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Felix O. Yarovinsky, M.D.


Showing all 45 journal articles & 0 books available

Journal Articles

López-Yglesias AH, Burger E, Araujo A, Martin AT, Yarovinsky F. "T-bet-independent Th1 response induces intestinal immunopathology during Toxoplasma gondii infection." Mucosal immunology.. 2018 May 0; 11(3):921-931. Epub 2018 Jan 03.

Burger, E; Araujo, A; López-Yglesias, A; Rajala, MW; Geng, L; Levine, B; Hooper, LV; Burstein, E; Yarovinsky, F. "Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation". Cell Host & Microbe. 2018; .

Song J, Wilhelm CL, Wangdi T, Maira-Litran T, Lee SJ, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Bäumler AJ, Pier GB, Galán JE, Yarovinsky F. "Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi." Cell.. 2016 Feb 25; 164(5):827-8.

Sturge CR, Burger E, Raetz M, Hooper LV, Yarovinsky F. "Cutting Edge: Developmental Regulation of IFN-? Production by Mouse Neutrophil Precursor Cells." The Journal of immunology : official journal of the American Association of Immunologists.. 2015 Jul 1; 195(1):36-40. Epub 2015 May 29.

Oh JZ, Ravindran R, Chassaing B, Carvalho FA, Maddur MS, Bower M, Hakimpour P, Gill KP, Nakaya HI, Yarovinsky F, Sartor RB, Gewirtz AT, Pulendran B. "TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination." Immunity.. 2014 Sep 18; 41(3):478-492. Epub 2014 Sep 11.

Wilhelm CL, Yarovinsky F. "Apicomplexan infections in the gut." Parasite immunology.. 2014 Sep 0; 36(9):409-20.

Sturge CR, Yarovinsky F. "Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection." Infection and immunity.. 2014 Aug 0; 82(8):3090-7. Epub 2014 May 27.

Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E. "Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer." Gastroenterology.. 2014 Jul 0; 147(1):184-195.e3. Epub 2014 Apr 13.

Yarovinsky F. "Innate immunity to Toxoplasma gondii infection." Nature reviews. Immunology.. 2014 Feb 0; 14(2):109-21.

Mirpuri J, Raetz M, Sturge CR, Wilhelm CL, Benson A, Savani RC, Hooper LV, Yarovinsky F. "Proteobacteria-specific IgA regulates maturation of the intestinal microbiota." Gut microbes.. 2014 5(1):28-39. Epub 2013 Sep 25.

Raetz M, Kibardin A, Sturge CR, Pifer R, Li H, Burstein E, Ozato K, Larin S, Yarovinsky F. "Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin." The Journal of immunology : official journal of the American Association of Immunologists.. 2013 Nov 1; 191(9):4818-27. Epub 2013 Sep 27.

Sturge CR, Benson A, Raetz M, Wilhelm CL, Mirpuri J, Vitetta ES, Yarovinsky F. "TLR-independent neutrophil-derived IFN-? is important for host resistance to intracellular pathogens." Proceedings of the National Academy of Sciences of the United States of America.. 2013 Jun 25; 110(26):10711-6. Epub 2013 Jun 10.

Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F. "Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-?-dependent elimination of Paneth cells." Nature immunology.. 2013 Feb 0; 14(2):136-42. Epub 2012 Dec 23.

Hwang SH, Lee H, Yamamoto M, Jones LA, Dayalan J, Hopkins R, Zhou XJ, Yarovinsky F, Connolly JE, Curotto de Lafaille MA, Wakeland EK, Fairhurst AM. "B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice." The Journal of immunology : official journal of the American Association of Immunologists.. 2012 Dec 15; 189(12):5786-96. Epub 2012 Nov 12.

Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M. "Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth." Nature.. 2012 Nov 8; 491(7423):254-8.

Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, DeFranco AL, Yarovinsky F. "B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage." Immunity.. 2012 Feb 24; 36(2):228-38. Epub 2012 Feb 01.

