Benjamin J. Frisch, Ph.D.

Contact Information

Biography

Research

Since 2007 my research career has had a translational focus, with a particular interest in microenvironmental support for the hematopoietic stem cell (HSC). Discovery of mechanisms of support for HSCs during both homeostatic and stressed hematopoiesis has evolved to the identification of novel therapeutic targets in malignant hematopoiesis, such as acute myeloid leukemia. My current research is focused on alterations of the bone marrow microenvironment induced by myeloid malignancies. This research has led to the identification of the chemokine CCL3 as a potential target for the treatment of acute myeloid leukemia. My future interests are in further characterization of the interactions between malignant hematopoiesis and the bone marrow microenvironment, with the ultimate goal of translation of novel therapeutic targets to clinical use.

Patents

Patent Title: Compositions and Methods for Controlled Localized Delivery of Bone Forming Therapeutic Agents
Patent #: 10,195,284
Issue Date: Feb 05, 2019
Country: United States
Invented By: Danielle SW Benoit, Benjamin J Frisch, Maureen Newman, J. Edward Puzas, Tzong-Jen Sheu

Publications

Journal Articles

2/2019
Frisch BJ. "The hematopoietic stem cell niche: What's so special about bone?" Bone.. 2019 Feb; 119:8-12. Epub 2018 May 17.

10/12/2018
Ayoub E, Wilson MP, McGrath KE, Li AJ, Frisch BJ, Palis J, Calvi LM, Zhang Y, Perkins AS. "EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription." Nature communications.. 2018 Oct 12; 9(1):4239. Epub 2018 Oct 12.

10/2/2018
Staversky RJ, Byun DK, Georger MA, Zaffuto BJ, Goodman A, Becker MW, Calvi LM, Frisch BJ. "The Chemokine CCL3 Regulates Myeloid Differentiation and Hematopoietic Stem Cell Numbers." Scientific reports.. 2018 Oct 2; 8(1):14691. Epub 2018 Oct 02.

Books & Chapters

2014
Chapter Title: Hematopoietic Stem Cell Cultures and Assays
Book Title: Methods in Molecular Biology
Author List: Benjamin J Frisch, Laura M Calvi
Edited By: Mathew J Hilton
Published By: Springer 2014

2013
Chapter Title: Hematopoiesis and Bone
Book Title: Primer on Metabolic Bone Diseases and Disorders of Mineral Nutrition
Author List: Benjamin J Frisch, Laura M Calvi
Edited By: Clifford J Rosen
Published By: Wiley-Blackwell 2013

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