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Archibald S. Perkins, M.D., Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-3399

Fax: (585) 756-4468

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Research Labs

Cancer research, using mouse models to investigate molecular mechanisms in acute myeloid leukemia and myelodysplastic syndrome, with focus on the function of the zinc finger oncoprotein EVI1.

Visit Cancer research, using mouse models to investigate molecular mechanisms in acute myeloid leukemia and myelodysplastic syndrome, with focus on the function of the zinc finger oncoprotein EVI1. Lab Website

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Faculty Appointments

Patient Care Setting

Pathology

Biography

Dr. Perkins is an active participant in the clinical hematopathology service as well as a researcher exploring the genes that impact the development of leukemias and other human malignancies. His primary focus is acute myeloid leukemia (AML), a particularly lethal type of cancer with no effective therapies at present. His clinical responsibilities include interpretation of bone marrow biopsies and smears, lymph node biopsies, and spleen; and laboratory analyses of coagulation disorders and hemoglobinopathies.

Professional Background

Dr. Perkins is an active participant in the clinical hematopathology service as well as a researcher exploring the genes that impact the development of leukemias and other human malignancies. His primary focus is acute myeloid leukemia (AML), a particularly lethal type of cancer with no effective therapies at present.

Research

Dr. Perkins' current research focus is on Evi1, a complex locus that plays a critical role in both normal Hematopoiesis and myeloid leukemogenesis. Evidence indicates that Evi1 is an important player in maintenance of the leukemic stem cell compartment by increasing proliferation and prolonging survival, in part through regulation of the transcription factor Gata2 and the anti-apoptotic molecule Bc12a1. His current work encompasses embryogenesis in genetically modified mice, identification of chromosomal Evi1 binding targets, Evi1 protein-protein interactions, clinical implications of chromosomal rearrangements involving Evi1, and exploration of potential therapeutic approaches to block the function of Evi1 in leukemia.

Credentials

Education

1986
MD | Columbia University College of Physicians & Surgeons

Post-doctoral Training & Residency

07/01/1988 - 06/30/1992
Fellowship at National Cancer Institute/National Institute of Health

07/01/1987 - 06/30/1988
Residency in Pathology, Anatomic Pathology & Clinical Pathology at Brigham & Womens Hospital

07/01/1986 - 06/30/1987
Internship in Pathology at Brigham & Womens Hospital

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Awards

1979
Phi Beta Kappa

1979
Sigma Xi

Publications

Journal Articles

11/16/2017
Crane GM, Perkins AS. "Leukemic presentation of diffuse large B-cell lymphoma: an unusual pattern associated with splenic involvement." Blood.. 2017 Nov 16; 130(20):2233.

5/11/2017
Mateo F, Arenas EJ, Aguilar H, Serra-Musach J, de Garibay GR, Boni J, Maicas M, Du S, Iorio F, Herranz-Ors C, Islam A, Prado X, Llorente A, Petit A, Vidal A, Català I, Soler T, Venturas G, Rojo-Sebastian A, Serra H, Cuadras D, Blanco I, Lozano J, Canals F, Sieuwerts AM, de Weerd V, Look MP, Puertas S, García N, Perkins AS, Bonifaci N, Skowron M, Gómez-Baldó L, Hernández V, Martínez-Aranda A, Martínez-Iniesta M, Serrat X, Cerón J, Brunet J, Barretina MP, Gil M, Falo C, Fernández A, Morilla I, Pernas S, Plà MJ, Andreu X, Seguí MA, Ballester R, Castellà E, Nellist M, Morales S, Valls J, Velasco A, Matias-Guiu X, Figueras A, Sánchez-Mut JV, Sánchez-Céspedes M, Cordero A, Gómez-Miragaya J, Palomero L, Gómez A, Gajewski TF, Cohen EE, Jesiotr M, Bodnar L, Quintela-Fandino M, López-Bigas N, Valdés-Mas R, Puente XS, Viñals F, Casanovas O, Graupera M, Hernández-Losa J, Ramón Y Cajal S, García-Alonso L, Saez-Rodriguez J, Esteller M, Sierra A, Martín-Martín N, Matheu A, Carracedo A, González-Suárez E, Nanjundan M, Cortés J, Lázaro C, Odero MD, Martens JW, Moreno-Bueno G, Barcellos-Hoff MH, Villanueva A, Gomis RR, Pujana MA. "Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition." Oncogene.. 2017 May 11; 36(19):2737-2749. Epub 2016 Dec 19.

6/24/2016
Wilson M, Tsakraklides V, Tran M, Xiao YY, Zhang Y, Perkins AS. "EVI1 Interferes with Myeloid Maturation via Transcriptional Repression of Cebpa, via Binding to Two Far Downstream Regulatory Elements." The Journal of biological chemistry.. 2016 Jun 24; 291(26):13591-607. Epub 2016 Apr 21.

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