Publications
Showing all 325 journal articles & 5 books available
Journal Articles
3/27/2023
Ren Y, Zhang S, Weeks J, Rangel-Moreno J, He B, Xue T, Rainbolt J, Morita Y, Shu Y, Liu Y, Kates SL, Schwarz EM, Xie C. "Reduced Angiogenesis and Delayed Endochondral Ossification in CD163-/- Mice Highlights a Role of M2 Macrophages During Bone Fracture Repair." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2023 Mar 27; Epub 2023 Mar 27.
3/14/2023
Zhang H, Liesveld JL, Calvi LM, Lipe BC, Xing L, Becker MW, Schwarz EM, Yeh SA. "The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies." Bone research.. 2023 Mar 14; 11(1):15. Epub 2023 Mar 14.
2/20/2023
Kenney HM, Dieudonne G, Yee S, Maki JH, Wood RW, Schwarz EM, Ritchlin CT, Rahimi H. "Near-Infrared Imaging of Indocyanine Green Identifies Novel Routes of Lymphatic Drainage from Metacarpophalangeal Joints in Healthy Human Hands." Lymphatic research and biology.. 2023 Feb 20; Epub 2023 Feb 20.
2/2/2023
Kenney HM, Wood RW, Ramirez G, Bell RD, Chen KL, Schnur L, Rahimi H, Korman BD, Xing L, Ritchlin CT, Schwarz EM, Cole CL. "Implementation of automated behavior metrics to evaluate voluntary wheel running effects on inflammatory-erosive arthritis and interstitial lung disease in TNF-Tg mice." Arthritis research & therapy.. 2023 Feb 2; 25(1):17. Epub 2023 Feb 02.
1/27/2023
Kenney HM, Peng Y, de Mesy Bentley KL, Xing L, Ritchlin CT, Schwarz EM. "The Enigmas of Lymphatic Muscle Cells: Where Do They Come From, How Are They Maintained, and Can They Regenerate?" Current rheumatology reviews.. 2023 Jan 27; Epub 2023 Jan 27.
1/10/2023
Lin X, Bell RD, Catheline SE, Takano T, McDavid A, Jonason JH, Schwarz EM, Xing L. "Targeting synovial lymphatic function as a novel therapeutic intervention for age-related osteoarthritis in mice." Arthritis & rheumatology.. 2023 Jan 10; Epub 2023 Jan 10.
10/20/2022
Moriarty TF, Metsemakers WJ, Morgenstern M, Hofstee MI, Vallejo Diaz A, Cassat JE, Wildemann B, Depypere M, Schwarz EM, Richards RG. "Fracture-related infection." Nature reviews. Disease primers.. 2022 Oct 20; 8(1):67. Epub 2022 Oct 20.
10/4/2022
Young M, Walsh DJ, Masters E, Gondil VS, Laskey E, Klaczko M, Awad H, McGrath J, Schwarz EM, Melander C, Dunman PM. "Identification of Penicillin Binding Protein 4 (PBP4) Inhibitors." Antibiotics.. 2022 Oct 4; 11(10)Epub 2022 Oct 04.
9/7/2022
Siegel RJ, Singh AK, Panipinto PM, Shaikh FS, Vinh J, Han SU, Kenney HM, Schwarz EM, Crowson CS, Khuder SA, Khuder BS, Fox DA, Ahmed S. "Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF-?-induced inflammatory activation of synovial fibroblasts." Cellular & molecular immunology.. 2022 Sep 7; Epub 2022 Sep 07.
8/26/2022
Morita Y, Saito M, Rangel-Moreno J, Franchini AM, Owen JR, Martinez JC, Daiss JL, de Mesy Bentley KL, Kates SL, Schwarz EM, Muthukrishnan G. "Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation." Bone research.. 2022 Aug 26; 10(1):56. Epub 2022 Aug 26.
7/26/2022
Kenney HM, Peng Y, Bell RD, Wood RW, Xing L, Ritchlin CT, Schwarz EM. "Persistent popliteal lymphatic muscle cell coverage defects despite amelioration of arthritis and recovery of popliteal lymphatic vessel function in TNF-Tg mice following anti-TNF therapy." Scientific reports.. 2022 Jul 26; 12(1):12751. Epub 2022 Jul 26.
6/2022
Kenney HM, Peng Y, Chen KL, Ajalik R, Schnur L, Wood RW, Schwarz EM, Awad HA. "A high-throughput semi-automated bone segmentation workflow for murine hindpaw micro-CT datasets." Bone reports.. 2022 Jun; 16:101167. Epub 2022 Jan 20.
5/4/2022
Kong P, Ren Y, Yang J, Fu W, Liu Z, Li Z, He W, Wang Y, Zheng Z, Ding M, Schwarz EM, Deng Z, Xie C. "Relapsed boyhood tibia polymicrobial osteomyelitis linked to dermatophytosis: a case report." BMC surgery.. 2022 May 4; 22(1):156. Epub 2022 May 04.
4/18/2022
Schwarz EM. "What are the immune responses that allow us to live with incurable bone infection, and how can they be augmented to improve outcomes following prosthetic joint infection?" Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2022 Apr 18; Epub 2022 Apr 18.
3/7/2022
Kenney HM, Wu CL, Loiselle AE, Xing L, Ritchlin CT, Schwarz EM. "Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model." Arthritis research & therapy.. 2022 Mar 7; 24(1):64. Epub 2022 Mar 07.
3/5/2022
Cohn-Schwartz D, Schary Y, Yalon E, Krut Z, Da X, Schwarz EM, Gazit D, Pelled G, Gazit Z. "PTH-Induced Bone Regeneration and Vascular Modulation Are Both Dependent on Endothelial Signaling." Cells.. 2022 Mar 5; 11(5)Epub 2022 Mar 05.
2/15/2022
Masters EA, Ricciardi BF, Bentley KLM, Moriarty TF, Schwarz EM, Muthukrishnan G. "Skeletal infections: microbial pathogenesis, immunity and clinical management." Nature reviews. Microbiology.. 2022 Feb 15; Epub 2022 Feb 15.
2022
Ren Y, Xue T, Rainbolt J, Bentley KLM, Galloway CA, Liu Y, Cherian P, Neighbors J, Hofstee MI, Ebetino FH, Moriarty TF, Sun S, Schwarz EM, Xie C. "Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of Osteomyelitis: Evidence of "Target & Release" Kinetics and Killing of Bacteria Within Canaliculi." Frontiers in cellular and infection microbiology.. 2022 12:910970. Epub 2022 Jun 24.
2022
Sherchand SP, Adhikari RP, Muthukrishnan G, Kanipakala T, Owen JR, Xie C, Aman MJ, Proctor RA, Schwarz EM, Kates SL. "Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With Osteomyelitis and Their Association With Clinical Outcome Following Surgery in a Clinical Pilot." Frontiers in cellular and infection microbiology.. 2022 12:876898. Epub 2022 Jul 18.
2022
Garcia-Hernandez ML, Rangel-Moreno J, Garcia-Castaneda M, Kenney HM, Paine A, Thullen M, Anandarajah AP, Schwarz EM, Dirksen RT, Ritchlin CT. "Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis." Frontiers in immunology.. 2022 13:1026574. Epub 2022 Nov 07.
11/11/2021
Sutipornpalangkul W, Nishitani K, Schwarz EM. "Quantitative flow chamber system for evaluating in vitro biofilms and the kinetics of S. aureus biofilm formation in human plasma media." BMC microbiology.. 2021 Nov 11; 21(1):314. Epub 2021 Nov 11.
6/17/2021
Adjei-Sowah E, Peng Y, Weeks J, Jonason JH, de Mesy Bentley KL, Masters E, Morita Y, Muthukrishnan G, Cherian P, Hu XE, McKenna CE, Ebetino FH, Sun S, Schwarz EM, Xie C. "Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid." Antibiotics.. 2021 Jun 17; 10(6)Epub 2021 Jun 17.
5/7/2021
Cole CL, Bachman JF, Ye J, Murphy J, Gerber SA, Beck CA, Boyce BF, Muthukrishnan G, Chakkalakal JV, Schwarz EM, Linehan D. "Increased myocellular lipid and IGFBP-3 expression in a pre-clinical model of pancreatic cancer-related skeletal muscle wasting." Journal of cachexia, sarcopenia and muscle.. 2021 May 7; Epub 2021 May 07.
2/19/2021
Liang Q, Zhang L, Xu H, Li J, Chen Y, Schwarz EM, Shi Q, Wang Y, Xing L. "Lymphatic muscle cells contribute to dysfunction of the synovial lymphatic system in inflammatory arthritis in mice." Arthritis research & therapy.. 2021 Feb 19; 23(1):58. Epub 2021 Feb 19.
1/17/2021
Schwarz EM, Arts JJC, Chen AF. "Introduction for the Journal of Orthopaedic Research Special Issue on musculoskeletal infection." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2021 Jan 17; Epub 2021 Jan 17.
2021
Muthukrishnan G, Wallimann A, Rangel-Moreno J, Bentley KLM, Hildebrand M, Mys K, Kenney HM, Sumrall ET, Daiss JL, Zeiter S, Richards RG, Schwarz EM, Moriarty TF. "Humanized Mice Exhibit Exacerbated Abscess Formation and Osteolysis During the Establishment of Implant-Associated Osteomyelitis." Frontiers in immunology.. 2021 12:651515. Epub 2021 Mar 18.
2021
Morita Y, Masters EA, Schwarz EM, Muthukrishnan G. "Interleukin-27 and Its Diverse Effects on Bacterial Infections." Frontiers in immunology.. 2021 12:678515. Epub 2021 May 17.
2021
Masters EA, Muthukrishnan G, Ho L, Gill AL, de Mesy Bentley KL, Galloway CA, McGrath JL, Awad HA, Gill SR, Schwarz EM. "Cell Wall Biosynthesis Modulates Bone Invasion and Osteomyelitis Pathogenesis." Frontiers in microbiology.. 2021 12:723498. Epub 2021 Aug 16.
2021
Scallan JP, Bouta EM, Rahimi H, Kenney HM, Ritchlin CT, Davis MJ, Schwarz EM. "Demonstration of Functional Deficiencies in Popliteal Lymphatic Vessels From TNF-Transgenic Mice With Inflammatory Arthritis." Frontiers in physiology.. 2021 12:745096. Epub 2021 Sep 27.
12/30/2020
de Mesy Bentley KL, Galloway CA, Muthukrishnan G, Echternacht SR, Masters EA, Zeiter S, Schwarz EM, Leckenby JI. "Emerging Electron Microscopy and 3D Methodologies to Interrogate Staphylococcus aureus Osteomyelitis in Murine Models." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 Dec 30; Epub 2020 Dec 30.
12/18/2020
Masters EA, Hao SP, Mark Kenney H, Morita Y, Galloway CA, de Mesy Bentley KL, Ricciardi BF, Boyce BF, Schwarz EM, Oh I. "Distinct Vasculotropic vs. Osteotropic Features of S. agalactiae vs. S. aureus Implant-Associated Bone Infection in Mice." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 Dec 18; Epub 2020 Dec 18.
12/4/2020
Sulovari A, Ninomiya MJ, Beck CA, Ricciardi BF, Ketonis C, Mesfin A, Kaplan NB, Soin SP, McDowell SM, Mahmood B, Daiss JL, Schwarz EM, Oh I. "Clinical Utilization of Species-Specific Immunoassays for Identification of S. aureus and Streptococcus agalactiae in Orthopaedic Infections." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 Dec 4; Epub 2020 Dec 04.
