cell Targeted Gene Delivery
Patent #: FR1867715
Issue Date: Mar 18, 2009
Country: France
Invented By: Jarod C Finlay, Thomas H Foster, Regis O'Keefe, Paul T Rubery, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: 9,988,448
Issue Date: Jun 05, 2018
Country: United States
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: 2,760,330
Issue Date: Jul 25, 2017
Country: Canada
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: 2424892
Issue Date: Jun 07, 2017
Country: Europe
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: FR2424892
Issue Date: Jun 07, 2017
Country: France
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: 602010042851.6
Issue Date: Jun 07, 2017
Country: Germany
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: IT2424892
Issue Date: Jun 07, 2017
Country: Italy
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: ES2424892
Issue Date: Jun 07, 2017
Country: Spain
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: GB2424892
Issue Date: Jun 07, 2017
Country: United Kingdom
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: DC-STAMP Antibodies
Patent #: 9,018,358
Issue Date: Apr 28, 2015
Country: United States
Invented By: Yahui Grace Chiu, Kofi A Mensah, Christopher T Ritchlin, Edward M Schwarz

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 2785376
Issue Date: Sep 18, 2019
Country: Europe
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: FR2785376
Issue Date: Sep 18, 2019
Country: France
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: DE2785376
Issue Date: Sep 18, 2019
Country: Germany
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: GB2785376
Issue Date: Sep 18, 2019
Country: United Kingdom
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 6580649
Issue Date: Sep 06, 2019
Country: Japan
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 6559302
Issue Date: Jul 26, 2019
Country: Japan
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 2017201748
Issue Date: May 30, 2019
Country: Australia
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 10,179,170
Issue Date: Jan 15, 2019
Country: United States
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 10,112,986
Issue Date: Oct 30, 2018
Country: United States
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 6360938
Issue Date: Jun 29, 2018
Country: Japan
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 6227092
Issue Date: Oct 20, 2017
Country: Japan
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 9,758,572
Issue Date: Sep 12, 2017
Country: United States
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 9,737,601
Issue Date: Aug 22, 2017
Country: United States
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 6120924
Issue Date: Apr 07, 2017
Country: Japan
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 2015224393
Issue Date: Mar 30, 2017
Country: Australia
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 6038777
Issue Date: Nov 11, 2016
Country: Japan
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 9,487,577
Issue Date: Nov 08, 2016
Country: United States
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 2566891
Issue Date: Nov 02, 2016
Country: Europe
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: BE2566891
Issue Date: Nov 02, 2016
Country: Belgium
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: FR2566891
Issue Date: Nov 02, 2016
Country: France
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 602011031979.5
Issue Date: Nov 02, 2016
Country: Germany
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 502017000008079
Issue Date: Nov 02, 2016
Country: Italy
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: NL2566891
Issue Date: Nov 02, 2016
Country: Netherlands
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 2566891
Issue Date: Nov 02, 2016
Country: Spain
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: CH2566891
Issue Date: Nov 02, 2016
Country: Switzerland/Liechtenstein
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 2017/01247
Issue Date: Nov 02, 2016
Country: Turkey
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: GB2566891
Issue Date: Nov 02, 2016
Country: United Kingdom
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 2011248209
Issue Date: Jun 30, 2016
Country: Australia
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 2012332777
Issue Date: Dec 17, 2015
Country: Australia
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 2,853,943
Issue Date: Dec 08, 2015
Country: Canada
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

Patent Title: Anti-Glucosaminidase Passive Immunization for Staphylococcus Aureus Infections
Patent #: 5837215
Issue Date: Nov 13, 2015
Country: Japan
Invented By: John L Daiss, Edward M Schwarz, Mark A Sullivan

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Publications

Journal Articles

9/2019
Wu EK, Eliseeva S, Rahimi H, Schwarz EM, Georas SN. "Restrictive lung disease in TNF-transgenic mice: correlation of pulmonary function testing and micro-CT imaging." Experimental lung research.. 2019 Sep 0; 45(7):175-187. Epub 2019 Jul 18.

6/27/2019
Trombetta RP, de Mesy Bentley KL, Schwarz EM, Kate SL, Awad HA. "A murine femoral ostectomy model with hardware exchange to assess antibiotic-impregnated spacers for implant-associated osteomyelitis." European cells & materials. 2019 Jun 27; 37:431-443. Epub 2019 Jun 27.

6/24/2019
Masters EA, Salminen AT, Begolo S, Luke EN, Barrett SC, Overby CT, Gill AL, de Mesy Bentley KL, Awad HA, Gill SR, Schwarz EM, McGrath JL. "An in vitro platform for elucidating the molecular genetics of S. aureus invasion of the osteocyte lacuno-canalicular network during chronic osteomyelitis." Nanomedicine : nanotechnology, biology, and medicine.. 2019 Jun 24; :102039. Epub 2019 Jun 24.

Books & Chapters

2003
Chapter Title: Signal Transduction in Rheumatic Diseases
Book Title: Kelley's Textbook of Rheumatology
Author List: Schwarz, E.M.
Published By: W.B. Saunders Company 2003

2003
Chapter Title: Biologic Agents as Antiresorptive Therapy
Book Title: Molecular Biology in Orthopaedics
Author List: Schwarz, E.M.
Edited By: Rosier, R.N. & Evans, C.H.
Published By: American Academy of Orthopaedic Surgeons: 241 2003

2001
Book Title: Implant Wear in Total Joint Replacement
Author List: Wright. T.M. Goodman, S.B., Schwarz, E.M.
Published By: American Academy of Orthopaedic Surgeons 2001

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