Dr. Maiken Nedergaard

and Dr. Lauren Hablitz

Postdoc/Asst Prof – The Glymphatic System, Brain Clearance and Neuroglia under physiological conditions and in disease models.

The Center for Translational Neuromedicine at the University of Rochester invites applications for postdoctoral research associates and/or junior faculty positions in neuroscience to join the laboratory of Maiken Nedergaard, to study the glymphatic system and neuroglia signaling under physiological conditions and in disease models.

Full Postdoctoral Position Description

Paul Brookes

Twitter DM: @PSBROOKES

Department of Anesthesiology and Perioperative Medicine

Brookes Lab

Post-doctoral Position in Cardiac Metabolism

A post-doctoral fellowship position is available in the lab of Paul S. Brookes, PhD at the University of Rochester Medical Center (URMC). Our lab studies metabolism and mitochondria in the context of cardiac ischemia-reperfusion (IR) injury. This NIH-funded project (R01-HL071158) will investigate signaling pathways downstream of glycolysis and their roles as mediators of IR injury or cardioprotection.

This includes acidic pH, methylglyoxal and glycative stress-signaling, and succinate driven generation of reactive oxygen species. The project uses transgenic mouse models, chemical biology, in-situ fluorescence, and LC-MS based metabolomics analysis.

Full Postdoctoral Position Description

Dongmei Li

Clinical and Translational Science Institute (CTSI)

Dongmei Li Lab

Postdoctoral Research Fellowship

A postdoctoral research fellowship (up to 1 year with the possibility of continuation depends on the availability of funding) is available under the direction of Dongmei Li, PhD (Associate Professor of Clinical and Translational Research, University of Rochester Medical Center) at the University of Rochester.

This position is supported by an NIH/FDA-funded U54 center grant focused on research in flavored tobacco products. The Fellow will assist with analyzing the genetic and epigenetic data generated from the projects in the U54 grant as well as developing new methods to integrate and analyze multimodality data collected from different projects.

Dr. Deborah Ossip

Postdoctoral Fellowship in Population Health Research

The CTSI is seeking outstanding candidates for a Population Health Research Postdoctoral Fellowship. The position is fully funded for a one-year period with start dates in August 2022 and January 2023. The goal is to produce a diverse group of interdisciplinary researchers trained in team science and competency-based skills who can conceptualize research across the translational continuum from basic research through population health. Fellows choose one of three tracks: Electronic Health Record as a Resource for Research; National, Regional and Local Database Analytics; and Population Health Behavior Change.

Full Postdoctoral Position Description

Dr. Bin Zhang

Staff Scientist or Postdoctoral Position in Chromosome Biology & Synthetic Biology

A staff scientist/postdoctoral position available to work in the area of chromosome biology and synthetic biology. Dr. Bin Zhang’s lab in the department of Pathology and Laboratory Medicine, University of Rochester, NY, is looking for a highly motivated staff scientist or postdoctoral fellow to study the formation, plasticity and epigenetic inheritance of human centromere, and its applications for synthetic biology and potential clinical applications. 

Full Postdoctoral Position Description

Dr. Yi-Tao Yu
 

Postdoctoral Position in the Yu Lab

A Post-Doctoral Positions is available in the Yu Lab at the University of Rochester Medical Center in Rochester, NY. Applicants should hold a PhD or MD/PhD degree(s) and have expertise in molecular or cellular biology to study one of many ongoing projects: Nonsense suppression by RNA-guided RNA modification. Although not required, a computational or RNA biology background would facilitate the project. 

Full Postdoctoral Position Description

gail_johnsonvoll@urmc.rochester.edu

A postdoctoral position is available in the Nehrke and Johnson laboratories  at the University of Rochester School of Medicine and Dentistry to study how site-specific, Alzheimer’s disease (AD)-relevant posttranslational modifications (PTMs) of tau exert toxic effects through their impact on mitochondrial quality control pathways.

