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Hsi-Min Jim HsiaoHsi-Min Jim Hsiao , a graduate student in the lab of Drs. Patricia Sime and Richard Phipps, will give a podium talk entitled, Resolvin D1 Inhibits Cigarette Smoke-Induced Emphysema in Mice at the American Thoracic Society (ATS) International Conference in Philadelphia, PA, May 21, 2013.

 

 

 

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Jonathan CherrySpace Travel is Harmful to the Brain

Jonathan Cherry, a graduate student in the laboratory of Drs. O’Banion and Olschowka, is the first author of a paper showing that cosmic radiation – which would bombard astronauts on deep space missions to places like Mars – could accelerate the onset of Alzheimer’s disease:

Galactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer’s Disease

Jonathan D. Cherry, Bin Liu, Jeffrey L. Frost, Cynthia A. Lemere, Jacqueline P. Williams, John A. Olschowka, M. Kerry O'Banion.

I-Hsin Fiona Kuo, a graduate student in the lab of Dr. Lisa Beck, was selected to I-Hsin Fiona Kuoreceive a Domestic In-Training FITs/PhD Post DocFITs Travel Scholarship for the 2013 American Academy of Allergy Asthma & Immunology (AAAAI) Annual Meeting in San Antonio, TX, February 22-26, 2013.. She will present a poster entitled, T helper cytokines (Th1,Th2 and Th17) differentially regulate the epidermal tight junction barrier.

 

2012

Tristan NicholsonTristan Nicholson, an MD/PhD student in Dr. William Ricke's lab, has been awarded a National Institutes of Health NRSA F30 individual predctoral MD/PhD fellowship. This felloship, which will cover the remainder of her graduate and medical educations, will support her thesis project focused on estrogen receptors in benigh prostatic hyperplasia. Tristan also received a travel award and gave a podium presentation, Early Decreased Uroflow, Bladder Enlargement and Prostate Growth in Male Mice Treated with Testosterone and 17-beta Estradiol at the Society for Basic Urologic Research Annual meeting in Miami Beach, FL, November 15-18, 2012.

     

 

   

Amali Epa

Amali Epa won a poster award at the Gordon Research Conference on Transglutaminases in Human Disease Process, July 15 - 20, 2012, Davidson, NC. The poster was entitled: Role of Epithelial Tissue Transglutaminase in the Development of Pulmonary Fibrosis. Amali is a graduate student in the lab of Dr. Patricia Sime.

 

 

 

 

cuicui wang

Cuicui Wang won an American Society of Bone and Mineral Research (ASBMR) Young Investigator Travel Grant. She will have a plenary poster presentation of her work, Manipulating the Notch Pathway to Accelerate Fracture Repair at the ASBMR Annual Meeting in Minneapolis, MN, October 11-15, 2012. Cuicui is a graduate student in the lab of Dr. Matthew Hilton.

 

 

 

Hsing-Yu Warner Chen

Hsing-Yu Chen, advisor Dr. Mark Noble, won the GSS Merit Award (HHMI Award of Excellence) 2012 for his poster, Restoration of c-Cbl Function, by Inhibiting Cdc42, Confers Tamoxifen Sensitivity on Basal-like (Triple Negative) Breast Cancer Cells, April 20, 2012.

 

 

 

 

Benjamin Plog

Scientists Discover Previously Unknown Cleansing System in Brain

Benjamin Plog, an MD/PhD student in Dr. Maiken Nedergaard’s lab, is a co-author of a fascinating paper just published in Science Translational Medicine which reports the discovery of a previously unrecognized ‘glymphatic system’ that drains waste from the brain:

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Jeffrey J. Iliff, Minghuan Wang, Younghong Liao, Benjamin A. Plog, Weiguo Peng, Georg A. Gundersen, Helene Benveniste, G. Edward Vates, Rashid Deane, Steven A. Goldman, Erlend A. Nagelhus, and Maiken Nedergaard

 

 

Best Grad Schools

US News & World Report’s annual ranking of the nation’s best graduate schools was released earlier today, giving the University of Rochester School of Medicine and Dentistry a noticeable boost. Among the best research medical schools, Rochester scored #29, its highest ranking since 2002. In the primary care schools category, the University of Rochester was listed as the #15 best medical school, up slightly from last year. The rankings are widely used by college students when choosing medical schools which to apply.

