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Dmitri N. Ermolenko, Ph.D.

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Office: (585) 275-3704

Fax: (585) 271-2683

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We are interested in the mechanisms of the ribosome function. The ribosome is a central component of cell metabolism, translating genetic code and synthesizing proteins in all living organism. The ribosome is an extremely complex and highly dynamic machine. Our research is focused on the mechanics of ribosome movement along mRNA during protein synthesis. Movement of ribosomes along mRNA is essential attribute of protein synthesis in all organisms and often used to regulate protein expression.


Journal Articles

Lai WC, Zhu M, Belinite M, Ballard G, Mathews DH, Ermolenko DN. "Intrinsically unstructured sequences in the mRNA 3' UTR reduce the ability of poly(A) tail to enhance translation." Journal of molecular biology.. 2022 Nov 8; :167877. Epub 2022 Nov 08.

Bao C, Zhu M, Nykonchuk I, Wakabayashi H, Mathews DH, Ermolenko DN. "Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translation." Nature communications.. 2022 Feb 21; 13(1):988. Epub 2022 Feb 21.

Bao C, Ermolenko DN. "Ribosome as a Translocase and Helicase." Biochemistry. Biokhimii?a?.. 2021 Aug; 86(8):992-1002.