This position is funded through a multi-PI R01 NIH grant. This collaborative project utilizes both C. elegans and mammalian model systems to: (1) determine the impact of AD relevant tau PTMs on mitochondrial stress responses and how this influences healthy aging of neurons, (2) test whether tau with AD relevant PTMs alters mitophagy and whether changes in mitophagy contribute to phenotypic severity, (3) address whether enhancing mitochondrial quality control pathways is a viable therapeutic avenue. See pdf to view full postdoctoral job description.

Requirements:

A PhD in neuroscience or a relevant field is preferable, and the candidate must be eligible for employment in the U.S. Candidates are required to have at least one first author publication and be independently motivated with excellent written and oral communication skills. URMC has a 5 year limit on post-doctoral tenure and preference will be given to recent graduates. Interested applicants should submit (1) a cover letter with (2) a brief summary of research interests, (3) a complete curriculum vitae, and (4) contact information of three references to Gail Johnson (gail_johnsonvoll@urmc.rochester.edu).

Timeline: Review of applications will begin immediately, and will continue until the position is filled.

Full Postdoctoral Position Description

Kavaljit Chhabra

The Department of Medicine, Division of Endocrinology, is hiring a Postdoctoral Research Fellow to work in Dr. Kavaljit Chhabra’s lab. https://pubmed.ncbi.nlm.nih.gov/?term=kavaljit+chhabra&sort=date  

A major focus of the Chhabra lab is to determine how the brain regulates blood glucose levels in health and diabetes using mouse models. More information about the research can be found in these publications: https://pubmed.ncbi.nlm.nih.gov/?term=kavaljit+chhabra&sort=date  

Full Postdoctoral Position Description

Dr. Michael Telias

A Postdoctoral Research Associate position is available in the Laboratory of Dr. Michael Telias (Retinal Degeneration Lab) in the Flaum Eye Institute, Department of Ophthalmology, at the University of Rochester Medical Center.

This position will focus on using mouse and rat models of retinal degeneration, including mutations that cause retinitis pigmentosa, induced photo-toxicity and retinal detachment, to investigate the physiological and molecular mechanisms that underlie pathophysiological changes in the neuronal network of the inner retina. Death of the photoreceptors in the outer retina triggers a major pathophysiological phenomenon in the inner retina known as remodeling, which degrades residual vision and precludes meaningful vision restoration. We have identified retinoic acid and its receptor as critical in triggering remodeling and are designing and implementing therapeutic strategies to block its activation in the relevant retinal neurons. We are also interested in identifying other targets and elucidating the signaling cascade downstream to retinoic acid receptor activation. We employ methodology encompassing molecular biology, electrophysiology and visually-guided behavioral tasks. 

Applicants are required to have a Ph.D. and should have a strong background in cellular and molecular neuroscience, physiology and pharmacology, or vision science. Prior experience working with rodents, or in molecular cloning and genetic engineering is preferred. Experience in any electrophysiological technique, Calcium-imaging, neuronal morphology reconstruction and other imaging-related methods would be advantageous. Proven understanding of advanced statistical analysis is required. Please submit your application including a CV and the names and contact information of three professional references to Michael_Telias@urmc.rochester.edu or go to Telias Lab Job Openings

margie_shaw@urmc.rochester.edu

The Paul M. Schyve, MD, Center for Bioethics at the University of Rochester School of Medicine and Dentistry is offering a two-year Postdoctoral Associate position for PhDs.  

The 2022-2024 Postdoctoral Associate position is offered in collaboration with the University of Rochester Medical Center’s Office of Equity and Inclusion, with the Department of Health Humanities & Bioethics in the School of Medicine and the Department of History on the main campus.  The Fellowship is directed to candidates in the history of medicine and bioethics, with a focus on the history of race and medicine. This position is a full-time post-doctoral position.  The successful candidate will have experience working on questions of 19th or 20th century racism and medicine and be well-equipped to analyze the ethical dimensions of their findings. The Postdoctoral Associate will have mentorship opportunities available from historians and bioethicists on faculty as they work on this project.

