Mark R. Buckley, Ph.D.

Contact Information

Faculty Appointments

Associate Professor - Department of Biomedical Engineering (RC)
Associate Professor - Department of Ophthalmology (SMD) - Joint

Biography

Professional Background

Mark Buckley received his PhD in physics from Cornell University in 2010 and worked under Dr. Louis Soslowsky as a post-doctoral fellow at the University of Pennsylvania from 2010-2012. He joined the faculty of the Department of Biomedical Engineering at the University of Rochester in January of 2013. He has co-authored 16 publications on diverse topics ranging from three-dimensional tracking of swimming bacteria to the mechanical properties of cartilage under shear loading. Dr. Buckley is currently interested in "viscoelastic" soft biological tissues like cartilage and tendon that exhibit both fluid- and solid-like mechanical properties. His research emphasizes finding ways to control and exploit these complex properties to diagnose damage and disease, guide rehabilitation protocols and evaluate treatment and repair strategies in these tissues.

Research

Mechanics plays a key role in the onset, progression and treatment of several diseases that affect cartilage, tendon, cornea, sclera and other connective tissues. The Buckley Lab is interested in evaluating pathology-associated mechanical changes in these tissues and using our findings to develop novel diagnostic tools and therapeutic strategies. We characterize the viscoelastic (i.e., rate- and time-dependent) mechanical response of connective tissues in vivo and in viable explants across multiple length scales using image-guided mechanical testing methods. Our current focus is on diseases of the musculoskeletal system (e.g., osteoarthritis and tendinopathy) and diseases of the eye (e.g., keratoconus and glaucoma) with significant public health impacts.

Publications

Journal Articles

1/22/2021
Best KT, Korcari A, Mora KE, Nichols AE, Muscat SN, Knapp E, Buckley MR, Loiselle AE. "Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis." eLife.. 2021 Jan 22; 10Epub 2021 Jan 22.

10/28/2020
Taguchi T, Kotelsky A, Takasugi M, Chang M, Ke Z, Betancourt M, Buckley MR, Zuscik M, Seluanov A, Gorbunova V. "Naked mole-rats are extremely resistant to post-traumatic osteoarthritis." Aging cell.. 2020 Oct 28; :e13255. Epub 2020 Oct 28.

8/19/2020
Bah I, Fernandes NRJ, Chimenti RL, Ketz J, Flemister AS, Buckley MR. "Tensile mechanical changes in the Achilles tendon due to Insertional Achilles tendinopathy." Journal of the mechanical behavior of biomedical materials.. 2020 Aug 19; 112:104031. Epub 2020 Aug 19.

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