Faculty Appointments
Patient Care Settings
Cancer, Palliative Care, Pediatrics
Biography
I believe that children with cancer do best when they and their parents are full partners on the treatment team. That means sitting down, taking time, listening to them and their struggles, showing them you care, responding to them with openness and honesty, and offering our expertise (and our team's expertise) to meet their needs.
Pediatric hematology/oncology is an exciting and challenging field, and I feel very lucky and privileged to have an opportunity to work in this field. We are doing so much better than when I started a quarter century ago, but there is still much to be done and I still strive to make a difference for the children we treat. .My areas of expertise are pediatric neuro-oncology, in addition to adult and pediatric palliative care. I am just a regular guy who happened to choose pediatric hematology/ oncology as my life's work. My dress shirt and tie is a work costume – my real outfit is jeans and a T-shirt!
Conditions I Treat:
All pediatric cancers
Palliative care for children and adults
Professional Background
Professor of Pediatrics
Pediatric Hematology/Oncology
Hospice and Palliative Care Medicine
Dr. Korones is board certified in Pediatrics, Pediatric Hematology/Oncology, and Hospice and Palliative Medicine. He currently directs the Pediatric Brain Tumor Program and is the founder and director of the Pediatric Palliative Care Program at Golisano Children's Hospital at Strong. He is active locally, nationally and internationally, serving locally on the Board of Directors of Camp Good Days and DayStar, nationally, on the Editorial Board of the Art of Oncology for Journal of Clinical Oncology and on the Data Safety Monitoring and Review Board at St. Jude Children's Research Hospital. Internationally, he is a member of the steering committee of a program to bring formal pediatric hematology/oncology care and training to Ethiopia, and is a member of the SIOP-sponsored Pediatric Oncology in Developing Countries Wilms tumor study committee.
Research
My interests are focused on brain tumors in adults and children, and palliative care. I have conducted, and continue to conduct clinical trials for both children and adults with newly diagnosed and recurrent brain tumors. I have conducted a clinical trial through the Children's Oncology Group, and my current studies are local and multi-institutional investigator-initiated pharmaceutical-sponsored trials. I also have written review articles and chapters on brain tumors and palliative care, and conducted retrospective studies related to palliative care for children with cancer.
Credentials
Education
1983
MD | Vanderbilt University Medical Center
Post-doctoral Training & Residency
07/01/1988 - 06/30/1991
Fellowship in Pediatric Hematology-Oncology at University of Rochester Medical Center
07/01/1986 - 06/30/1988
Fellowship in Pediatrics at Yale New Haven Hospital
07/01/1984 - 06/30/1986
Residency in Pediatrics at University of Rochester Medical Center
07/01/1983 - 06/30/1984
Internship in Pediatrics at University of Rochester Medical Center
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Awards
2019
Connie Raffa Hospice Hero Award
Sponsor: Hospice & Palliative Care Association of New York(HPCANYS)
2015 - 2015
CURE Hometown Hero Award
Sponsor: CURE Childhood Cancer Association
Location: Rochester, New York
2015 - 2015
Rochester Business Journal Health Care Achievement Award
Location: Rochester, New York
2015 - 2015
Hastings Center Cunniff-Dixon Senior Physician Award in Palliative Care
2015
CURE Hometown Hero Award
Sponsor: CURE (Childhood Cancer Association)
2013 - 2013
Fellow of the American Academy of Hospice and Palliative Medicine
2010
Camp Good Days and Special Times Ring of Honor
Location: Rochester, NY
2009
Ruth A. Lawrence Academic Faculty Service Award in Clinical Services
Location: SMH, Rochester, NY
2008
Gold Humanism Honor Society
2007 - 2014
America's Top Cancer Doctors
2006
Make a Difference Award
Sponsor: Melissa's Living Legacy Foundation
2006
Leonard Tow Humanism in Medicine Award
2004 - 2009
Best Doctors in America list
Sponsor: America's Best Doctors
2004
The Rising Star Humanitarian Award
Sponsor: Make-a-Wish Foundation
2000
The Gitelman Award
Sponsor: Cancer Action and Gilda's Club
2000
The 2000 Miracle Maker Award for Outstanding Service by a Physician
2000
The Teddi Award
Sponsor: Camp Good Days and Special Times
1992
American Society of Clinical Oncology Young Investigator Award
1991
Outstanding Fellow Teaching Award
Sponsor: University of Rochester Medical Students of the Class of 1992
Location: University of Rochester
1989
Outstanding Fellow Teaching Award
Sponsor: University of Rochester Medical Students of the Class of 1990
Location: University of Rochester
1986
Outstanding Resident Teaching Award
Sponsor: University of Rochester Medical Students of the Class of 1987
Location: University of Rochester
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Clinical Trials
LOGGIC/FIREFLY-2: A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients With Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy
Lead Researcher: David N Korones
This is a 2-arm, randomized, open-label, multicenter, global, Phase 3 trial to evaluate the efficacy, safety, and tolerability of DAY101 monotherapy versus standard of care (SoC) chemotherapy in patients with pediatric low-grade glioma (LGG) harboring an activating rapidly accelerated fibrosarcoma (RAF) alteration requiring front-line systemic therapy.
