CONTACT INFORMATIONBIOGRAPHYCREDENTIALSPUBLICATIONSIsaac S. Harris, Ph.D.Contact InformationPhone NumbersOffice: (585) 273-4353Research LabsVisit Lab WebsiteLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 633Rochester, NY 14642Faculty AppointmentsAssistant Professor - Department of Biomedical Genetics (SMD) BiographyProfessional BackgroundBorn in the Great White North of Canada, Isaac received both his undergraduate and graduate degrees from the University of Toronto and conducted research in the lab of Dr. Tak Mak at Princess Margaret Cancer Center. Afterwards, he joined the lab of Dr. Joan Brugge at Harvard Medical School in Boston. Recently, Isaac moved to Rochester, NY to open his independent lab at the University of Rochester/Wilmot Cancer Institute.ResearchThere has been a long-standing belief that supplementation with antioxidants could prevent or treat cancer. However, results of large-scale clinical trials have proven the opposite: supplementation with antioxidants promote, rather than prevent, cancer. The Harris Lab at the University of Rochester Medical Center and Wilmot Cancer Institute focuses on uncovering the various roles of antioxidants in cancer by using in vivo mouse modeling approaches and high-throughput pharmacologic screening techniques.PublicationsJournal Articles10/1/2019Harris IS, Brugge JS. "United They Stand, Divided They Fall." Cell metabolism.. 2019 Oct 1; 30(4):624-625. 5/7/2019Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG, Brugge JS. "Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion." Cell metabolism.. 2019 May 7; 29(5):1166-1181.e6. Epub 2019 Feb 21. 7/3/2018Lee JJ, van de Ven RAH, Zaganjor E, Ng MR, Barakat A, Demmers JJPG, Finley LWS, Gonzalez Herrera KN, Hung YP, Harris IS, Jeong SM, Danuser G, McAllister SS, Haigis MC. "Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3." Proceedings of the National Academy of Sciences of the United States of America.. 2018 Jul 3; 115(27):7057-7062. Epub 2018 Jun 18. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Isaac S. Harris, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Isaac S. Harris, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.