Both scores were aided by improvements in the school’s selectivity as it accepts students with higher grade point averages in their undergraduate studies and better performance on medical school entrance exams. Among research schools, the University of Rochester also outpaced more schools in research funding than it did in last year’s ranking.

 

Benjamin Frisch and Laura Calvi

URMC Finds Leukemia Cells are "Bad to the Bone"

Benjamin J. Frisch, a graduate student in the lab of Dr. Laura Calvi, led research discovering new links between leukemia cells and cells involved in bone formation, offering a fresh perspective on how the blood cancer progresses. Results were published in the journal Blood.

Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia.

Frisch BJ, Ashton JM, Xing L, Becker MW, Jordan CT, Calvi LM

Fiona Kuo and Warner Chen

I-Hsin (Fiona) Kuo, a graduate student work in Dr. Lisa Beck's Lab, was selected and invited by European Academy of Allergy and Clinical Immunology (EAACI) to attend the 10th EAACI-Ga2len Immunology Winter School at Åre, Sweden, February 12-15, 2012. She will give an oral presentation entitled, Barrier function of epidermal toll-like receptor 2 (TLR2) and its relevance for atopic dermatitis.

http://www.eaaci.net/activities/allergy-schools/1743-2012-winter-school-in%3E-are-sweden

Benjamin Frisch, Scott Peslak and Julianne Smith each received an Abstract Achievement Award to attend the 53rd American Society of Hematology Annual Meeting in San Diego, CA, December 10-13, 2011. They will give oral presentations: Functional Inhibition of Osteoblastic Cells in an In Vivo Mouse Model of Myeloid Leukemia (Frisch), EPO-Dependent Recovery of Late-Stage Erythroid Progenitors in the Marrow Precedes Splenic Expansion: Insights from a Sublethal Radiation Model (Peslak), PTH Stimulates Osteoblastic VEGF-A Production and Remodels Bone Marrow Micro-Endothelial Structures (Smith).

The Merritt and Marjorie Cleveland Fellowship Award is given to a PhD student entering graduate study through the University of Rochester Graduate Education in the Biomedica Sciences Program with an interest in developing a neuroscience-related research career. Salvador Pena is the distinguished recipient for the 2011-2012 academic year.

 

Hsing-Yu Warner ChenHsing-Yu Chen, a graduate student in Dr. Mark Noble's Lab, received a scholar-in-training award (http://www.aacr.org/home/scientists/meetings--workshops/special-conferences/advances-in-breast-cancer-research/financial-support-for-attendance.aspx) to the AACR Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications meeting being held on Oct 12 - Oct 15, 2011 in San Francisco. He will present a poster entitled, Restoration of c-Cbl function, by inhibiting Cdc42, confers tamoxifen sensitivity on basal-like (triple negative) breast cancer cells.

 

 

 

 

Angela AggreyAngela Aggrey received an Under-represented Minority Fellowship http://www.grc.org/diversity.aspx

to the Gordon Research Conference on Malaria, July 31 -August 5, 2011 in Lucca, Italy. She presented a poster: Platelet Induction of the Acute Phase Response & Subsequent Complement Activation is Protective in ECM. Angela is a graduate student in Dr. Craig Morrell's lab.

Jeffrey Harder received a travel grant from the National Eye Institute (NEI) to attend Harder and present a poster entitled JNK-dependent JUN signaling is critical to retinal ganglion cell death after axonal injury at the Annual Association for Research in Vision and Ophthalmology (ARVO) meeting, May 1-5, 2011 in Fort Lauderdale, FL. Jeffrey is a graduate student in the lab of Dr. Richard Libby.