Benson A, Murray S, Divakar P, Burnaevskiy N, Pifer R, Forman J, Yarovinsky F. "Microbial infection-induced expansion of effector T cells overcomes the suppressive effects of regulatory T cells via an IL-2 deprivation mechanism." The Journal of immunology : official journal of the American Association of Immunologists.. 2012 Jan 15; 188(2):800-10. Epub 2011 Dec 05.

Mirpuri J, Yarovinsky F. "IL-6 signaling SOCS critical for IL-12 host response to Toxoplasma gondii." Future microbiology.. 2012 Jan 0; 7(1):13-6.

Broadhurst MJ, Ardeshir A, Kanwar B, Mirpuri J, Gundra UM, Leung JM, Wiens KE, Vujkovic-Cvijin I, Kim CC, Yarovinsky F, Lerche NW, McCune JM, Loke P. "Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon." PLoS pathogens.. 2012 8(11):e1003000. Epub 2012 Nov 15.

Mirpuri J, Sotnikov I, Myers L, Denning TL, Yarovinsky F, Parkos CA, Denning PW, Louis NA. "Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit." PloS one.. 2012 7(12):e51955. Epub 2012 Dec 18.

McFadden N, Bailey D, Carrara G, Benson A, Chaudhry Y, Shortland A, Heeney J, Yarovinsky F, Simmonds P, Macdonald A, Goodfellow I. "Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4." PLoS pathogens.. 2011 Dec 0; 7(12):e1002413. Epub 2011 Dec 08.

Pifer R, Yarovinsky F. "Innate responses to Toxoplasma gondii in mice and humans." Trends in parasitology.. 2011 Sep 0; 27(9):388-93.

Butcher BA, Fox BA, Rommereim LM, Kim SG, Maurer KJ, Yarovinsky F, Herbert DR, Bzik DJ, Denkers EY. "Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control." PLoS pathogens.. 2011 Sep 0; 7(9):e1002236. Epub 2011 Sep 08.

Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV. "Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface." Proceedings of the National Academy of Sciences of the United States of America.. 2011 May 24; 108(21):8743-8. Epub 2011 May 09.

Pifer R, Benson A, Sturge CR, Yarovinsky F. "UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii." The Journal of biological chemistry.. 2011 Feb 4; 286(5):3307-14. Epub 2010 Nov 19.

Hou B, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F. "Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors." Proceedings of the National Academy of Sciences of the United States of America.. 2011 Jan 4; 108(1):278-83. Epub 2010 Dec 20.

Becker AM, Blevins JS, Tomson FL, Eitson JL, Medeiros JJ, Yarovinsky F, Norgard MV, van Oers NS. "Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs." The Journal of immunology : official journal of the American Association of Immunologists.. 2010 Jun 15; 184(12):6822-32. Epub 2010 May 14.

Wilson MS, Feng CG, Barber DL, Yarovinsky F, Cheever AW, Sher A, Grigg M, Collins M, Fouser L, Wynn TA. "Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections." The Journal of immunology : official journal of the American Association of Immunologists.. 2010 Apr 15; 184(8):4378-90. Epub 2010 Mar 10.

Bailey D, Karakasiliotis I, Vashist S, Chung LM, Rees J, Reese J, McFadden N, Benson A, Yarovinsky F, Simmonds P, Goodfellow I. "Functional analysis of RNA structures present at the 3' extremity of the murine norovirus genome: the variable polypyrimidine tract plays a role in viral virulence." Journal of virology.. 2010 Mar 0; 84(6):2859-70. Epub 2010 Jan 06.

Sassi A, Brichacek B, Hieny S, Yarovinsky F, Golding H, Grivel JC, Sher A, Margolis L. "Toxoplasma gondii inhibits R5 HIV-1 replication in human lymphoid tissues ex vivo." Microbes and infection. 2009 Dec 0; 11(14-15):1106-13. Epub 2009 Aug 09.

