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Laurie A. Steiner, M.D.

Laurie A. Steiner, M.D.

Pediatrics, Neonatology

UR Medicine Faculty The University of Rochester Medical Faculty Group (URMFG) consists of over 900 specialist and primary care providers spanning 19 departments. URMFG is certified by the National Committee for Quality Assurance.
Accountable Health Partner Accountable Health Partners (AHP) is a network of over 2,000 community and UR medical faculty and a dozen leading hospitals throughout the region. AHP offers a full range of care.
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About Me

Neonatal Hematology

Faculty Appointments

Professor - Department of Pediatrics, Neonatology (SMD)

Lindsey Distinguished Professorship for Pediatric Research - Department of Pediatrics (SMD)

Credentials

Residency & Fellowship

Fellowship, Fellow, Yale New Haven Hospital. 2006 - 2010

Residency, Internship/Residency, Yale New Haven Hospital. 2004 - 2006

Internship, Pediatrics, Yale New Haven Hospital. 2003 - 2004

Education

MD | Mount Sinai Medical Center (USA). 2003

Awards

Ruth Lawrence Academic Faculty Service Award-Research. 2022

Strong Star Recognition for Excellence in Family Centered Care. 2022 - 2016

Ruth Lawrence Academic Faculty Service Award-Research. 2016

Inducted, Society for Pediatric Research. 2015

Basil O'Connor Starter Research Award. 2014

ICARE Bronze Star. 2014

American Society of Hematology Junior Faculty Scholar Award. 2013

Fellow's Basic Research Award. 2009

Best Basic Science Presentation. 2008

NIH Loan Repayment. 2008

Pediatric Scientist Development Program. 2006

Alpha Omega Alpha. 2003

Phi Beta Kappa. 1999

De Kiewit Research Fellowship. 1998

Research

~Genomics
~Epigenetics
~Hematology

The Steiner laboratory utilizes genomics techniques to study the molecular mechanisms underlying erythroid maturation and development. The laboratory is particularly interested in studying how specific DNA sequences, DNA binding proteins, and chromatin...
~Genomics
~Epigenetics
~Hematology

The Steiner laboratory utilizes genomics techniques to study the molecular mechanisms underlying erythroid maturation and development. The laboratory is particularly interested in studying how specific DNA sequences, DNA binding proteins, and chromatin structure interact during normal erythropoiesis. The laboratory is also interested in studying how those interactions are perturbed in disease states.

Research Lab

Publications

Journal Articles

Phenotypic and proteomic characterization of the human erythroid progenitor continuum reveal dynamic changes in cell cycle and in metabolic pathways.

Papoin J, Yan H, Leduc M, Le Gall M, Narla A, Palis J, Steiner LA, Gallagher PG, Hillyer CD, Gautier EF, Mohandas N, Blanc L

American journal of hematology.. 2023 November 6 Epub 11/06/2023.

HEXIM1 is an Essential Transcription Regulator During Human Erythropoiesis.

Lv X, Murphy K, Murphy Z, Getman MR, Rahman NF, Nakamura Y, Blanc L, Gallagher PG, Palis J, Mohandas N, Steiner LA

Blood.. 2023 September 22 Epub 09/22/2023.

Fetal akinesia deformation sequence syndrome associated with recessive TTN variants.

Alkhunaizi E, Martin N, Jelin AC, Rosner M, Bailey DJ, Steiner LA, Lakhani S, Ji W, Katzman PJ, Forster KR, Jarinova O, Shannon P, Chitayat D,

American journal of medical genetics. Part A.. 2022 December 10 Epub 12/10/2022.

Arid1a mutation suppresses TGF-? signaling and induces cholangiocarcinoma.

Guo B, Friedland SC, Alexander W, Myers JA, Wang W, O'Dell MR, Getman M, Whitney-Miller CL, Agostini-Vulaj D, Huber AR, Mello SS, Vertino PM, Land HK, Steiner LA, Hezel AF

Cell reports.. 2022 August 3040 (9):111253. Epub 1900 01 01.

HMGB1-Mediated Restriction of EPO Signaling Contributes to Anemia of Inflammation.