The post-doctoral responsibilities include leading and supervising a research project on the local, institutional history of racism at the University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital. The Postdoctoral Associate will lead a research team including graduate students and undergraduate researchers who will examine local archives, practices and the impact of these legacies on current practices at the medical school and beyond.

Qualifications: Terminal degree with excellent oral and written communication skills, project management skills, and demonstrated ability to work with archival materials. The successful candidate is expected to have experience in collaborative projects.

Application: To assure full consideration, applicants should send a cover letter explaining background and interest in working with the Schyve Center. Please also include a c.v., three references with contact information, and a writing sample. 

Applications due by February 21, 2022.  Send by email or mail to:

Margie Hodges Shaw, JD, PhD, HEC-C
University of Rochester Medical Center,
601 Elmwood Ave, Box 676, Rochester, NY 14642

Full Postdoctoral Position Description

paul_dunman@urmc.rochester.edu.

A Post-Doctoral trainee position is available at the University of Rochester within the Department of Microbiology and Immunology to support research in antimicrobial drug discovery and bacterial pathogenesis. 

Successful applicants should have a strong background in microbiology and biochemistry or molecular biology.  Individuals with experience in animal models of infection and high throughput screening are highly encouraged to apply.  A Ph.D. in a relevant field and strong demonstration of research accomplishments is required.  Individuals must be able to work efficiently with a highly integrated research team, yet independently develop and perform studies and quickly interpret data in real time.  Applicants should email a cover letter, CV, and contact information for at least three references to paul_dunman@urmc.rochester.edu.

Review of applicants will begin immediately with flexible start dates.

The Department of Microbiology and Immunology strives to respect and acknowledge the experiences of the diverse backgrounds of all people. Our differences drive innovation and foster a collaborative culture that is essential to our educational and research missions.

elizabeth_leverenz@urmc.rochester.edu .

A Post-Doctoral Position is open in the Maquat Lab at the University of Rochester Medical Center in Rochester, NY.

Applicants should hold a PhD or MD/PhD degree(s) and have expertise in molecular, cellular, or structural biology to study one of a number of very exciting and ongoing projects, including but not limited to FMRP function in Fragile X Syndrome (FXS), newly defined effectors of nonsense-mediated mRNA decay, or the mechanistic coupling of transcription and RNA processing on chromatin and beyond. A background in neurobiology and/or stem-cell biology would facilitate the work on FXS (see, e.g., https://www.nature.com/articles/s41556-020-00618-1), and a background in computational biology would facilitate all projects, but neither is required.  

Full Postdoctoral Position Description

Benjamin Korman, M.D.

Qualifications: We are seeking a highly motivated individual who has excellent interpersonal skills, proactive attitude, attention to detail, and good work ethic. The individual must be dependable, and able to work both independently and in a team setting.

A strong candidate will have:

• A PhD in Pathology, Molecular Biology, Biochemistry, Immunology, or related disciplines or MD or MD/PhD and relevant experience
• Prior experience in molecular biology, cell culture, histologic techniques, and animal studies. Preference will be given to individuals with previous research experience in the areas of fibrosis, skin biology, or vascular biology
• Proven ability to present and publish research data
• Proficiency in spoken and written English.

How to Apply: Candidates should provide a cover letter and CV electronically to: Benjamin Korman, M.D., Assistant Professor of Medicine,
The University of Rochester, an Equal Opportunity Employer, has a strong commitment to diversity and actively encourages applications from candidates from groups underrepresented in high education.

Ruchira Singh

A  Postdoctoral Research Associate position is available in the Laboratory of Dr. Ruchira Singh (Stem Cell and Disease Modeling Laboratory) in the Department of Ophthalmology at the University of Rochester Medical Center.

This position will focus on using patient-derived  induced pluripotent stem cells (iPSCs) and relevant animal models for mechanistic and therapeutic approaches towards retinal degenerative diseases, including CLN3-Batten disease. CLN3-Batten/CLN3 disease is a lysosomal storage disorder characterized by childhood-onset vision loss, neurological impairment, and premature death. However, how disease-causing mutations in CLN3 cause photoreceptor cell death is not known. Applicants are required to have a Ph.D. and should have a strong background in cell and molecular biology with hands on experience in related techniques, including mammalian cell culture.

