Dmitri N. Ermolenko, Ph.D.

Dmitri N. Ermolenko, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Fax: (585) 271-2683
Office: (585) 275-3704

Research Bio

We are interested in the mechanisms of the ribosome function. The ribosome is a central component of cell metabolism, translating genetic code and synthesizing proteins in all living organism. The ribosome is an extremely complex and highly dynamic machine. Our research is focused on the mechanics of ribosome movement along mRNA during protein synthesis. Movement of ribosomes along mRNA is essential attribute of protein synthesis in all organisms and often used to regulate protein expression.

Recent Journal Articles

Showing the 5 most recent journal articles. 31 available »

2016 Sep
Ling C, Ermolenko DN. "Structural insights into ribosome translocation." Wiley interdisciplinary reviews. RNA. 2016 Sep; 7(5):620-36. Epub 2016 Apr 27.
2016 May 22
Salsi E, Farah E, Ermolenko DN. "EF-G Activation by Phosphate Analogs." Journal of molecular biology. 2016 May 22; 428(10 Pt B):2248-58. Epub 2016 Apr 08.
2016 Mar 8
Agrawal AA, Salsi E, Chatrikhi R, Henderson S, Jenkins JL, Green MR, Ermolenko DN, Kielkopf CL. "An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal." Nature communications. 2016 Mar 8; 7:10950. Epub 2016 Mar 08.
2015 Dec 29
Ling C, Ermolenko DN. "Initiation factor 2 stabilizes the ribosome in a semirotated conformation." Proceedings of the National Academy of Sciences of the United States of America. 2015 Dec 29; 112(52):15874-9. Epub 2015 Dec 14.
2015 Jun 2
Ling C, Ermolenko DN. "Ribosome subunit joining frozen in time." Structure. 2015 Jun 2; 23(6):977-8.

Current Appointments

Associate Professor - Department of Biochemistry and Biophysics (SMD) - Primary