12/2/2020
Metsemakers WJ, Zalavras C, Schwarz EM, Chen AF, Trampuz A, Moriarty TF. "Antimicrobial Resistance, the COVID-19 Pandemic, and Lessons for the Orthopaedic Community." The Journal of bone and joint surgery. American volume.. 2020 Dec 2; Epub 2020 Dec 02.
11/9/2020
Hao SP, Masters EA, Ninomiya MJ, Beck CA, Schwarz EM, Daiss JL, Oh I. "Species-Specific Immunoassay Aids Identification of Pathogen and Tracks Infectivity in Foot Infection." Foot & ankle international.. 2020 Nov 9; :1071100720965136. Epub 2020 Nov 09.
10/22/2020
Masters EA, de Mesy Bentley KL, Gill AL, Hao SP, Galloway CA, Salminen AT, Guy DR, McGrath JL, Awad HA, Gill SR, Schwarz EM. "Identification of Penicillin Binding Protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice." PLoS pathogens.. 2020 Oct 22; 16(10):e1008988. Epub 2020 Oct 22.
10/22/2020
Kenney HM, Bell RD, Masters EA, Xing L, Ritchlin CT, Schwarz EM. "Lineage tracing reveals evidence of a popliteal lymphatic muscle progenitor cell that is distinct from skeletal and vascular muscle progenitors." Scientific reports.. 2020 Oct 22; 10(1):18088. Epub 2020 Oct 22.
10/2/2020
Nishitani K, Ishikawa M, Morita Y, Yokogawa N, Xie C, de Mesy Bentley KL, Ito H, Kates SL, Daiss JL, Schwarz EM. "IsdB antibody-mediated sepsis following S. aureus surgical site infection." JCI insight.. 2020 Oct 2; 5(19)Epub 2020 Oct 02.
8/27/2020
Kates SL, Owen JR, Beck CA, Xie C, Muthukrishnan G, Daiss JL, Schwarz EM. "Lack of Humoral Immunity Against Glucosaminidase Is Associated with Postoperative Complications in Staphylococcus aureus Osteomyelitis." The Journal of bone and joint surgery. American volume.. 2020 Aug 27; Epub 2020 Aug 27.
6/22/2020
Muthukrishnan G, Soin S, Beck CA, Grier A, Brodell JD, Lee CC, Ackert-Bicknell CL, Lee FE, Schwarz EM, Daiss JL. "A Bioinformatic Approach to Utilize a Patient's Antibody-Secreting Cells against to Detect Challenging Musculoskeletal Infections." ImmunoHorizons.. 2020 Jun 22; 4(6):339-351. Epub 2020 Jun 22.
6/1/2020
Pelled G, Lieber R, Avalos P, Cohn-Yakubovich D, Tawackoli W, Roth J, Knapp E, Schwarz EM, Awad HA, Gazit D, Gazit Z. "Teriparatide (rPTH1-34) enhances bone allograft integration in a clinically relevant pig model of segmental mandibulectomy." Journal of tissue engineering and regenerative medicine.. 2020 Jun 1; Epub 2020 Jun 01.
6/2020
Schwarz EM. "CORR Insights®: Does the Alpha Defensin ELISA Test Perform Better Than the Alpha Defensin Lateral Flow Test for PJI Diagnosis? A Systematic Review and Meta-analysis of Prospective Studies." Clinical orthopaedics and related research.. 2020 Jun; 478(6):1345-1347.
5/18/2020
Bell RD, Rahimi H, Kenney HM, Lieberman AA, Wood RW, Schwarz EM, Ritchlin CT. "Altered Lymphatic Vessel Anatomy and Markedly Diminished Lymph Clearance in the Rheumatoid Hand with Active Arthritis." Arthritis & rheumatology.. 2020 May 18; Epub 2020 May 18.
5/10/2020
Bell RD, White RJ, Garcia-Hernandez ML, Wu E, Rahimi H, Marangoni RG, Slattery P, Duemmel S, Nuzzo M, Huertas N, Yee M, O'Reilly MA, Morrell C, Ritchlin CT, Schwarz EM, Korman BD. "TNF Induces Obliterative Pulmonary Vascular Disease in a Novel Model of Connective Tissue Disease Associated Pulmonary Arterial Hypertension (CTD-PAH)." Arthritis & rheumatology.. 2020 May 10; Epub 2020 May 10.
5/2020
Anderson DE, Kuhns BD, Kaupp S, Schwarz EM, Rubery PT, Mannava S. "Lack of Additional Advanced Graduate Training by Orthopaedic Surgeons in Academic Practice: Current Employment and Recruitment Trends." Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews.. 2020 May; 4(5):e2000003.
4/7/2020
Saeed K, Sendi P, Arnold WV, Bauer TW, Coraça-Huber DC, Chen AF, Choe H, Daiss JL, Ghert M, Hickok NJ, Nishitani K, Springer BD, Stoodley P, Sculco TP, Brause BD, Parvizi J, McLaren AC, Schwarz EM. "Bacterial toxins in musculoskeletal infections." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 Apr 7; Epub 2020 Apr 07.
3/2020
O'Keefe RJ, Tuan RS, Lane NE, Awad HA, Barry F, Bunnell BA, Colnot C, Drake MT, Drissi H, Dyment NA, Fortier LA, Guldberg RE, Kandel R, Little DG, Marshall MF, Mao JJ, Nakamura N, Proffen BL, Rodeo SA, Rosen V, Thomopoulos S, Schwarz EM, Serra R. "American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies - Secondary Publication." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 Mar; 38(3):485-502. Epub 2020 Jan 29.
1/31/2020
Lee CC, Southgate RD, Jiao C, Gersz E, Owen JR, Kates SL, Beck CA, Xie C, Daiss JL, Post V, Moriarty TF, Zeiter S, Schwarz EM, Muthukrishnan G. "Deriving a dose and regimen for anti-glucosaminidase antibody passive-immunisation for patients with Staphylococcus aureus osteomyelitis." European cells & materials.. 2020 Jan 31; 39:96-107. Epub 2020 Jan 31.
1/30/2020
Schwarz EM, McLaren AC, Sculco TP, Brause B, Bostrom M, Kates SL, Parvizi J, Alt V, Arnold WV, Carli A, Chen AF, Choe H, Coraça-Huber DC, Cross M, Ghert M, Hickok N, Jennings JA, Joshi M, Metsemakers WJ, Ninomiya M, Nishitani K, Oh I, Padgett D, Ricciardi B, Saeed K, Sendi P, Springer B, Stoodley P, Wenke JC. "Adjuvant antibiotic-loaded bone cement: Concerns with current use and research to make it work." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 Jan 30; Epub 2020 Jan 30.
1/22/2020
Ricciardi BF, Muthukrishnan G, Masters EA, Kaplan N, Daiss JL, Schwarz EM. "New Developments and Future Challenges in Prevention, Diagnosis, and Treatment of Prosthetic Joint Infection." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 Jan 22; Epub 2020 Jan 22.
2020
Cole CL, Beck CA, Robinson D, Ye J, Mills B, Gerber SA, Schwarz EM, Linehan D. "Dual Energy X-ray Absorptiometry (DEXA) as a longitudinal outcome measure of cancer-related muscle wasting in mice." PloS one.. 2020 15(6):e0230695. Epub 2020 Jun 19.
2020
Cole CL, Vasalos K, Nicandri G, Apt C, Osterling E, Ferrara Z, Maloney MD, Schwarz EM, Rizzone K. "Use of Fitbit Data to Evaluate the Effects of an Athletic Performance and Injury Prevention Training Program on Daily Physical Levels in Underrepresented Minority Female High School Athletes: A Prospective Study." Orthopedics and sports medicine : open access journal.. 2020 4(2):370-376. Epub 2020 Jul 10.
11/14/2019
Bell RD, Slattery PN, Wu EK, Xing L, Ritchlin CT, Schwarz EM. "iNOS dependent and independent phases of lymph node expansion in mice with TNF-induced inflammatory-erosive arthritis." Arthritis research & therapy.. 2019 Nov 14; 21(1):240. Epub 2019 Nov 14.
11/13/2019
Muthukrishnan G, Masters EA, Daiss JL, Schwarz EM. "Mechanisms of Immune Evasion and Bone Tissue Colonization That Make Staphylococcus aureus the Primary Pathogen in Osteomyelitis." Current osteoporosis reports.. 2019 Nov 13; Epub 2019 Nov 13.
11/6/2019
Tomizawa T, Ishikawa M, Bello-Irizarry SN, de Mesy Bentley KL, Ito H, Kates SL, Daiss JL, Beck C, Matsuda S, Schwarz EM, Nishitani K. "Biofilm producing Staphylococcus epidermidis (RP62A strain) inhibits osseous integration without osteolysis and histopathology in a murine septic implant model." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 Nov 6; Epub 2019 Nov 06.
10/28/2019
Wu EK, Henkes ZI, McGowan B, Bell RD, Velez MJ, Livingstone AM, Ritchlin CT, Schwarz EM, Rahimi H. "TNF-Induced Interstitial Lung Disease in a Murine Arthritis Model: Accumulation of Activated Monocytes, Conventional Dendritic Cells, and CD21/CD23 B Cell Follicles Is Prevented with Anti-TNF Therapy." The Journal of immunology : official journal of the American Association of Immunologists.. 2019 Oct 28; Epub 2019 Oct 28.
9/23/2019
O'Keefe RJ, Tuan RS, Lane NE, Barry F, Bunnell BA, Colnot C, Drake MT, Drissi H, Fortier LA, Guldberg RE, Little DG, Marshall MF, Mao JJ, Nakamura N, Robey PG, Rosen V, Rowe DW, Schwarz EM. "American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2019 Sep 23; Epub 2019 Sep 23.
9/17/2019
Liang Q, Zhang L, Wood RW, Ji RC, Boyce BF, Schwarz EM, Wang Y, Xing L. "RelB regulates lymphatic endothelial cells during vessel maturation and is required for lymphatic vessel function in adult mice." The American journal of pathology.. 2019 Sep 17; Epub 2019 Sep 17.
9/2019
Wu EK, Eliseeva S, Rahimi H, Schwarz EM, Georas SN. "Restrictive lung disease in TNF-transgenic mice: correlation of pulmonary function testing and micro-CT imaging." Experimental lung research.. 2019 Sep; 45(7):175-187. Epub 2019 Jul 18.
7/2019
MacDonald A, Brodell JD, Daiss JL, Schwarz EM, Oh I. "Evidence of differential microbiomes in healing versus non-healing diabetic foot ulcers prior to and following foot salvage therapy." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 Jul; 37(7):1596-1603. Epub 2019 Mar 28.
6/27/2019
Trombetta RP, de Mesy Bentley KL, Schwarz EM, Kate SL, Awad HA. "A murine femoral ostectomy model with hardware exchange to assess antibiotic-impregnated spacers for implant-associated osteomyelitis." European cells & materials.. 2019 Jun 27; 37:431-443. Epub 2019 Jun 27.