Prior experience in retinal cell biology, animal models, cell culture and CRISPR/Cas9 gene editing  is preferred; especially experience working with hiPSCs and retinal cells. Experience with and knowledge of statistical and image analysis software would be advantageous. Please submit your application including a cover letter, CV, and names of three professional references to ruchira_singh@urmc.rochester.edu.

Dr. Matthew McCall

Dr. Matthew N McCall is seeking to hire a postdoctoral research associate to join his research group at the University of Rochester Medical Center (URMC). This position is funded by an NIH/NIGMS R01 grant to develop novel methods for microRNA-seq data; however, the postdoctoral researcher will have the flexibility to engage in additional research areas such as modeling the effects of tissue composition and cellular localization on genomic measurements, developing methods to quantify and analyze changes in cell morphology, and modeling cellular networks. 

The McCall lab seeks to develop and apply the statistical methods required to tackle challenging problems in biomedical genomic research through open, rigorous, and reproducible methods and analyses. Our approach is highly interdisciplinary and collaborative, demonstrated by our affiliation with the Department of Biomedical Genetics, the Center for Biomedical Informatics, and the Goergen Institute for Data Science, and our long-term collaborations at both URMC and other institutions. 

Dr. McCall will provide consistent mentorship and work with the postdoctoral research to achieve their career goals. To this end, the postdoctoral researcher will have the opportunity to engage in scientific and professional development including presenting their work at local and national conferences, mentoring students, and participating in coursework or teaching, if they so choose. 

Environment: The University of Rochester is committed to fostering, cultivating, and preserving a culture of equity and inclusion. The University believes that a diverse workforce and inclusive workplace culture enhances the performance of our organization and our ability to fulfill our important missions. The University is committed to fostering and supporting a workplace culture inclusive of people regardless of their race, ethnicity, national origin, gender, sexual orientation, socio-economic status, marital status, age, physical abilities, political affiliation, religious beliefs or any other non-merit fact, so that all employees feel included, equal valued and supported. The University of Rochester has an active Postdoc Association that provides highly enriched environment for postdocs including career development workshops and social opportunities to get to know other postdocs. More information about postdoc activities and opportunities is available on this webpage: https://ccc.rochester.edu/pda/home/

Qualifications: The applicant should have a PhD in statistics, data science, biostatistics, bioinformatics, computational biology, or a related field.  Candidates with a background in the biological sciences and strong quantitative skills are also encouraged to apply. Experience with statistical programming in R is desirable. Successful candidates will also have excellent communication skills, strong organizational skills, and a proven track record of collaborative, peer-reviewed publications.

How to Apply: The start date for this position is flexible. Applicants should email a single PDF containing a statement of research interests, contact information for two references, and a current CV to Dr. Matthew McCall: Matthew_Mccall@urmc.rochester.edu

Apply online to Job ID 234081

POSITION SUMMARY:
The department of Pathology and Laboratory Medicine, University of Rochester, New York is looking for a highly motivated development technologist to work in the department of Molecular Diagnostics.  The candidate should hold a PhD degree, or Master’s degree with stand-out research experience, and have a strong background in Molecular biology.  
 
KEY JOB RESPONSIBILITIES:

• Leads the development, maintenance and enhancement of molecular assays; performs test verification studies in accordance with NYSDOH submission packets, validations and writes procedure manuals and training checklists. Maintains written and verbal communication with supervisors and lab directors.
• May assist in training of some laboratory personnel.
• Investigates problems and initiates solutions either independently or in consultation with supervisor, as of situation warrants. Keeps supervisor apprised of problems and actions.
• Keeps abreast of trends in the field of interest by studying current research literature

QUALIFICATIONS:
Master's degree in related science and at least 6 years of relevant molecular experience or PhD in a related science with 3 years of relevant molecular experience or an equivalent combination of education and experience. Ph.D. preferred.

