Skip to main content
Explore URMC
menu

Mark R. Buckley, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-4195

Research Labs

Faculty Appointments

Biography

Professional Background

Mark Buckley received his PhD in physics from Cornell University in 2010 and worked under Dr. Louis Soslowsky as a post-doctoral fellow at the University of Pennsylvania from 2010-2012. He joined the faculty of the Department of Biomedical Engineering at the University of Rochester in January of 2013. He has co-authored 16 publications on diverse topics ranging from three-dimensional tracking of swimming bacteria to the mechanical properties of cartilage under shear loading. Dr. Buckley is currently interested in "viscoelastic" soft biological tissues like cartilage and tendon that exhibit both fluid- and solid-like mechanical properties. His research emphasizes finding ways to control and exploit these complex properties to diagnose damage and disease, guide rehabilitation protocols and evaluate treatment and repair strategies in these tissues.

Research

Mechanics plays a key role in the onset, progression and treatment of several diseases that affect cartilage, tendon, cornea, sclera and other connective tissues. The Buckley Lab is interested in evaluating pathology-associated mechanical changes in these tissues and using our findings to develop novel diagnostic tools and therapeutic strategies. We characterize the viscoelastic (i.e., rate- and time-dependent) mechanical response of connective tissues in vivo and in viable explants across multiple length scales using image-guided mechanical testing methods. Our current focus is on diseases of the musculoskeletal system (e.g., osteoarthritis and tendinopathy) and diseases of the eye (e.g., keratoconus and glaucoma) with significant public health impacts.

Publications

Journal Articles

1/19/2023
Korcari A, Nichols AEC, Buckley MR, Loiselle AE. "Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype." eLife.. 2023 Jan 19; 12Epub 2023 Jan 19.

3/23/2022
Korcari A, Buckley MR, Loiselle AE. "Characterization of scar tissue biomechanics during adult murine flexor tendon healing." Journal of the mechanical behavior of biomedical materials.. 2022 Mar 23; 130:105192. Epub 2022 Mar 23.

2/22/2022
Kallenbach JG, Freeberg MAT, Abplanalp D, Alenchery RG, Ajalik RE, Muscat S, Myers JA, Ashton JM, Loiselle A, Buckley MR, van Wijnen AJ, Awad HA. "Altered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse." Scientific reports.. 2022 Feb 22; 12(1):3026. Epub 2022 Feb 22.

VIEW ALL PUBLICATIONS