 

 

Robert D. BellRobert D. Bell, PhD received the University of Rochester's prestigious Wallace O. Fenn Award for his PhD research and thesis at the Doctoral Graduation Dinner, May 14, 2011.

 

 

I-Hsin Fiona Kuo

An Albert M. Kligman Travel Fellowship Award was granted to I-Hsin Kuo, a graduate student in Dr. Lisa Beck's lab, by the Society for Investigative Dermatology to attend the Annual Meeting of the Society for Investigative Dermatology (SID) in Phoenix, AZ, May 4 - 7, 2011.

 

Dawn Lee, a graduate student in the lab of Dr. Margot Mayer-Proschel, has been image awarded a Young Investigator Educational Enhancement travel award for the American Society for Neurochemistry 2011 Annual Meeting March 19 - 23, 2011 in St. Louis, MO. http://www.asneurochem.org/library/YoungTravelAward.htm

Researchers Focus on Human Cells for Spinal Cord Injury Repair

 

Chung-Hsuan (Richard) Shih (Advisor: Dr. Chris Proschel) is a co-author of a studyChung-Hsuan Richard Shih just published in PLoS ONE indicating that transplantation of astrocytes represents a potential new avenue for the treatment of spinal cord injuries and other central nervous system disorders:

Transplantation of Specific Human Astrocytes Promotes Functional Recovery after Spinal Cord Injury

Stephen J. A. Davies, Chung-Hsuan Shih, Mark Noble, Margot Mayer-Proschel, Jeannette E. Davies, Christoph Proschel

Nikesha Haynes will present a poster at the Department of Defense IMPACT Nikesha Haynesconference, March 9 - 12, 2011 in Orlando, FL. The title of her poster is, Isolation and Characterization of Prostate Cancer Progression Lines Derived from a Clonal Benign Cell. Nikesha is a graduate student in the lab of

Dr. Jacques Robert.

Tzu-Hua Lin

Tzu-Hua Dennis Lin (Advisor: Dr. Chawnshang Chang) will give a poster presentation entitled, The role of androgen receptor in prostate luminal epithelial cells in normal development and carcinogenesis, at the Department of Defense IMPACT conference, March 9 - 12, 2011 in Orlando, FL.

Sara Montgomery, Bandelier National Monument, NMSara Montgomerya graduate student in the lab of Dr. William Bowers, attended the Keystone Symposia Conference on Neurodegenerative Diseases: The Molecular and Cellular Basis for Neurodegeneration, Februry 21 - 26, 2011 in Taos, NM. Her poster presentation was entitled, Ablated TNF-alpha Receptor Expression Leads to Enhanced Alzheimer's Disease Pathology in 3xTg-AD Mice.

 

I-Hsin Kuo (Advisor: Dr. Lisa A. Beck) will give oral presentations at two conferences: I-Hsin Fiona Kuothe 2011 Annual Meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI), to be held March 18-22, 2011 in San Francisco, CA. The title of the talk is Reduced Epidermal Expression of Toll-like Receptor 2 in Atopic Dermatitis--Another Explanation for Tight Junction Dysfunction? The 2nd presentation will be at the 71st Society for Investigative Dermatology Annual Meeting, May 4-7, 2011, in Phoenix, AZ. The title is Staphylococcus Aureus-derived PGN Enhances the Integrity of Epidermal Tight Junctions.

John Varrone

Researchers Unzip MRSA and Discover Route for Vaccine

John Varrone, a graduate student in Dr. Edward Schwarz’s lab, presented a talk, Evaluation of Anti-Glucosaminidase Monoclonal Antibodies as a Passive Immunization for Methicillin-Resistant Staphylococcus aureus (MRSA) Osteomyelitis, at the Orthopaedic Research Society Meeting in Long Beach, CA on January 13-16, 2011

 

Hsing-Yu Chen, a PhD student working in Dr. Mark Noble’s lab, won a poster award Hsing-Yu Warner Chenin the 15th Wilmot Cancer Center symposium on Nov 11th, 2010. The title of the poster was Sequestration of c-Cbl by Cdc42 cause resistance to Tamoxifen in breast cancer cells.

