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Richard T. Libby, Ph.D.


Showing all 79 journal articles & 0 books available

Journal Articles

Marola OJ, Syc-Mazurek SB, Howell GR, Libby RT. "Endothelin 1-induced retinal ganglion cell death is largely mediated by JUN activation." Cell death & disease.. 2020 Sep 26; 11(9):811. Epub 2020 Sep 26.

Heffer A, Wang V, Sridhar J, Feldon SE, Libby RT, Woeller CF, Kuriyan AE. "A Mouse Model of Proliferative Vitreoretinopathy Induced by Intravitreal Injection of Gas and RPE Cells." Translational vision science & technology.. 2020 Jun 0; 9(7):9. Epub 2020 Jun 05.

Wang X, Lou N, Eberhardt A, Yang Y, Kusk P, Xu Q, Förstera B, Peng S, Shi M, Ladrón-de-Guevara A, Delle C, Sigurdsson B, Xavier ALR, Ertürk A, Libby RT, Chen L, Thrane AS, Nedergaard M. "An ocular glymphatic clearance system removes ?-amyloid from the rodent eye." Science translational medicine.. 2020 Mar 25; 12(536)

Heffer AM, Wang V, Libby RT, Feldon SE, Woeller CF, Kuriyan AE. "Salinomycin inhibits proliferative vitreoretinopathy formation in a mouse model." PloS one.. 2020 15(12):e0243626. Epub 2020 Dec 21.

Yoon C, Qi Y, Mestre H, Canavesi C, Marola OJ, Cogliati A, Nedergaard M, Libby RT, Rolland JP. "Gabor domain optical coherence microscopy combined with laser scanning confocal fluorescence microscopy." Biomedical optics express.. 2019 Dec 1; 10(12):6242-6257. Epub 2019 Nov 14.

Syc-Mazurek SB, Libby RT. "Axon injury signaling and compartmentalized injury response in glaucoma." Progress in retinal and eye research. 2019 Jul 10; Epub 2019 Jul 10.

Heffer AM, Proaño J, Roztocil E, Phipps RP, Feldon SE, Huxlin KR, Sime PJ, Libby RT, Woeller CF, Kuriyan AE. "The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology." PloS one.. 2019 14(9):e0222596. Epub 2019 Sep 17.

Marola OJ, Syc-Mazurek SB, Libby RT. "DDIT3 (CHOP) contributes to retinal ganglion cell somal loss but not axonal degeneration in DBA/2J mice." Cell death discovery.. 2019 5:140. Epub 2019 Oct 10.

Syc-Mazurek SB, Rausch RL, Fernandes KA, Wilson MP, Libby RT. "Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death." Cell death & disease.. 2018 Oct 26; 9(11):1095. Epub 2018 Oct 26.

Harder JM, Williams PA, Soto I, Foxworth NE, Fernandes KA, Freeburg NF, Libby RT, John SWM. "Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice." Cell death & disease.. 2018 Jun 13; 9(6):705. Epub 2018 Jun 13.

Fernandes KA, Mitchell KL, Patel A, Marola OJ, Shrager P, Zack DJ, Libby RT, Welsbie DS. "Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury." Experimental eye research.. 2018 Jun 0; 171:54-61. Epub 2018 Mar 08.

Rausch RL, Libby RT, Kiernan AE. "Trabecular meshwork morphogenesis: A comparative analysis of wildtype and anterior segment dysgenesis mouse models." Experimental eye research.. 2018 May 0; 170:81-91. Epub 2018 Feb 13.

Fahrenthold BK, Fernandes KA, Libby RT. "Assessment of intrinsic and extrinsic signaling pathway in excitotoxic retinal ganglion cell death." Scientific reports.. 2018 Mar 15; 8(1):4641. Epub 2018 Mar 15.

Rausch RL, Libby RT, Kiernan AE. "Ciliary margin-derived BMP4 does not have a major role in ocular development." PloS one.. 2018 13(5):e0197048. Epub 2018 May 08.

