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Jesse B. Schallek, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-4848

Research Labs

Schallek Lab- Flaum Eye Institute

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Faculty Appointments

Biography

My laboratory invents new tools to evaluate eye health by measuring function. We are developing cutting-edge cameras to view the cells of the living eye with microscope resolution. In this way, we can study retinal health and disease within single cells of the retina without ever requiring a biopsy.

Research

Our lab investigates blood flow in the living eye by using a specialized camera called an Adaptive Optics Scanning Light Ophthalmoscope (AOSLO) to correct for small imperfections of the optics of the eye. Once corrected, we can image the microscopic integrity of the smallest vessels that are ten-times thinner than a human hair. Additionally, capturing videos of this tissue enables study of the movement of single blood cells flowing within this network. We are developing and applying this cutting-edge technology to study blood flow in the retina in conditions of health and disease.

These advances are critical for studying neural cells that line the back of our eyes are sensitive to light and initiate our ability to see. These cells are among the most metabolically active tissues in the human body and are nourished by a dense network of capillaries that circulate blood to deliver nutrients and remove waste products from these hard-working cells. We use and develop adaptive optics eye cameras to study the dysfunction of this neural-vascular system associates with a variety of retinal diseases and collectively gives rise to the leading cause of blindness in the developed world.

Credentials

Education

2003
BS | Syracuse University
Bioengineering

2010
PhD | SUNY Upstate Medical University
Neuroscience

Post-doctoral Training & Residency

2010 - 2015
Adaptive Optics Imaging in the Living Eye- Advisor: David Williams

Publications

Journal Articles

3/21/2018
Alarcon-Martinez L, Yilmaz-Ozcan S, Yemisci M, Schallek J, K?l?ç K, Can A, Di Polo A, Dalkara T. "Capillary pericytes express ?-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection." eLife.. 2018 Mar 21; 7Epub 2018 Mar 21.

3/2017
Marcos S, Werner JS, Burns SA, Merigan WH, Artal P, Atchison DA, Hampson KM, Legras R, Lundstrom L, Yoon G, Carroll J, Choi SS, Doble N, Dubis AM, Dubra A, Elsner A, Jonnal R, Miller DT, Paques M, Smithson HE, Young LK, Zhang Y, Campbell M, Hunter J, Metha A, Palczewska G, Schallek J, Sincich LC. "Vision science and adaptive optics, the state of the field." Vision research.. 2017 Mar 0; 132:3-33. Epub 2017 Feb 27.

10/1/2016
Guevara-Torres A, Joseph A, Schallek JB. "Label free measurement of retinal blood cell flux, velocity, hematocrit and capillary width in the living mouse eye." Biomedical optics express.. 2016 Oct 1; 7(10):4228-4249. Epub 2016 Sep 23.

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