 

Robert D. Bell

The Pericyte Becomes a Player in Alzheimer’s, Other Neurodegenerative Diseases

Robert Bell (Advisor: Dr. Berislav Zlokovic) is a first co-author of a study just published in Neuron that demonstrates a key role for pericytes in brain capillary perfusion and blood flow, and that loss of pericytes results in progressive age-dependent neurodegeneration:

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

Robert D. Bell, Ethan A. Winkler, Abhay P. Sagare, Itender Singh, Barb LaRue, Rashid Deane, Berislav V. Zlokovic

See the Video Abstract at the article link above!

Sara Montgomery

Sara Montgomery, a PhD student in Dr. William Bowers ’ lab, has been awarded a National Institutes of Health NRSA F31 individual predoctoral fellowship. 

For the next four years, this fellowship will support her thesis project focused on stage-specific impact of TNF-alpha receptor signaling in Alzheimer's disease.

 

Mustimbo RobertsMustimbo Roberts, a graduate student in Dr. Inaki Sanz's lab, was selected to attend the Fifth Annual NIH National Graduate Student Research Festival, October 25-26, 2010 in Bethesda, MD. He will present a poster, B-cell Memory Heterogeneity Reveals Aberrant B-cell Homeostasis as a Signature of Primary Sjogren’s Syndrome. Mustimbo will also present a poster entitled B-cell Profiling Using Multi-color Flow cytometry as Biomarker of Disease Progression in Primary Sjogren’s Syndrome (pSS) at the 2010 American College of Rheumatology Annual Scientific Meeting in Atlanta, GA Nov 6-11th.

Scott Peslak in HawaiiScott Peslak, Advisor Dr. James Palis, was selected to receive a Scholars-in-Training (SIT) Travel Award for the Radiation Research Society 56th Annual Meeting, held in Maui, HI, September 26-29, 2010. His poster presentation was entitled Differential Dose Response Kinetics of Erythroblasts Following Sublethal Total Body Irradiation.

Shin-Jen LinShin-Jen Lin, Advisor Dr. Chawnshang Chang, presented a talk, Identify Natural and Synthetic Ligands/Activators for Testicular Nuclear Receptor 4 in San Diego at ENDO 2010, June 19 - 22, 2010.

 

 

Laura Nguyen

Laura Nguyen, a graduate student in Dr. Baek Kim's lab, presented a poster entitled Elevated Strand Transfer by Multiple NRTI Resistant HIV-1 RT Mutant Harboring a Two Amino Acid Insertion in the Fingers Domain at the Cold Spring Harbor Retrovirology conference May 24-29, 2010.

 

Study Helps Explain Male Dominance in Liver Cancer A study by Chawnshang Chang's laboratory published in Science Translational Medicine shows that the androgen receptor promotes liver cancer when hepatitis B is present by altering DNA replication of the virus. Androgen Receptor Promotes Hepatitis B Virus-Induced Hepatocarcinogenesis through Modulation of Hepatitis B Virus RNA Transcription

Ming-Heng Wu, Wen-Lung Ma, Cheng-Lung Hsu, Yuh-Ling Chen, Jing-Hsiung James Ou, Charlotte K. Ryan, Yao-Ching Hung, Shuyuan Yeh and Chawnshang Chang

Sara Montgomery

Sara Montgomery, Advisor Dr. William Bowers, won the 1st Place GSS Merit Award 2010 in the 1st - 3rd Year Category for her poster, Stage-specific Impact of TNF-alpha Receptor Signaling in Alzheimer's Disease, May 21, 2010.

