Skip to main content
Explore URMC

URMC Logo

menu

Jesse B. Schallek, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Research Labs

Biography

Research

The neural cells that line the back of our eyes are sensitive to light and initiate our ability to see. These cells are among the most metabolically active tissues in the human body and are nourished by a dense network of capillaries that circulate blood to deliver nutrients and remove waste products from these hard-working cells. However, dysfunction of this neural-vascular system associates with a variety of retinal diseases and collectively gives rise to the leading cause of blindness in the developed world.

Our lab investigates blood flow in the living eye by using a specialized camera called an Adaptive Optics Scanning Light Ophthalmoscope (AOSLO) to correct for small imperfections of the optics of the eye. Once corrected, we can image the microscopic integrity of the smallest vessels that are ten-times thinner than a human hair. Additionally, capturing videos of this tissue enables study of the movement of single blood cells flowing within this network. We are developing and applying this cutting-edge technology to study blood flow in the retina in conditions of health and disease.

Credentials

Faculty Appointments

Education

2003
BS | Syracuse University
Bioengineering

2010
PhD | SUNY Upstate Medical University
Neuroscience

Publications

Journal Articles

12/19/2013
Schallek JB, Geng Y, Nguyen H, Williams DR. "Morphology and topography of retinal pericytes in the living mouse retina using in vivo adaptive optics imaging and ex vivo characterization." Investigative ophthalmology & visual science.. 2013 Dec 19; 54(13):8237-50. Epub 2013 Dec 19.

4/18/2012
Schallek JB, McLellan GJ, Viswanathan S, Ts'o DY. "Retinal intrinsic optical signals in a cat model of primary congenital glaucoma." Investigative ophthalmology & visual science.. 2012 Apr 18; 53(4):1971-81. Epub 2012 Apr 18.

3/2011
Schallek J, Ts'o D. "Blood contrast agents enhance intrinsic signals in the retina: evidence for an underlying blood volume component." Investigative ophthalmology & visual science.. 2011 Mar 0; 52(3):1325-35. Epub 2011 Mar 10.

VIEW ALL PUBLICATIONS