Benson A, Pifer R, Behrendt CL, Hooper LV, Yarovinsky F. "Gut commensal bacteria direct a protective immune response against Toxoplasma gondii." Cell host & microbe.. 2009 Aug 20; 6(2):187-96.

Sanders CJ, Franchi L, Yarovinsky F, Uematsu S, Akira S, Núñez G, Gewirtz AT. "Induction of adaptive immunity by flagellin does not require robust activation of innate immunity." European journal of immunology.. 2009 Feb 0; 39(2):359-71.

Yarovinsky F, Hieny S, Sher A. "Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology." The Journal of immunology : official journal of the American Association of Immunologists.. 2008 Dec 15; 181(12):8478-84.

Yarovinsky F. "Toll-like receptors and their role in host resistance to Toxoplasma gondii." Immunology letters.. 2008 Aug 15; 119(1-2):17-21. Epub 2008 Jun 18.

Pepper M, Dzierszinski F, Wilson E, Tait E, Fang Q, Yarovinsky F, Laufer TM, Roos D, Hunter CA. "Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines." The Journal of immunology : official journal of the American Association of Immunologists.. 2008 May 1; 180(9):6229-36.

Plattner F, Yarovinsky F, Romero S, Didry D, Carlier MF, Sher A, Soldati-Favre D. "Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response." Cell host & microbe.. 2008 Feb 14; 3(2):77-87.

Yarovinsky F, Kanzler H, Hieny S, Coffman RL, Sher A. "Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response." Immunity.. 2006 Oct 0; 25(4):655-64. Epub 2006 Sep 28.

Yarovinsky F, Sher A. "Toll-like receptor recognition of Toxoplasma gondii." International journal for parasitology.. 2006 Mar 0; 36(3):255-9. Epub 2006 Jan 13.

Golding H, Khurana S, Yarovinsky F, King LR, Abdoulaeva G, Antonsson L, Owman C, Platt EJ, Kabat D, Andersen JF, Sher A. "CCR5 N-terminal region plays a critical role in HIV-1 inhibition by Toxoplasma gondii-derived cyclophilin-18." The Journal of biological chemistry.. 2005 Aug 19; 280(33):29570-7. Epub 2005 Jun 23.

Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, Hieny S, Sutterwala FS, Flavell RA, Ghosh S, Sher A. "TLR11 activation of dendritic cells by a protozoan profilin-like protein." Science.. 2005 Jun 10; 308(5728):1626-9. Epub 2005 Apr 28.

Kurosaka K, Chen Q, Yarovinsky F, Oppenheim JJ, Yang D. "Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant." The Journal of immunology : official journal of the American Association of Immunologists.. 2005 May 15; 174(10):6257-65.

Yarovinsky F, Andersen JF, King LR, Caspar P, Aliberti J, Golding H, Sher A. "Structural determinants of the anti-HIV activity of a CCR5 antagonist derived from Toxoplasma gondii." The Journal of biological chemistry.. 2004 Dec 17; 279(51):53635-42. Epub 2004 Oct 06.

Abe K, Yarovinsky FO, Murakami T, Shakhov AN, Tumanov AV, Ito D, Drutskaya LN, Pfeffer K, Kuprash DV, Komschlies KL, Nedospasov SA. "Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo." Blood.. 2003 Feb 15; 101(4):1477-83.

Kuprash DV, Boitchenko VE, Yarovinsky FO, Rice NR, Nordheim A, Rühlmann A, Nedospasov SA. "Cyclosporin A blocks the expression of lymphotoxin alpha, but not lymphotoxin beta, in human peripheral blood mononuclear cells." Blood.. 2002 Sep 1; 100(5):1721-7.

Surovoi AY, Sukhacheva EA, Wert MY, Yarovinsky FO, Zeinalova ES, Gaunitz F, Uberahm E, Gebhardt R. "Obtaining of monoclonal antibodies by means of DNA immunization." Doklady. Biochemistry and biophysics.. 2001 379:255-6.