Research projects in the Division of Pediatric Cardiology at the University of Rochester Medical Center include the following:
The Division participates as a sub-site for the Yale University Center of the National Heart, Lung, and Blood Institute-sponsored Pediatric Cardiac Genomics Consortium (PCGC). This international consortium will enroll thousands of patients and their families in the "Congenital Heart Disease Genetic Network Study (CHD Genes)," a multicenter, prospective observational study designed to investigate relationships between genetic factors and phenotypic and clinical outcomes of patients with congenital heart disease. The PCGC is part of the Bench to Bassinet Program, which also includes the Cardiovascular Development Consortium and the Pediatric Heart Network. Dr. George Porter is the site principal investigator for this study.
Evaluation of clinical outcomes after pediatric surgical and catheter intervention procedures
Noninvasive evaluation of cardiac structure and function in patients with congenital and acquired heart disease
Exercise evaluation of patients with congenital and acquired cardiovascular disease
Evaluation of vascular function in patients with risk factors for atherosclerotic disease
Dr. George Porter’s laboratory studies early heart development. The goal of these studies is to understand the basic mechanisms that control the development of the heart and the differentiation of cardiac myocytes. Active areas include understanding the role of bioenergetics, mitochondrial biology, and intracellular calcium signaling in the early heart. In addition, the Porter laboratory collaborates with Dr. Shey-Shing Sheu (formerly in the Department of Pharmacology and Physiology) and Dr. Robert Dirksen (Department of Pharmacology and Physiology) to investigate the role of the ryanodine receptor type 2 in regulating cardiac mitochondrial calcium levels and mitochondrial function. This work is relevant to the generation of congenital heart defects, the development of cardiomyopathies, and cardiac regeneration.
Funded by: American Heart Association, National Institutes of Health/National Heart, Lung, and Blood Institute