A Randomized Phase II Study of Gemcitabine and Nab-Paclitaxel Compared With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan in Older Patients With Treatment Naïve Metastatic Pancreatic Cancer (GIANT)
Lead Researcher: Jason Zittel
This phase II trial compares two treatment combinations: gemcitabine hydrochloride and nab-paclitaxel, or fluorouracil, leucovorin calcium, and liposomal irinotecan in older patients with pancreatic cancer that has spread to other places in the body (metastatic). Drugs used in chemotherapy, such as gemcitabine hydrochloride, nab-paclitaxel, fluorouracil, leucovorin calcium, and liposomal irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This study may help doctors find out which treatment combination is better at prolonging life in older patients with metastatic pancreatic cancer.
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DiGiovanni G, Mousaw K, Lloyd T, Dukelow N, Fitzgerald B, D'Aurizio H, Loh KP, Mohile S, Ramsdale E, Maggiore R, Zittel J, Kadambi S, Magnuson A. "Development of a telehealth geriatric assessment model in response to the COVID-19 pandemic." Journal of geriatric oncology.. 2020 Apr 17; Epub 2020 Apr 17.
Loh KP, Kaushik R, Mohile SG, Ogie S, Kadambi S, Zittel J, Yousefi-Nooraie R, Moorthi K, Patil A, Sanapala C, Yang S, Ramsdale E. "Speeding the dissemination and implementation of geriatric assessment: What we can learn from the business world." Journal of geriatric oncology.. 2020 Mar 24; Epub 2020 Mar 24.
Loh KP, Duberstein P, Zittel J, Lei L, Culakova E, Xu H, Plumb S, Flannery MA, Magnuson A, Bautista J, Wittink M, Gilmore N, Targia V, Conlin A, Berenberg J, Vogel VG, Mohile SG. "Relationships of self-perceived age with geriatric assessment domains in older adults with cancer." Journal of geriatric oncology.. 2019 Dec 30; Epub 2019 Dec 30.
Books & Chapters
Chapter Title: Comorbidity in Aging and Cancer
Book Title: Geriatric Oncology
Author List: Ramsdale E.E., Zittel J., Sarfati D
Published By: Springer 2018
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