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Fabeha Fazal, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-5948

Office: (585) 275-9917

Fax: (585) 756-7780

Faculty Appointments

Biography

Research

A major focus of research in my laboratory deals with understanding the role and regulation of actin-myosin interactions in endothelial cell (EC) inflammation, permeability, and apoptosis, especially in the settings of acute and chronic lung injury. We study pathways of EC inflammation, barrier dysfunction and apoptosis on the molecular, cellular, and animal level. We have uncovered novel and previously unrecognized role of actin cytoskeleton and non-muscle myosin light chain kinase (nmMLCK) in the regulation of cytoplasmic trafficking of NF-k? for its nuclear import to cause EC inflammation associate with intravascular coagulation and sepsis. More recently we have been involved in the identification of endoplasmic reticulum (ER) stress as an important determinant of EC inflammation and permeability associated with acute lung injury (ALI). In our most recent work, we have focused on understanding the role of nmMLCK in the pathogenesis of pulmonary emphysema caused by cigarette smoke (CS). The approaches ranging from biochemical, cellular, and molecular biology to in vivo gene delivery and lung physiology to study how pulmonary endothelium responds during acute and chronic lung inflammation/injury.

Credentials

Education

1985
BSc | A.M. University
Chemistry

1987
MSc | A.M. University
Biochemistry

1992
PhD | A.M. University
Biochemistry

Post-doctoral Training & Residency

2003 - 2011
Research Assistant Professor, Department of Pediatrics, University of Rochester, Rochester, NY

1999 - 2003
Research Assistant Professor, Department of Physiology and Biophysics, University of Illinois, Chicago, IL

1995 - 1998
Research Associate, Loyola University Medical Center, Maywood, IL

1992 - 1995
Research Associate, Loyola University Medical Center, Maywood, IL; Advisor: Susan Baker, PhD

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Awards

1987
University Gold Medal for standing first in M.S. Examination

1985
University Gold Medal for standing first in B.S. Examination

Publications

Journal Articles

5/1/2019
"Critical role of autophagy regulator Beclin1 in endothelial cell inflammation and barrier disruption." Cellular signalling.. 2019 May 1; Epub 2019 May 01.

2/14/2019
"Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury." Scientific reports.. 2019 Feb 14; 9(1):2096. Epub 2019 Feb 14.

4/2018
Leonard A, Rahman A, Fazal F. "Importins ? and ? signaling mediates endothelial cell inflammation and barrier disruption." Cellular signalling.. 2018 Apr 0; 44:103-117. Epub 2018 Jan 11.

Books & Chapters

1993
Chapter Title: Strand scission in DNA induced by dietary flavonoids: Role of Cu (II) and oxygen free radicals.
Book Title: Glimpses in Plant Research XI: Medicinal Plants; New Vistas of Research [Part 2]
Author List: Rahman A, Fazal F, Hadi SM
Edited By: Govil JN, Singh VK, Hashmi S
Published By: Today and Tomorrow's Printers and Publishers 1993 in New Delhi, India

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