Apara A, Galvao J, Wang Y, Blackmore M, Trillo A, Iwao K, Brown DP, Fernandes KA, Huang A, Nguyen T, Ashouri M, Zhang X, Shaw PX, Kunzevitzky NJ, Moore DL, Libby RT, Goldberg JL. "KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2017 Oct 4; 37(40):9632-9644. Epub 2017 Sep 04.

Syc-Mazurek SB, Fernandes KA, Wilson MP, Shrager P, Libby RT. "Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury." Molecular neurodegeneration.. 2017 Oct 2; 12(1):71. Epub 2017 Oct 02.

Syc-Mazurek SB, Fernandes KA, Libby RT. "JUN is important for ocular hypertension-induced retinal ganglion cell degeneration." Cell death & disease.. 2017 Jul 20; 8(7):e2945. Epub 2017 Jul 20.

Harder JM, Braine CE, Williams PA, Zhu X, MacNicoll KH, Sousa GL, Buchanan RA, Smith RS, Libby RT, Howell GR, John SWM. "Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective." Proceedings of the National Academy of Sciences of the United States of America.. 2017 May 9; 114(19):E3839-E3848. Epub 2017 Apr 26.

Majumder S, Zhu G, Xu X, Senchanthisai S, Jiang D, Liu H, Xue C, Wang X, Coia H, Cui Z, Smolock EM, Libby RT, Berk BC, Pang J. "G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling." Cell reports.. 2016 Dec 6; 17(10):2532-2541.

Hedberg-Buenz A, Christopher MA, Lewis CJ, Fernandes KA, Dutca LM, Wang K, Scheetz TE, Abramoff MD, Libby RT, Garvin MK, Anderson MG. "Quantitative measurement of retinal ganglion cell populations via histology-based random forest classification." Experimental eye research.. 2016 May 0; 146:370-85. Epub 2015 Oct 22.

Fernandes KA, Bloomsburg SJ, Miller CJ, Billingslea SA, Merrill MM, Burgess RW, Libby RT, Fuerst PG. "Novel axon projection after stress and degeneration in the Dscam mutant retina." Molecular and cellular neurosciences.. 2016 Mar 0; 71:1-12. Epub 2015 Dec 10.

Alavi MV, Mao M, Pawlikowski BT, Kvezereli M, Duncan JL, Libby RT, John SW, Gould DB. "Col4a1 mutations cause progressive retinal neovascular defects and retinopathy." Scientific reports.. 2016 Jan 27; 6:18602. Epub 2016 Jan 27.

Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair KS, Anderson MG, John SW, Howell GR, Libby RT. "Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities." Experimental eye research.. 2015 Dec 0; 141:42-56. Epub 2015 Jun 24.

Mao M, Smith RS, Alavi MV, Marchant JK, Cosma M, Libby RT, John SW, Gould DB. "Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma in Col4a1 Mutant Mice." Investigative ophthalmology & visual science.. 2015 Oct 0; 56(11):6823-31.

Mac Nair CE, Fernandes KA, Schlamp CL, Libby RT, Nickells RW. "Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush." Journal of neuroinflammation.. 2014 Nov 19; 11:194. Epub 2014 Nov 19.

Fernandes KA, Harder JM, John SW, Shrager P, Libby RT. "DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury." Neurobiology of disease.. 2014 Sep 0; 69:108-16. Epub 2014 May 27.

Coleman JA, Zhu X, Djajadi HR, Molday LL, Smith RS, Libby RT, John SW, Molday RS. "Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival." Journal of cell science.. 2014 Mar 1; 127(Pt 5):1138-49. Epub 2014 Jan 10.

Strazzeri JM, Hunter JJ, Masella BD, Yin L, Fischer WS, Diloreto DA, Libby RT, Williams DR, Merigan WH. "Focal damage to macaque photoreceptors produces persistent visual loss." Experimental eye research.. 2014 Feb 0; 119:88-96. Epub 2013 Dec 05.

