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Stem Cell & Disease Modeling Lab

Ruchira Singh, PhD

  • Assistant Professor - Department of Ophthalmology (SMD) - Primary Appointment
  • Assistant Professor - Department of Biomedical Genetics (SMD)
  • Assistant Professor - Center for Visual Science (RC)
  • PhD | Physiology | Kansas State University (2008)

Research Overview

The overall objective of our laboratory is to understand the molecular mechanism(s) of specific retinal and neurodegenerative diseases with the goal of developing pharmacological therapies. The current projects in the laboratory are focused on delineating the molecular and cellular basis of specific diseases that affect the outer retina including inherited and age-related macular degeneration. The approach to studying retinal physiology and disease development in the laboratory is utilizing patient-derived human induced pluripotent stem cells (hiPSCs) is summarized in the following schematic:

Singh research model

Current Projects

Publications

2014 Jun
Phillips MJ, Perez ET, Martin JM, Reshel ST, Wallace KA, Capowski EE, Singh R, Wright LS, Clark EM, Barney PM, Stewart R, Dickerson SJ, Miller MJ, Percin EF, Thomson JA, Gamm DM. "Modeling human retinal development with patient-specific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2."Stem cells. 2014 Jun; 32(6):1480-92.
2013 Oct
Singh R, Phillips MJ, Kuai D, Meyer J, Martin JM, Smith MA, Perez ET, Shen W, Wallace KA, Capowski EE, Wright LS, Gamm DM. "Functional analysis of serially expanded human iPS cell-derived RPE cultures." Investigative ophthalmology & visual science. 2013 Oct; 54(10):6767-78. Epub 2013 Oct 17.
2013 Sep 13
McDowell TS, Wang ZY, Singh R, Bjorling D. "CB1 cannabinoid receptor agonist prevents NGF-induced sensitization of TRPV1 in sensory neurons." Neuroscience letters. 2013 Sep 13; 551:34-8. Epub 2013 Jul 12.
2013 Jun 1
Gamm DM, Phillips MJ, Singh R. "Modeling retinal degenerative diseases with human iPS-derived cells: current status and future implications." Expert review of ophthalmology. 2013 Jun 1; 8(3):213-216.
2013 Feb 1
Singh R, Shen W, Kuai D, Martin JM, Guo X, Smith MA, Perez ET, Phillips MJ, Simonett JM, Wallace KA, Verhoeven AD, Capowski EE, Zhang X, Yin Y, Halbach PJ, Fishman GA, Wright LS, Pattnaik BR, Gamm DM. "iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration." Human molecular genetics. 2013 Feb 1; 22(3):593-607. Epub 2012 Nov 08.
2010
Yamauchi D, Nakaya K, Raveendran NN, Harbidge DG, Singh R, Wangemann P, Marcus DC. "Expression of epithelial calcium transport system in rat cochlea and vestibular labyrinth." BMC physiology. 2010 10:1. Epub 2010 Jan 29.
2009 Nov
Wangemann P, Kim HM, Billings S, Nakaya K, Li X, Singh R, Sharlin DS, Forrest D, Marcus DC, Fong P. "Developmental delays consistent with cochlear hypothyroidism contribute to failure to develop hearing in mice lacking Slc26a4/pendrin expression." American journal of physiology. Renal physiology. 2009 Nov; 297(5):F1435-47. Epub 2009 Aug 19.
2008 Jan
Singh R, Wangemann P. "Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model."American journal of physiology. Renal physiology. 2008 Jan; 294(1):F139-48. Epub 2007 Oct 24.
2006
Jabba SV, Oelke A, Singh R, Maganti RJ, Fleming S, Wall SM, Everett LA, Green ED, Wangemann P. "Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model." BMC medicine. 2006 4:37. Epub 2006 Dec 22.
2005 May
Singh R, Maganti RJ, Jabba SV, Wang M, Deng G, Heath JD, Kurn N, Wangemann P. "Microarray-based comparison of three amplification methods for nanogram amounts of total RNA." American journal of physiology. Cell physiology. 2005 May; 288(5):C1179-89. Epub 2004 Dec 21.