Welcome to the Harris Lab
There has been a long-standing belief that supplementation with antioxidants could prevent or treat cancer. However, results of large-scale clinical trials have proven the opposite: supplementation with antioxidants promote, rather than prevent, cancer. The Harris Lab at the University of Rochester Medical Center and Wilmot Cancer Institute focuses on uncovering the various roles of antioxidants in cancer by using in vivo mouse modeling approaches and high-throughput pharmacologic screening techniques.
Isaac S. Harris, Ph.D.
Principal Investigator
- Catabolism of extracellular glutathione supplies cysteine to support tumours.; Nature. 2026 Mar 18.
- Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.; JCI insight; Vol 9(13). 2024 May 30.
- United They Stand, Divided They Fall.; Cell metabolism; Vol 30(4). 2019 Oct 01.
- Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.; Cell metabolism; Vol 29(5). 2019 May 07.
Contact Us
Harris Lab
Wilmot Cancer Institute
KMRB G.9872
415 Elmwood Avenue
Rochester, NY 14642