Publications
Showing all 42 journal articles & 0 books available
Journal Articles
2/10/2023
Schroeder GM, Akinyemi O, Malik J, Focht CM, Pritchett EM, Baker CD, McSally JP, Jenkins JL, Mathews DH, Wedekind JE. "A riboswitch separated from its ribosome-binding site still regulates translation." Nucleic acids research.. 2023 Feb 10; Epub 2023 Feb 10.
6/30/2022
Galardi JW, Bela VN, Jeffery N, He X, Glasser E, Loerch S, Jenkins JL, Pulvino MJ, Boutz PL, Kielkopf CL. "A UHM - ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing." The Journal of biological chemistry.. 2022 Jun 30; :102224. Epub 2022 Jun 30.
5/7/2022
Glasser E, Maji D, Biancon G, Puthenpeedikakkal AMK, Cavender CE, Tebaldi T, Jenkins JL, Mathews DH, Halene S, Kielkopf CL. "Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal." Nucleic acids research.. 2022 May 7; Epub 2022 May 07.
1/11/2022
Schroeder GM, Cavender CE, Blau ME, Jenkins JL, Mathews DH, Wedekind JE. "A small RNA that cooperatively senses two stacked metabolites in one pocket for gene control." Nature communications.. 2022 Jan 11; 13(1):199. Epub 2022 Jan 11.
3/2021
Srivastava Y, Bonn-Breach R, Chavali SS, Lippa GM, Jenkins JL, Wedekind JE. "Affinity and Structural Analysis of the U1A RNA Recognition Motif with Engineered Methionines to Improve Experimental Phasing." Crystals.. 2021 Mar; 11(3)Epub 2021 Mar 10.
2/26/2021
Chatrikhi R, Feeney CF, Pulvino MJ, Alachouzos G, MacRae AJ, Falls Z, Rai S, Brennessel WW, Jenkins JL, Walter MJ, Graubert TA, Samudrala R, Jurica MS, Frontier AJ, Kielkopf CL. "A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex." Cell chemical biology.. 2021 Feb 26; Epub 2021 Feb 26.
12/11/2020
Maji D, Glasser E, Henderson S, Galardi J, Pulvino MJ, Jenkins JL, Kielkopf CL. "Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing." The Journal of biological chemistry.. 2020 Dec 11; 295(50):17148-17157.
12/4/2020
Chavali SS, Mali SM, Jenkins JL, Fasan R, Wedekind JE. "Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors." The Journal of biological chemistry.. 2020 Dec 4; 295(49):16470-16486.
11/5/2020
Sparks RP, Arango AS, Jenkins JL, Guida WC, Tajkhorshid E, Sparks CE, Sparks JD, Fratti RA. "An Allosteric Binding Site on Sortilin Regulates the Trafficking of VLDL, PCSK9, and LDLR in Hepatocytes." Biochemistry.. 2020 Nov 5; Epub 2020 Nov 05.
10/13/2020
Chavali SS, Mali SM, Jenkins JL, Fasan R, Wedekind JE. "Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors." The Journal of biological chemistry.. 2020 Oct 13; Epub 2020 Oct 13.
10/5/2020
Maji D, Glasser E, Henderson S, Galardi J, Pulvino MJ, Jenkins JL, Kielkopf CL. "Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing." The Journal of biological chemistry.. 2020 Oct 5; Epub 2020 Oct 05.
6/29/2020
Schroeder GM, Dutta D, Cavender CE, Jenkins JL, Pritchett EM, Baker CD, Ashton JM, Mathews DH, Wedekind JE. "Analysis of a preQ1-I riboswitch in effector-free and bound states reveals a metabolite-programmed nucleobase-stacking spine that controls gene regulation." Nucleic acids research.. 2020 Jun 29; Epub 2020 Jun 29.
9/12/2019
Sparks RP, Arango AS, Starr ML, Aboff ZL, Hurst LR, Rivera-Kohr DA, Zhang C, Harden KA, Jenkins JL, Guida WC, Tajkhorshid E, Fratti RA. "A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion." The Journal of biological chemistry.. 2019 Sep 12; Epub 2019 Sep 12.
