Edward M. Schwarz, Ph.D.

Edward M. Schwarz, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, NY 14642

Research Bio

Dr. Schwarz is Professor of Orthopaedics and Associate Director of the
Center for Musculoskeletal Research at URMC. His laboratory focuses on
finding solutions to bone loss due to conditions such as rheumatoid
arthritis, infections, tumors that spread to bone, and bone destruction near
the implants used in reconstructive surgery.

Several genes are known to turn on the healing process in bone. Dr.
Schwarz's group loads these genes into harmless virus particles. The
particles are coated onto experimental bone implants to deliver therapeutic
genes to the area of reconstruction, thus improving bone healing. The
cartilage that lines joints in mice can be encouraged to heal more
completely when virus particles deliver therapeutic genes too.

An additional interest of Dr. Schwarz's lab is the use of magnetic resonance
imaging (MRI) and high resolution computed tomography (CT) scans to
visualize the formation of new blood vessels as patients heal.

Awards & Honors (Local)

J.R. Neff Award, Musculoskeletal Research Foundation 2007
Orthopaedic Research Society's Kappa Delta Young Investigator Award 2005
Orthopaedic Research Society's Harris Award 2003
New Investigator Research Award, The Association of Bone & Joint Surgeons . 1999
University of Rochester Nominee for the Sinshimmer Award. 1999
University of Rochester Nominee for the Elison Award. 1999

Recent Journal Articles

Showing the 5 most recent journal articles. 229 available »

2017 Jan
Trombetta R, Inzana JA, Schwarz EM, Kates SL, Awad HA. "3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery." Annals of biomedical engineering. 2017 Jan; 45(1):23-44. Epub 2016 Jun 20.
2016 Sep 1
Rahimi H, Bell R, Bouta EM, Wood RW, Xing L, Ritchlin CT, Schwarz EM. "Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential." Arthritis research & therapy. 2016 Sep 1; 18:194. Epub 2016 Sep 01.
2016 Jul
Kuzin II, Kates SL, Ju Y, Zhang L, Rahimi H, Wojciechowski W, Bernstein SH, Burack R, Schwarz EM, Bottaro A. "Increased numbers of CD23(+) CD21(hi) Bin-like B cells in human reactive and rheumatoid arthritis lymph nodes." European journal of immunology. 2016 Jul; 46(7):1752-7. Epub 2016 May 06.
2016 May
Chen Y, Hallab NJ, Liao YS, Narayan V, Schwarz EM, Xie C. "Antioxidant impregnated ultra-high molecular weight polyethylene wear debris particles display increased bone remodeling and a superior osteogenic:osteolytic profile vs. conventional UHMWPE particles in a murine calvaria model." Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2016 May; 34(5):845-51. Epub 2015 Nov 23.
2016 Mar 12
Liang Q, Ju Y, Chen Y, Wang W, Li J, Zhang L, Xu H, Wood RW, Schwarz EM, Boyce BF, Wang Y, Xing L. "Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice." Arthritis research & therapy. 2016 Mar 12; 18:62. Epub 2016 Mar 12.

Current Appointments

Director - Center for Musculoskeletal Research - Primary Administrative
Richard and Margaret Burton Distinguished Professor in Orthopaedics - Department of Orthopaedics (SMD)
Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD) - Primary
Professor - Department of Biomedical Engineering (SMD)
Professor - Department of Medicine, Allergy/Immunology and Rheumatology (SMD)
Professor - Department of Microbiology and Immunology (SMD)
Professor - Department of Pathology and Laboratory Medicine (SMD)
Professor - Department of Urology (SMD)


PhD | Immunology, All Other | Einstein College Medicine1993
MA | Immunology, All Other | Einstein College Medicine1990
BS | Biology | Worcester Polytech Inst1988

Post-Doctoral Training & Residency

Laboratory of Inder M. Verma, Ph.D., Laboratory of Genetics The Salk Institute, La Jolla, California, Concentrations: Gene Therapy, NFkB Signal, Transduction, Transgenic Mice. 1997
Training - Pre-doctoral Fellow, Laboratory of Barry R. Bloom, Ph.D., Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York 1993
Training - Summer Student - Laboratory of Carl Shilkraut, Ph.D., Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 0
Training - Undergraduate Research Laboratory of Donald J. Tipper, Ph.D., Department of Microbiology & Molecular Genetics, University of Massachusetts Medical School, Worcester, Massachusetts 1988
Training - Summer Student - Laboratory of Fritz Herz, Ph.D., Department of Pathology, Montefiore Medical Center, Bronx, New York 0