6/24/2019
Masters EA, Salminen AT, Begolo S, Luke EN, Barrett SC, Overby CT, Gill AL, de Mesy Bentley KL, Awad HA, Gill SR, Schwarz EM, McGrath JL. "An in vitro platform for elucidating the molecular genetics of S. aureus invasion of the osteocyte lacuno-canalicular network during chronic osteomyelitis." Nanomedicine : nanotechnology, biology, and medicine.. 2019 Jun 24; :102039. Epub 2019 Jun 24.
5/20/2019
Kiontke KC, Herrera RA, Vuong E, Luo J, Schwarz EM, Fitch DHA, Portman DS. "The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28." Developmental cell.. 2019 May 20; 49(4):542-555.e9. Epub 2019 Apr 04.
4/12/2019
Schwarz EM, Parvizi J, Gehrke T, Aiyer A, Battenberg A, Brown SA, Callaghan JJ, Citak M, Egol K, Garrigues GE, Ghert M, Goswami K, Green A, Hammoud S, Kates SL, McLaren AC, Mont MA, Namdari S, Obremskey WT, O'Toole R, Raikin S, Restrepo C, Ricciardi B, Saeed K, Sanchez-Sotelo J, Shohat N, Tan T, Thirukumaran CP, Winters B. "The 2018 International Consensus Meeting on Musculoskeletal Infection: Research Priorities from the General Assembly Questions." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 Apr 12; Epub 2019 Apr 12.
4/10/2019
Bell DR, Wu E, Rudmann C, Forney M, Kaiser C, Wood R, Chakkalakal J, Paris N, Klose A, Xiao GQ, Rangel-Moreno J, Garcia-Hernandez M, Ritchlin C, Schwarz E, Rahimi H. "Selective sexual dimorphism in musculoskeletal-cardiopulmonary pathologies and mortality in the TNF-transgenic mouse model of rheumatoid arthritis." Arthritis & rheumatology.. 2019 Apr 10; Epub 2019 Apr 10.
2/22/2019
Trombetta RP, Ninomiya MJ, El-Atawneh IM, Knapp EK, de Mesy Bentley KL, Dunman PM, Schwarz EM, Kates SL, Awad HA. "Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis." Pharmaceutics.. 2019 Feb 22; 11(2)Epub 2019 Feb 22.
1/22/2019
Saeed K, McLaren AC, Schwarz EM, Antoci V, Arnold WV, Chen AF, Clauss M, Esteban J, Gant V, Hendershot E, Hickok N, Higuera CA, Coraça-Huber DC, Choe H, Jennings JA, Joshi M, Li WT, Noble PC, Phillips KS, Pottinger PS, Restrepo C, Rohde H, Schaer TP, Shen H, Smeltzer M, Stoodley P, Webb JCJ, Witsø E. "2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 Jan 22; Epub 2019 Jan 22.
1/15/2019
Wu EK, Ambrosini RD, Kottmann RM, Ritchlin CT, Schwarz EM, Rahimi H. "Reinterpreting Evidence of Rheumatoid Arthritis-Associated Interstitial Lung Disease to Understand Etiology." Current rheumatology reviews.. 2019 Jan 15; Epub 2019 Jan 15.
2019
Masters EA, Trombetta RP, de Mesy Bentley KL, Boyce BF, Gill AL, Gill SR, Nishitani K, Ishikawa M, Morita Y, Ito H, Bello-Irizarry SN, Ninomiya M, Brodell JD, Lee CC, Hao SP, Oh I, Xie C, Awad HA, Daiss JL, Owen JR, Kates SL, Schwarz EM, Muthukrishnan G. "Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy"." Bone research.. 2019 7:20. Epub 2019 Jul 15.
2019
Cole CL, Vasalos K, Nicandri G, Apt C, Osterling E, Ferrara Z, Maloney MD, Schwarz EM, Rizzone K. "Use of PROMIS and Functional Movement System (FMS) Testing to Evaluate the Effects of Athletic Performance and Injury Prevention Training in Female High School Athletes." Orthopedics and sports medicine : open access journal.. 2019 3(2):255-258. Epub 2019 Dec 18.
12/2018
Oh I, Muthukrishnan G, Ninomiya MJ, Brodell JD, Smith BL, Lee CC, Gill SR, Beck CA, Schwarz EM, Daiss JL. "Tracking Anti- Antibodies Produced and during Foot Salvage Therapy for Diabetic Foot Infections Reveals Prognostic Insights and Evidence of Diversified Humoral Immunity." Infection and immunity.. 2018 Dec; 86(12)Epub 2018 Nov 20.
10/31/2018
Trombetta RP, Dunman PM, Schwarz EM, Kates SL, Awad HA. "A High-Throughput Screening Approach To Repurpose FDA-Approved Drugs for Bactericidal Applications against Staphylococcus aureus Small-Colony Variants." mSphere.. 2018 Oct 31; 3(5)Epub 2018 Oct 31.
8/25/2018
Wang W, Lin X, Xu H, Sun W, Bouta EM, Zuscik MJ, Chen D, Schwarz EM, Xing L. "Bortezomib Attenuates Joint Tissue Damage in a Mouse Model of Experimental Post-Traumatic Osteoarthritis, which is Associated with Improved Synovial Lymphatic Function." Arthritis & rheumatology.. 2018 Aug 25; Epub 2018 Aug 25.
7/15/2018
Farnsworth CW, Schott EM, Benvie A, Kates SL, Schwarz EM, Gill SR, Zuscik MJ, Mooney RA. "Exacerbated Foot Infections in Obese/Diabetic Mice Are Associated with Impaired Germinal Center Reactions, Ig Class Switching, and Humoral Immunity." The Journal of immunology : official journal of the American Association of Immunologists.. 2018 Jul 15; 201(2):560-572. Epub 2018 Jun 01.
7/9/2018
Ricciardi BF, Muthukrishnan G, Masters E, Ninomiya M, Lee CC, Schwarz EM. "Staphylococcus aureus Evasion of Host Immunity in the Setting of Prosthetic Joint Infection: Biofilm and Beyond." Current reviews in musculoskeletal medicine.. 2018 Jul 9; Epub 2018 Jul 09.
6/2018
Farnsworth CW, Schott EM, Benvie AM, Zukoski J, Kates SL, Schwarz EM, Gill SR, Zuscik MJ, Mooney RA. "Obesity/type 2 diabetes increases inflammation, periosteal reactive bone formation, and osteolysis during Staphylococcus aureus implant-associated bone infection." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2018 Jun; 36(6):1614-1623. Epub 2018 Jan 03.
6/2018
Yokogawa N, Ishikawa M, Nishitani K, Beck CA, Tsuchiya H, Mesfin A, Kates SL, Daiss JL, Xie C, Schwarz EM. "Immunotherapy synergizes with debridement and antibiotic therapy in a murine 1-stage exchange model of MRSA implant-associated osteomyelitis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2018 Jun; 36(6):1590-1598. Epub 2018 Feb 05.
5/2018
Yukata K, Xie C, Li TF, Brown ML, Kanchiku T, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. "Teriparatide (human PTH) compensates for impaired fracture healing in COX-2 deficient mice." Bone.. 2018 May; 110:150-159. Epub 2018 Feb 03.
3/2018
Chen X, Wang Z, Duan N, Zhu G, Schwarz EM, Xie C. "Osteoblast-osteoclast interactions." Connective tissue research.. 2018 Mar; 59(2):99-107. Epub 2017 Mar 21.
2/2018
Bouta EM, Bell RD, Rahimi H, Xing L, Wood RW, Bingham CO, Ritchlin CT, Schwarz EM. "Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis." Nature reviews. Rheumatology.. 2018 Feb; 14(2):94-106. Epub 2018 Jan 11.
2018
Bell RD, Rudmann C, Wood RW, Schwarz EM, Rahimi H. "Longitudinal micro-CT as an outcome measure of interstitial lung disease in TNF-transgenic mice." PloS one.. 2018 13(1):e0190678. Epub 2018 Jan 10.
2018
de Mesy Bentley KL, MacDonald A, Schwarz EM, Oh I. "Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes: A Case Report." JBJS case connector.. 2018 8(1):e8.
2018
Cole CL, Kleckner IR, Jatoi A, Schwarz EM, Dunne RF. "The Role of Systemic Inflammation in Cancer-Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention." JCSM clinical reports.. 2018 3(2)
12/2017
Ishikawa M, de Mesy Bentley KL, McEntire BJ, Bal BS, Schwarz EM, Xie C. "Surface topography of silicon nitride affects antimicrobial and osseointegrative properties of tibial implants in a murine model." Journal of biomedical materials research. Part A.. 2017 Dec; 105(12):3413-3421. Epub 2017 Sep 26.
9/2017
Zhang L, Wang T, Chang M, Kaiser C, Kim JD, Wu T, Cao X, Zhang X, Schwarz EM. "Teriparatide Treatment Improves Bone Defect Healing Via Anabolic Effects on New Bone Formation and Non-Anabolic Effects on Inhibition of Mast Cells in a Murine Cranial Window Model." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 Sep; 32(9):1870-1883. Epub 2017 Jul 19.
6/2017
Bouta EM, Kuzin I, de Mesy Bentley K, Wood RW, Rahimi H, Ji RC, Ritchlin CT, Bottaro A, Xing L, Schwarz EM. "Brief Report: Treatment of Tumor Necrosis Factor-Transgenic Mice With Anti-Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte/Macrophage Egress." Arthritis & rheumatology.. 2017 Jun; 69(6):1187-1193. Epub 2017 Apr 04.
6/2017
Farnsworth CW, Schott EM, Jensen SE, Zukoski J, Benvie AM, Refaai MA, Kates SL, Schwarz EM, Zuscik MJ, Gill SR, Mooney RA. "Adaptive Upregulation of Clumping Factor A (ClfA) by Staphylococcus aureus in the Obese, Type 2 Diabetic Host Mediates Increased Virulence." Infection and immunity.. 2017 Jun; 85(6)Epub 2017 May 23.
5/2017
de Mesy Bentley KL, Trombetta R, Nishitani K, Bello-Irizarry SN, Ninomiya M, Zhang L, Chung HL, McGrath JL, Daiss JL, Awad HA, Kates SL, Schwarz EM. "Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 May; 32(5):985-990. Epub 2017 Jan 26.
4/19/2017
Schwarz EM. "Confirmation of Sexual Dimorphisms in Metal Hypersensitivity and Joint Pain Following Total Joint Arthroplasty: Commentary on an article by Marco S. Caicedo, PhD, et al.: "Females with Unexplained Joint Pain Following Total Joint Arthroplasty Exhibit a Higher Rate and Severity of Hypersensitivity to Implant Metals Compared with Males. Implications of Sex-Based Bioreactivity Differences"." The Journal of bone and joint surgery. American volume.. 2017 Apr 19; 99(8):e41.
1/2017
Trombetta R, Inzana JA, Schwarz EM, Kates SL, Awad HA. "3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery." Annals of biomedical engineering.. 2017 Jan; 45(1):23-44. Epub 2016 Jun 20.
2017
Peng J, Ren Y, He W, Li Z, Yang J, Liu Y, Zheng Z, Kates SL, Schwarz EM, Xie C, Xu Y. "Epidemiological, Clinical and Microbiological Characteristics of Patients with Post-Traumatic Osteomyelitis of Limb Fractures in Southwest China: A Hospital-Based Study." Journal of bone and joint infection.. 2017 2(3):149-153. Epub 2017 May 04.