 

 

I-Hsin Kuo

I-Hsin Kuo, a graduate student in Dr. Lisa Beck's lab, won the 2nd Place GSS Merit Award 2010 in the 1st - 3rd Year Category for her poster, Defect of Toll-like Receptor 2-mediated Barrier Function of Tight Junctions in Atopic Dermatitis, May 21, 2010.

 

 

Angela Aggrey

Angela Aggrey, a PhD student in Dr. Craig Morrell's lab, was awarded a National Institute of General Medical Sciences (NIGMS) Ancillary Training Program Travel Award for the Keystone Symposium: Malaria: New Approaches to Understanding Host-Parasite Interactions. The meeting took place April 11 - April 16, 2010 at Copper Mountain, Colorado. Her poster and platform presentation was entitled, "The Role of Platelets in Expermental Cerebral Malaria".

 

Scott Peslak

Scott Peslak, an MD/PhD student in Dr. James Palis’ lab, has been awarded a National Institutes of Health NRSA F30 individual predoctoral MD/PhD fellowship.  This fellowship, which will cover the remainder of his graduate and medical education, will support his thesis project focused on the response of the erythroid lineage to radiation and the mechanisms underlying marrow injury and recovery following sublethal radiation damage.

Tzu-Hua Dennis Lin

 

TzuHua Lin, a graduate student in the laboratory of Dr. ChawnShang Chang, has received a predoctoral fellowship from the Department of Defense Prostate Cancer Research Program. This fellowship supports up to three years of graduate stipend and travel funds. It will fund TzuHua's thesis project on the role of androgen receptor in prostate cancer.

 

 

Promoting Healing by Keeping Skeletal Stem Cells ‘Young’

Matthew Hilton, Ph.D.Dr. Matthew Hilton and his team published a study in the journal Development about how to increase the number and delay the development of stem cells that create bones, cartilage, muscle and fat, which in the future could aid treatment of osteoporosis, fractures, and arthritis.

RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

Yufeng Dong, Alana M. Jesse, Anat Kohn, Lea M. Gunnell, Tasuku Honjo, Michael J. Zuscik, Regis J. O'Keefe, and Matthew J. Hilton

Wen-Lung Maverick MaWen-Lung (Maverick) Ma has received a Scholar-in-Training Award from the American Association for Cancer Research. This prestigious award, which is offered for top-ranked abstracts, will provide $1000 for Maverick to present his talk, Androgen Receptor Roles in Hepatocellular Carcinoma, at the AACR 101st Annual Meeting in Washington, DC, April 17 - 21, 2010 (Advisor: Dr. Chawnshang Chang).

Jiann-Jyh Lai Kuo-Pao Lai

Jiann-Jyh Lai and Kuo-Pao Lai (Advisor: Dr. Chawnshang Chang) are co-authors of a study just published in the Journal of Clinical Investigation:

Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-α expression

Protein Central to Being Male Plays Key Role in Wound Healing

Jiann-Jyh Lai, Kuo-Pao Lai, Kuang-Hsiang Chuang, Philip Chang, I-Chen Yu, Wen-Jye Lin and Chawnshang Chang

Nikesha Haynes

Nikesha Haynes, a graduate student in the laboratory of Dr. William Ricke, has received a predoctoral fellowship from the Department of Defense Prostate Cancer Research Program. This fellowship supports up to three years of graduate stipend and travel funds. It will fund Nikesha's thesis project on prostate cancer.

mercedes szpunar

Mercedes Szpunar, an MD/PhD student in Dr. Edward Brown's lab, has received a Department of Defense Breast Cancer Research Program predoctoral fellowship. This fellowship, which supports up to three years of graduate stipend and travel funds, funds her thesis project focused on the effects of chronic stressor exposure on breast cancer growth. This study seeks to delineate how stress hormones alter tumor cell signaling, thereby promoting tumor growth and metastasis.