TO APPLY:
Apply online to Job ID 234081.   Include a CV, names of three references, and a brief summary of previous research experience and future interests with the application.   

The University of Rochester is committed to fostering, cultivating, and preserving a culture of equity and inclusion. The University believes that a diverse workforce and inclusive workplace culture enhance the performance of our organization and our ability to fulfill our important missions. The University is committed to fostering and supporting a workplace culture inclusive of people regardless of their race, ethnicity, national origin, gender, sexual orientation, socio-economic status, marital status, age, physical abilities, political affiliation, religious beliefs, or any other non-merit fact so that all employees feel included, equal valued and supported.

Dr. David MacLean

An NIH-funded postdoctoral position is immediately available in the MacLean lab in the Department of Pharmacology and Physiology at the University of Rochester, NY.

We seek an enthusiastic and motivated researcher to join our team to study the biophysics of glutamate receptors and acid-sensing ion channels. Research will be focused on understanding essential mechanisms of channel activation and desensitization and how these processes can be modulated. Our work combines patch clamp electrophysiology with fast perfusion, non-canonical amino acid incorporation, mathematical modelling and fluorescence spectroscopy approaches.

Martha Susiarjo,PhD

A Post-Doctoral Position is open in the Susiarjo Lab in the Department of Environmental Medicine, at the University of Rochester Medical Center in Rochester, NY. 

Applicants should hold a PhD and have expertise in developmental biology, environmental health science, molecular, or cellular biology. As a member of the Susiarjo lab, the postdoc will investigate how environmental factors (e.g., exposure to endocrine disrupting chemicals and differences in micronutrient status) during pregnancy can modulate maternal and fetal health outcomes. Members of the Susiarjo lab utilize genetic and epigenetic methods in combination with reproductive and metabolic studies to elucidate how gene-environment interaction during pregnancy reprograms epigenetic marks during development and modulates disease susceptibilities using the mouse model. Researchers are expected to carry out standard molecular biology and epigenetic methods. We offer a very collaborative, collegial atmosphere, along with a lively, supportive research community spanning the University of Rochester Medical Center. 

The city of Rochester provides a safe, beautiful, affordable, and family-friendly environment. Qualified applicants will have earned a Ph.D. and should be highly motivated and possess a genuine interest in research directions pursued by the Susiarjo laboratory. 

Applicants should provide a cover letter describing their past projects and career goals, and their CV with names and contacts of three references. Please send emails to martha_susiarjo@urmc.rochester.edu

Dr. Collynn Woeller

NIH Funded Postdoctoral Position in the Woeller Lab

An NIH-funded postdoctoral position is available in the laboratory of Dr. Collynn F. Woeller at the Flaum Eye Institute at the University of Rochester to study the molecular and cellular pathways that drive tissue remodeling and scarring in eye disease.  Individuals who have recently earned a Ph.D. or MD/Ph.D. degree and are passionate about research are encouraged to apply.  Experience in molecular and cellular biology is required.  Our laboratory investigates molecular pathways that drive thyroid eye disease and ocular scarring to: 1) understand the underlying pathophysiology and 2) identify novel targets that may help treat, prevent and even cure fibrotic eye disease.

Experience with cell culture models, molecular biology, animal models of disease, whole genome profiling and CRISPR are a plus. Interested applicants should send curriculum vitae, a brief description of research interests, and the contact information of three references to Dr. Collynn Woeller at collynn_woeller@urmc.rochester.edu.

Piera Inglese

Post-doctoral Fellowship, Cardiac Mitochondrial Biology, University of Rochester NY.

A post-doctoral fellowship position is available in the lab of George Porter at the University of Rochester Medical Center (URMC), to work on cardiac mitochondrial biology during cardiac development. The NIH-funded project focuses on the role of the mitochondrial chaperone protein, cyclophilin D,  in regulating mitochondrial function and myocyte differentiation in the neonatal heart (see related recent publications: PMIDs 28141792, 29101324, 28530678, 30558250). Please submit your application including a cover letter, CV, and names of three professional references to Piera_Inglese@URMC.Rochester.edu.

