Faculty Member Laboratory Research Focus
Xin Bi, Ph.D.
Associate Professor of Biology

Bi Lab

Chromatin-mediated regulation of gene expression in eukaryotes.

Dirk Bohmann, Ph.D.
Professor of Biomedical Genetics

Bohmann Lab

The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease

Paul S. Brookes, Ph.D.
Associate Professor of Anesthesiology

Brookes Lab

Mitochondria and free radicals in cardiac ischemia-reperfusion

Michael D. Bulger, Ph.D.
Associate Professor of Pediatrics

Bulger Lab

Chromatin domains and long-range activation by enhancers

J. Scott Butler, Ph.D.
Associate Professor of Microbiology & Immunology

Butler Lab

Roles of ribonuclease toxins in the control of persistence and latency in pathogenic bacteria.

Gloria Culver, Ph.D.
Chair  and  Professor of Biology

Culver Lab

Assembly of the E. coli 30S ribosomal subunit, which is essential for cellular growth, so as to understand how infections might be controlled through selective inhibition of specific assembly control points.

Ian Dickerson, Ph.D.
Associate Professor of Neurobiology & Anatomy

Dickerson Lab

Molecular mechanisms of neuropeptide signal transduction

Mark E. Dumont, Ph.D.

Dumont Lab

Signal transduction; membrane protein structure, yeast molecular biology

Dmitri N. Ermolenko, Ph.D.
Assistant Professor of Biochemistry & Biophysics

Ermolenko Lab

Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.

Sina Ghaemmaghami, Ph.D.
Assistant Professor of Biology

Ghaemmaghami Lab

Molecular mechanisms of prion propagation and pathogenesis

David S. Goldfarb, Ph.D.
Professor of Biology

Goldfarb Lab

Molecular mechanisms that control the exchange of molecules and information between the nucleus and cytoplasm

Vera Gorbunova, Ph.D.
Professor of Biology

Gorbunova Lab

Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.

Elizabeth Grayhack, Ph.D.
Associate Professor of Biochemistry & Biophysics

Grayhack Lab

Role of the genetic code in regulating protein synthesis and mRNA metabolism in Saccharomyces cerevisiae.

Alan M. Grossfield, Ph.D.
Associate Professor of Biochemistry & Biophysics

Grossfield Lab

Investigating membranes and membrane proteins via computer simulation

Jeffrey J. Hayes, Ph.D.
Chair  and  Professor of Biochemistry & Biophysics

Hayes Lab

William A. Bernhard Memorial Lab

DNA structure; chromatin; protein-DNA interactions

Clara L. Kielkopf, Ph.D.
Associate Professor of Biochemistry & Biophysics

Kielkopf Lab

Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.

Hartmut Land, Ph.D.
Chair  and  Professor of Biomedical Genetics

Land Lab

Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism

Xin Zhiguo Li, Ph.D.
Assistant Professor of Biochemistry & Biophysics

Xin Li Lab

Small non-coding RNA regulation in germ cells; meiosis; male infertility.

Mahin Maines, Ph.D.

Maines Lab

Heme oxygenases and second messenger gases: CO and NO.

Lynne Maquat, Ph.D.

Maquat Lab

RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.

David H. Mathews, M.D., Ph.D.
Associate Professor of Biochemistry & Biophysics

Mathews Lab

Computational biology of RNA, including structure prediction, molecular dynamics, and genomics.

Margot Mayer-Pröschel, Ph.D.
Associate Professor of Biomedical Genetics

Mayer-Pröschel Lab

Stem Cells in the mammalian CNS / Gestational insults and embryonic CNS development / Astrocyte dysfunction

Benjamin L. Miller, Ph.D.
Professor of Dermatology

Benjamin Miller Lab

Carbohydrate and protein recognition, molecular design, and biomolecular sensing

Joshua C. Munger, Ph.D.
Associate Professor of Biochemistry & Biophysics

Munger Lab

Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.

Eric Phizicky, Ph.D.

Phizicky Lab

tRNA biogenesis, function and quality control; intellectual disability due to deficiencies in tRNA modifications.

Elaine Sia, Ph.D.
Associate Professor of Biology

Sia Lab

Mutagenesis and repair of the mitochondrial genome.

Harold C. Smith, Ph.D.

Smith Lab

RNA regulation of innate immune modulators and small molecule inhibitors of HIV RNA-binding proteins.

Alan Victor Smrcka, Ph.D.

Smrcka Lab

Molecular Mechanisms of Signal Transduction

Douglas H. Turner, Ph.D.
Professor of Chemistry

Turner Lab

Biophysical chemistry of RNA folding/stacking using NMR; RNA-targeted therapeutics (e.g., pseudoknot-regulated influenza A RNA translation; 3’-splice site and other regulatory intronic structures in influenza A).

Joseph E. Wedekind, Ph.D.

Wedekind Lab

Structure and function analysis of gene regulation by riboswitches and microRNAs as a basis for therapeutic development.

Yi-Tao Yu, Ph.D.

Yu Lab

RNA modification; pre-mRNA splicing; snRNP biogenesis; telomerase RNA modification and aging; nonsense-disease therapeutics.

Jiyong Zhao, Ph.D.
Associate Professor of Biomedical Genetics

Zhao Lab

Signal transduction and development of therapeutic agents in B-lymphomas; Cell cycle regulation

Jian Zhu, Ph.D.
Assistant Professor of Microbiology & Immunology

Zhu Lab

Host-virus interactions, particularly for HIV and herpes viruses