BGG Student Marco Zocchi Defends Thesis!
Wednesday, October 15, 2025
Congratulations to Marco Zocchi — Thesis Defense
Today, BGG Student Marco Zocchi successfully defended his thesis. After coming to Rochester from Boulder, Colorado, Marco pursued his thesis research in the lab of Isaac S. Harris, Ph.D. We congratulate Marco for reaching this milestone and wish him the best in his future endeavors.
Thesis title: Investigating the catabolism of extracellular glutathione by γ-glutamyltransferases as a non-canonical amino acid source and targetable vulnerability in cancers.
Short summary: Glutathione (GSH) is abundant in the tumor microenvironment and may act as a vehicle for amino acid delivery to tumors after GGT-mediated catabolism. Marco's work demonstrates that extracellular GSH and its catabolic products can support breast tumor growth and points to inhibiting GGT or depriving tumors of extracellular GSH as a potential therapeutic strategy.
University of Rochester Awarded Prestigious Aging Research Center Grant
Tuesday, July 15, 2025
The National Institutes of Health has awarded University of Rochester aging researcher Vera Gorbunova, PhD, a prestigious Nathan Shock Center grant. The grant will provide nearly $1 million per year over the next five years to establish the Upstate NY Comparative Biology of Aging Nathan Shock Center.
Lifespans vary widely—more than 100-fold—across the animal kingdom. The new center will compare the biology of various long- and short-lived animal species to identify biological mechanisms that promote longevity.
“It is about making people healthier overall,” says Gorbunova, the Doris Johns Cherry Professor of Biology, co-director of the Rochester Aging Research Center, and professor of Geriatrics/Aging at the University of Rochester Medical Center. “It really is about preventing all diseases.”
Gorbunova will lead a transdisciplinary team of faculty spanning the University and Medical Center, with expertise in veterinary biology, molecular biology, biochemistry, genetics, mass spectrometry, and bioinformatics.
“There are only eight centers like this in the country, so receiving this grant really puts us on the map in a more prominent way,” says Gorbunova.
Read More: University of Rochester Awarded Prestigious Aging Research Center GrantWhy Don’t Bats Get Cancer? Researchers Discover Protection from Genes and Strong Immune Systems
Monday, June 9, 2025
UR scientists studying longevity are seeking to apply their findings to humans.
A study to look at why long-lived bats do not get cancer has broken new ground about the biological defenses that resist the disease.
Reported in the journal Nature Communications, a University of Rochester research team found that four common species of bats have superpowers allowing them to live up to 35 years, which is equal to about 180 human years, without cancer.
Vera Gorbunova, PhD, and Andrei Seluanov, PhD, members of the UR Department of Biology and Wilmot Cancer Institute, led the work. Their key discoveries on how bats prevent cancer:
- Bats and humans have a gene called p53, a tumor-suppressor that can shut down cancer. (Mutations in p53, limiting its ability act properly, occur in about half of all human cancers.) A species known as the “little brown” bat—found in Rochester and upstate New York—contain two copies of p53 and have elevated p53 activity compared to humans. High levels of p53 in the body can kill cancer cells before they become harmful in a process known as apoptosis. If levels of p53 are too high, however, this is bad because it eliminates too many cells. But bats have an enhanced system that balances apoptosis effectively.
- An enzyme, telomerase, is inherently active in bats, which allows their cells to proliferate indefinitely. This is an advantage in aging because it supports tissue regeneration during aging and injury. If cells divide uncontrollably, though, the higher p53 activity in bats compensates and can remove cancerous cells that may arise.
- Bats have an extremely efficient immune system, knocking out multiple deadly pathogens. This also contributes to bats’ anti-cancer abilities by recognizing and wiping out cancer cells, Gorbunova said. As humans age, the immune system slows, and people tend to get more inflammation (in joints and other organs), but bats are good at controlling inflammation, too. This intricate system allows them to stave off viruses and age-related diseases.