2017
Xu H, Bouta EM, Wood RW, Schwarz EM, Wang Y, Xing L. "Utilization of longitudinal ultrasound to quantify joint soft-tissue changes in a mouse model of posttraumatic osteoarthritis." Bone research.. 2017 5:17012. Epub 2017 Jun 13.
2017
Nishitani K, Mietus Z, Beck CA, Ito H, Matsuda S, Awad HA, Ehrhart N, Schwarz EM. "High dose teriparatide (rPTH1-34) therapy increases callus volume and enhances radiographic healing at 8-weeks in a massive canine femoral allograft model." PloS one.. 2017 12(10):e0185446. Epub 2017 Oct 11.
9/1/2016
Rahimi H, Bell R, Bouta EM, Wood RW, Xing L, Ritchlin CT, Schwarz EM. "Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential." Arthritis research & therapy.. 2016 Sep 1; 18:194. Epub 2016 Sep 01.
7/2016
Kuzin II, Kates SL, Ju Y, Zhang L, Rahimi H, Wojciechowski W, Bernstein SH, Burack R, Schwarz EM, Bottaro A. "Increased numbers of CD23(+) CD21(hi) Bin-like B cells in human reactive and rheumatoid arthritis lymph nodes." European journal of immunology.. 2016 Jul; 46(7):1752-7. Epub 2016 May 06.
5/2016
Chen Y, Hallab NJ, Liao YS, Narayan V, Schwarz EM, Xie C. "Antioxidant impregnated ultra-high molecular weight polyethylene wear debris particles display increased bone remodeling and a superior osteogenic:osteolytic profile vs. conventional UHMWPE particles in a murine calvaria model." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2016 May; 34(5):845-51. Epub 2015 Nov 23.
4/2016
Moriarty TF, Kuehl R, Coenye T, Metsemakers WJ, Morgenstern M, Schwarz EM, Riool M, Zaat SAJ, Khana N, Kates SL, Richards RG. "Orthopaedic device-related infection: current and future interventions for improved prevention and treatment." EFORT open reviews.. 2016 Apr; 1(4):89-99. Epub 2017 Mar 13.
3/12/2016
Liang Q, Ju Y, Chen Y, Wang W, Li J, Zhang L, Xu H, Wood RW, Schwarz EM, Boyce BF, Wang Y, Xing L. "Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice." Arthritis research & therapy.. 2016 Mar 12; 18:62. Epub 2016 Mar 12.
3/2016
Inzana JA, Schwarz EM, Kates SL, Awad HA. "Biomaterials approaches to treating implant-associated osteomyelitis." Biomaterials.. 2016 Mar; 81:58-71. Epub 2015 Dec 18.
3/2016
Antebi B, Zhang L, Sheyn D, Pelled G, Zhang X, Gazit Z, Schwarz EM, Gazit D. "Controlling Arteriogenesis and Mast Cells Are Central to Bioengineering Solutions for Critical Bone Defect Repair Using Allografts." Bioengineering.. 2016 Mar; 3(1)
2/2016
Sheyn D, Shapiro G, Tawackoli W, Jun DS, Koh Y, Kang KB, Su S, Da X, Ben-David S, Bez M, Yalon E, Antebi B, Avalos P, Stern T, Zelzer E, Schwarz EM, Gazit Z, Pelled G, Bae HM, Gazit D. "PTH Induces Systemically Administered Mesenchymal Stem Cells to Migrate to and Regenerate Spine Injuries." Molecular therapy : the journal of the American Society of Gene Therapy.. 2016 Feb; 24(2):318-330. Epub 2015 Nov 20.
1/11/2016
Antebi B, Zhang L, Sheyn D, Pelled G, Zhang X, Gazit Z, Schwarz EM, Gazit D. "Controlling Arteriogenesis and Mast Cells Are Central to Bioengineering Solutions for Critical Bone Defect Repair Using Allografts." Bioengineering.. 2016 Jan 11; 3(1)Epub 2016 Jan 11.
2016
Zhang L, Chang M, Beck CA, Schwarz EM, Boyce BF. "Analysis of new bone, cartilage, and fibrosis tissue in healing murine allografts using whole slide imaging and a new automated histomorphometric algorithm." Bone research.. 2016 4:15037. Epub 2016 Jan 19.
2016
Rahimi H, Dieudonne G, Kheyfits V, Bouta EM, Wood RW, Barrett R, Moorehead S, Schwarz EM, Ritchlin CT. "Relationship Between Lymph Node Volume and Pain Following Certolizumab Therapy for Rheumatoid Arthritis Flare: A Pilot Study." Clinical medicine insights. Arthritis and musculoskeletal disorders. 2016 9:203-208. Epub 2016 Dec 14.
11/4/2015
Inzana JA, Trombetta RP, Schwarz EM, Kates SL, Awad HA. "3D printed bioceramics for dual antibiotic delivery to treat implant-associated bone infection." European cells & materials.. 2015 Nov 4; 30:232-47. Epub 2015 Nov 04.
9/2015
Nishitani K, Sutipornpalangkul W, de Mesy Bentley KL, Varrone JJ, Bello-Irizarry SN, Ito H, Matsuda S, Kates SL, Daiss JL, Schwarz EM. "Quantifying the natural history of biofilm formation in vivo during the establishment of chronic implant-associated Staphylococcus aureus osteomyelitis in mice to identify critical pathogen and host factors." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2015 Sep; 33(9):1311-9. Epub 2015 May 18.
9/2015
Nishitani K, Beck CA, Rosenberg AF, Kates SL, Schwarz EM, Daiss JL. "A Diagnostic Serum Antibody Test for Patients With Staphylococcus aureus Osteomyelitis." Clinical orthopaedics and related research.. 2015 Sep; 473(9):2735-49. Epub 2015 May 27.
9/2015
Xie C, Li Y, Li Q, Chen Y, Yao J, Yin G, Bi Q, O'Keefe RJ, Schwarz EM, Tyler W. "Increased Insulin mRNA Binding Protein-3 Expression Correlates with Vascular Enhancement of Renal Cell Carcinoma by Intravenous Contrast-CT and is Associated with Bone Metastasis." Journal of bone oncology.. 2015 Sep; 4(3):69-76. Epub 2015 Sep 12.
8/2015
Kuzin II, Bouta EM, Schwarz EM, Bottaro A. "TNF signals are dispensable for the generation of CD23+ CD21/35-high CD1d-high B cells in inflamed lymph nodes." Cellular immunology.. 2015 Aug; 296(2):133-7. Epub 2015 Apr 28.
6/2015
Farnsworth CW, Shehatou CT, Maynard R, Nishitani K, Kates SL, Zuscik MJ, Schwarz EM, Daiss JL, Mooney RA. "A humoral immune defect distinguishes the response to Staphylococcus aureus infections in mice with obesity and type 2 diabetes from that in mice with type 1 diabetes." Infection and immunity.. 2015 Jun; 83(6):2264-74. Epub 2015 Mar 23.
4/2015
Bouta EM, Banik PD, Wood RW, Rahimi H, Ritchlin CT, Thiele RG, Schwarz EM. "Validation of power Doppler versus contrast-enhanced magnetic resonance imaging quantification of joint inflammation in murine inflammatory arthritis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2015 Apr; 30(4):690-4.
3/2015
Zhang M, Feigenson M, Sheu TJ, Awad HA, Schwarz EM, Jonason JH, Loiselle AE, O'Keefe RJ. "Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength." Bone.. 2015 Mar; 72:92-100. Epub 2014 Nov 29.
3/2015
Inzana JA, Schwarz EM, Kates SL, Awad HA. "A novel murine model of established Staphylococcal bone infection in the presence of a fracture fixation plate to study therapies utilizing antibiotic-laden spacers after revision surgery." Bone.. 2015 Mar; 72:128-36. Epub 2014 Nov 29.
2/2015
Farhat YM, Al-Maliki AA, Easa A, O'Keefe RJ, Schwarz EM, Awad HA. "TGF-?1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair." Journal of cellular physiology.. 2015 Feb; 230(2):318-26.
2/2015
Bouta EM, Li J, Ju Y, Brown EB, Ritchlin CT, Xing L, Schwarz EM. "The role of the lymphatic system in inflammatory-erosive arthritis." Seminars in cell & developmental biology.. 2015 Feb; 38:90-7. Epub 2015 Jan 15.
10/2014
Varrone JJ, de Mesy Bentley KL, Bello-Irizarry SN, Nishitani K, Mack S, Hunter JG, Kates SL, Daiss JL, Schwarz EM. "Passive immunization with anti-glucosaminidase monoclonal antibodies protects mice from implant-associated osteomyelitis by mediating opsonophagocytosis of Staphylococcus aureus megaclusters." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2014 Oct; 32(10):1389-96. Epub 2014 Jul 03.
6/2014
Papuga MO, Beck CA, Kates SL, Schwarz EM, Maloney MD. "Validation of GAITRite and PROMIS as high-throughput physical function outcome measures following ACL reconstruction." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2014 Jun; 32(6):793-801. Epub 2014 Feb 14.
5/2014
Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. "Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment." Bone.. 2014 May; 62:79-89. Epub 2014 Feb 12.
4/2014
Inzana JA, Olvera D, Fuller SM, Kelly JP, Graeve OA, Schwarz EM, Kates SL, Awad HA. "3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration." Biomaterials.. 2014 Apr; 35(13):4026-34. Epub 2014 Feb 14.
3/15/2014
Bouta EM, Wood RW, Brown EB, Rahimi H, Ritchlin CT, Schwarz EM. "In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice." The Journal of physiology.. 2014 Mar 15; 592(6):1213-23. Epub 2014 Jan 13.
3/2014
Long T, Zhu Z, Awad HA, Schwarz EM, Hilton MJ, Dong Y. "The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice." Biomaterials.. 2014 Mar; 35(9):2752-9. Epub 2014 Jan 03.
3/2014
Nishitani K, Schwarz EM. "Regenerative medicine: Cartilage transplants hold promise for challenging bone defects." Nature reviews. Rheumatology.. 2014 Mar; 10(3):129-30. Epub 2014 Jan 14.
3/2014
Rahimi H, Wood R, Kuzin I, Tyler W, Dieudonne G, Kates S, Ritchlin CT, Schwarz EM. "A127: validating popliteal lymph node phenotype and bin expansion as biomarkers of rheumatoid arthritis knee flare in clinical pilot studies." Arthritis & rheumatology.. 2014 Mar; 66 Suppl 3:S166-7.
1/2014
Schwarz EM, Alt V, Kates SL. "The 1st International Consensus Meeting on Periprosthetic Joint Infection." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2014 Jan; 32 Suppl 1:S1.
2014
Dhillon RS, Zhang L, Schwarz EM, Boyce BF, Xie C. "The murine femoral bone graft model and a semiautomated histomorphometric analysis tool." Methods in molecular biology.. 2014 1130:45-59.
2014
Hasslund S, Dadali T, Ulrich-Vinther M, Søballe K, Schwarz EM, Awad HA. "Freeze-dried allograft-mediated gene or protein delivery of growth and differentiation factor 5 reduces reconstructed murine flexor tendon adhesions." Journal of tissue engineering. 2014 5:2041731414528736. Epub 2014 Mar 19.