Scott Peslak

Scott Peslak, an MD/PhD student in Dr. James Palis' lab, will be presenting a poster entitled Erythropoietin-Associated CFU-E Expansion: A Novel Mechanism Responsible for Erythroid Recovery following Sublethal Radiation at the 51st Annual American Society for Hematology Annual Meeting and Exposition in New Orleans, LA, December 5-8, 2009.

Weber

Jon Weber, in Dr. Laura Calvi's lab, will present a poster, In Vivo Parathyroid Hormone Treatment Expands All Multipotent Primitive Hematopoietic Cell Subsets at the 51st American Society for Hematology Annual Meeting and Exposition, New Orleans, LA, December 5-8, 2009.

 

chen

Chun-Wei David Chen, of Dr. Peter Sims' lab, will present a poster entitled The Role of Phospholipid Scramblase 1 in G-CSF-induced Granulopoiesis at the 49th Annual Meeting of the American Society for Cell Biology (2009 ASCB) in San Diego, CA, December 5 - 9.

Edward Puzas, Ph.D.

Dr. J. Edward Puzas, who was appointed Senior Associate Dean for Basic Science Research earlier this year, Reveals New Visions for Research.

Benjamin Frisch and Laura Calvi

Ben Frisch, Rebecca Porter and Jon Weber (Advisor: Dr. Laura Calvi) are co-authors on a paper just published in BLOOD:

In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells

Study Promises Faster Recovery from Life-Threatening Blood Cell Shortages

Benjamin J. Frisch, Rebecca L. Porter, Benjamin J. Gigliotti, Adam J. Olm-Shipman, Jonathan M. Weber, Regis J. O'Keefe, Craig T. Jordan, and Laura M. Calvi*

Mustimbo Roberts

Mustimbo Roberts was selected to give an Oral Presentation at the Pathophysiology section of the 10th International Symposium on Sjogren's Syndrome to be held in October 2009 in Brest, France. UPDATE: Mustimbo won the Chairman's Award for best abstract of the session where he presented his work. (Advisor: Dr. Ignacio Sanz)

bell

Robert Bell will present a poster, The Role of Apolipoprotein E in Alzheimer's Disease Neurovascular Dysfunction, at the Society of Neuroscience conference, Neuroscience 2009, October 17 - 21, in Chicago.

Compound Shows Potential for Slowing Progression of ALS

Robert Bell (Advisor: Dr. Berislav Zlokovic) is a co-author of a paper just published in the Journal of Clinical Investigation:

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

Zhihui Zhong, Hristelina Ilieva, Lee Hallagan, Robert Bell, Itender Singh, Nicole Paquette, Meenakshisundaram Thiyagarajan, Rashid Deane, Jose A. Fernandez, Steven Lane, Anna B. Zlokovic, Todd Liu, John H. Griffin, Nienwen Chow, Francis J. Castellino, Konstantin Stojanovic, Don W. Cleveland and Berislav V. Zlokovic

Meina Wang

At the 31st ASBMR Annual Meeting, September 11-15, 2009 in Denver, Colorado, Meina Wang received the American Society for Bone and Mineral Research (ASBMR) Young Investigator Award of $1000 for her top-ranking abstract of her oral presentation," Overexpression of ß-catenin in Intervertebral Disc Cells Leads to Severe Destruction of Intervertebral Disc Tissue". (Advisors: Dr. Michael Zuscik and Dr. Di Chen)

Meina Wang won a travel award of $1100.00 to the 2009 Bones and Teeth Gordon Research Conference, July 11th-17th, 2009, at the University of New England in Biddeford, Maine. (Advisors: Dr. Michael Zuscik and Dr. Di Chen)

Dunn

David Dunn won First Place for Outstanding Poster Presentation entitled "Allotopic Expression of ATP6: mtDNA Mutation Modeling" at the 2nd Annual Boshell Diabetes and Metabolic Diseases Research Day , March 6, 2009, Auburn Alabama.

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