8/2019
Talkish J, Igel H, Hunter O, Horner SW, Jeffery NN, Leach JR, Jenkins JL, Kielkopf CL, Ares M. "Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction." RNA.. 2019 Aug; 25(8):1020-1037. Epub 2019 May 20.
1/31/2019
Hilt ZT, Pariser DN, Ture SK, Mohan A, Quijada P, Asante A, Cameron SJ, Sterling JA, Merkel AR, Johanson AL, Jenkins JL, Small EM, McGrath KE, Palis J, Elliott MR, Morrell CN. "Platelet-derived ?2M regulates monocyte inflammatory responses." JCI insight.. 2019 Jan 31; Epub 2019 Jan 31.
1/7/2019
Starr ML, Sparks RP, Arango AS, Hurst LR, Zhao Z, Lihan M, Jenkins JL, Tajkhorshid E, Fratti RA. "Phosphatidic acid induces conformational changes in Sec18 protomers that prevent SNARE priming." The Journal of biological chemistry.. 2019 Jan 7; Epub 2019 Jan 07.
2019
Sparks RP, Jenkins JL, Fratti R. "Use of Surface Plasmon Resonance (SPR) to Determine Binding Affinities and Kinetic Parameters Between Components Important in Fusion Machinery." Methods in molecular biology.. 2019 1860:199-210.
12/19/2018
Loerch S, Leach JR, Horner SW, Maji D, Jenkins JL, Pulvino M, Kielkopf CL. "The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface." The Journal of biological chemistry.. 2018 Dec 19; Epub 2018 Dec 19.
9/12/2017
Glasser E, Agrawal A, Jenkins JL, Kielkopf CL. "Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs." Biochemistry.. 2017 Sep 12; 56(36):4757-4761. Epub 2017 Sep 01.
6/9/2017
Wedekind JE, Dutta D, Belashov IA, Jenkins JL. "Metalloriboswitches: RNA-based inorganic ion sensors that regulate genes." The Journal of biological chemistry.. 2017 Jun 9; 292(23):9441-9450. Epub 2017 Apr 28.
5/2017
Jenkins JL, Kielkopf CL. "Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures." Trends in genetics : TIG.. 2017 May; 33(5):336-348. Epub 2017 Mar 31.
2/2017
Clark KM, Jenkins JL, Fedoriw N, Dumont ME. "Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors." Protein science : a publication of the Protein Society.. 2017 Feb; 26(2):242-257. Epub 2016 Nov 11.
10/21/2016
Sparks RP, Jenkins JL, Miner GE, Wang Y, Guida WC, Sparks CE, Fratti RA, Sparks JD. "Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding." Biochemical and biophysical research communications.. 2016 Oct 21; 479(3):551-556. Epub 2016 Sep 22.
9/16/2016
Sparks RP, Guida WC, Sowden MP, Jenkins JL, Starr ML, Fratti RA, Sparks CE, Sparks JD. "Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells." Biochemical and biophysical research communications.. 2016 Sep 16; 478(2):546-52. Epub 2016 Aug 02.
8/2016
Miralem T, Lerner-Marmarosh N, Gibbs PE, Jenkins JL, Heimiller C, Maines MD. "Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2016 Aug; 30(8):2926-44. Epub 2016 May 10.
3/8/2016
Agrawal AA, Salsi E, Chatrikhi R, Henderson S, Jenkins JL, Green MR, Ermolenko DN, Kielkopf CL. "An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal." Nature communications.. 2016 Mar 8; 7:10950. Epub 2016 Mar 08.
2016
Jenkins JL, Wedekind JE. "The Quick and the Dead: A Guide to Fast Phasing of Small Ribozyme and Riboswitch Crystal Structures." Methods in molecular biology.. 2016 1490:265-80.
12/9/2014
Agrawal AA, McLaughlin KJ, Jenkins JL, Kielkopf CL. "Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA." Proceedings of the National Academy of Sciences of the United States of America.. 2014 Dec 9; 111(49):17420-5. Epub 2014 Nov 24.