Huang L, Hu F, Xie X, Harder J, Fernandes K, Zeng XY, Libby R, Gan L. "Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice." PloS one.. 2014 9(4):e94173. Epub 2014 Apr 15.

Soto I, Howell GR, John CW, Kief JL, Libby RT, John SW. "DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation." PloS one.. 2014 9(9):e107291. Epub 2014 Sep 10.

Howell GR, Soto I, Libby RT, John SW. "Intrinsic axonal degeneration pathways are critical for glaucomatous damage." Experimental neurology.. 2013 Aug 0; 246:54-61. Epub 2012 Jan 18.

Fernandes KA, Harder JM, Kim J, Libby RT. "JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells." Experimental eye research.. 2013 Jul 0; 112:106-17. Epub 2013 May 03.

Jiang Y, Ding Q, Xie X, Libby R, Lefebvre V, Gan L. "Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells." The Journal of biological chemistry.. 2013 Jun 21; 288(25):18429-38. Epub 2013 May 06.

Howell GR, Libby RT. "Adding metabolomics to the toolbox for studying retinal disease." Investigative ophthalmology & visual science.. 2013 Jun 21; 54(6):4260. Epub 2013 Jun 21.

Zhou Y, Tanzie C, Yan Z, Chen S, Duncan M, Gaudenz K, Li H, Seidel C, Lewis B, Moran A, Libby RT, Kiernan AE, Xie T. "Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye." Proceedings of the National Academy of Sciences of the United States of America.. 2013 May 28; 110(22):8966-71. Epub 2013 May 15.

Harder JM, Libby RT. "Deficiency in Bim, Bid and Bbc3 (Puma) do not prevent axonal injury induced death." Cell death and differentiation.. 2013 Jan 0; 20(1):182. Epub 2012 Sep 21.

Harder JM, Ding Q, Fernandes KA, Cherry JD, Gan L, Libby RT. "BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cells." Molecular and cellular neurosciences.. 2012 Aug 0; 51(1-2):53-9. Epub 2012 Jul 24.

Fernandes KA, Harder JM, Fornarola LB, Freeman RS, Clark AF, Pang IH, John SW, Libby RT. "JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death." Neurobiology of disease.. 2012 May 0; 46(2):393-401. Epub 2012 Feb 14.

Geng Y, Dubra A, Yin L, Merigan WH, Sharma R, Libby RT, Williams DR. "Adaptive optics retinal imaging in the living mouse eye." Biomedical optics express.. 2012 Apr 1; 3(4):715-34. Epub 2012 Mar 15.

Howell GR, Soto I, Zhu X, Ryan M, Macalinao DG, Sousa GL, Caddle LB, Macnicoll KH, Barbay JM, Porciatti V, Anderson MG, Smith RS, Clark AF, Libby RT, John SW. "Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma." The Journal of clinical investigation.. 2012 Apr 0; 122(4):1246-61. Epub 2012 Mar 19.

Harder JM, Fernandes KA, Libby RT. "The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice." Scientific reports.. 2012 2:530. Epub 2012 Jul 25.

Zhu X, Libby RT, de Vries WN, Smith RS, Wright DL, Bronson RT, Seburn KL, John SW. "Mutations in a P-type ATPase gene cause axonal degeneration." PLoS genetics.. 2012 8(8):e1002853. Epub 2012 Aug 09.

Howell GR, Walton DO, King BL, Libby RT, John SW. "Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data." BMC genomics.. 2011 Aug 24; 12:429. Epub 2011 Aug 24.

Harder JM, Libby RT. "BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina." Molecular neurodegeneration.. 2011 Jul 15; 6:50. Epub 2011 Jul 15.

Lopes VS, Gibbs D, Libby RT, Aleman TS, Welch DL, Lillo C, Jacobson SG, Radu RA, Steel KP, Williams DS. "The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65." Human molecular genetics.. 2011 Jul 1; 20(13):2560-70. Epub 2011 Apr 14.