Ruchira Singh

A NIH funded postdoctoral position is available in the Stem Cell and Disease Modeling Laboratory at University of Rochester to study the role of extracellular matrix (ECM) alterations in macular degeneration. The specific focus of this project would include matrix metalloproteinase activity and regulation, ECM turnover and its impact on the function of retinal pigment epithelium and retinal pigment epithelium-vascular interaction in a relevant animal model and 3D bioengineered induced pluripotent stem cell model of macular degeneration recently developed by our laboratory. Ultimately the goal is to identify the molecular basis of drusen formation and choroidal neovascularization in patient-derived “human cell models” of inherited and age-related maculopathies. The overall objective of our laboratory is to understand the molecular mechanism(s) of specific retinal and neurodegenerative diseases with the goal of developing pharmacological therapies. Furthermore, the research projects in the laboratory have an integrated focus on retinal physiology, neurodegenerative diseases, stem cells and pharmacology. The tissue/cells utilized to interrogate the molecular mechanism(s) of retinal and neurodegenerative diseases, including inherited and age-related macular degeneration, include patient-derived human iPSCs, gene-edited (CRISPR) hiPSCs, primary eye tissue and relevant animal models. 

Well-qualified candidates will have the following qualifications/ experience: A Ph.D. in biological sciences. Prior experience in retinal cell biology, animal models, cell culture and CRISPR/Cas9 gene editing  is preferred; especially experience working with hiPSCs and retinal cells. Experience with and knowledge of statistical and image analysis software would be advantageous.

Please submit your application including a cover letter, CV, and names of three professional references to ruchira_singh@urmc.rochester.edu.

Dr. Douglas Anderson

A postdoctoral position in the laboratory of Dr. Douglas M. Anderson in the Cardiovascular Research Institute and Center for RNA Biology is available to develop novel RNA and DNA targeting technologies, such as CRISPR-Cas systems, to investigate the molecular mechanisms underlying cardiovascular biology and as potential therapeutics for treating cardiovascular disease. Candidates should have recently earned a Ph.D. or MD/Ph.D degree(s). Expertise in cell and molecular biology is required, and experience with mouse handling a plus. Interested applicants should send curriculum vitae, a brief description of research interests, and contact information of three references to Dr. Douglas Anderson at: Doug_Anderson@urmc.rochester.edu.

The University of Rochester School of Medicine and Dentistry is an Equal Opportunity Employer.
 

Amanda Augustin

Postdoc fellow for an NIH-funded study of late-stage erythropoiesis.

The focus of the lab is to investigate the mechanisms behind the dramatic condensation of chromatin that occurs during erythropoiesis, prior to enucleation. Evidence from our group and others suggests that this involves the activation of pathways that are otherwise limited to apoptotic cells.

The project therefore involves studies of chromatin structure, gene expression, post-translational modifications of histones and other proteins, erythroid differentiation and apoptotic processes, and has relevance to disorders that result in anemia, including myelodysplastic syndromes (MDS).

Full Postdoctoral Position Description

Dr. John Foxe
 

Dr. Ed Freedman

Department of Neuroscience 
 

Cognitive Neurophysiology Lab

Postdoctoral Position in Cognitive Neuroscience
 

The Cognitive Neurophysiology Laboratory (CNL) directed by Dr. John Foxe and co-directed by Dr. Ed Freedman is hiring post-doctoral fellows specializing in the human and/or murine neurophysiology.

The CNL at Rochester is a large lab with a wide-ranging program of research including, but not limited to mouse models of neurodevelopmental disorders, human electrocorticography, stationary and mobile human electroencephalography, and both structural and functional MRI. In addition to basic neurophysiology, current and future projects will involve the study of processing impairments associated with such diseases as schizophrenia, autism, Rett Syndrome, Alzheimer's disease and other neurologic disorders and diseases.

Full Postdoctoral Position Description