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Nimish A. Mohile, M.D.

Contact Information

Phone Numbers

Appointment: (585) 275-5830

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Patient Care Settings

Cancer, Neurology

Biography

A board certified neurologist with specialty training in neuro-oncology, Dr. Nimish Mohile completed his residency in neurology at Northwestern University followed by a fellowship in neuro-oncology at Memorial Sloan-Kettering Cancer Center. Dr. Mohile joined the faculty at the University of Rochester in 2007 where he has a joint appointment in neurology and oncology. He sees patients at the James P. Wilmot Cancer Center and at Strong Memorial Hospital.

Dr. Mohile sees patients with primary and metastatic brain tumors and is involved in administering chemotherapy, treating seizures and managing side effects of brain tumors and brain tumor therapy. In addition, he does consultations on patients with neurologic complications of cancer or cancer treatments.
His research focuses on understanding the role of cancer stem cells in the progression of brain tumors. He is interested in developing novel therapies for the treatment of all types of brain tumors and is currently the principal investigator of several clinical trials at the University of Rochester.

Research

A board certified neurologist with specialty training in neuro-oncology, Dr. Nimish Mohile completed his residency in neurology at Northwestern University followed by a fellowship in neuro-oncology at Memorial Sloan-Kettering Cancer Center. Dr. Mohile joined the faculty at the University of Rochester in 2007 where he has a joint appointment in neurology and oncology. He sees patients at the James P. Wilmot Cancer Center and at Strong Memorial Hospital.

Dr. Mohile sees patients with primary and metastatic brain tumors and is involved in administering chemotherapy, treating seizures and managing side effects of brain tumors and brain tumor therapy. In addition, he does consultations on patients with neurologic complications of cancer or cancer treatments.
His research focuses on understanding the role of cancer stem cells in the progression of brain tumors. He is interested in developing novel therapies for the treatment of all types of brain tumors and is currently the principal investigator of several clinical trials at the University of Rochester.

Credentials

Specialties

  • Neurology - American Board of Psychiatry and Neurology

Education

2000
MD | St. George's University School of Medicine

Post-doctoral Training & Residency

07/01/2005 - 06/30/2007
Fellowship in at Memorial Sloan-Kettering Cancer Center

07/01/2004 - 06/30/2005
Fellowship in Neurophysiology at Northwestern University Medical School

07/01/2001 - 06/30/2004
Residency in Neurology at Northwestern University Medical School

07/01/2000 - 06/30/2001
Internship in Internal Medicine at Norwalk Hospital

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Awards

2015
A. B. Baker Teacher Recognition Award
Sponsor: American Academy of Neurology

2011
SWOG Travel Award Recipient
Sponsor: Southwest Oncology Group

2011
Neurology Faculty Teaching Award
Sponsor: University of Rochester
Location: Rochester, NY

2009
American Neurological Association Junior Academic Scholarship Award

2007
American Society of Clinical Oncology Foundation Merit Award
Sponsor: American Society of Clinical Oncology Foundation

2004
Graduate Medical Education Award for excellence in teaching medical students

2004
AAN Resident Annual Meeting Scholarship
Sponsor: American Academy of Neurology

1996 - 2000
Dean's List
Sponsor: St George's University
Location: Grenada, WI

1994
Dean's List
Sponsor: Duke University
Location: Durham, NC

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Clinical Trials

A Randomized, Multicenter, Phase 2 Study of DSP-7888 Dosing Emulsion in Combination with Bevacizumab versus Bevacizumab Alone in Patients with Recurrent or Progressive Glioblastoma following Initial Therapy,A Randomized, Multicenter, Phase 2 Study of DSP-7888 Dosing Emulsion in Combination with Bevacizumab versus Bevacizumab Alone in Patients with Recurrent or Progressive Glioblastoma following Initial Therapy

Lead Researcher: Nimish A Mohile

This is a dose-escalation study of DSP-7888 Dosing Emulsion administered to adult patients with advanced malignancies. Patients will be administered escalating doses of DSP-7888 Dosing Emulsion intradermally (between the skin layers) or subcutaneously (under the skin) in accordance with the following regimen: once weekly for four weeks during the Induction Phase, once every 7 to 14 days for 6 weeks during the Consolidation Phase, and once every 14 to 28 days until a discontinuation criterion is met during the Maintenance Phase. Once the highest dose with acceptable toxicity is determined from either the intradermal or subcutaneous group, an additional 40 patients may be enrolled as an expansion cohort at this dose and route of administration to confirm safety and tolerability. Separate from the dose-ascending cohort and expansion cohort described previously, and once the intradermal dose-ascending cohort is completed, up to 20 myelodysplastic syndrome (MDS) patients who are resistant to treatment with hypomethylating agents (HMAs) will be enrolled into an MDS expansion cohort. Of these 20 MDS patients, one-half will receive DSP-7888 at 10.5 mg according to the modified schedule employed in Phase 1 (every week for 4 weeks, every 2 weeks until Week 24, and then every 4 weeks [Named MDS Cohort 1]). The other half of the MDS patients will receive DSP-7888 at 10.5 mg in an alternative dosing schedule where DSP-7888 is administered every 2 weeks until Week 24, after which it will be administered every 4 weeks (Named MDS Cohort 2).

View Study Details

Publications

Journal Articles

1/2017
Gewandter JS, Dworkin RH, Finnerup NB, Mohile NA. "Painful chemotherapy-induced peripheral neuropathy: lack of treatment efficacy or the wrong clinical trial methodology?" Pain.. 2017 Jan 0; 158(1):30-33.

1/2017
Trusheim J, Dunbar E, Battiste J, Iwamoto F, Mohile N, Damek D, Bota DA, Connelly J. "A state-of-the-art review and guidelines for tumor treating fields treatment planning and patient follow-up in glioblastoma." CNS oncology.. 2017 Jan 0; 6(1):29-43. Epub 2016 Sep 15.

9/2016
Herr MM, Mohile NA, Barr PM, van Wijngaarden E, Brown EB, Rich DQ. "Survival of Secondary Central Nervous System Lymphoma Patients in the Rituximab Era." Clinical lymphoma, myeloma & leukemia.. 2016 Sep 0; 16(9):e123-e127. Epub 2016 Jun 08.

Books & Chapters

2007
Chapter Title: Principles of Chemotherapy
Book Title: Brain Tumors: Practical Guide to Diagnosis and Treatment
Author List: Abrey LE and Mohile NA
Edited By: Baehring J, Piepmeier J
Published By: Informa Health Care, USA 2007 in New York

2006
Chapter Title: Chemotherapy of Neuronal Tumors
Book Title: Handbook of Brain Tumor Chemotherapy
Author List: Mohile, N.A.; Raizer, J.J.
Edited By: Newton, H.B.
Published By: Elsevier 2006 in Amsterdam: Boston

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