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Yarovinsky Lab

Welcome to the Yarovinsky Lab

Our lab has two major areas of interest:

  • Innate immunity to protozoan parasites
  • Paneth cells in the regulation of intestinal homeostasis and mucosal immunity

The major interests of our lab involve studying innate immune sensing pathways and their role in regulation of host defense to intracellular pathogens.  Our lab is focused on understanding how Toll-like receptors cooperate with other recognition systems to detect protozoan parasites Toxoplasma gondii, Cryprosporidium and malaria and how innate immune recognition regulates host defense. 

We also aim to understand the mechanisms controlling host-pathogen interactions in the gut, a highly specialized environment with distinct structures, epithelial cell types, and innate defense mechanisms required for mucosal host defense.

Our lab uses a combination of cellular and molecular techniques including germ-free mouse models to investigate mucosal immune cells and their contribution to the composition of microbiota and the development of intestinal immune response and inflammation.

Felix O. Yarovinsky, M.D.

Felix O. Yarovinsky, M.D.
Principal Investigator

Selected Publications

    1. Safronova A
    2. Araujo A
    3. Camanzo ET
    4. Moon TJ
    5. Elliott MR
    6. Beiting DP
    7. Yarovinsky F  
    (2019 Jan). Alarmin.  S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii. Nature Immunology.
    1. López-Yglesias AH
    2. Camanzo E
    3. Martin AT
    4. Araujo AM
    5. Yarovinsky F  
    (2019 Jun). TLR11-independent inflammasome activation is critical for CD4+ T cell-derived IFN-γ production and host resistance to Toxoplasma gondii. PLoS Pathog.
    1. Burger E
    2. Araujo A
    3. López-Yglesias A
    4. Rajala MW
    5. Geng L
    6. Levine B
    7. Hooper LV
    8. Burstein E
    9. Yarovinsky F
    (2018 Feb). Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation. Cell Host & Microbe.


View All Publications

Contact Us

  Yarovinsky Lab
KMRB 3-9838
601 Elmwood Ave,
Rochester, NY 14642