2014
Liberman JA, Bogue JT, Jenkins JL, Salim M, Wedekind JE. "ITC analysis of ligand binding to preQ? riboswitches." Methods in enzymology.. 2014 549:435-50.
4/1/2013
Jenkins JL, Agrawal AA, Gupta A, Green MR, Kielkopf CL. "U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs." Nucleic acids research.. 2013 Apr 1; 41(6):3859-73. Epub 2013 Feb 01.
10/17/2012
Liberman JA, Guo M, Jenkins JL, Krucinska J, Chen Y, Carey PR, Wedekind JE. "A transition-state interaction shifts nucleobase ionization toward neutrality to facilitate small ribozyme catalysis." Journal of the American Chemical Society.. 2012 Oct 17; 134(41):16933-6. Epub 2012 Oct 03.
7/3/2012
Jenkins JL, Laird KM, Kielkopf CL. "A Broad range of conformations contribute to the solution ensemble of the essential splicing factor U2AF(65)." Biochemistry.. 2012 Jul 3; 51(26):5223-5. Epub 2012 Jun 19.
1/27/2012
Bauer WJ, Heath J, Jenkins JL, Kielkopf CL. "Three RNA recognition motifs participate in RNA recognition and structural organization by the pro-apoptotic factor TIA-1." Journal of molecular biology.. 2012 Jan 27; 415(4):727-40. Epub 2011 Dec 02.
2012
Lippa GM, Liberman JA, Jenkins JL, Krucinska J, Salim M, Wedekind JE. "Crystallographic analysis of small ribozymes and riboswitches." Methods in molecular biology.. 2012 848:159-84.
7/15/2011
Jenkins JL, Krucinska J, McCarty RM, Bandarian V, Wedekind JE. "Comparison of a preQ1 riboswitch aptamer in metabolite-bound and free states with implications for gene regulation." The Journal of biological chemistry.. 2011 Jul 15; 286(28):24626-37. Epub 2011 May 18.
3/8/2011
McLaughlin KJ, Jenkins JL, Kielkopf CL. "Large favorable enthalpy changes drive specific RNA recognition by RNA recognition motif proteins." Biochemistry.. 2011 Mar 8; 50(9):1429-31. Epub 2011 Feb 02.
2/4/2011
Gupta A, Jenkins JL, Kielkopf CL. "RNA induces conformational changes in the SF1/U2AF65 splicing factor complex." Journal of molecular biology.. 2011 Feb 4; 405(5):1128-38. Epub 2010 Dec 10.
11/28/2008
Jenkins JL, Shen H, Green MR, Kielkopf CL. "Solution conformation and thermodynamic characteristics of RNA binding by the splicing factor U2AF65." The Journal of biological chemistry.. 2008 Nov 28; 283(48):33641-9. Epub 2008 Oct 08.
2008
Jenkins, J.L; Shen H.; Green M.R.; Kielkopf. "Solution Conformation and Thermodynamic Characteristics of RNA binding by Splicing Factor U2AF65". J. Biol. Chem. 2008; 283: 33641-33649.
2008
Zhou Y.; Larson J.D.; Bottoms C.A.; Arturo E.C.; Henzl M.T.; Jenkins, J.L; Nix J.C.; Becker D.F.; Tanner, J.J. "Structural Basis of the Transcriptional Regulation of the Proline Utilization Regulon by Multifunctional PutA". J. Mol. Biol. 2008; 381: 174-188.
2006
Larson, J.D.; Jenkins, J.L.; Schuermann, J.P.; Zhou, Y.; Becker, D.F.; Tanner, J.J. "Crystal Structures of the DNA-binding Domain of Escherichia coli Proline Utilization A Flavoprotein and Analysis of the Role of Lys9 in DNA Recognition". Protein Science. 2006; v15: 2630-2641.
2006
Jenkins, J.L.; Tanner, J.J. "High Resolution Crystal Structure of Human D-Glyceraldehyde-3-Phosphate Dehydrogenase". Acta Crystallogr. 2006; D62: 290-301.