2014
Rosenberg A, Fan H, Chiu YG, Bolce R, Tabechian D, Barrett R, Moorehead S, Baribaud F, Liu H, Peffer N, Shealy D, Schwarz EM, Ritchlin CT. "Divergent gene activation in peripheral blood and tissues of patients with rheumatoid arthritis, psoriatic arthritis and psoriasis following infliximab therapy." PloS one.. 2014 9(10):e110657. Epub 2014 Oct 21.
12/15/2013
Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH. "TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages." Journal of cell science.. 2013 Dec 15; 126(Pt 24):5704-13. Epub 2013 Oct 21.
11/20/2013
Gedbjerg N, Larosa R, Hunter JG, Varrone JJ, Kates SL, Schwarz EM, Daiss JL. "Anti-glucosaminidase IgG in sera as a biomarker of host immunity against Staphylococcus aureus in orthopaedic surgery patients." The Journal of bone and joint surgery. American volume.. 2013 Nov 20; 95(22):e171.
9/2013
Ju Y, Li J, Xie C, Ritchlin CT, Xing L, Hilton MJ, Schwarz EM. "Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice." Genesis : the journal of genetics and development.. 2013 Sep; 51(9):667-75. Epub 2013 Jul 09.
5/2013
Green JM, Hallab NJ, Liao YS, Narayan V, Schwarz EM, Xie C. "Anti-oxidation treatment of ultra high molecular weight polyethylene components to decrease periprosthetic osteolysis: evaluation of osteolytic and osteogenic properties of wear debris particles in a murine calvaria model." Current rheumatology reports.. 2013 May; 15(5):325.
3/2013
Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM. "PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2013 Mar; 28(3):586-97.
2/22/2013
Inzana JA, Maher JR, Takahata M, Schwarz EM, Berger AJ, Awad HA. "Bone fragility beyond strength and mineral density: Raman spectroscopy predicts femoral fracture toughness in a murine model of rheumatoid arthritis." Journal of biomechanics.. 2013 Feb 22; 46(4):723-30. Epub 2012 Dec 20.
1/2013
Li J, Ju Y, Bouta EM, Xing L, Wood RW, Kuzin I, Bottaro A, Ritchlin CT, Schwarz EM. "Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow." Arthritis and rheumatism.. 2013 Jan; 65(1):130-8.
2013
Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA. "Cellular and molecular factors in flexor tendon repair and adhesions: a histological and gene expression analysis." Connective tissue research.. 2013 54(3):218-26. Epub 2013 Apr 15.
2013
Liu H, Schwarz EM, Xie C. "Dual differentiation-exogenous mesenchymal stem cell therapy for traumatic spinal cord injury repair in a murine hemisection model." Stem cells international. 2013 2013:928982. Epub 2013 Aug 20.
2013
Bouta EM, Ju Y, Rahimi H, de Mesy-Bentley KL, Wood RW, Xing L, Schwarz EM. "Power Doppler ultrasound phenotyping of expanding versus collapsed popliteal lymph nodes in murine inflammatory arthritis." PloS one.. 2013 8(9):e73766. Epub 2013 Sep 09.
11/2012
Takahata M, Maher JR, Juneja SC, Inzana J, Xing L, Schwarz EM, Berger AJ, Awad HA. "Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk." Arthritis and rheumatism.. 2012 Nov; 64(11):3649-59.
9/2012
Santoni BG, Ehrhart N, Betancourt-Benitez R, Beck CA, Schwarz EM. "Quantifying massive allograft healing of the canine femur in vivo and ex vivo: a pilot study." Clinical orthopaedics and related research.. 2012 Sep; 470(9):2478-87.
8/8/2012
Dhillon RS, Schwarz EM, Maloney MD. "Platelet-rich plasma therapy - future or trend?" Arthritis research & therapy.. 2012 Aug 8; 14(4):219. Epub 2012 Aug 08.
8/2012
Wang M, Tang D, Shu B, Wang B, Jin H, Hao S, Dresser KA, Shen J, Im HJ, Sampson ER, Rubery PT, Zuscik MJ, Schwarz EM, O'Keefe RJ, Wang Y, Chen D. "Conditional activation of ?-catenin signaling in mice leads to severe defects in intervertebral disc tissue." Arthritis and rheumatism.. 2012 Aug; 64(8):2611-23.
6/15/2012
Moshkani S, Kuzin II, Adewale F, Jansson J, Sanz I, Schwarz EM, Bottaro A. "CD23+ CD21(high) CD1d(high) B cells in inflamed lymph nodes are a locally differentiated population with increased antigen capture and activation potential." The Journal of immunology : official journal of the American Association of Immunologists.. 2012 Jun 15; 188(12):5944-53. Epub 2012 May 16.
6/2012
Ju Y, Rahimi H, Li J, Wood RW, Xing L, Schwarz EM. "Validation of 3-dimensional ultrasound versus magnetic resonance imaging quantification of popliteal lymph node volume as a biomarker of erosive inflammatory arthritis in mice." Arthritis and rheumatism.. 2012 Jun; 64(6):2048-50. Epub 2012 Feb 21.
3/2012
Takahata M, Awad HA, O'Keefe RJ, Bukata SV, Schwarz EM. "Endogenous tissue engineering: PTH therapy for skeletal repair." Cell and tissue research.. 2012 Mar; 347(3):545-52. Epub 2011 May 31.
2/2012
Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W. "Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2012 Feb; 30(2):325-33. Epub 2011 Aug 01.
1/2012
Takahata M, Schwarz EM, Chen T, O'Keefe RJ, Awad HA. "Delayed short-course treatment with teriparatide (PTH(1-34)) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2012 Jan; 27(1):26-37.
1/2012
Chiu YH, Mensah KA, Schwarz EM, Ju Y, Takahata M, Feng C, McMahon LA, Hicks DG, Panepento B, Keng PC, Ritchlin CT. "Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP)." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2012 Jan; 27(1):79-92.
2012
Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA, O'Keefe RJ. "Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury." PloS one.. 2012 7(7):e40602. Epub 2012 Jul 11.
2012
Farhat YM, Al-Maliki AA, Chen T, Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA. "Gene expression analysis of the pleiotropic effects of TGF-?1 in an in vitro model of flexor tendon healing." PloS one.. 2012 7(12):e51411. Epub 2012 Dec 10.
12/2011
Bouta EM, Wood RW, Perry SW, Brown EB, Ritchlin CT, Xing L, Schwarz EM. "Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomes." Annals of the New York Academy of Sciences.. 2011 Dec; 1240:47-52.
11/2011
Myakishev-Rempel M, Kuper J, Mintz B, Hutchinson S, Voris J, Zavislan K, Offley S, Nardia FB, Yaseen Z, Yen T, Zavislan JM, Maloney MD, Schwarz EM. "Investigation of the peak action wavelength of light-activated gene transduction." Gene therapy.. 2011 Nov; 18(11):1043-51. Epub 2011 Apr 14.
9/21/2011
Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ. "Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis." Science translational medicine.. 2011 Sep 21; 3(101):101ra93.
9/2011
Papuga MO, Kwok E, You Z, Rubery PT, Dougherty PE, Pryhuber G, Beck CA, Hilton MJ, Awad HA, Schwarz EM. "TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 Sep; 29(9):1367-74. Epub 2011 Mar 28.
8/31/2011
Li J, Zhou Q, Wood R, Kuzin I, Bottaro A, Ritchlin C, Xing L, Schwarz E. "CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice." Arthritis research & therapy.. 2011 Aug 31; 13(4):R138. Epub 2011 Aug 31.
8/2011
Yazici C, Takahata M, Reynolds DG, Xie C, Samulski RJ, Samulski J, Beecham EJ, Gertzman AA, Spilker M, Zhang X, O'Keefe RJ, Awad HA, Schwarz EM. "Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur." Molecular therapy : the journal of the American Society of Gene Therapy.. 2011 Aug; 19(8):1416-25. Epub 2011 Jan 04.
8/2011
Sampson ER, Beck CA, Ketz J, Canary KL, Hilton MJ, Awad H, Schwarz EM, Chen D, O'Keefe RJ, Rosier RN, Zuscik MJ. "Establishment of an index with increased sensitivity for assessing murine arthritis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 Aug; 29(8):1145-51. Epub 2011 Mar 03.
6/15/2011
Dhillon RS, Schwarz EM. "Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials." Materials.. 2011 Jun 15; 4(6):1117-1131. Epub 2011 Jun 15.
6/1/2011
Dhillon RS, Schwarz EM. "Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials." Journal of materials research. 2011 Jun 1; 4(6):1117-1131.
6/2011
Sampson ER, Martin BA, Morris AE, Xie C, Schwarz EM, O'Keefe RJ, Rosier RN. "The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2011 Jun; 26(6):1283-94.
4/1/2011
Varrone JJ, Li D, Daiss JL, Schwarz EM. "Anti-Glucosaminidase Monoclonal Antibodies as a Passive Immunization for Methicillin-Resistant Staphylococcus aureus (MRSA) Orthopaedic Infections." BoneKEy osteovision. 2011 Apr 1; 8:187-194.
4/2011
Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O'Keefe RJ. "EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2011 Apr; 26(4):792-802.
4/2011
Sampson ER, Amin V, Schwarz EM, O'Keefe RJ, Rosier RN. "The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 Apr; 29(4):623-32. Epub 2010 Oct 18.
3/1/2011
Reynolds DG, Takahata M, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA. "Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model." Bone.. 2011 Mar 1; 48(3):562-70. Epub 2010 Oct 13.
2/2011
Jacobson JA, Yanoso Scholl L, Reynolds DG, Dadali T, Bradica G, Bukata S, Puzas JE, Zuscik MJ, Rosier R, O'Keefe RJ, Schwarz E, Awad H. "Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects." Tissue engineering. Part A.. 2011 Feb; 17(3-4):389-98. Epub 2010 Oct 29.
12/1/2010
Yanoso-Scholl L, Jacobson JA, Bradica G, Lerner AL, O'Keefe RJ, Schwarz EM, Zuscik MJ, Awad HA. "Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering." Journal of biomedical materials research. Part A.. 2010 Dec 1; 95(3):717-26.
9/2010
Papuga MO, Proulx ST, Kwok E, You Z, Rubery PT, Dougherty PE, Hilton MJ, Awad HA, Schwarz EM. "Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2010 Sep; 28(9):1220-8.
8/2010
Gunnell LM, Jonason JH, Loiselle AE, Kohn A, Schwarz EM, Hilton MJ, O'Keefe RJ. "TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2010 Aug; 25(8):1784-97.
8/2010
Li TF, Gao L, Sheu TJ, Sampson ER, Flick LM, Konttinen YT, Chen D, Schwarz EM, Zuscik MJ, Jonason JH, O'Keefe RJ. "Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis." Arthritis and rheumatism.. 2010 Aug; 62(8):2359-69.
6/1/2010
Li J, Kuzin I, Moshkani S, Proulx ST, Xing L, Skrombolas D, Dunn R, Sanz I, Schwarz EM, Bottaro A. "Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy." The Journal of immunology : official journal of the American Association of Immunologists.. 2010 Jun 1; 184(11):6142-50. Epub 2010 Apr 30.
4/2010
Mensah KA, Ritchlin CT, Schwarz EM. "RANKL induces heterogeneous DC-STAMP(lo) and DC-STAMP(hi) osteoclast precursors of which the DC-STAMP(lo) precursors are the master fusogens." Journal of cellular physiology.. 2010 Apr; 223(1):76-83.