Xi X, McMillan DH, Lehmann GM, Sime PJ, Libby RT, Huxlin KR, Feldon SE, Phipps RP. "Ocular fibroblast diversity: implications for inflammation and ocular wound healing." Investigative ophthalmology & visual science.. 2011 Jul 1; 52(7):4859-65. Epub 2011 Jul 01.

Yin L, Greenberg K, Hunter JJ, Dalkara D, Kolstad KD, Masella BD, Wolfe R, Visel M, Stone D, Libby RT, Diloreto D, Schaffer D, Flannery J, Williams DR, Merigan WH. "Intravitreal injection of AAV2 transduces macaque inner retina." Investigative ophthalmology & visual science.. 2011 Apr 25; 52(5):2775-83. Epub 2011 Apr 25.

Howell GR, Macalinao DG, Sousa GL, Walden M, Soto I, Kneeland SC, Barbay JM, King BL, Marchant JK, Hibbs M, Stevens B, Barres BA, Clark AF, Libby RT, John SW. "Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma." The Journal of clinical investigation.. 2011 Apr 0; 121(4):1429-44. Epub 2011 Mar 07.

Geng Y, Schery LA, Sharma R, Dubra A, Ahmad K, Libby RT, Williams DR. "Optical properties of the mouse eye." Biomedical optics express.. 2011 Feb 28; 2(4):717-38. Epub 2011 Feb 28.

Feng L, Xie ZH, Ding Q, Xie X, Libby RT, Gan L. "MATH5 controls the acquisition of multiple retinal cell fates." Molecular brain.. 2010 Nov 18; 3:36. Epub 2010 Nov 18.

Libby RT, Gould DB. "Endoplasmic reticulum stress as a primary pathogenic mechanism leading to age-related macular degeneration." Advances in experimental medicine and biology.. 2010 664:403-9.

Bertram KM, Baglole CJ, Phipps RP, Libby RT. "Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration." American journal of physiology. Cell physiology.. 2009 Nov 0; 297(5):C1200-10. Epub 2009 Sep 16.

Scoles D, Gray DC, Hunter JJ, Wolfe R, Gee BP, Geng Y, Masella BD, Libby RT, Russell S, Williams DR, Merigan WH. "In-vivo imaging of retinal nerve fiber layer vasculature: imaging histology comparison." BMC ophthalmology. 2009 Aug 23; 9:9. Epub 2009 Aug 23.

Ding Q, Chen H, Xie X, Libby RT, Tian N, Gan L. "BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2009 Apr 1; 29(13):3992-4003.

Howell GR, Libby RT, John SW. "Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection." Progress in brain research.. 2008 173:303-21.

Howell GR, Libby RT, Jakobs TC, Smith RS, Phalan FC, Barter JW, Barbay JM, Marchant JK, Mahesh N, Porciatti V, Whitmore AV, Masland RH, John SW. "Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma." The Journal of cell biology.. 2007 Dec 31; 179(7):1523-37. Epub 2007 Dec 24.

Libby RT, Howell GR, Pang IH, Savinova OV, Mehalow AK, Barter JW, Smith RS, Clark AF, John SW. "Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model." BMC neuroscience.. 2007 Dec 19; 8:108. Epub 2007 Dec 19.

Howell GR, Libby RT, Marchant JK, Wilson LA, Cosma IM, Smith RS, Anderson MG, John SW. "Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1." BMC genetics.. 2007 Jul 3; 8:45. Epub 2007 Jul 03.

Anderson MG, Libby RT, Mao M, Cosma IM, Wilson LA, Smith RS, John SW. "Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma." BMC biology. 2006 Jul 7; 4:20. Epub 2006 Jul 07.

Whitmore AV, Libby RT, John SW. "Glaucoma: thinking in new ways-a rôle for autonomous axonal self-destruction and other compartmentalised processes?" Progress in retinal and eye research. 2005 Nov 0; 24(6):639-62.

Jakobs TC, Libby RT, Ben Y, John SW, Masland RH. "Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice." The Journal of cell biology.. 2005 Oct 24; 171(2):313-25.