Dulmovits BM, Tang Y, Papoin J, He M, Li J, Yang H, Addorisio ME, Kennedy L, Khan M, Brindley EC, Ashley RJ, Ackert-Bicknell C, Hale J, Kurita RK, Nakamura Y, Diamond B, Barnes BJ, Hermine O, Gallagher PG, Steiner LA, Lipton JM, Taylor N, Mohandas N, Andersson U, Al-Abed Y, Tracey KJ, Blanc L

Blood.. 2022 January 18 Epub 01/18/2022.

Regulation of RNA Polymerase II Activity is Essential for Terminal Erythroid Maturation.

Murphy Z, Murphy K, Myers JA, Getman MR, Couch T, Schulz V, Lezon-Geyda K, Palumbo C, Yan H, Narla M, Gallagher PG, Steiner LA

Blood.. 2021 June 1 Epub 06/01/2021.

Codanin-1 Mutations Engineered in Human Erythroid Cells Demonstrate Role of CDAN1 in Terminal Erythroid Maturation.

Murphy ZC, Getman MR, Myers JA, Villar KNB, Leshen E, Kurita R, Nakamura Y, Steiner LA

Experimental hematology.. 2020 October 16 Epub 10/16/2020.

The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation.

Myers JA, Couch T, Murphy Z, Malik J, Getman M, Steiner LA

Epigenetics & chromatin.. 2020 March 1613 (1):16. Epub 03/16/2020.

Disruption of normal patterns of FOXF1 expression in a lethal disorder of lung development.

Steiner LA, Getman M, Schiralli Lester GM, Iqbal MA, Katzman P, Szafranski P, Stankiewicz P, Bhattacharya S, Mariani T, Pryhuber G, Lin X, Young JL, Dean DA, Scheible K

Journal of medical genetics.. 2019 October 29 Epub 10/29/2019.

Human erythroblasts with c-Kit activating mutations have reduced cell culture costs and remain capable of terminal maturation.

Couch T, Murphy Z, Getman M, Kurita R, Nakamura Y, Steiner LA

Experimental hematology.. 2019 June 74 :19-24.e4. Epub 04/18/2019.

ARID1A, a SWI/SNF subunit, is critical to acinar cell homeostasis and regeneration and is a barrier to transformation and epithelial-mesenchymal transition in the pancreas.

Wang W, Friedland SC, Guo B, O'Dell MR, Alexander WB, Whitney-Miller CL, Agostini-Vulaj D, Huber AR, Myers JR, Ashton JM, Dunne RF, Steiner LA, Hezel AF

Gut.. 2018 September 18 Epub 09/18/2018.

The Methyltransferase Setd8 Is Essential for Erythroblast Survival and Maturation.

Malik J, Lillis JA, Couch T, Getman M, Steiner LA

Cell reports.. 2017 November 2821 (9):2376-2383. Epub 1900 01 01.

Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation.

Li Y, Schulz VP, Deng C, Li G, Shen Y, Tusi BK, Ma G, Stees J, Qiu Y, Steiner LA, Zhou L, Zhao K, Bungert J, Gallagher PG, Huang S

Nucleic acids research.. 2016 September 644 (15):7173-88. Epub 05/03/2016.

CTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells.

Steiner LA, Schulz V, Makismova Y, Lezon-Geyda K, Gallagher PG

PloS one.. 2016 11 (5):e0155378. Epub 05/24/2016.

Histone methyltransferase Setd8 represses Gata2 expression and regulates erythroid maturation.

Malik J, Getman M, Steiner LA

Molecular and cellular biology.. 2015 June 35 (12):2059-72. Epub 04/06/2015.

Extensively self-renewing erythroblasts derived from transgenic ?-yac mice is a novel model system for studying globin switching and erythroid maturation.

Getman M, England SJ, Malik J, Peterson K, Palis J, Steiner LA

Experimental hematology.. 2014 July 42 (7):536-46.e8. Epub 04/02/2014.

Identification of biologically relevant enhancers in human erythroid cells.