4/2010
Mensah KA, Mathian A, Ma L, Xing L, Ritchlin CT, Schwarz EM. "Mediation of nonerosive arthritis in a mouse model of lupus by interferon-alpha-stimulated monocyte differentiation that is nonpermissive of osteoclastogenesis." Arthritis and rheumatism.. 2010 Apr; 62(4):1127-37.
3/2010
Li D, Gromov K, Proulx ST, Xie C, Li J, Crane DP, Søballe K, O'Keefe RJ, Awad HA, Xing L, Schwarz EM. "Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw." Annals of the New York Academy of Sciences.. 2010 Mar; 1192:84-94.
2010
Schwarz EM, Proulx ST, Ritchlin CT, Boyce BF, Xing L. "The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis." Advances in experimental medicine and biology.. 2010 658:1-10.
2010
Chiu YG, Shao T, Feng C, Mensah KA, Thullen M, Schwarz EM, Ritchlin CT. "CD16 (FcRgammaIII) as a potential marker of osteoclast precursors in psoriatic arthritis." Arthritis research & therapy.. 2010 12(1):R14. Epub 2010 Jan 26.
12/2009
Mensah KA, Li J, Schwarz EM. "The emerging field of osteoimmunology." Immunologic research.. 2009 Dec; 45(2-3):100-13. Epub 2009 Jan 30.
10/2009
Tsutsumi R, Xie C, Wei X, Zhang X, Flick LM, Schwarz EM, O'Keefe RJ. "PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 Oct; 24(10):1753-62.
10/2009
Darowish M, Rahman R, Li P, Bukata SV, Gelinas J, Huang W, Flick LM, Schwarz EM, O'Keefe RJ. "Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation." Bone.. 2009 Oct; 45(4):661-8. Epub 2009 Jun 12.
9/2009
Guo R, Zhou Q, Proulx ST, Wood R, Ji RC, Ritchlin CT, Pytowski B, Zhu Z, Wang YJ, Schwarz EM, Xing L. "Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis." Arthritis and rheumatism.. 2009 Sep; 60(9):2666-76.
8/2009
Crane DP, Gromov K, Li D, Søballe K, Wahnes C, Büchner H, Hilton MJ, O'Keefe RJ, Murray CK, Schwarz EM. "Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2009 Aug; 27(8):1008-15.
8/2009
Xie C, Liang B, Xue M, Lin AS, Loiselle A, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X. "Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4." The American journal of pathology.. 2009 Aug; 175(2):772-85. Epub 2009 Jul 23.
6/2009
Loiselle AE, Bragdon GA, Jacobson JA, Hasslund S, Cortes ZE, Schwarz EM, Mitten DJ, Awad HA, O'Keefe RJ. "Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2009 Jun; 27(6):833-40.
5/2009
Reynolds DG, Shaikh S, Papuga MO, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA. "muCT-based measurement of cortical bone graft-to-host union." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 May; 24(5):899-907.
2/2009
Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg R, Drissi H, Puzas JE, Boyce B, Zhang X, O'Keefe RJ. "Reduced COX-2 expression in aged mice is associated with impaired fracture healing." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2009 Feb; 24(2):251-64.
12/2008
Xie C, Ming X, Wang Q, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X. "COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing." Bone.. 2008 Dec; 43(6):1075-83. Epub 2008 Aug 16.
10/2008
Tsutsumi R, Hock C, Bechtold CD, Proulx ST, Bukata SV, Ito H, Awad HA, Nakamura T, O'Keefe RJ, Schwarz EM. "Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 Oct; 26(10):1340-6.
10/2008
Yazici C, Yanoso L, Xie C, Reynolds DG, Samulski RJ, Samulski J, Yannariello-Brown J, Gertzman AA, Zhang X, Awad HA, Schwarz EM. "The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings." Biomaterials.. 2008 Oct; 29(28):3882-7. Epub 2008 Jun 30.
10/2008
Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ, Zuscik MJ, Rosier RN. "Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice." Arthritis and rheumatism.. 2008 Oct; 58(10):3132-44.
9/1/2008
Kaback LA, Soung do Y, Naik A, Geneau G, Schwarz EM, Rosier RN, O'Keefe RJ, Drissi H. "Teriparatide (1-34 human PTH) regulation of osterix during fracture repair." Journal of cellular biochemistry.. 2008 Sep 1; 105(1):219-26.
8/22/2008
Guo R, Yamashita M, Zhang Q, Zhou Q, Chen D, Reynolds DG, Awad HA, Yanoso L, Zhao L, Schwarz EM, Zhang YE, Boyce BF, Xing L. "Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins." The Journal of biological chemistry.. 2008 Aug 22; 283(34):23084-92. Epub 2008 Jun 19.
8/2008
Zhang X, Awad HA, O'Keefe RJ, Guldberg RE, Schwarz EM. "A perspective: engineering periosteum for structural bone graft healing." Clinical orthopaedics and related research.. 2008 Aug; 466(8):1777-87. Epub 2008 May 29.
8/2008
Mensah KA, Schwarz EM, Ritchlin CT. "Altered bone remodeling in psoriatic arthritis." Current rheumatology reports.. 2008 Aug; 10(4):311-7.
7/2008
Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Calvi LM, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM. "Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging." Arthritis and rheumatism.. 2008 Jul; 58(7):2019-29.
6/5/2008
Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH. "Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis." Oncogene.. 2008 Jun 5; 27(25):3605-14. Epub 2008 Jan 28.
6/2008
Hasslund S, Jacobson JA, Dadali T, Basile P, Ulrich-Vinther M, Søballe K, Schwarz EM, O'Keefe RJ, Mitten DJ, Awad HA. "Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 Jun; 26(6):824-33.
5/9/2008
Zhang Q, Guo R, Lu Y, Zhao L, Zhou Q, Schwarz EM, Huang J, Chen D, Jin ZG, Boyce BF, Xing L. "VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism." The Journal of biological chemistry.. 2008 May 9; 283(19):13491-9. Epub 2008 Mar 20.
4/11/2008
Yao Z, Xing L, Qin C, Schwarz EM, Boyce BF. "Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism." The Journal of biological chemistry.. 2008 Apr 11; 283(15):9917-24. Epub 2008 Feb 04.
3/2008
Anandarajah AP, Schwarz EM, Totterman S, Monu J, Feng CY, Shao T, Haas-Smith SA, Ritchlin CT. "The effect of etanercept on osteoclast precursor frequency and enhancing bone marrow oedema in patients with psoriatic arthritis." Annals of the rheumatic diseases.. 2008 Mar; 67(3):296-301. Epub 2007 Oct 29.
3/2008
Basile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Søballe K, Nishio Y, Drissi MH, Langstein HN, Mitten DJ, O'Keefe RJ, Schwarz EM, Awad HA. "Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery." Molecular therapy : the journal of the American Society of Gene Therapy.. 2008 Mar; 16(3):466-73. Epub 2008 Jan 08.
2/2008
Xie C, Xue M, Wang Q, Schwarz EM, O'Keefe RJ, Zhang X. "Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation." The Journal of bone and joint surgery. American volume.. 2008 Feb; 90 Suppl 1:9-13.
1/2008
Kaback LA, Soung do Y, Naik A, Smith N, Schwarz EM, O'Keefe RJ, Drissi H. "Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification." Journal of cellular physiology.. 2008 Jan; 214(1):173-82.
1/2008
Li D, Gromov K, Søballe K, Puzas JE, O'Keefe RJ, Awad H, Drissi H, Schwarz EM. "Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 Jan; 26(1):96-105.
2008
Zhang Q, Guo R, Schwarz EM, Boyce BF, Xing L. "TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood." Arthritis research & therapy.. 2008 10(2):R37. Epub 2008 Mar 27.
2008
Schwarz EM, . "What potential biologic treatments are available for osteolysis?" The Journal of the American Academy of Orthopaedic Surgeons.. 2008 16 Suppl 1:S72-5.
12/2007
Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM. "Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography." Arthritis and rheumatism.. 2007 Dec; 56(12):4024-37.
11/2007
Proulx ST, Kwok E, You Z, Beck CA, Shealy DJ, Ritchlin CT, Boyce BF, Xing L, Schwarz EM. "MRI and quantification of draining lymph node function in inflammatory arthritis." Annals of the New York Academy of Sciences.. 2007 Nov; 1117:106-23. Epub 2007 Jul 23.
11/2007
Dong YF, Soung do Y, Chang Y, Enomoto-Iwamoto M, Paris M, O'Keefe RJ, Schwarz EM, Drissi H. "Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner." Molecular endocrinology.. 2007 Nov; 21(11):2805-20. Epub 2007 Aug 07.
11/2007
Boyce BF, Yao Z, Zhang Q, Guo R, Lu Y, Schwarz EM, Xing L. "New roles for osteoclasts in bone." Annals of the New York Academy of Sciences.. 2007 Nov; 1116:245-54.
9/2007
Zuscik MJ, Ma L, Buckley T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ. "Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations." Environmental health perspectives.. 2007 Sep; 115(9):1276-82.
8/2007
Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. "Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2007 Aug; 22(8):1260-70.
8/2007
Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM. "Recent advances in gene delivery for structural bone allografts." Tissue engineering.. 2007 Aug; 13(8):1973-85.
6/22/2007
Yamashita T, Yao Z, Li F, Zhang Q, Badell IR, Schwarz EM, Takeshita S, Wagner EF, Noda M, Matsuo K, Xing L, Boyce BF. "NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1." The Journal of biological chemistry.. 2007 Jun 22; 282(25):18245-53. Epub 2007 May 07.
3/2007
Xie C, Reynolds D, Awad H, Rubery PT, Pelled G, Gazit D, Guldberg RE, Schwarz EM, O'Keefe RJ, Zhang X. "Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering." Tissue engineering.. 2007 Mar; 13(3):435-45.
2007
Reynolds DG, Hock C, Shaikh S, Jacobson J, Zhang X, Rubery PT, Beck CA, O'keefe RJ, Lerner AL, Schwarz EM, Awad HA. "Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts." Journal of biomechanics.. 2007 40(14):3178-86. Epub 2007 May 23.
2007
Schwarz EM, Ritchlin CT. "Clinical development of anti-RANKL therapy." Arthritis research & therapy.. 2007 9 Suppl 1:S7.
2007
Zhang Q, Lu Y, Proulx ST, Guo R, Yao Z, Schwarz EM, Boyce BF, Xing L. "Increased lymphangiogenesis in joints of mice with inflammatory arthritis." Arthritis research & therapy.. 2007 9(6):R118.
10/2006
Robertson G, Xie C, Chen D, Awad H, Schwarz EM, O'Keefe RJ, Guldberg RE, Zhang X. "Alteration of femoral bone morphology and density in COX-2-/- mice." Bone.. 2006 Oct; 39(4):767-72. Epub 2006 May 30.
7/28/2006
Li TF, Chen D, Wu Q, Chen M, Sheu TJ, Schwarz EM, Drissi H, Zuscik M, O'Keefe RJ. "Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes." The Journal of biological chemistry.. 2006 Jul 28; 281(30):21296-304. Epub 2006 May 10.
7/2006
Dong YF, Soung do Y, Schwarz EM, O'Keefe RJ, Drissi H. "Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor." Journal of cellular physiology.. 2006 Jul; 208(1):77-86.