Kitamoto J, Libby RT, Gibbs D, Steel KP, Williams DS. "Myosin VI is required for normal retinal function." Experimental eye research.. 2005 Jul 0; 81(1):116-20.

Libby RT, Li Y, Savinova OV, Barter J, Smith RS, Nickells RW, John SW. "Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage." PLoS genetics.. 2005 Jul 0; 1(1):17-26. Epub 2005 Jul 25.

Anderson MG, Libby RT, Gould DB, Smith RS, John SW. "High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma." Proceedings of the National Academy of Sciences of the United States of America.. 2005 Mar 22; 102(12):4566-71. Epub 2005 Mar 09.

Libby RT, Gould DB, Anderson MG, John SW. "Complex genetics of glaucoma susceptibility." Annual review of genomics and human genetics. 2005 6:15-44.

Libby RT, Anderson MG, Pang IH, Robinson ZH, Savinova OV, Cosma IM, Snow A, Wilson LA, Smith RS, Clark AF, John SW. "Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration." Visual neuroscience.. 2005 22(5):637-48.

Gibbs D, Azarian SM, Lillo C, Kitamoto J, Klomp AE, Steel KP, Libby RT, Williams DS. "Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes." Journal of cell science.. 2004 Dec 15; 117(Pt 26):6473-83. Epub 2004 Nov 30.

Libby RT, Lillo C, Kitamoto J, Williams DS, Steel KP. "Myosin Va is required for normal photoreceptor synaptic activity." Journal of cell science.. 2004 Sep 1; 117(Pt 19):4509-15. Epub 2004 Aug 17.

Libby RT, Kitamoto J, Holme RH, Williams DS, Steel KP. "Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration." Experimental eye research.. 2003 Dec 0; 77(6):731-9.

Libby RT, Smith RS, Savinova OV, Zabaleta A, Martin JE, Gonzalez FJ, John SW. "Modification of ocular defects in mouse developmental glaucoma models by tyrosinase." Science.. 2003 Mar 7; 299(5612):1578-81.

Warner CL, Stewart A, Luzio JP, Steel KP, Libby RT, Kendrick-Jones J, Buss F. "Loss of myosin VI reduces secretion and the size of the Golgi in fibroblasts from Snell's waltzer mice." The EMBO journal.. 2003 Feb 3; 22(3):569-79.

Kros CJ, Marcotti W, van Netten SM, Self TJ, Libby RT, Brown SD, Richardson GP, Steel KP. "Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations." Nature neuroscience.. 2002 Jan 0; 5(1):41-7.

Libby RT, Steel KP. "Electroretinographic anomalies in mice with mutations in Myo7a, the gene involved in human Usher syndrome type 1B." Investigative ophthalmology & visual science.. 2001 Mar 0; 42(3):770-8.

Libby RT, Champliaud MF, Claudepierre T, Xu Y, Gibbons EP, Koch M, Burgeson RE, Hunter DD, Brunken WJ. "Laminin expression in adult and developing retinae: evidence of two novel CNS laminins." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2000 Sep 1; 20(17):6517-28.

Libby RT, Brunken WJ, Hunter DD. "Roles of the extracellular matrix in retinal development and maintenance." Results and problems in cell differentiation.. 2000 31:115-40.

Libby RT, Steel KP. "The roles of unconventional myosins in hearing and deafness." Essays in biochemistry.. 2000 35:159-74.

Libby RT, Lavallee CR, Balkema GW, Brunken WJ, Hunter DD. "Disruption of laminin beta2 chain production causes alterations in morphology and function in the CNS." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1999 Nov 1; 19(21):9399-411.

Libby RT, Xu Y, Selfors LM, Brunken WJ, Hunter DD. "Identification of the cellular source of laminin beta2 in adult and developing vertebrate retinae." The Journal of comparative neurology.. 1997 Dec 29; 389(4):655-67.

Libby RT, Hunter DD, Brunken WJ. "Developmental expression of laminin beta 2 in rat retina. Further support for a role in rod morphogenesis." Investigative ophthalmology & visual science.. 1996 Jul 0; 37(8):1651-61.