Su MY, Steiner LA, Bogardus H, Mishra T, Schulz VP, Hardison RC, Gallagher PG

The Journal of biological chemistry.. 2013 March 22288 (12):8433-44. Epub 01/22/2013.

A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter.

Yocum AO, Steiner LA, Seidel NE, Cline AP, Rout ED, Lin JY, Wong C, Garrett LJ, Gallagher PG, Bodine DM

Blood.. 2012 October 25120 (17):3586-93. Epub 09/11/2012.

Patterns of histone H3 lysine 27 monomethylation and erythroid cell type-specific gene expression.

Steiner LA, Schulz VP, Maksimova Y, Wong C, Gallagher PG

The Journal of biological chemistry.. 2011 November 11286 (45):39457-65. Epub 09/21/2011.

Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation.

Pilon AM, Ajay SS, Kumar SA, Steiner LA, Cherukuri PF, Wincovitch S, Anderson SM, , Mullikin JC, Gallagher PG, Hardison RC, Margulies EH, Bodine DM

Blood.. 2011 October 27118 (17):e139-48. Epub 09/06/2011.

Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.

Li X, Wang S, Li Y, Deng C, Steiner LA, Xiao H, Wu C, Bungert J, Gallagher PG, Felsenfeld G, Qiu Y, Huang S

Blood.. 2011 August 4118 (5):1386-94. Epub 06/08/2011.

Partial exchange transfusion for polycythemia hyperviscosity syndrome.

Hopewell B, Steiner LA, Ehrenkranz RA, Bizzarro MJ, Gallagher PG

American journal of perinatology.. 2011 August 28 (7):557-64. Epub 03/01/2011.

Perinatal onset mevalonate kinase deficiency.

Steiner LA, Ehrenkranz RA, Peterec S, Steiner RD, Reyes-Múgica M, Gallagher P

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.. 2011 14 (4):301-6. Epub 03/22/2011.

Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis.

Gallagher PG, Steiner LA, Liem RI, Owen AN, Cline AP, Seidel NE, Garrett LJ, Bodine DM

The Journal of clinical investigation.. 2010 December 120 (12):4453-65. Epub 11/22/2010.

Functional analysis of a novel cis-acting regulatory region within the human ankyrin gene (ANK-1) promoter.

Laflamme K, Owen AN, Devlin EE, Yang MQ, Wong C, Steiner LA, Garrett LJ, Elnitski L, Gallagher PG, Bodine DM

Molecular and cellular biology.. 2010 July 30 (14):3493-502. Epub 05/17/2010.

Chromatin architecture and transcription factor binding regulate expression of erythrocyte membrane protein genes.

Steiner LA, Maksimova Y, Schulz V, Wong C, Raha D, Mahajan MC, Weissman SM, Gallagher PG

Molecular and cellular biology.. 2009 October 29 (20):5399-412. Epub 08/17/2009.

Canine elliptocytosis due to a mutant beta-spectrin.

Di Terlizzi R, Gallagher PG, Mohandas N, Steiner LA, Dolce KS, Guo X, Wilkerson MJ, Stockham SL

Veterinary clinical pathology. 2009 March 38 (1):52-8. Epub 10/28/2008.

An insulator with barrier-element activity promotes alpha-spectrin gene expression in erythroid cells.

Gallagher PG, Nilson DG, Steiner LA, Maksimova YD, Lin JY, Bodine DM

Blood.. 2009 February 12113 (7):1547-54. Epub 11/13/2008.

Erythrocyte disorders in the perinatal period.

Steiner LA, Gallagher PG

Seminars in perinatology.. 2007 August 31 (4):254-61. Epub 1900 01 01.

A decline in the frequency of neonatal exchange transfusions and its effect on exchange-related morbidity and mortality.

Steiner LA, Bizzarro MJ, Ehrenkranz RA, Gallagher PG

Pediatrics.. 2007 July 120 (1):27-32. Epub 1900 01 01.

Books

Neonatal Hematology Section; Avery's Neonatology Review. (2017)

Chapter: Neonatal Hematology Section; Avery's Neonatology Review.

Authors: Steiner, LA.

Publisher: N/A 2017