7/2006
Boyce BF, Schwarz EM, Xing L. "Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone disease." Current opinion in rheumatology.. 2006 Jul; 18(4):427-32.
6/2006
Wood RW, Baggs RB, Schwarz EM, Messing EM. "Initial observations of reduced uroflow in transgenic adenocarcinoma of murine prostate." Urology.. 2006 Jun; 67(6):1324-8.
5/10/2006
Nishio Y, Dong Y, Paris M, O'Keefe RJ, Schwarz EM, Drissi H. "Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene." Gene.. 2006 May 10; 372:62-70. Epub 2006 Mar 29.
4/28/2006
Yao Z, Li P, Zhang Q, Schwarz EM, Keng P, Arbini A, Boyce BF, Xing L. "Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression." The Journal of biological chemistry.. 2006 Apr 28; 281(17):11846-55. Epub 2006 Feb 06.
4/2006
Maloney MD, Goater JJ, Parsons R, Ito H, O'Keefe RJ, Rubery PT, Drissi MH, Schwarz EM. "Safety and efficacy of ultraviolet-a light-activated gene transduction for gene therapy of articular cartilage defects." The Journal of bone and joint surgery. American volume.. 2006 Apr; 88(4):753-61.
4/2006
Schwarz EM, Looney RJ, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT. "Autoimmunity and bone." Annals of the New York Academy of Sciences.. 2006 Apr; 1068:275-83.
4/2006
O'Keefe RJ, Tiyapatanaputi P, Xie C, Li TF, Clark C, Zuscik MJ, Chen D, Drissi H, Schwarz E, Zhang X. "COX-2 has a critical role during incorporation of structural bone allografts." Annals of the New York Academy of Sciences.. 2006 Apr; 1068:532-42.
2/17/2006
Kaneki H, Guo R, Chen D, Yao Z, Schwarz EM, Zhang YE, Boyce BF, Xing L. "Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts." The Journal of biological chemistry.. 2006 Feb 17; 281(7):4326-33. Epub 2005 Dec 22.
2/1/2006
Anandarajah AP, Schwarz EM. "Anti-RANKL therapy for inflammatory bone disorders: Mechanisms and potential clinical applications." Journal of cellular biochemistry.. 2006 Feb 1; 97(2):226-32.
1/1/2006
Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN. "Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB." Experimental cell research.. 2006 Jan 1; 312(1):40-50. Epub 2005 Nov 02.
1/2006
Looney RJ, Schwarz EM, Boyd A, O'Keefe RJ. "Periprosthetic osteolysis: an immunologist's update." Current opinion in rheumatology.. 2006 Jan; 18(1):80-7.
1/2006
Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ. "Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2006 Jan; 21(1):4-16. Epub 2005 Sep 19.
12/19/2005
Andela VB, Schwarz EM, O'Keefe RJ, Puzas EJ, Rosenblatt JD, Rosier RN. "A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival." FEBS letters.. 2005 Dec 19; 579(30):6814-20. Epub 2005 Nov 28.
12/15/2005
Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN. "Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase." Journal of cellular biochemistry.. 2005 Dec 15; 96(6):1262-73.
12/2005
Zhang X, Xie C, Lin AS, Ito H, Awad H, Lieberman JR, Rubery PT, Schwarz EM, O'Keefe RJ, Guldberg RE. "Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 Dec; 20(12):2124-37. Epub 2005 Aug 08.
12/2005
Xing L, Schwarz EM, Boyce BF. "Osteoclast precursors, RANKL/RANK, and immunology." Immunological reviews.. 2005 Dec; 208:19-29.
11/2005
Soloviev A, Schwarz EM, Darowish M, O'Keefe RJ. "Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: a role for free radicals, NFkappaB, and TNFalpha." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2005 Nov; 23(6):1258-65. Epub 2005 Jun 09.
9/2005
Wang Y, Belflower RM, Dong YF, Schwarz EM, O'Keefe RJ, Drissi H. "Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 Sep; 20(9):1624-36. Epub 2005 May 23.
9/2005
Zhang Q, Badell IR, Schwarz EM, Boulukos KE, Yao Z, Boyce BF, Xing L. "Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2." Arthritis and rheumatism.. 2005 Sep; 52(9):2708-18.
9/2005
Boyce BF, Li P, Yao Z, Zhang Q, Badell IR, Schwarz EM, O'Keefe RJ, Xing L. "TNF-alpha and pathologic bone resorption." The Keio journal of medicine.. 2005 Sep; 54(3):127-31.
8/1/2005
Dong Y, Drissi H, Chen M, Chen D, Zuscik MJ, Schwarz EM, O'Keefe RJ. "Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta." Journal of cellular biochemistry.. 2005 Aug 1; 95(5):1057-68.
8/2005
Koefoed M, Ito H, Gromov K, Reynolds DG, Awad HA, Rubery PT, Ulrich-Vinther M, Soballe K, Guldberg RE, Lin AS, O'Keefe RJ, Zhang X, Schwarz EM. "Biological effects of rAAV-caAlk2 coating on structural allograft healing." Molecular therapy : the journal of the American Society of Gene Therapy.. 2005 Aug; 12(2):212-8.
7/2005
Mandelin J, Liljeström M, Li TF, Ainola M, Hukkanen M, Salo J, Santavirta S, Konttinen YT. "Pseudosynovial fluid from loosened total hip prosthesis induces osteoclast formation." Journal of biomedical materials research. Part B, Applied biomaterials.. 2005 Jul; 74(1):582-8.
7/2005
Wei X, Zhang X, Zuscik MJ, Drissi MH, Schwarz EM, O'Keefe RJ. "Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2005 Jul; 20(7):1136-48. Epub 2005 Feb 14.
6/2005
Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. "Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency." Environmental health perspectives.. 2005 Jun; 113(6):749-55.
4/15/2005
Gordon AH, O'Keefe RJ, Schwarz EM, Rosier RN, Puzas JE. "Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone." Cancer research.. 2005 Apr 15; 65(8):3209-17.
4/2005
Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'Keefe RJ, Stein GS, Drissi MH. "Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development." Journal of cellular physiology.. 2005 Apr; 203(1):133-43.
4/2005
Mandelin J, Li TF, Hukkanen M, Liljeström M, Salo J, Santavirta S, Konttinen YT. "Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K." The Journal of rheumatology.. 2005 Apr; 32(4):713-20.
3/18/2005
Clark CA, Schwarz EM, Zhang X, Ziran NM, Drissi H, O'Keefe RJ, Zuscik MJ. "Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation." Biochemical and biophysical research communications.. 2005 Mar 18; 328(3):764-76.
3/2005
Ito H, Koefoed M, Tiyapatanaputi P, Gromov K, Goater JJ, Carmouche J, Zhang X, Rubery PT, Rabinowitz J, Samulski RJ, Nakamura T, Soballe K, O'Keefe RJ, Boyce BF, Schwarz EM. "Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy." Nature medicine.. 2005 Mar; 11(3):291-7. Epub 2005 Feb 13.
2/2005
Yu S, Zhang X, He Z, Liu Y. "[Corrosiveness of Ti-Fe-Mo-Mn-Nb-Zr alloys in various pH lactic acids]." Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi.. 2005 Feb; 22(1):91-4.
1/1/2005
Li TF, O'Keefe RJ, Chen D. "TGF-beta signaling in chondrocytes." Frontiers in bioscience : a journal and virtual library.. 2005 Jan 1; 10:681-8. Epub 2005 Jan 01.
12/2004
Schwarz EM, O'Keefe RJ, Looney RJ. "Bone implant interface, osteolysis and potential therapies." Journal of musculoskeletal & neuronal interactions.. 2004 Dec; 4(4):390-2.
12/2004
Guldberg RE, Oest M, Lin AS, Ito H, Chao X, Gromov K, Goater JJ, Koefoed M, Schwarz EM, O'Keefe RJ, Zhang X. "Functional integration of tissue-engineered bone constructs." Journal of musculoskeletal & neuronal interactions.. 2004 Dec; 4(4):399-400.
11/2004
Tiyapatanaputi P, Rubery PT, Carmouche J, Schwarz EM, O'keefe RJ, Zhang X. "A novel murine segmental femoral graft model." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Nov; 22(6):1254-60.
11/2004
Anandarajah AP, Schwarz EM. "Dynamic exercises in patients with rheumatoid arthritis." Annals of the rheumatic diseases.. 2004 Nov; 63(11):1359-61.
10/15/2004
Li TF, Zuscik MJ, Ionescu AM, Zhang X, Rosier RN, Schwarz EM, Drissi H, O'Keefe RJ. "PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling." Experimental cell research.. 2004 Oct 15; 300(1):159-69.
9/10/2004
Li TF, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. "Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway." Experimental cell research.. 2004 Sep 10; 299(1):128-36.
9/2004
Ritchlin CT, Schwarz EM, O'Keefe RJ, Looney RJ. "RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis." Journal of musculoskeletal & neuronal interactions.. 2004 Sep; 4(3):276-84.
8/2004
Leung YY, Schwarz EM, Silvers CR, Messing EM, Wood RW. "Uroflow in murine urethritis." Urology.. 2004 Aug; 64(2):378-82.
7/2004
Ferguson CM, Schwarz EM, Puzas JE, Zuscik MJ, Drissi H, O'Keefe RJ. "Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivo." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Jul; 22(4):687-96.
7/2004
Ulrich-Vinther M, Duch MR, Søballe K, O'Keefe RJ, Schwarz EM, Pedersen FS. "In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Jul; 22(4):726-34.
5/15/2004
Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN. "5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes." Journal of cellular biochemistry.. 2004 May 15; 92(2):316-31.
5/2004
Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ. "Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation." Bone.. 2004 May; 34(5):809-17.
3/2004
Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ. "CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter." Journal of cellular physiology.. 2004 Mar; 198(3):428-40.
2/2004
Li P, Schwarz EM, O'Keefe RJ, Ma L, Boyce BF, Xing L. "RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2004 Feb; 19(2):207-13.
2/2004
Yu S, Zhang X, He Z, Gao Z, Wang C. "[The influence of Ce on microstructures and mechanics performances of Ti-Fe-Mo-Mn-Nb-Zr alloys]." Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi.. 2004 Feb; 21(1):102-6.
1/2004
Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ. "PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Jan; 22(1):6-12.
1/2004
Ito H, Goater JJ, Tiyapatanaputi P, Rubery PT, O'Keefe RJ, Schwarz EM. "Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells." Gene therapy.. 2004 Jan; 11(1):34-41.
1/2004
Li P, Schwarz EM, O'Keefe RJ, Ma L, Looney RJ, Ritchlin CT, Boyce BF, Xing L. "Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice." Arthritis and rheumatism.. 2004 Jan; 50(1):265-76.
12/15/2003
Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. "Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes." Journal of cellular biochemistry.. 2003 Dec 15; 90(6):1287-98.
12/2003
Huang W, Drissi MH, O'Keefe RJ, Schwarz EM. "A rapid multiparameter approach to study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesis." Calcified tissue international.. 2003 Dec; 73(6):584-93. Epub 2003 Oct 02.
12/2003
Puzas JE, O'Keefe RJ, Schwarz EM, Zhang X. "Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition." Journal of musculoskeletal & neuronal interactions.. 2003 Dec; 3(4):308-12; discussion 320-1.
11/2003
Schwarz EM, Campbell D, Totterman S, Boyd A, O'Keefe RJ, Looney RJ. "Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placebo." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 Nov; 21(6):1049-55.
