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Isaac S. Harris, Ph.D.

Publications

Showing all 22 journal articles & 0 books available

Journal Articles

10/1/2019
Harris IS, Brugge JS. "United They Stand, Divided They Fall." Cell metabolism.. 2019 Oct 1; 30(4):624-625.

5/7/2019
Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG, Brugge JS. "Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion." Cell metabolism.. 2019 May 7; 29(5):1166-1181.e6. Epub 2019 Feb 21.

7/3/2018
Lee JJ, van de Ven RAH, Zaganjor E, Ng MR, Barakat A, Demmers JJPG, Finley LWS, Gonzalez Herrera KN, Hung YP, Harris IS, Jeong SM, Danuser G, McAllister SS, Haigis MC. "Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3." Proceedings of the National Academy of Sciences of the United States of America.. 2018 Jul 3; 115(27):7057-7062. Epub 2018 Jun 18.

6/11/2018
Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS. "Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance." Cancer cell.. 2018 Jun 11; 33(6):985-1003.e7. Epub 2018 May 24.

3/2018
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G. "Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018." Cell death and differentiation.. 2018 Mar 0; 25(3):486-541. Epub 2018 Jan 23.

12/26/2017
Selfors LM, Stover DG, Harris IS, Brugge JS, Coloff JL. "Identification of cancer genes that are independent of dominant proliferation and lineage programs." Proceedings of the National Academy of Sciences of the United States of America.. 2017 Dec 26; 114(52):E11276-E11284. Epub 2017 Dec 11.

6/20/2017
Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D. "Glutathione Primes T Cell Metabolism for Inflammation." Immunity.. 2017 Jun 20; 46(6):1089-1090.

4/18/2017
Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D. "Glutathione Primes T Cell Metabolism for Inflammation." Immunity.. 2017 Apr 18; 46(4):675-689.

5/10/2016
Coloff JL, Murphy JP, Braun CR, Harris IS, Shelton LM, Kami K, Gygi SP, Selfors LM, Brugge JS. "Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells." Cell metabolism.. 2016 May 10; 23(5):867-80. Epub 2016 Apr 28.

11/12/2015
Harris IS, Brugge JS. "Cancer: The enemy of my enemy is my friend." Nature.. 2015 Nov 12; 527(7577):170-1. Epub 2015 Oct 21.

2/9/2015
Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, Yung KY, Brenner D, Knobbe-Thomsen CB, Cox MA, Elia A, Berger T, Cescon DW, Adeoye A, Brüstle A, Molyneux SD, Mason JM, Li WY, Yamamoto K, Wakeham A, Berman HK, Khokha R, Done SJ, Kavanagh TJ, Lam CW, Mak TW. "Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression." Cancer cell.. 2015 Feb 9; 27(2):211-22. Epub 2015 Jan 22.

9/2014
Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Izsvák Z, Iszvak Z, Lupien M, Mak TW, Khokha R. "Human somatic cell mutagenesis creates genetically tractable sarcomas." Nature genetics.. 2014 Sep 0; 46(9):964-72. Epub 2014 Aug 17.

2/4/2014
Inoue S, Tomasini R, Rufini A, Elia AJ, Agostini M, Amelio I, Cescon D, Dinsdale D, Zhou L, Harris IS, Lac S, Silvester J, Li WY, Sasaki M, Haight J, Brüstle A, Wakeham A, McKerlie C, Jurisicova A, Melino G, Mak TW. "TAp73 is required for spermatogenesis and the maintenance of male fertility." Proceedings of the National Academy of Sciences of the United States of America.. 2014 Feb 4; 111(5):1843-8. Epub 2014 Jan 21.

12/2013
Gorrini C, Harris IS, Mak TW. "Modulation of oxidative stress as an anticancer strategy." Nature reviews. Drug discovery.. 2013 Dec 0; 12(12):931-47.

7/29/2013
Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, Brenner D, Tseng A, Musgrave M, Berman HK, Khokha R, Jonkers J, Mak TW, Gauthier ML. "BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival." The Journal of experimental medicine.. 2013 Jul 29; 210(8):1529-44. Epub 2013 Jul 15.

5/15/2013
Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW. "Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15." Genes & development.. 2013 May 15; 27(10):1101-14.

9/15/2012
Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW. "D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function." Genes & development.. 2012 Sep 15; 26(18):2038-49. Epub 2012 Aug 27.

9/15/2012
Rufini A, Niklison-Chirou MV, Inoue S, Tomasini R, Harris IS, Marino A, Federici M, Dinsdale D, Knight RA, Melino G, Mak TW. "TAp73 depletion accelerates aging through metabolic dysregulation." Genes & development.. 2012 Sep 15; 26(18):2009-14.

8/30/2012
Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brüstle A, Harris IS, Holmes R, Wakeham A, Haight J, You-Ten A, Li WY, Schalm S, Su SM, Virtanen C, Reifenberger G, Ohashi PS, Barber DL, Figueroa ME, Melnick A, Zúñiga-Pflücker JC, Mak TW. "IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics." Nature.. 2012 Aug 30; 488(7413):656-9.

9/2/2011
Karisch R, Fernandez M, Taylor P, Virtanen C, St-Germain JR, Jin LL, Harris IS, Mori J, Mak TW, Senis YA, Östman A, Moran MF, Neel BG. "Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome"." Cell.. 2011 Sep 2; 146(5):826-40.

2/2011
Cairns RA, Harris IS, Mak TW. "Regulation of cancer cell metabolism." Nature reviews. Cancer.. 2011 Feb 0; 11(2):85-95.

12/28/2007
Bakker WJ, Harris IS, Mak TW. "FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2." Molecular cell.. 2007 Dec 28; 28(6):941-53.