Cellular Signaling and Regulation

G protein Coupled Receptors
Calcium Signaling
Protein Kinases
Second Messenger Pathways

Signal transduction is the molecular basis for cellular communication, i.e., how hormones, growth factors, or pharmacological compounds regulate cell physiology, mitogenesis, and differentiation through binding to receptors. Defects in this cellular communication are responsible for a number of cancers and cardiovascular diseases. G protein coupled receptors are major targets for current therapeutics and therapeutic development. Understanding mechanisms of action of these receptor regulated systems will lead to novel strategies for therapeutic development.

	Jun-Ichi Abe, M.D., Ph.D. Mechanism and significance of kinase and transcriptional factors in diabetes-related cardiovascular disease. View Full Profile
	Bradford C. Berk, M.D., Ph.D. Molecular biology and genetics of cardiovascular disease. View Full Profile
	Jean M. Bidlack, Ph.D. Pharmacology of brain and lymphocytic opioid receptors. View Full Profile
	Burns C. Blaxall, Ph.D. Cardiac gene expression and G-protein coupled receptor signaling. View Full Profile
	Ian Dickerson, Ph.D. Molecular mechanisms of neuropeptide signal transduction. View Full Profile
	Robert S. Freeman, Ph.D. Molecular mechanisms of neuronal death. View Full Profile
	Angela J. Glading, Ph.D. Regulation of cell-cell contact in health and disease. View Full Profile
	Stephen R. Hammes, M.D., Ph.D. The Hammes laboratory studies ovarian development and function, focusing on how dysregulation of steroidogenesis and steroid signaling leads to diseases of androgen excess such as polycystic ovarian syndrome. View Full Profile
	Denise C. Hocking, Ph.D. Regulation of cell behavior by the extracellular matrix. View Full Profile
	Andrei I. Ivanov, Ph.D. Basic mechanism regulating the formation and functions of epithelial apical junctions as well as on mechanisms mediating disruption of epithelial cell-cell adhesions in inflammation and cancer. View Full Profile
	Zheng-Gen Jin, Ph.D. Molecular regulation of vascular endothelial function and vascular diseases. View Full Profile
	Paul J. Kammermeier, Ph.D. G protein coupled receptor signaling and modulation of ion channels in neurons. View Full Profile
	Nancy S. Krieger, Ph.D. Mechanisms of regulation of bone calcium metabolism, with an emphasis on signal transduction pathways involved in hormonal and acid-mediated effects on bone-cell function. View Full Profile
	Coeli M.B. Lopes, Ph.D. Molecular mechanisms of cardiac potassium channel regulation in health and disease. View Full Profile
	Keith Nehrke, Ph.D. Integrative physiology in the nematode C. elegans. View Full Profile
	George A. Porter, Jr., M.D., Ph.D. Regulation of cardiac development by intracellular calcium signaling and mitochondrial biogenesis. View Full Profile
	Ingrid H. Sarelius, Ph.D. Vascular cell communication and signaling. View Full Profile
	Alan V. Smrcka, Ph.D. Molecular mechanisms of signal transduction. View Full Profile
	Jane Sottile, Ph.D. Molecular mechanisms by which the extracellular matrix controls cell behavior. View Full Profile
	Gregory G. Tall, Ph.D. Mechanisms of signal transduction, heterotrimeric G protein signaling. View Full Profile
	Soundarapandian Vijayakumar, Ph.D. Signaling mechanisms that regulate epithelial differentiation; Mechanisms that contribute to cyst formation in Polycystic Kidney Disease (PKD). View Full Profile
	Richard E. Waugh, Ph.D. Regulation and molecular basis of the mechanical stability of cells, cell membranes, and cell adhesion. View Full Profile
	Chen Yan, Ph.D. Regulation and function of cyclic nucleotide phosphodiesterases in the cardiovascular system. View Full Profile
	David I. Yule, Ph.D. Mechanisms underlying Ca2+ signaling events in exocrine cells. View Full Profile