10/2003
Andela VB, Pirri M, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosenblatt JD, Rosier RN. "The mevalonate synthesis pathway as a therapeutic target in cancer." Clinical orthopaedics and related research.. 2003 Oct; (415 Suppl):S59-66.
10/2003
Andela VB, Gordon AH, Zotalis G, Rosier RN, Goater JJ, Lewis GD, Schwarz EM, Puzas JE, O'Keefe RJ. "NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone." Clinical orthopaedics and related research.. 2003 Oct; (415 Suppl):S75-85.
9/2003
Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ. "Smad6 is induced by BMP-2 and modulates chondrocyte differentiation." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 Sep; 21(5):908-13.
9/2003
Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ. "ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2003 Sep; 18(9):1593-604.
8/1/2003
Ionescu AM, Schwarz EM, Zuscik MJ, Drissi H, Puzas JE, Rosier RN, O'Keefe RJ. "ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation." Experimental cell research.. 2003 Aug 1; 288(1):198-207.
8/2003
Li P, Schwarz EM. "The TNF-alpha transgenic mouse model of inflammatory arthritis." Springer seminars in immunopathology.. 2003 Aug; 25(1):19-33.
7/2003
Flick LM, Weaver JM, Ulrich-Vinther M, Abuzzahab F, Zhang X, Dougall WC, Anderson D, O'Keefe RJ, Schwarz EM. "Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healing." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 Jul; 21(4):676-84.
6/2003
Li X, Schwarz EM, Zuscik MJ, Rosier RN, Ionescu AM, Puzas JE, Drissi H, Sheu TJ, O'Keefe RJ. "Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5." Endocrinology.. 2003 Jun; 144(6):2514-23.
5/8/2003
Andela VB, Gingold BI, Souza MD, O'Keefe RJ, Puzas EJ, Schwarz EM, Rosier RN. "Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB." Cancer letters.. 2003 May 8; 194(1):37-43.
3/2003
Ritchlin CT, Haas-Smith SA, Li P, Hicks DG, Schwarz EM. "Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis." The Journal of clinical investigation.. 2003 Mar; 111(6):821-31.
1/3/2003
Sheu TJ, Schwarz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE. "A phage display technique identifies a novel regulator of cell differentiation." The Journal of biological chemistry.. 2003 Jan 3; 278(1):438-43. Epub 2002 Oct 25.
2003
Huang W, O'Keefe RJ, Schwarz EM. "Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation." Arthritis research & therapy.. 2003 5(1):R49-59. Epub 2002 Nov 12.
2003
Ulrich-Vinther M, Maloney MD, Schwarz EM, Rosier R, O'Keefe RJ. "Articular cartilage biology." The Journal of the American Academy of Orthopaedic Surgeons.. 2003 11(6):421-30.
12/2002
Huang W, Schwarz EM. "Mechanisms of bone resorption and new bone formation in spondyloarthropathies." Current rheumatology reports.. 2002 Dec; 4(6):513-7.
9/20/2002
Andela VB, Sheu TJ, Puzas EJ, Schwarz EM, O'Keefe RJ, Rosier RN. "Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB." Biochemical and biophysical research communications.. 2002 Sep 20; 297(2):237-41.
9/2002
Zuscik MJ, O'Keefe RJ, Gunter TE, Puzas JE, Schwarz EM, Rosier RN. "Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Sep; 20(5):1079-90.
8/2002
Ulrich-Vinther M, Carmody EE, Goater JJ, S balle K, O'Keefe RJ, Schwarz EM. "Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis." The Journal of bone and joint surgery. American volume.. 2002 Aug; 84-A(8):1405-12.
8/2002
Ulrich-Vinther M, Maloney MD, Goater JJ, Søballe K, Goldring MB, O'Keefe RJ, Schwarz EM. "Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes." Arthritis and rheumatism.. 2002 Aug; 46(8):2095-104.
7/2002
Soloviev A, Schwarz EM, Kuprash DV, Nedospasov SA, Puzas JE, Rosier RN, O'Keefe RJ. "The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jul; 20(4):714-22.
7/2002
Zuscik MJ, Pateder DB, Puzas JE, Schwarz EM, Rosier RN, O'Keefe RJ. "Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jul; 20(4):811-8.
6/10/2002
Zuscik MJ, D'Souza M, Ionescu AM, Gunter KK, Gunter TE, O'Keefe RJ, Schwarz EM, Puzas JE, Rosier RN. "Growth plate chondrocyte maturation is regulated by basal intracellular calcium." Experimental cell research.. 2002 Jun 10; 276(2):310-9.
6/2002
Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ. "Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair." The Journal of clinical investigation.. 2002 Jun; 109(11):1405-15.
6/2002
O'Keefe RJ. "Determination of responsiveness in biological systems is dependent on highly sensitive quantitative measures." Annals of the New York Academy of Sciences.. 2002 Jun; 961:206.
5/2002
Yin G, Liu W, An P, Li P, Ding I, Planelles V, Schwarz EM, Min W. "Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis." Molecular therapy : the journal of the American Society of Gene Therapy.. 2002 May; 5(5 Pt 1):547-54.
5/2002
Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE. "Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 May; 17(5):915-22.
5/2002
Carmody EE, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. "Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles." Arthritis and rheumatism.. 2002 May; 46(5):1298-308.
4/2002
Andela VB, Rosenblatt JD, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosier RN. "Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor metastasis." Clinical orthopaedics and related research.. 2002 Apr; (397):228-39.
3/2002
Good CR, O'Keefe RJ, Puzas JE, Schwarz EM, Rosier RN. "Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors." Journal of surgical oncology.. 2002 Mar; 79(3):174-9.
3/2002
Goater JJ, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. "Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Mar; 20(2):169-73.
2/2002
Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM. "In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 Feb; 17(2):192-9.
1/2002
Pateder DB, Sheu TJ, O'Keefe RJ, Puzas JE, Schwarz EM, Constine LS, Okunieff P, Rosier RN. "Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes." Radiation research.. 2002 Jan; 157(1):62-8.
1/2002
Mungo DV, Zhang X, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. "COX-1 and COX-2 expression in osteoid osteomas." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jan; 20(1):159-62.
2002
Looney RJ, Boyd A, Totterman S, Seo GS, Tamez-Pena J, Campbell D, Novotny L, Olcott C, Martell J, Hayes FA, O'Keefe RJ, Schwarz EM. "Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear." Arthritis research.. 2002 4(1):59-63. Epub 2001 Oct 03.
12/2001
Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM. "Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis." The Journal of bone and joint surgery. American volume.. 2001 Dec; 83-A(12):1789-97.
9/2001
Pateder DB, Ferguson CM, Ionescu AM, Schwarz EM, Rosier RN, Puzas JE, O'Keefe RJ. "PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling." Journal of cellular physiology.. 2001 Sep; 188(3):343-51.
7/2001
Pollice PF, Rosier RN, Looney RJ, Puzas JE, Schwarz EM, O'Keefe RJ. "Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components." The Journal of bone and joint surgery. American volume.. 2001 Jul; 83-A(7):1057-61.
6/2001
Pateder DB, Eliseev RA, O'Keefe RJ, Schwarz EM, Okunieff P, Constine LS, Puzas JE, Rosier RN. "The role of autocrine growth factors in radiation damage to the epiphyseal growth plate." Radiation research.. 2001 Jun; 155(6):847-57.
4/13/2001
Ionescu AM, Schwarz EM, Vinson C, Puzas JE, Rosier R, Reynolds PR, O'Keefe RJ. "PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling." The Journal of biological chemistry.. 2001 Apr 13; 276(15):11639-47. Epub 2001 Jan 02.
4/2001
Zhang X, Morham SG, Langenbach R, Young DA, Xing L, Boyce BF, Puzas EJ, Rosier RN, O'Keefe RJ, Schwarz EM. "Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2001 Apr; 16(4):660-70.
2/2001
Childs LM, Goater JJ, O'Keefe RJ, Schwarz EM. "Efficacy of etanercept for wear debris-induced osteolysis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2001 Feb; 16(2):338-47.
1/2001
Grimsrud CD, Romano PR, D'Souza M, Puzas JE, Schwarz EM, Reynolds PR, Roiser RN, O'Keefe RJ. "BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehog." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2001 Jan; 19(1):18-25.
2001
Puzas JE, Landeau JM, Tallents R, Albright J, Schwarz EM, Landesberg R. "Degradative pathways in tissues of the temporomandibular joint. Use of in vitro and in vivo models to characterize matrix metalloproteinase and cytokine activity." Cells, tissues, organs. 2001 169(3):248-56.
12/1/2000
Andela VB, Schwarz EM, Puzas JE, O'Keefe RJ, Rosier RN. "Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB." Cancer research.. 2000 Dec 1; 60(23):6557-62.
12/1/2000
Ferguson CM, Schwarz EM, Reynolds PR, Puzas JE, Rosier RN, O'Keefe RJ. "Smad2 and 3 Mediate Transforming Growth Factor-?1-Induced Inhibition of Chondrocyte Maturation* *The work was supported by National Health Services Grant AR-38945 (to R.J.O.) and an Orthopaedic Research Education Foundation Award (to C.M.F.)." Endocrinology.. 2000 Dec 1; 141(12):4728-4735.
12/2000
Ferguson CM, Schwarz EM, Reynolds PR, Puzas JE, Rosier RN, O'Keefe RJ. "Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation." Endocrinology.. 2000 Dec; 141(12):4728-35.
11/2000
Schwarz EM, Benz EB, Lu AP, Goater JJ, Mollano AV, Rosier RN, Puzas JE, Okeefe RJ. "Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2000 Nov; 18(6):849-55.
10/2000
Schwarz EM. "The adeno-associated virus vector for orthopaedic gene therapy." Clinical orthopaedics and related research.. 2000 Oct; (379 Suppl):S31-9.
9/2000
Chi H, Yang X, Kingsley PD, O'Keefe RJ, Puzas JE, Rosier RN, Shears SB, Reynolds PR. "Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo." Molecular and cellular biology.. 2000 Sep; 20(17):6496-507.
6/1/2000
Li P, Sanz I, O'Keefe RJ, Schwarz EM. "NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes." The Journal of immunology : official journal of the American Association of Immunologists.. 2000 Jun 1; 164(11):5990-7.
5/1/2000
Pateder DB, Rosier RN, Schwarz EM, Reynolds PR, Puzas JE, D'Souza M, O'Keefe RJ. "PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes." Experimental cell research.. 2000 May 1; 256(2):555-62.
5/2000
Schwarz EM, Lu AP, Goater JJ, Benz EB, Kollias G, Rosier RN, Puzas JE, O'Keefe RJ. "Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2000 May; 18(3):472-80.
4/2000
Goater J, Müller R, Kollias G, Firestein GS, Sanz I, O'Keefe RJ, Schwarz EM. "Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis." The Journal of rheumatology.. 2000 Apr; 27(4):983-9.
2000
Schwarz EM, Looney RJ, O'Keefe RJ. "Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysis." Arthritis research.. 2000 2(3):165-8. Epub 2000 Mar 27.
8/1994
Scully SP, Mott MP, Temple HT, O'Keefe RJ, O'Donnell RJ, Mankin HJ. "Late recurrence of giant-cell tumor of bone. A report of four cases." The Journal of bone and joint surgery. American volume.. 1994 Aug; 76(8):1231-3.