Department of Pediatrics - Cardiology Research

Cardiology Research

Research projects in the Division of Pediatric Cardiology at the University of Rochester Medical Center include the following:

Clinical Research

  • The Division participates as a sub-site for the Yale University Center of the National Heart, Lung, and Blood Institute-sponsored Pediatric Cardiac Genomics Consortium (PCGC). This international consortium will enroll thousands of patients and their families in the "Congenital Heart Disease Genetic Network Study (CHD Genes)," a multicenter, prospective observational study designed to investigate relationships between genetic factors and phenotypic and clinical outcomes of patients with congenital heart disease. The PCGC is part of the Bench to Bassinet Program, which also includes the Cardiovascular Development Consortium and the Pediatric Heart Network. Dr. George Porter is the site principal investigator for this study.
  • Dr. George Porter is recognized for his contributions to the landmark study called CHD Genes in a news release. The first published data from the study appeared in the journal Nature and focused on children with very serious heart defects.
  • Evaluation of clinical outcomes after pediatric surgical and catheter intervention procedures
  • Noninvasive evaluation of cardiac structure and function in patients with congenital and acquired heart disease
  • Exercise evaluation of patients with congenital and acquired cardiovascular disease
  • Evaluation of vascular function in patients with risk factors for atherosclerotic disease

Basic Science

  • Dr. George Porter’s laboratory studies mechanisms that control heart development from the embryo to that neonate. Active areas include understanding the role of bioenergetics, mitochondrial biology, and intracellular calcium signaling in the early heart. His group has recently determined that mitochondria can control myocyte differentiation in the embryo, and they are now determining if the same controls exist in the neonatal heart, where these findings can be used clinically. In addition, they are studying the basic mechanisms that control changes in energy production in the developing heart—how mitochondria become active and what controls this process. This work is relevant to the generation of congenital heart defects, the development of cardiomyopathies, and cardiac regeneration.

    Funded by: American Heart Association, National Institutes of Health/National Heart, Lung, and Blood Institute