View Study Details
A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients
Lead Researcher: David N Korones
This phase II trial studies how well reduced doses of radiation therapy to the brain and spine (craniospinal) and chemotherapy work in treating patients with newly diagnosed type of brain tumor called WNT)/Wingless (WNT)-driven medulloblastoma. Recent studies using chemotherapy and radiation therapy have been shown to be effective in treating patients with WNT-driven medulloblastoma. However, there is a concern about the late side effects of treatment, such as learning difficulties, lower amounts of hormones, or other problems in performing daily activities. Radiotherapy uses high-energy radiation from x-rays to kill cancer cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin, vincristine sulfate, cyclophosphamide and lomustine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving reduced craniospinal radiation therapy and chemotherapy may kill tumor cells and may also reduce the late side effects of treatment.
View Study Details
Publications
Journal Articles
5/18/2021
Fries C, Girvin AR, Korones DN, Weintraub L, Fitzpatrick L, Andolina JR. "Myeloablative Carboplatin and Thiotepa With Autologous Stem Cell Rescue for Nonmedulloblastoma High-risk CNS Tumors in Young Children." Journal of pediatric hematology/oncology.. 2021 May 18; Epub 2021 May 18.
12/20/2020
Buhlinger KM, Borlagdan J, Agegnehu B, Fentie AM, Bernstein AT, Urick BY, Roberts M, Weitzman S, Bekele W, Korones D, Alexander TB, Broas J, Shad A, Dinkiye AM, Clark SM, Adam H, Hailu D, Muluneh B. "Results of a pre-implementation analysis of Ethiopia's National Pediatric Cancer Registry." Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.. 2020 Dec 20; :1078155220980051. Epub 2020 Dec 20.
12/2020
Hailu D, Fufu Hordofa D, Adam Endalew H, Karimi Mutua D, Bekele W, Bonilla M, Çeliker MY, Challinor J, Dotan A, Habashy C, Kumar PN, Rodriguez-Galindo C, Wali RM, Weitzman S, Broas J, Korones DN, Alexander TB, Shad AT. "Training pediatric hematologist/oncologists for capacity building in Ethiopia." Pediatric blood & cancer.. 2020 Dec; 67(12):e28760. Epub 2020 Oct 13.
Books & Chapters
2017
Book Title: Pediatric Palliative Care and Hospice
Author List: Weaver M, Carter B, Keefer P, Korones DN, Miller ED
Published By: . 2017
2014
Chapter Title: Diffuse intrinsic pontine gliomas in children: treatment (an update)
Book Title: Tumors of the Central Nervous System
Author List: Bredlau AL, Korones DN
Edited By: MA Hayat
Published By: Springer 2014 in Netherlands
2014
Chapter Title: Palliative and Supportive Care
Book Title: Pediatric Hematology-Oncology in Countries with Limited Resources:
Author List: DuPlessis J, Korones DN
Edited By: Stefan DC, Rodriguez-Galindo C.
Published By: Springer 2014 in NY
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Videos
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Pediatric oncologist shares importance of supportive care team